Clinical trials: Intracranial Arterial Diseases
Frontotemporal Dementia, Huntington Disease
Evaluation and Characterization of Behavioural Disorders and Dementias by the Behavioural Dysexecutive Syndrome Inventory (BDSI)
Behavioural disorders are very common right from the initial stage of dementia and contribute to loss of autonomy. Behavioural dysexecutive disorders have a particular status due to their prevalence and their diagnostic…
- Conditions
- Frontotemporal Dementia, Huntington Disease, Alzheimer Disease, Semantic Dementia
- Trial name
- ISDC (NCT02819700)
- Testing
- prevalence of behavioural dysexecutive syndrome
- Where
- 2 sites in France
- Volunteers
- 49 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Dementia (Diagnosis), Alzheimer Dementia (AD)
Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI)
The goal of this observational study is to learn if an artificial intelligence (AI)-based speech analysis tool can identify which patients with memory problems need specialist evaluation at a memory clinic.
- Conditions
- Dementia (Diagnosis), Alzheimer Dementia (AD), Vascular Dementia (VaD), Lewy Body Dementia (LBD)
- Trial name
- DetectAI (NCT07200739)
- Testing
- Mini-mental State Examination, Addenbrooke's Cognitive Examination, Speech Task - Picture Description
- Where
- Denmark
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Stroke, Superior Sagittal Sinus Thrombosis
Comparison of the Radiological Pattern Between the Cerebral Stroke of Arterial and Venous Origin
There are few published data on the patterns of parenchymal imaging abnormalities in a context of cerebral venous thrombosis (CVT).
- Conditions
- Stroke, Superior Sagittal Sinus Thrombosis, Venous Thromboses
- Trial name
- PATTERN (NCT03611894)
- Testing
- radiological comparison
- Where
- 2 sites in France
- Volunteers
- 98 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Dementia, Vascular
Perfusion by Arterial Spin Labelling Following Single Dose Tadalafil in Small Vessel Disease (PASTIS) Trial
Could Tadalafil improve blood flow in deep brain tissue and potentially improve cognitive function in patients with cerebral small vessel disease
- Trial name
- PASTIS (NCT02450253)
- Testing
- Tadalafil, Cognitive functioning tests, Neuropsychological tests
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- St George's, University of London
Cerebral Hemorrhage, Intracranial Arteriovenous Malformations
MRI for the Early Evaluation of Acute Intracerebral Hemorrhage
What happens in the borderzone of a cerebral hemorrhage remains widely onknown and furhter the best timing for doing MR to look for vascular pathology in cerebral hemorrhage has not yet been determined.
- Conditions
- Cerebral Hemorrhage, Intracranial Arteriovenous Malformations, Intracranial Hemorrhage, Hypertensive, Brain Neoplasms
- Trial name
- NCT01689402
- Testing
- MRI Scan with the specified sequences below:
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Bispebjerg Hospital
Intracranial Aneurysms
A Volumetric Coiling in Aneurysm Registry of the Penumbra Coil 400TM System
This study is a prospective, multi-center registry of patients with intracranial aneurysms who are treated by the PC 400 System. Data for each patient are collected up to 12 ± 3 months post-procedure for the study.
- Trial name
- VOLCAN (NCT01754051)
- Testing
- PC 400 coils
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Penumbra Inc.
Dementia, Mild Cognitive Impairment
Stories in the Moment: Dance Program for People Living With Dementia
This study is designed to evaluate the impact on the quality of life and wellbeing of a person-centered online dance program on people living with dementia or MCI and care partners. The duration of the study will be 1 year.
- Conditions
- Dementia, Mild Cognitive Impairment, Alzheimer Disease, Lewy Body Disease
- Trial name
- NCT06221202
- Testing
- Stories in the Moment Dance Program - Online
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- DanceStream Projects
Intracranial Aneurysm
Neuroform Atlas Stent for Intracranial Aneurysm Treatment
The primary objective of this study is to demonstrate effectiveness and safety of the NeuroForm Atlas stent system for use in patients requiring stent assisted intracranial aneurysm treatment.
- Trial name
- ATLAS EU PMCF (NCT02783339)
- Where
- 11 sites in France, Germany and 1 more
- Volunteers
- 105 people
- Sponsor
- Stryker Neurovascular
Cognitive Decline, Dementia
MIND Diet Intervention and Cognitive Decline
Phase III randomized controlled trial designed to test the effects of a 3-year intervention of the MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) on cognitive decline and brain neurodegeneration among 600…
- Conditions
- Cognitive Decline, Dementia, Alzheimer Disease, Vascular Dementia
- Trial name
- MIND (NCT02817074)
- Testing
- MIND Diet, Mild Weight Loss
- Where
- 2 sites in United States
- Volunteers
- 604 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Intracranial Aneurysm
Safety and Efficacy Analysis of FRED™/FRED™Jr Embolic Device in Aneurysm Treatment
A prospective, multicenter, observational evaluation of the safety and efficacy of the FRED® device in the treatment of intracranial aneurysms
- Trial name
- NCT03423290
- Testing
- FRED and FRED Jr
- Where
- 7 sites in United Kingdom
- Volunteers
- 61 people
- Sponsor
- Microvention-Terumo, Inc.
