Clinical trials: Intraabdominal Infections
Complicated Intra-abdominal Infection
Study to Assess Efficacy and Safety of PF-06947386 in Japanese Adult Patients With Complicated Intra-abdominal Infection
Study C3591036 is a Phase 3 study to assess the efficacy and safety of PF-06947386 in Japanese adult patients with complicated intra-abdominal infection requiring hospitalization.
- Trial name
- NCT04927312
- Testing
- PF-06947386, Metronidazole
- Where
- 29 sites in Japan
- Volunteers
- 60 people
- Sponsor
- Pfizer
Acute Appendicitis
Acute Appendicitis and Microbiota - Etiology of Appendicitis and Antibiotic Therapy Effects
Appendicectomy has been the treatment of acute appendicitis for over a hundred years. Appendicectomy, however, includes operative and postoperative risks despite being a routine procedure.
- Trial name
- MAPPAC (NCT03257423)
- Testing
- Ertapenem followed by levofloxacin and metronidazole, Moxifloxacin, Appendectomy
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Turku University Hospital
Appendicitis, Appendicitis Acute
a Retrospective Observational Study Comparing Outcomes of Retrocaecal Appendicitis With Non-retrocaecal Appendicitis
A retrospective observational study investigating whether retrocecal appendicitis associated with worse operative and postoperative outcomes than non-retrocecal appendicitis.
- Conditions
- Appendicitis, Appendicitis Acute, Retrocecal Appendicitis
- Trial name
- NCT05315869
- Testing
- Appendectomy
- Where
- Czechia
- Volunteers
- 754 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Acute Uncomplicated Appendicitis
Direct Visualization ERAT Versus Laparoscopic Appendectomy in Adults With Acute Uncomplicated Appendicitis
This study compares two ways of treating acute uncomplicated appendicitis, which is a mild form of appendicitis. In the Direct Visualization ERAT group, participants will receive Endoscopic Retrograde Appendicitis Therapy (ERAT).
- Trial name
- E-APPEND (NCT07230379)
- Testing
- Direct Visualization Endoscopic Retrograde Appendicitis Therapy, Laparoscopic appendectomy
- Where
- 14 sites in China
- Volunteers
- 376 people
- Sponsor
- Changhai Hospital
Covid19, Appendicitis
the Impact of COVID-19 Pandemic on the Incidence and Outcome of Complicated Appendicitis
During the COVID-19 pandemic, we noticed a rise in complicated appendicitis cases presenting to our medical center. We collected objective data on all patients admitted to the surgical department with appendicitis during February…
- Trial name
- NCT04786041
- Testing
- laparoscopic appendectomy
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
Abdominal Compartment Syndrome, Intra-abdominal Hypertension
Peritoneal Vacuum Therapy to Reduce Inflammatory Response From Abdominal Sepsis/Injury
This pilot study will evaluate the effectiveness in actively removing the peritoneal fluid through the use of a commercial suction device compared to passive drainage of the same peritoneal fluid drained through standard surgical…
- Trial name
- SAD (NCT01355094)
- Testing
- KCI AbThera, "Stampede" VAC
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Acute Appendicitis
Preoperative Immature Granulocyte Count and Percentage for Acute Appendisitis
Appendectomy is the most effective treatment option for acute appendisitis, which is the most commen emergent surgical pathology. However with in time period, surgical treatment borders are narrowed.
- Trial name
- NCT04440150
- Testing
- Appendectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Sepsis Abdominal
Perioperative Sepsis. An Epigenetic Perspective
This single-center, prospective, observational study evaluates the impact of perioperative sepsis on inflammatory response, coagulation abnormalities, cardiac dysfunction, and microRNA expression in adult patients undergoing…
- Trial name
- PESE (NCT07442552)
- Testing
- • Presepsin • C-reactive protein (CRP) • Fibrinogen • Aspartate aminotransferase (AST) • Alanine aminotransferase (ALT) • Creatinine • Urea • Creatine kinase (CK) • Creatine kinase-MB (CK-MB) • NT-pro
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Appendicitis With Perforation, Appendectomy
Effect of Probiotic's Consumption on Several Markers in Perforated Appendix Patients With Diffuse Peritonitis
Does the administration of the probiotic Lactobacillus plantarum sp. have an impact on reducing leukocyte levels, segmented neutrophil counts, postoperative pain, and length of hospitalization in patients with diffuse peritonitis…
- Conditions
- Appendicitis With Perforation, Appendectomy, Probiotic
- Trial name
- NCT06856434
- Testing
- Lactobacillus plantarum sp Probiotic
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Padjadjaran
Acute Complicated Appendicitis With Diffuse Peritonitis
Laparoscopic Versus Open Appendectomy Plus Peritoneal Lavage for Acute Complicated Appendicitis Patients With Diffuse Peritonitis
This study aim to evaluate the efficacy and safety of laparoscopic versus open appendectomy in the treatment of acute complicated appendicitis with diffuse peritonitis.
- Trial name
- NCT06633744
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
Infection
A Comparative Phase IV Study Evaluating Efficacy & Safety Of Magnex(Cefoperazone-Sulbactam) In Intraabdominal Infections
Intra-abdominal infections are often polymicrobial, and include aerobic as well as anaerobic bacteria. Antibiotics used in intra-abdominal infections should aim to cover organisms such as Enterobacteriaceae and Bacteroides…
- Trial name
- NCT00360607
- Testing
- Magnex (Sulbactam Sodium/Cefoperazone Sodium 1:1) Pfizer Ltd., Fortum (Ceftazidime for injection USP) Glaxo Smith Kline Pharmaceuticals Limited, Metrogyl (Metronidazole Injection IP) J.B.Chemicals & Pharmaceuticals Ltd.
