Clinical trials: Intracranial Arterial Aneurysm
Intracranial Aneurysm
LARGE Aneurysm Randomized Trial: Flow Diversion Versus Traditional Endovascular Coiling Therapy
In this study, patients with large anterior circulation IAs with neck and fundus morphologies amenable to either traditional endovascular treatments using coils or reconstruction with the flow diversion will be randomly assigned…
- Trial name
- LARGE (NCT01762137)
- Testing
- Flow Diversion, Coiling
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Medical University of South Carolina
Intracranial Aneurysm, Surgical Clip
Rapid Ventricular Pacing in Surgical Treatment of Intracranial Aneurysms
Treatment of complex unruptured intracranial aneurysms (UIA) remains challenging to date. Therefore, advanced techniques are required to achieve an optimal result in treating these patients safely.
- Trial name
- NCT02766972
- Testing
- Rapid Ventricular Pacing
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Clinic Frankfurt
Cerebral Aneurysms
Registry for Study of Coils in Intracranial Aneurysms
The current proposal describes a post-market, clinical registry of HydroSoft, aimed at gaining robust clinical data in a large set of patients to better define the advantages, and potentially, the disadvantages of the HydroSoft…
- Trial name
- Gel-the-nec (NCT01000675)
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Mayo Clinic
Intracranial Aneurysm
Safety and Efficacy of the LVIS and LVIS JR Devices in the Endovascular Treatment of Intracranial Aneurysms
A French, multicenter, prospective, observational, "real life" assessment of the safety and efficacy of LVIS and LVIS JR devices in the treatment of intracranial aneurysms
- Trial name
- NCT03553771
- Testing
- LVIS and LVIS JR
- Where
- 20 sites in France
- Volunteers
- 130 people
- Sponsor
- Microvention-Terumo, Inc.
Intracranial Aneurysms, Flow Diverter
Surface-Modified Flow Diverter for Intracranial Aneurysms: Assessment of Ischemic and Clinical Outcomes
Flow diverters (FDs) have become a mainstay of endovascular therapy for unruptured intracranial aneurysms (UIAs), yet their implantation carries an inherent risk of ischemic complications.
- Trial name
- PRISMATIC (NCT07674004)
- Testing
- LFD, PED Shield
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Henan Provincial People's Hospital
Intracranial Aneurysm
A Feasibility Study to Evaluate the Safety and Effectiveness of Implantation of Flowise Cerebral Flow Diverter (Flowise)
The purpose of this study is to evaluate the safety and short-term effectiveness of implantation of 'Flowise Cerebral Flow Diverter' for the treatment of unruptured wide-necked cerebral aneurysm in the internal carotid artery.
- Trial name
- NCT02609867
- Testing
- Flowise Cerebral Flow Diverter
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Yonsei University
Intracranial Aneurysm
COMPLEX Post Market Surveillance Electronic Registry
To demonstrate performance of TRUFILL DCS and TRUFILL DCS ORBIT Detachable Coils in the treatment of aneurysms.
- Trial name
- COMPLEX (NCT00663299)
- Testing
- Endovascular Embolization Device
- Where
- Japan
- Volunteers
- 299 people
- Sponsor
- Codman & Shurtleff
Aneurysmal Subarachnoid Hemorrhage (aSAH), Headache Disorders
Efficacy of Scalp Block in Managing Post Subarachnoid Hemorrhage Headache in Critically Ill Patients. A Single Centre Randomized Controlled Trial
Subarachnoid hemorrhage (SAH) is a devastating neurological disorder associated with significant mortality and morbidity rates, arising not just from the hemorrhage itself but also because of the catastrophic multisystem sequelae…
- Trial name
- SAH-BLOCK (NCT07307508)
- Testing
- Levobupivacaine Scalp block, Conventional analgesic therapy
- Where
- Qatar
- Volunteers
- 22 people
- Sponsor
- Hamad Medical Corporation
Intracranial Aneurysms
Treatment of Intracranial Wide-neck Aneurysms Using Stent-assisted Coil Embolization
This device was designed to assist in the stent-assisted coil embolization of intracranial aneurysms, specifically those that have a wide neck that would not otherwise maintain the coil embolization material within the aneurysm…
- Trial name
- NCT04566263
- Testing
- Neuroform EZ Stent System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Methodist Health System
Randomized Controlled Trial, Intracranial Aneurysm
Comparison of Clipping Via Keyhole Versus Traditional Approaches and Coiling for Ruptured Aneurysms
Endovascular coiling has become a strategy of choice of intracranial aneurysms due to its minimally invasiveness. However, there has few prospective randomized controlled studies on the comparison of therapeutic effect between…
- Conditions
- Randomized Controlled Trial, Intracranial Aneurysm, Microsurgery, Endovascular Procedures
- Trial name
- NCT05049564
- Testing
- keyhole microneurosurgery, conventional microneurosurgery, endovascular coiling
- Volunteers
- 150 people
- Sponsor
- ZhuQing
Cerebral Vasospasm, Subarachnoid Hemorrhage
Safety Study of Sildenafil in Treatment of Cerebral Aneurysm Vasospasm
Rupture of a cerebral aneurysm is a serious medical condition that may result in permanent disability or even death just related to the aneurysm rupture itself.
