Clinical trials: Intracranial Arterial Diseases
Pupillary Function, Abnormal, Cerebral Aneurysm
Impact of Acute Cerebral Diseases on the Autonomous Nervous System: Progression and Correlation to Therapy and Outcome
The pupilometer determines the alteration of the pupil diameter after a defined light stimulus. In this study data is collected from pupilometer measurements of patients with an acute cerebral disease.
- Trial name
- Pupillometry (NCT02999659)
- Testing
- Pupilometer
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- RWTH Aachen University
Moyamoya Disease
Remimazolam Consumption: TCI vs. Manual Infusion
The purpose of this prospective randomized controlled trial is to compare the total consumption of remimazolam between two different administration methods-Target-Controlled Infusion (TCI) and manual infusion-in patients…
- Trial name
- NCT07377695
- Testing
- Target-Controlled Infusion (TCI) of Remimazolam, Manual Infusion of Remimazolam
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Chronic Subdural Hematomas
Middle Meningeal Artery Coagulation During Burr-Hole Drainage for Chronic Subdural Haematoma (BURR-MMA)
Chronic subdural haematoma (cSDH) is a common condition in older adults, usually treated by burr-hole surgery to drain the collection.
- Trial name
- BURR-MMA (NCT07549893)
- Testing
- CT-Guided Intra-Operative Middle Meningeal Artery Interruption
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Cerebral Aneurysm, Arteriovenous Malformations
Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 2
In the stage of randomized controlled study, our purpose is to obtain the Intraoperative anticoagulation program supported by evidence-based medicine.
- Trial name
- EAPCAAMHO2 (NCT03306836)
- Testing
- Heparin Sodium
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Beijing Tiantan Hospital
Traumatic Brain Injury, Cerebral Hemorrhage
TCD Detection of Ophthalmic Artery Blood Flow Velocity Prediction Feasibility Study of Intracranial Pressure
Increased intracranial pressure is a cause of disease progression in patients with brain disease, a common cause of poor prognosis.
- Conditions
- Traumatic Brain Injury, Cerebral Hemorrhage, Increased Intracranial Pressure
- Trial name
- NCT02240394
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Alzheimer's Disease, Vascular Dementia
A Noval Tau Tracer in Young Onset Dementia
Dementia is a clinical syndrome which characterized by progressive cognitive impairment, behavior disturbance and dysfunction of daily activity.
- Conditions
- Alzheimer's Disease, Vascular Dementia, Dementia
- Trial name
- NCT04248270
- Testing
- 18F-PM-PBB3
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Ischemic Stroke, MCA Infarction
Intraarterial Stem Cells in Subacute Ischemic Stroke
Stroke is a leading cause of morbidity and mortality.Acute ischemia causes irreversible damage to neurons and glial cells, leading to functional deficits and chronic sequelae with variable degrees of spontaneous recovery of…
- Trial name
- NCT03080571
- Testing
- autologous BMMNC stem cells, standard care
- Volunteers
- 20 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Cerebral Aneurysm Unruptured, Cerebral Aneurysm
Use of Classic LMA During Endovascular Therapy
Background: Earlier treatment and resolution for patients with cerebral aneurysms is now possible due to earlier diagnosis. This observational study aims to evaluate the intraoperative cardiovascular parameters in patients with…
- Conditions
- Cerebral Aneurysm Unruptured, Cerebral Aneurysm, Hemodynamic Instability, Airway Morbidity
- Trial name
- NCT03288519
- Volunteers
- 60 people
- Sponsor
- Universidad de Antioquia
Intracranial Arteriosclerosis, Collateral Circulation
Study of Urinary Kallikrein to Enhance Collateral Circulation in Symptomatic Intracranial Atherosclerosis
The purpose of this study is to determine whether Urinary Kallikrein has an additional effect on enhancing collateral circulation in symptomatic intracranial atherosclerotic patients under clopidogrel and aspirin dual…
- Conditions
- Intracranial Arteriosclerosis, Collateral Circulation, Anterior Cerebral Circulation Infarction
- Trial name
- NCT04325932
- Testing
- Urinary Kallikrein
- Where
- China
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intracranial Atherosclerosis
A Study of Implantation of CRENEOUS ENTERPRISE 2 Intracranial Stent in Participants With Severe Symptomatic Intracranial Atherosclerotic Stenosis
The purpose of this study is to evaluate the safety and effectiveness of CERENOVUS ENTERPRISE 2 intracranial stent implantation in treatment of participants with severe symptomatic intracranial atherosclerotic stenosis.
- Trial name
- NCT05316311
- Testing
- CERENOVUS ENTERPRISE 2 Intracranial Stent
- Where
- 14 sites in China
- Volunteers
- 194 people
- Sponsor
- Medos International SARL
Dementia, Dementia, Vascular
Virtual Individual Cognitive Stimulation Therapy: a Proof of Concept Study
Due to COVID-19, the routine treatment for dementia, Cognitive Stimulation Therapy (CST), is currently suspended in multiple countries. Access to treatment is, therefore, paramount.