- Where
- 20 sites in India
- Volunteers
- 307 people
- Sponsor
- Pfizer
Urinary Tract Infection (cUTI), Intra-abdominal Infection (cIAI) and
Reporting Patterns and Results of Initial Antibiotic Treatment in Patients With cUTI, cIAI,NP Including VAP
Reporting patterns and results of initial antibiotic treatment in patients with complicated urinary tract infection (cUTI), complicated intra-abdominal infection (cIAI) and nosocomial pneumonia (NP) including…
- Conditions
- Urinary Tract Infection (cUTI), Intra-abdominal Infection (cIAI) and, Nosocomial Pneumonia (NP)
- Trial name
- RECOMMEND (NCT02364284)
- Where
- 27 sites in Brazil, France and 4 more
- Volunteers
- 1,322 people
- Sponsor
- Pfizer
Appendicitis, Surgery
Raja Isteri Pengiran Anak Saleha Appendicitis Treatment Without Operation
The RIPASA score is a Clinical Prediction Rule (CPR) for the diagnosis of acute appendicitis. Since its inception in 2009, the RIPASA score has been validated in various population in healthcare institutions around the world and…
- Trial name
- RIPASA-TWO (NCT03169114)
- Testing
- Amikacin Injection, Appendicectomy
- Where
- Brunei
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Raja Isteri Pengiran Anak Saleha Hospital
Acute Appendicitis, Acute Abdomen
Transversus Abdominis Plane Block in Acute Appendicitis Pain Managment
In this study, it was aimed to investigate the analgesic efficacy of the preoperatively applied Transversus Abdominis Plane (TAP) Block in the management of acute appendicitis-related abdominal pain and post-appendectomy pain.
- Conditions
- Acute Appendicitis, Acute Abdomen, Postoperative Pain
- Trial name
- NCT05004532
- Volunteers
- 22 people
- Sponsor
- Erol Olcok Corum Training and Research Hospital
Perforated Appendicitis
Perforated Appendicitis and Postoperative Antibiotics Pilot Trial
The goal of this clinical trial is to learn if not giving antibiotics is as effective as giving antibiotics after surgery for patients who have surgery for a perforated (burst) appendix.
- Trial name
- PAPA Pilot (NCT07656636)
- Testing
- Postoperative antibiotico-prophylaxis, No postoperative antibiotics
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Surgery, Pancreatitis
Active Versus Non Active Drainage for the Treatment of Infected Intra-abdominal Collection
The Percutaneous drainage of symptomatic intra-abdominal collection (primary or secondary to surgery)is the treatment of choice in the absence of peritonitis signs.
- Conditions
- Surgery, Pancreatitis, Diverticulitis, Appendicitis
- Trial name
- NCT01513421
- Testing
- Percutaneous drainage of intra-abdominal collection
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Ascites, Peritoneal Carcinomatosis
Comparison of "Roll-over' Technique With Standard Abdominal Paracentesis in Suspected Peritoneal Carcinomatosis
The study will be a randomized trial that will compare two techniques of abdominal paracentesis in patients with suspected peritoneal carcinomatosis.
- Conditions
- Ascites, Peritoneal Carcinomatosis, Peritoneum Neoplasm, Tuberculous Peritonitis
- Trial name
- ROLLON (NCT04232384)
- Testing
- Standard Paracentesis, Roll Over Paracentesis
- Where
- India
- Volunteers
- 71 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Peritoneal Inflammation, Peritoneum; Injury
Effect of Warmed Humidified CO2 on Peritoneum During Laparotomy
The operating theatre is deliberately made to be cold and dry to prevent bacteria from growing. The problem with this is that during open abdominal surgery, the intestine and the overlying peritoneum is exposed to cold dry air.
- Trial name
- NCT02975947
- Testing
- Humidified, warmed CO2 insufflation of open peritoneum using Fisher & Paykel's HUMIGARD (Fisher & Paykel Healthcare Ltd, Auckland, New Zealand), Standard heating
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Concord Repatriation General Hospital
Laparoscopic Surgery, Acute Appendicitis With Rupture
Open to Laparoscopic Reverse Conversion of Perforated Appendicitis
A Prospective Randomized Controlled Trial of Reverse Conversion (Open to Laparoscopic) in management of Acute Perforated Appendicitis
- Conditions
- Laparoscopic Surgery, Acute Appendicitis With Rupture, Sepsis, Abdominal Abscess
- Trial name
- reverse (NCT05283733)
- Testing
- reverse conversion technique
- Where
- Egypt
- Volunteers
- 426 people
- Sponsor
- Zagazig University
Complicated Intra-Abdominal Infection
Impact Of Bacterial Resistance On Healthcare Costs For Hospitalized Patients With Complicated Intra-Abdominal Infections
The objective of this study is to estimate the costs of empiric antibiotic therapy and hospitalization costs for patients with a complicated intra-abdominal infection, and to assess the impact of treatment failure of initial…
- Trial name
- NCT00929643
- Testing
- no intervention
- Where
- 13 sites in Greece
- Volunteers
- 203 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer