Clinical trials: Intracranial Arterial Aneurysm
Aneurysm, Cerebral
Lidocaine and Perioperative Cytokine Levels in Blood and Cerebrospinal Fluid in Cerebral Aneurysm Patients
Cerebral aneurysm surgery has significant mortality and morbidity rate. Inflammation plays a key role in the pathogenesis of intracranial aneurysms, their rupture, subarachnoid haemorrhage and neurologic complications.
- Trial name
- NCT03823482
- Testing
- Lidocaine
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- Clinical Hospital Centre Zagreb
Intracranial Aneurysm, Subarachnoid Hemorrhage, Aneurysmal
Epidemiological Insights Into the Formation, Progression, and Rupture of Intracranial Aneurysms: A Retrospective, Multi-Center Hospital-Based Study in China
This is a retrospective, hospital-based and multi-center study aiming at investigating the potential exposures associated with the formation, progression, and rupture of intracranial aneurysms in Chinese population.
- Conditions
- Intracranial Aneurysm, Subarachnoid Hemorrhage, Aneurysmal, Cerebral Aneurysm, Brain Aneurysm
- Trial name
- NCT06456814
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Intracranial Aneurysm, Flow Diverter
DERIVO® 2heal® Study: Clinical Safety and Efficacy of the DERIVO® 2heal® Embolisation Device
To analyse the clinical safety and efficacy of the DERIVO® 2heal® Embolisation Device in the standard clinical routine of flow diversion treatment with respect to the mid- and long-term clinical and angiographic outcomes.
- Trial name
- REheal (NCT05543447)
- Testing
- Flow Diverter Treatment with DERIVO 2 Heal Embolisation Device
- Where
- 17 sites in Germany
- Volunteers
- 158 people
- Sponsor
- Acandis GmbH
Ischemic Heart Disease, Cardiac Arrest
Registry of Multicenter Brain-Heart Comorbidity in China
This study is a multi-center, prospective, registry study. This research was supported by the National Key Research and Development Program.
- Conditions
- Ischemic Heart Disease, Cardiac Arrest, Atrial Fibrillation, Heart Failure
- Trial name
- BHC-C (NCT05961748)
- Testing
- Multi-disciplinary assessment
- Where
- 14 sites in China
- Volunteers
- 100,000 people
- Sponsor
- Beijing Tiantan Hospital
Cardiac Rhythm Disorders, Urological Disorders
Product Surveillance Registry
The purpose of the Registry is to provide continuing evaluation and periodic reporting of safety and effectiveness of Medtronic market-released products.
- Conditions
- Cardiac Rhythm Disorders, Urological Disorders, Neurological Disorders, Cardiovascular Disorders
- Trial name
- PSR (NCT01524276)
- Where
- 402 sites in United States, Argentina and 39 more
- Volunteers
- 100,000 people
- Sponsor
- Medtronic
Brain Diseases, Aneurysm
Registration Trial of the Intracranial Visualized Stent for the Wide-necked Intracranial Aneurysms
A registration trial of the Intracranial Visualized stent in the treatment of wide-necked intracranial aneurysms
- Conditions
- Brain Diseases, Aneurysm, Intracranial Aneurysm, Cardiovascular Diseases
- Trial name
- PROMISE (NCT05275296)
- Testing
- Intracranial stent for wide-necked aneurysms
- Where
- China
- Volunteers
- 200 people
- Sponsor
- MicroPort NeuroTech Co., Ltd.
Intracranial Aneurysm, Aneurysm, Brain
Dimethyl Fumarate Treatment for Intracranial Unruptured Aneurysms.
This study was designed to identify whether there is a measurable reduction in inflammation in walls of intracranial aneurysms with oral dimethyl fumarate.
- Conditions
- Intracranial Aneurysm, Aneurysm, Brain, Inflammation Vascular
- Trial name
- NCT05959759
- Testing
- Dimethyl fumarate
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Arterial Aneurysm
Nuvascular Harbor Occlusion Device Pilot Study
The purpose of this study is to evaluate the safety and effectiveness of the HARBOR Occlusion Device for treating brain aneurysms.
- Trial name
- NCT07117526
- Testing
- Aneurysm occlusion with an intrasaccular device
- Where
- Bulgaria
- Volunteers
- 10 people
- Sponsor
- Nuvascular Inc
Wide Neck Bifurcation Intracranial Aneurysms, Intracranial Aneurysms
The WEB-IT Clinical Study
The study is a prospective, multicenter single-arm cohort. Patients with wide neck bifurcation aneurysms (WNBAs) have few choices for safe and effective endovascular treatment.
- Trial name
- WEB-IT (NCT02191618)
- Testing
- WEB
- Where
- 32 sites in United States, Canada and 4 more
- Volunteers
- 150 people
- Sponsor
- Microvention-Terumo, Inc.
Intracranial Aneurysm
AI for Detection of Brain Aneurysm: Low-cost Opportunistic Screening
The goal of this clinical trial is to verify the opportunistic screening potential of the AI software for detection of brain unruptured intracranial aneurysms (UIA) on routinely performed brain NECT scans in a prospective setting…
- Trial name
- AIDALOS-III (NCT07123818)
- Testing
- AI software
- Where
- 4 sites in Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ziekenhuis Oost-Limburg
Intracranial Aneurysm, Cerebral Ischemia
The Clinical Benefit and Risk of Oral Aspirin for Unruptured Intracranial Aneurysm Combined With Cerebral Ischemia
The first purpose of this study is to find out the clinical benefit and risk of oral aspirin for unruptured intracranial aneurysm (small than 7mm) combined with cerebral ischemia in patients in the real world.
- Trial name
- CBROAUNACCI (NCT02846259)
- Where
- China
- Volunteers
- 2,135 people
- Sponsor
- Beijing Tiantan Hospital
Cerebrovascular Disease, Intracranial Aneurysm
Investigation of Hemodynamics and Radiomics Based on High Resolution Magnetic Resonance Imaging for Predicting the Outcomes of Intracranial Dissecting Aneurysm
This study aims to conduct a comprehensive analysis by integrating clinical factors, aneurysm morphological characteristics, and factors reflecting pathophysiological processes (such as hemodynamic and radiomics features), in…
- Conditions
- Cerebrovascular Disease, Intracranial Aneurysm, Intracranial Arterial Dissection
- Trial name
- NCT07335029
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Beijing Neurosurgical Institute
Intracranial Aneurysm, Flow Diverter
Safety and Efficacy of Silk Vista and Silk Vista Baby Flow Diverter for Intracranial Aneurysm Treatment
The FIRST study is an observational, prospective, multi-center, international, single-arm, study. The aim of the study is to collect safety and efficacy information on the use of the silk vista and silk vista baby flow diverter…
- Trial name
- FIRST (NCT04034810)
- Testing
- Intracranial aneurysm treated with Silk vista and silk vista baby
- Where
- 29 sites in Austria, Belgium and 7 more
- Volunteers
- 234 people
- Sponsor
- Balt Extrusion
Cerebrovascular Disease, Ischemic Stroke
Florida Cerebrovascular Disease Biorepository and Genomics Center
The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by…
- Conditions
- Cerebrovascular Disease, Ischemic Stroke, Transient Ischemic Attack, Intracerebral Hemorrhage
- Trial name
- NCT05491980
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Mayo Clinic
Intracranial Aneurysm, Intracranial Neoplasms
Esmolol Versus Dexmedetomidine During Intracranial Procedures
Patients undergoing intracranial procedures may experience severe hypertension and tachycardia due to intracranial hypertension and to increased release of adrenaline.
- Trial name
- NCT02563288
- Testing
- Esmolol, Dexmedetomidine
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- George Papanicolaou Hospital
Intracranial Aneurysms
Feasibility Study of the LVIS™ (Low-profile Visualized Intraluminal Support)Device
The purpose of this study is to evaluate the safety and probable benefit of the Low-profile Visualized Intraluminal Support (LVIS™ and LVIS™ Jr.)devices from MicroVention, Inc.
- Trial name
- LVIS (NCT01541254)
- Testing
- Low profile Visualized Intraluminal Device (LVIS and LVIS Jr.)
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Microvention-Terumo, Inc.
Intracranial Aneurysm
A Study of Choydar Flow-Directed Mesh Stent in the Treatment of Unruptured Intracranial Aneurysms
The purpose of this study is to assess how safe choydar flow-directed mesh stent is and how well it works in the treatment of unruptured intracranial aneurysms (a condition in which a bulging blood vessel in the brain can burst…
- Trial name
- CROWN (NCT07228312)
- Where
- 8 sites in China
- Volunteers
- 200 people
- Sponsor
- Johnson & Johnson Medical (Shanghai) Ltd.
Aneurysmal Subarachnoid Hemorrhage, Vasospasm, Intracranial
Chemical and Mechanical Angioplasty for Vasospasm (SAVEBRAIN)
This is a monocentric randomized prospective trial comparing 2 different endovascular strategies of intracranial arterial angioplasty in case of refractory intracranial arterial vasospastic stenosis : chemical angioplasty…
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Vasospasm, Intracranial, Stenosis, Ruptured Cerebral Aneurysm
- Trial name
- SAVEBRAIN (NCT05268445)
- Testing
- Chemical and Mechanical Angioplasty for Refractory Intracranial Arterial Vasospastic Stenosis
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Erasme University Hospital
Intracranial Aneurysms
A Volumetric Coiling in Aneurysm Registry of the Penumbra Coil 400TM System
This study is a prospective, multi-center registry of patients with intracranial aneurysms who are treated by the PC 400 System. Data for each patient are collected up to 12 ± 3 months post-procedure for the study.
- Trial name
- VOLCAN (NCT01754051)
- Testing
- PC 400 coils
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Penumbra Inc.
Cardiac Pacing, Artificial, Aneurysm, Brain
Rapid Ventricular Pacing During Cerebral Aneurysm Surgery: a Study Concerning the Safety for Heart and Brain
Rapid ventricular pacing (RVP) is a technique to obtain flow arrest for short periods of time during dissection or rupture of the aneurysm. RVP results in an adequate fall in blood pressure which presents as an on-off phenomenon.
- Conditions
- Cardiac Pacing, Artificial, Aneurysm, Brain, Arteriovenous Malformations, Cerebral
- Trial name
- NCT03184233
- Testing
- Rapid ventricular pacing, No rapid ventricular pacing
- Where
- Belgium
- Volunteers
- 59 people
- Sponsor
- University Hospital, Antwerp