Clinical trials: Intracranial Arterial Aneurysm
Ruptured Aneurysm of Intracranial Artery, SAH (Subarachnoid Hemorrhage)
Efficacy of Daily IV Administration of Dornase Alfa up to 14 Days Post Subarachnoid Hemorrhage on Functional Independence at 6 Months
Subarachnoid hemorrhage due to aneurysm rupture (SAH) results in high mortality, while survivors frequently suffer reduced quality of life and even loss of autonomy, particularly in the active population.
- Conditions
- Ruptured Aneurysm of Intracranial Artery, SAH (Subarachnoid Hemorrhage), Delayed Cerebral Ischemia
- Trial name
- RESET (NCT06723717)
- Testing
- Daily infusion of dornase alfa
- Where
- 6 sites in France
- Volunteers
- 304 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Intracranial Aneurysms
Clinical, Organizational, and Care Impact of the GetReady Digital Platform as a Clinical Decision Support Tool in the Follow-up of Patients With Cerebral Aneurysm
This study evaluates the clinical, organizational, and care impact of the GetReady digital platform as a clinical decision support tool for the follow-up of patients with cerebral aneurysm.
- Trial name
- SAFO (NCT07569562)
- Testing
- GetReady digital platform
- Volunteers
- 200 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Subarachnoid Haemorrhage
Simvastatin in Aneurysmal Subarachnoid Haemorrhage (STASH) a Multicentre Randomised Controlled Clinical Trial
Intracranial bleeding from ruptured blood vessels (called a subarachnoid haemorrhage -SAH) affects 7000 patients each year in the UK and is a source of considerable death and disability, even in young adults.
- Trial name
- STASH (NCT00731627)
- Testing
- simvastatin
- Where
- 2 sites in United States
- Volunteers
- 803 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Intracranial Aneurysm
Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil
The primary objective of this study is to gather post market data on the Penumbra SMART COIL® System (Smart System) in the treatment of intracranial aneurysms and other malformations.
- Trial name
- SMART (NCT02729740)
- Testing
- Penumbra Smart Coil, Penumbra Coil 400TM (PC400), Penumbra Occlusion DeviceTM(POD)
- Where
- 72 sites in United States, Canada
- Volunteers
- 995 people
- Sponsor
- Penumbra Inc.
Intracranial Aneurysm
@neurIST : Intregrated Biomedical Informatics for the Management of Cerebral Aneurysms
The primary aim of the SwissNeuroFoundation AneurysmDataBase Project is to implement information technology based tools to create and use a holistic reference database specific to intracranial aneurysms (IA).
- Trial name
- @neurIST (NCT05526352)
- Where
- 22 sites in United States, Canada and 9 more
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Stroke
Evaluating Neuroprotection in Aneurysm Coiling Therapy
This is a randomized, double-blind, placebo-controlled, single-dose, design investigating the safety, tolerability and efficacy of NA-1, a peptide designed to reduce ischemic brain damage.
- Trial name
- ENACT (NCT00728182)
- Testing
- NA-1
- Where
- 14 sites in United States, Canada
- Volunteers
- 185 people
- Sponsor
- NoNO Inc.
Intracranial Aneurysm
Study to Evaluate the Safety and Effectiveness of the CODMAN ENTERPRISE® Vascular Reconstruction Device
The purpose of this study is to demonstrate effectiveness and safety of the CODMAN ENTERPRISE® Vascular Reconstruction Device and Delivery System.
- Trial name
- NCT02532517
- Testing
- CODMAN ENTERPRISE® Vascular Reconstruction Device and Delivery System
- Where
- 11 sites in United States
- Volunteers
- 45 people
- Sponsor
- Cerenovus, Part of DePuy Synthes Products, Inc.
Intracranial Aneurysm
To Evaluate the Safety and Effectiveness of Flow Modulation Device for Intracranial Aneurysms
The purpose of this study is to assess safety and effectiveness of the p64/p48 MW HPC Flow Modulation Device.
- Trial name
- NCT06158750
- Testing
- p64/p48 MW HPC Flow Modulation Device
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Wallaby Medical Technologies Co.,Inc.
Aneurism
Genetic Profile In Patients With Ruptured and Unruptured Intracranial Aneurysms
The project will involve multiple units within our Institute (Neurosurgery, Cerebrovascular Diseases, Neurology IV), as well as additional neurosurgical centers across Italy, for the enrollment of patients with saccular…
- Trial name
- ANEUBIO (NCT07233915)
- Where
- Italy
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Middle Cerebral Artery Aneurysm
Middle Cerebral Artery Aneurysm Trial
Intracranial aneurysms located on the middle cerebral artery (MCA) are considered by many surgeons to represent a distinct subgroup of aneurysms for which clipping may still be the best management option.