- Conditions
- Dementia, Dementia, Vascular, Dementia, Mixed, Dementia With Lewy Bodies
- Trial name
- V-iCST (NCT04828434)
- Testing
- Virtual Individual Cognitive Simulation Therapy
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University College, London
Moyamoya Disease
Neurocognitive and Radiological Assessments in Adult Moyamoya Undergoing Surgery
Adult patients with moyamoya disease (MMD) are reported to suffer from considerable impairment of executive function/attention. Although reduced cerebrovascular reserve (CVR) in frontal areas has been detected by perfusion MRI…
- Trial name
- NRAAMUS (NCT02305407)
- Testing
- Surgical Revascularization, Conservative treatment
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Moya Moya Disease, Moyamoya Syndrome
Efficacy and Safety of Ischemic Preconditioning Therapy Versus Optimal Medical Therapy in Reducing the Recurrence of Ischemic Events in Symptomatic Moyamoya Disease
This clinical trial aims to investigate whether remote ischemic conditioning (RIC) can reduce the risk of cerebral ischemic events, delay clinical progression, and improve long-term outcomes in patients with symptomatic Moyamoya…
- Trial name
- NCT07889531
- Testing
- Standard Remote Ischemic Preconditioning
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
Surgical Management of Complex Intracranial Aneurysms With Hybrid Operating Techniques
To evaluate the clinical benefits and risks of hybrid operating techniques in management of complex intracranial aneurysms, which could coexists with multiple risk factors.
- Trial name
- CIA-HOTs (NCT03206853)
- Testing
- Hybrid Operating Techniques
- Where
- China
- Volunteers
- 258 people
- Sponsor
- liuxingju
Intracranial Aneurysms
The Reverse Barrel™ VRD Intracranial Aneurysm Trial
The purpose of this clinical investigation is to evaluate the safety and effectiveness of the Barrel™ VRD when used to facilitate endovascular coiling of wide-neck bifurcating or branch intracranial aneurysms with any approved…
- Trial name
- Barrel (NCT02125097)
- Testing
- Barrel™ Vascular Reconstruction Device (VRD)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Medtronic Neurovascular Clinical Affairs
Moyamoya Disease
Clinical Safety and Efficacy Evaluation of the Blood-cooling and Stasis-removing Formula as an Adjunct to Atorvastatin in the Treatment of Hemorrhagic Moyamoya Disease.
Moyamoya disease is a relatively rare chronic cerebrovascular disease, and its exact cause is currently unknown. This disease is characterized by the gradual narrowing or even blockage of important blood vessels in the brain (the…
- Trial name
- NCT07894640
- Testing
- Atorvastatin, Blood-cooling and Stasis-clearing Formula
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Intracranial Aneurysm
Clinical Performance Evaluation of RDX-Aneurysm for Detecting Intracranial Aneurysms on TOF-MRA
This retrospective, multi-center, observational case-control study evaluates the standalone performance of RDX-Aneurysm, a computer-assisted detection software, for detecting and marking suspected saccular intracranial aneurysm…
- Trial name
- RDX-Aneurysm (NCT07655635)
- Where
- 3 sites in Taiwan
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Aneurysm Cerebral
Personalized Treatment Planning in Intracranial Aneurysm Surgeries.
Patients who will undergo a intracranial aneurysm (IA) surgery are educated concerning their disease and the surgical procedure.The objective of this study is to explore the advantages of conventional, virtual reality and 3D…
- Trial name
- 3 D (NCT05324605)
- Testing
- Questionnaire and use of 3 D tools
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Prof. Dr. med. Serge Marbacher
Intracranial Aneurysm
Enterprise Stent Aneurysm Treatment (ESAT) Study - France
The purpose of this study is to evaluate the morbidity, mortality, and efficacy of use of the Enterprise(TM) stent for the treatment of (ruptured or non-ruptured) intracranial aneurysms.
- Trial name
- ESAT (NCT00879580)
- Where
- 14 sites in France
- Volunteers
- 133 people
- Sponsor
- Codman & Shurtleff
Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke
Transcranial Doppler Evaluation After Endovascular Thrombectomy for Acute Ischemic Stroke (PRECISE-TCD)
Endovascular thrombectomy (EVT) improves outcomes in acute ischemic stroke caused by large vessel occlusion. Despite successful recanalization, early neurological deterioration (END) remains frequent and is associated with poor…
- Conditions
- Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke, Acute Ischemic Stroke, Cardioembolic Stroke
- Trial name
- NCT07013396
- Testing
- Transcranial Doppler (TCD) examination
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
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