Clinical trials: Intracranial Arterial Diseases
Self Efficacy, Medical Device Complication
Chinese Registry of Assisted Embolization for Unruptured Wide Necked Intracranial Aneurysm Using LVIS Stent
This study aims to investigating the efficacy and safety of low profile visualized intraluminal support (LVIS) stents for the treatment of unruptured intracranial saccular aneurysms.
- Trial name
- CRANIAL-1 (NCT02830373)
- Testing
- LVIS stents
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Changhai Hospital
Infarction, Anterior Cerebral Artery, Infarction, Middle Cerebral Artery
An Observational Registry Study of LUOTAI in Patients With Acute Ischemic Stroke in Vietnam
Ischemic stroke occurs when an artery to the brain is blocked. If the artery remains blocked for more than a few minutes, the brain cells may die. This is why immediate medical treatment is critical.
- Conditions
- Infarction, Anterior Cerebral Artery, Infarction, Middle Cerebral Artery, Ischemic Attack, Transient
- Trial name
- NCT03679364
- Where
- 3 sites in Vietnam
- Volunteers
- 364 people
- Sponsor
- KPC Pharmaceuticals, Inc
Intracranial Aneurysms, Antiplatelet Drugs
Comparison of the Antiplatelet Efficacy of Aspirin Combined With Clopidogrel and Aspirin Combined With Half-dose Ticagrelor in Patients With Unruptured Intracranial Aneurysms With Normal CYP2C19 Metabolizer Phenotype
The goal of this clinical trial is to compare the antiplatelet efficacy of aspirin combined with clopidogrel and aspirin combined with half-dose ticagrelor in in patients with unruptured intracranial aneurysms with normal CYP2C19…
- Trial name
- NCT06486363
- Testing
- Aspirin combined with clopidogrel, Aspirin combined with half-dose ticagrelor
- Volunteers
- 196 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Vascular Dementia
Efficacy and Safety of Rivastigmine Capsules in Patients With Probable Vascular Dementia
The goal of this research study is to evaluate the effectiveness, tolerability and safety of rivastigmine capsules in males and females between the ages of 50 and 85 years old with probable vascular dementia.
- Trial name
- NCT00099216
- Testing
- Rivastigmine
- Where
- 63 sites in United States, Austria and 8 more
- Volunteers
- 708 people
- Sponsor
- Novartis Pharmaceuticals
Intracranial Aneurysm, Coiling Therapy
Intracranial Aneurysms Treatment With the OPTIMA Coil System
International, non-randomized, European , multicenter, observational study to collect data for the treatment of intracranial aneurysms with OPTIMA coils system to further document its safety and efficacy
- Trial name
- INSTANT (NCT03642821)
- Testing
- intracranial aneurysm coiling
- Where
- 20 sites in Austria, France and 5 more
- Volunteers
- 300 people
- Sponsor
- Balt Extrusion
Intracranial Aneurysms
Safety and Efficacy Analysis of FRED® Embolic Device in Aneurysm Treatment
A prospective, multicenter, observational evaluation of the safety and efficacy of the FRED® device in the treatment of intracranial aneurysms.
- Trial name
- SAFE (NCT02921698)
- Testing
- FRED®
- Volunteers
- 100 people
- Sponsor
- Microvention-Terumo, Inc.
Cadasil, Blood Brain Barrier Defect
MRI Study of Blood-brain Barrier Function in CADASIL
Diffusion prepared pseudo-continuous ASL (DP-pCASL) is a newly proposed MRI method to noninvasively measure the function of blood-brain barrier (BBB).
- Trial name
- NCT05902039
- Testing
- MRI
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Chronic Subdural Hematoma, Subdural Hematoma
Prospective Study on the Use of Middle Meningeal Artery Embolization for Chronic Subdural Haematoma
Subdural haematoma is a common neurosurgical condition that results in different levels of neurological deficits in patients. It can be further classified into acute and chronic, which have different pathophysiology.
- Trial name
- NCT04500795
- Testing
- Middle meningeal artery embolization
- Where
- China
- Sponsor
- Chinese University of Hong Kong
Acute Ischemic Stroke, Intracranial Artery Occlusion
Intra-arterial TNK Following Endovascular Thrombectomy in Patients With Large Vessel Occlusion of Posterior Circulation
Rationale: Recently, one prospective multicenter RCT reported a potential beneficial effect of intra-arterial alteplase following successful endovascular thrombectomy (EVT) in patients with an acute intracranial large vessel…
- Conditions
- Acute Ischemic Stroke, Intracranial Artery Occlusion, Endovascular Thrombectomy
- Trial name
- NCT05684172
- Testing
- Tenecteplase, endovascular thrombectomy alone
- Where
- China
- Volunteers
- 208 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Aneurysm, Ruptured, Intracranial Aneurysm
Bare Platinum Coils Versus Second-generation Hydrocoils
Comparison of clinical and radiological outcomes between bare platinum coil group and second-generation hydrogel coils for treatment of ruptured intracranial aneurysms.