- Trial name
- NCT00871065
- Testing
- Sildenafil citrate
- Sponsor
- University of Nebraska
Aneurysm Cerebral, Bifurcation
LUMENS-1 EU EFS CIP
The primary objective of this clinical investigation is to evaluate the early safety and feasibility of the LuSeed Aneurysm Embolization System for treating unruptured intracranial aneurysms (IA).
- Conditions
- Aneurysm Cerebral, Bifurcation, Unruptured Intracranial Aneurysm, Saccular Aneurysm
- Trial name
- NCT06761365
- Testing
- LuSeed Aneurysm Embolization System
- Where
- 6 sites in Bulgaria, Germany and 2 more
- Volunteers
- 30 people
- Sponsor
- LuSeed Vascular LTD.
Cranial Aneurysm
Navigation Support With Mixed Reality With CORTEXPLORER MED
During the last 15 years, neuronavigation has become an essential neurosurgical tool for pursuing minimal invasiveness and safety.
- Trial name
- CXmed (NCT05269498)
- Testing
- CORTEXPLORER MED
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- cortEXplore GmbH
Intracranial Aneurysm, Subarachnoid Hemorrhage, Aneurysmal
Epidemiological Insights Into the Formation, Progression, and Rupture of Intracranial Aneurysms: A Retrospective, Multi-Center Hospital-Based Study in China
This is a retrospective, hospital-based and multi-center study aiming at investigating the potential exposures associated with the formation, progression, and rupture of intracranial aneurysms in Chinese population.
- Conditions
- Intracranial Aneurysm, Subarachnoid Hemorrhage, Aneurysmal, Cerebral Aneurysm, Brain Aneurysm
- Trial name
- NCT06456814
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Intracranial Aneurysm, Aneurysm, Intracranial
Transcranial Doppler Ultrasound Monitoring During Flow-Diverter Embolization
Flow diverters have been approved since 2012 for the treatment of large, wide neck intracranial aneurysms. These devices have been associated with embolic events which cause blockage in a blood vessel and can result in long term…
- Conditions
- Intracranial Aneurysm, Aneurysm, Intracranial, Giant Intracranial Aneurysm
- Trial name
- NCT02354300
- Testing
- TCD Ultrasound
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Florida
Intracranial Aneurysm
Bioabsorbable/Nufairy Coil Application Trial in China
The scope of this trial is the collection and analysis of effectiveness and safety endpoints, related to the use of the Bioabsorbable/Nufairy Coil Embolization System in the treatment of intracranial aneurysms.
- Trial name
- NuCATCH (NCT06466564)
- Testing
- Nufairy® Coil embolization system for intracranial aneurysm
- Where
- China
- Volunteers
- 258 people
- Sponsor
- MicroPort NeuroTech Co., Ltd.
Intracranial Aneurysm
Medina Embolization Device In Neurovascular Aneurysm Study
A global prospective, multi-center, single-arm, post-market clinical follow-up (PMCF) study conducted to assess the performance of the Medina Embolization Device when used in unruptured and ruptured intracranial aneurysms.
- Trial name
- MEDINA (NCT02982200)
- Where
- 3 sites in Austria, Italy and 1 more
- Volunteers
- 15 people
- Sponsor
- Medtronic Neurovascular Clinical Affairs
Intracranial Aneurysm
Evolve China PMCF Study
A prospective, multi-center, single-arm, open-label, observational, post-market clinical follow-up. The expected duration of the study is 8 years (including up to 5-years' follow-up).
- Trial name
- NCT06368622
- Testing
- Surpass Evolve Flow Diverter System
- Where
- 24 sites in China
- Volunteers
- 500 people
- Sponsor
- Stryker Neurovascular
Cerebral Aneurysm
Impact of Neurochecks on Sleep in Critically Ill Adults
Background: Following acute brain injury (ABI), patients are monitored in the intensive care unit (ICU) where providers rely on frequent neurological examinations ("neurochecks") to assess for neurodeterioration.
- Trial name
- NCT05864300
- Testing
- Neurocheck frequency
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Brain Aneurysm
Reduction in Volume and Prolonged Shrinkage of Brain Aneurysms After Combined Endovascular Interventions
The goal of this observational study is to learn about the long-term effects of combined endovascular interventions in participants over the age of 18 who take endovascular interventions employing endoluminal flow diverter…
- Trial name
- NCT06541275
- Testing
- brain MRI and CT
- Where
- Kazakhstan
- Volunteers
- 102 people
- Sponsor
- National Centre for Neurosurgery, Republic of Kazakhstan