- Trial name
- MCAAT (NCT05161377)
- Testing
- Surgical management, Endovascular management
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- University of Alberta
Cotinine Levels, Arterial Aneurysm Wall Enhancement on HRMRI
A Study on the Correlation Between Cotinine Levels and Aneurysm Wall Enhancement on HRMRI.
This study aims to collect clinical, laboratory, and imaging data from patients with unruptured intracranial aneurysms, and collect blood or urine samples for cotinine testing.
- Trial name
- NCT06447714
- Testing
- smoke
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Pupillary Function, Abnormal, Cerebral Aneurysm
Impact of Acute Cerebral Diseases on the Autonomous Nervous System: Progression and Correlation to Therapy and Outcome
The pupilometer determines the alteration of the pupil diameter after a defined light stimulus. In this study data is collected from pupilometer measurements of patients with an acute cerebral disease.
- Trial name
- Pupillometry (NCT02999659)
- Testing
- Pupilometer
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- RWTH Aachen University
Intracranial Aneurysm
Establishment of Online Registration Platform for Unruptured Intracranial Aneurysms Based on Regional Medical Centers in China and Population Follow-up Study (Phase Ⅱ)
Intracranial aneurysm is the main cause of subarachnoid hemorrhage, and the incidence of subarachnoid hemorrhage in Chinese population is about 5%.
- Trial name
- NCT05608122
- Testing
- Obervation
- Where
- China
- Volunteers
- 3,740 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
Biocollection on the Familial Forms of Intracranial Aneurysm
Intracranial aneurysm (IA) is an asymptomatic cerebrovascular abnormality affecting 3.2% of the general population. The devastating complication of IA is its rupture, resulting in subarachnoid haemorrhage that can lead to severe…
- Trial name
- GAÏA (NCT02848495)
- Testing
- Non-Interventional
- Where
- 8 sites in France
- Volunteers
- 411 people
- Sponsor
- Nantes University Hospital
Intracranial Aneurysms, Subarachnoid Hemorrhage, Aneurysmal
Screening in Relatives With Elevated Risk for Unruptured Intracranial Aneurysms
The purpose of this study is to screen first-degree relatives of patients with aneurysmal subarachnoid hemorrhage using magnetic resonance angiography to detect unruptured intracranial aneurysms.
- Trial name
- SIREN (NCT07387575)
- Where
- Serbia
- Volunteers
- 300 people
- Sponsor
- University of Novi Sad
Intracranial Aneurysm
WEB Clinical Assessment of IntraSaccular Aneurysm Therapy
The objective of this clinical study is to evaluate clinical utility of the WEB Aneurysm Embolization System used to embolize intracranial aneurysms
- Trial name
- WEBCAST (NCT01778322)
- Testing
- Intracranial aneurysm embolization
- Where
- 12 sites in Denmark, France and 2 more
- Volunteers
- 51 people
- Sponsor
- Microvention-Terumo, Inc.
Saccular Aneurysm, Intracranial Aneurysm
European eCLIPS™ Safety, Feasibility and Efficacy Study
An open label, prospective, multicentre, single-arm, post marketing study evaluating the safety, technical feasibility, and efficacy of the eCLIPs™ Family of Products for the treatment of bifurcation intracranial aneurysms.
- Trial name
- EESIS (NCT02607501)
- Testing
- Implant eCLIPs
- Where
- 4 sites in Denmark, Germany and 1 more
- Volunteers
- 20 people
- Sponsor
- Evasc Medical Systems Corp.
Acute Ischemic Stroke, Intracranial Aneurysms
Intracranial Distal Access Catheter in Neurointerventional Therapy
The study objective is to evaluate the safety and effectiveness of Intracranial Distal Access Catheter in neurointerventional therapy.
- Trial name
- NCT06989931
- Testing
- Intracranial Distal Access Catheter
- Where
- 6 sites in China
- Volunteers
- 114 people
- Sponsor
- MicroPort NeuroTech Co., Ltd.
Saccular Aneurysm, Intracranial Aneurysm
Comprehensive Aneurysm Management Trial
The uncertainty regarding the management of Unruptured Intracranial Aneurysms (UIAs) has not progressed in the last 30 years. The fundamental ethical basis for this study is that physicians should only offer a risky preventive…
- Conditions
- Saccular Aneurysm, Intracranial Aneurysm, Unruptured Cerebral Aneurysm
- Trial name
- CAM (NCT04155606)
- Testing
- microsurgery; endovascular interventions
- Where
- 6 sites in Canada, France and 1 more
- Volunteers
- 2,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Intracranial Aneurysm
pCONUS2 Treatment of Wide Neck Intracranial Aneurysms 2
To assess safety and efficacy of pCONUS2 for the treatment of wide neck bifurcation aneurysms.
- Trial name
- pToWin2 (NCT03273478)
- Testing
- Endovascular treatment of bifurcation aneurysm with pCONUS2
- Volunteers
- 100 people
- Sponsor
- Phenox GmbH