- Trial name
- NCT04988503
- Testing
- Coil embolization
- Where
- 3 sites in South Korea
- Volunteers
- 68 people
- Sponsor
- Seoul National University Hospital
Dementia, Alzheimer Disease
A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Behavioral Disturbances in Patients With Dementia
The purpose of the study is to evaluate the safety and efficacy of risperidone (an antipsychotic medication) versus placebo in the treatment of behavioral disturbances associated with dementia.
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular
- Trial name
- NCT00253123
- Testing
- risperidone
- Volunteers
- 626 people
- Sponsor
- Janssen, LP
Cerebral Aneurysm, Cerebral Aneurysm Unruptured
Parent Artery Reconstruction for Cerebral Aneurysms Using a Novel Flow Diverter With Surface Modification
The primary objective of this trial is to evaluate the safety and efficacy of the cerebral flow diverter in the endovascular treatment of wide-necked cerebral aneurysms
- Trial name
- NCT05774782
- Testing
- Cerebral flow diverter
- Where
- China
- Volunteers
- 143 people
- Sponsor
- Sinomed Neurovita Technology Inc.
Intracranial Aneurysm
Brain Low-risk Aneurysm Stereotactic Radiosurgical Trial
The goal of this clinical trial is to confirm the feasibility and safety of performing radiosurgery on unruptured, low-risk aneurysms in humans. Participants will choose if they want to undergo radiosurgery or not.
- Trial name
- BLAST (NCT06047951)
- Testing
- Stereotactic RadioSurgery (SRS)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Dr David Mathieu
Mild Cognitive Impairment, Alzheimer's Disease
The Swedish BioFINDER Study
The present study aims at combining biochemical methods with various types of imaging techniques to identify the pathophysiology of Alzheimer's disease (AD).
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Dementia With Lewy Bodies, Vascular Dementia
- Trial name
- NCT01208675
- Where
- 2 sites in Sweden
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Brain Diseases, Ischemic Stroke
Interleukin-6 Receptor Inhibition for Symptomatic Intracranial Atherosclerosis
IRIS-sICAS is a multicenter, randomized, double-blind, placebo-controlled clinical trialis a multicenter, randomized, double-blind, placebo-controlled clinical trial, to assess the safety and efficacy of tocilizumab injection in…
- Conditions
- Brain Diseases, Ischemic Stroke, Ischemia, Stroke
- Trial name
- IRIS-sICAS (NCT06447701)
- Testing
- Tocilizumab, NaCl 0.9% 100ml
- Volunteers
- 486 people
- Sponsor
- Zhujiang Hospital
Cerebral Aneurysm
Optical Coherence Tomography Imaging of Post Coil Aneurysm Healing.
The purpose of this study is to identify the healing of aneurysms in three month use Optical Coherence Tomography image to measure outcomes in post coiled aneurysms.
- Trial name
- OCT (NCT00556309)
- Testing
- Optical Coherence Tomography
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of California, Irvine
Cerebral Aneurysm
Goal-directed Therapy in Endovascular Coiling of Cerebral Aneurysm Patients
Goal directed therapy (GDT) is a technique, which employs a non-invasive cardiac output monitoring (NICOM) device to guide management of circulating blood volume and blood pressure during procedures.
- Trial name
- NCT02507999
- Testing
- Flotrac
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cerebrovascular Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis)
A SAD/MAD Study of Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Volunteers
Study BT200-01 is a first in human (FIH) study in male and female normal human volunteers (NHVs) that uses an Integrated Protocol Design.
- Conditions
- Cerebrovascular Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis), Intracranial Arteriosclerosis
- Trial name
- NCT04103034
- Testing
- BT200, Desmopressin
- Where
- Austria
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Band Therapeutics
Intracranial Aneurysms
Efficacy Trial of Intracranial Aneurysm Treatment Using Two Different Endovascular Techniques
To date the standard non-surgical treatment strategy for treating un-ruptured intracranial aneurysms is the use of either coils or self-expandable stents.
- Trial name
- NCT01084681
- Testing
- Endovascular treatment of intracranial aneurysms, Endovascular treatment of intracranial aneurysm with coils
- Where
- Germany
- Volunteers
- 160 people
- Sponsor
- Balt International
Aneurysm Cerebral
Study to Evaluate the TUBE Device Ability to Treat Unruptured, Wide-neck or Fusiform Aneurysms
To assess the safety and performance of the TUBE device in the endovascular treatment of unruptured, wide-neck or fusiform intracranial aneurysms located on the internal carotid artery (ICA) or its branches
- Trial name
- NV01 (NCT07079956)
- Testing
- TUBE Flow Diverter
- Where
- 3 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- NVMedTech
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