Ruptured Aneurysm of Intracranial Artery, SAH (Subarachnoid Hemorrhage)
Efficacy of Daily IV Administration of Dornase Alfa up to 14 Days Post Subarachnoid Hemorrhage on Functional Independence at 6 Months
Subarachnoid hemorrhage due to aneurysm rupture (SAH) results in high mortality, while survivors frequently suffer reduced quality of life and even loss of autonomy, particularly in the active population.
- Conditions
- Ruptured Aneurysm of Intracranial Artery, SAH (Subarachnoid Hemorrhage), Delayed Cerebral Ischemia
- Trial name
- RESET (NCT06723717)
- Testing
- Daily infusion of dornase alfa
- Where
- 6 sites in France
- Volunteers
- 304 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Ischaemic Stroke, Alzheimer's Disease
Cognition And Neocortical Volume After Stroke
Stroke and dementia are two of the most common and disabling conditions worldwide, responsible for an enormous and growing burden of disease.
- Conditions
- Ischaemic Stroke, Alzheimer's Disease, Vascular Dementia
- Trial name
- CANVAS (NCT02205424)
- Where
- 3 sites in Australia
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- The Florey Institute of Neuroscience and Mental Health
Cerebral Arteriovenous Malformation
Pediatric and Adult Cerebral Arteriovenous Malformation Neurofunctional Outcomes
Cerebral Arteriovenous malformations (AVMs) are abnormal tangles which are usually believed congenital. AVM can cause different symptoms depending on where it is located, but the most common symptoms are intracranial hemorrhage…
- Trial name
- DOPA (NCT04593966)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- yuanli Zhao
Age Related Cognitive Decline, Alzheimer's Disease
n-3 PUFA for Vascular Cognitive Aging
Brain scans can help identify changes that appear to increase risk for cognitive decline and dementia. Some of these brain changes are thought to reflect actual damage to the small blood vessels that support normal brain…
- Conditions
- Age Related Cognitive Decline, Alzheimer's Disease, Vascular Dementia, Endothelial Dysfunction
- Trial name
- NCT01953705
- Testing
- Omega 3 PUFA
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Intracerebral Hemorrhage
The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial II
The vast majority of intracerebral hemorrhage (ICH) patients present with elevated blood pressure(BP). Management of BP is controversial with two competing rationales.
- Trial name
- ICH-ADAPT II (NCT02281838)
- Testing
- labetalol/hydralazine/enalapril
- Where
- 2 sites in Canada
- Volunteers
- 142 people
- Sponsor
- University of Alberta
Cerebral Arteriovenous Malformation
Lovastatin for Treatment of Brain Arteriovenous Malformations
The purpose of this pilot study is to evaluate the disease-modifying efficacy of lovastatin in patients with brain arteriovenous malformation.
- Trial name
- NCT04297033
- Testing
- Lovastatin
- Where
- China
- Volunteers
- 1,244 people
- Sponsor
- Beijing Tiantan Hospital
Vascular Dementia, Cerebral Small Vessel Diseases
Trial of Remote Ischemic Pre-conditioning in Vascular Cognitive Impairment
Cerebral small vessel disease is a common cause of cognitive impairment. Remote ischemic pre-conditioning (RIC) is a technique to induce brief periods of limb ischemia-reperfusion that is hypothesized to increase tolerance of the…
- Conditions
- Vascular Dementia, Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischaemic Disease, Vascular Cognitive Impairment
- Trial name
- TRIC-VCI (NCT04109963)
- Testing
- Remote ischemic conditioning
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Intracranial Aneurysms, Saccular Aneurysm
PC400 Coils for Treatment of Intracranial Aneurysms
The goal of this prospective, observational study is to evaluate the long-term occlusion rates and safety of the Penumbra PC400 coil in the treatment of ruptured and unruptured intracranial aneurysms in adult subjects ages 18-80.
- Trial name
- PC400 (NCT07464847)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Semmes-Murphey Foundation
Mild Cognitive Impairment, Alzheimer Disease
Predicting the Conversion From Mild Cognitive Impairment to Dementia
Mild cognitive impairment (MCI) is believed to be the early stage of dementia. The investigators assume that some psychological and imaging risks may predict the conversion.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Dementia, Vascular
- Trial name
- PCMCItoD (NCT01823666)
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Dongzhimen Hospital, Beijing
Stroke
Minor Stroke Therapy Evaluation
Stroke represents the fourth leading cause of death in industrialized nations, after heart disease, cancer, and chronic lower respiratory disease.
- Trial name
- MOSTE (NCT03796468)
- Testing
- Best Medical Therapy, Mechanical Thrombectomy
- Where
- France
- Volunteers
- 824 people
- Sponsor
- University Hospital, Montpellier
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