Clinical trials: Intracranial Arterial Diseases
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Cerebral Nimodipine Concentrations Following Oral, Intra-venous and Intra-arterial Administration
Nimodipine reduces the risk of poor outcome and delayed cerebral ischemia in patients suffering aneurysmal subarachnoid haemorrhage (SAH), but its mode of action is unknown.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Vasospasm, Cerebral
- Trial name
- NCT04649398
- Testing
- Nimodipine
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Headaches Associated With Subarachnoid Hemorrhage (SAH)
IA Lidocaine and Methylprednisolone for Headache Associated With Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a type of bleeding around the brain that can cause sudden and severe headaches. These headaches can be debilitating and persist for weeks, significantly impacting a patient's comfort and recovery.
- Trial name
- LIMSAH (NCT07054801)
- Testing
- Lidocaine hydrochloride, Methylprednisolone sodium succinate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Daniel Raper, MBBS
Dementia, Alzheimer Disease
Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease…
- Conditions
- Dementia, Alzheimer Disease, Dementia With Lewy Bodies, Vascular Dementia
- Trial name
- CRND TorCA (NCT06529744)
- Where
- 4 sites in Canada
- Volunteers
- 500 people
- Sponsor
- University Health Network, Toronto
Brain Aneurysm
Post Market Registry Study of Intracranial Aneurysms Treated With Sugita Clipping Devices
The objective of this study is to verify the performance and safety of the Sugita Aneurysm Clips devices when used as intended and to identify possible risk factors.
- Trial name
- T2_PMCF (NCT06798740)
- Testing
- Sugita Titanium Aneurysm Clip II
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Mizuho Corporation
Saccular and Fusiform Aneurysms, Pseudoaneurysm
Targeting Real World Usage In Stroke Treatment
TRUST Registry is an observational, prospective, long-term, post-market surveillance registry of subjects treated with WallabyPhenox flow modulation devices, stent systems, bifurcation aneurysm implants including their HPC…
- Conditions
- Saccular and Fusiform Aneurysms, Pseudoaneurysm, Vascular Dissection, Perforation
- Trial name
- TRUST (NCT07474935)
- Testing
- Aneurysm Treatment with a Neurovascular Flow Diverter, Dissection Treatment with a Neurovascular Flow Diverter, Perforation Treatment with a Neurovascular Flow Diverter
- Where
- 13 sites in France, Germany and 3 more
- Volunteers
- 5,000 people
- Sponsor
- Phenox GmbH
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for the Treatment of Subdural Hematomas With TRUFILL® n-BCA
This is a prospective, multi-center, open-label, randomized controlled study in which subjects can receive standard of care (SOC) alone or SOC and TRUFILL n-BCA MMA embolization for the treatment of chronic subdural hematomas…
- Trial name
- MEMBRANE (NCT04816591)
- Testing
- Experimental: Interventional Cohort: TRUFILL n-Butyl Cyanoacrylate (n-BCA) Liquid Embolic System, Standard of Care Surgery, Experimental: Interventional Cohort: TRUFILL n-BCA Liquid Embolic System
- Where
- 33 sites in United States, China
- Volunteers
- 376 people
- Sponsor
- Cerenovus, Part of DePuy Synthes Products, Inc.
Intracranial Aneurysm, CT Angiography
Stepped-Wedge Cluster Randomized Trial of AI-Assisted CTA Detection for Intracranial Aneurysms in Regional Hospitals
This study (IDEAL 2) is a nationwide stepped-wedge cluster-randomized trial designed to prospectively enroll over 14,400 patients undergoing outpatient head CT angiography (CTA).
- Conditions
- Intracranial Aneurysm, CT Angiography, AI (Artificial Intelligence), Cluster Randomized Trial
- Trial name
- IDEAL2 (NCT07124624)
- Testing
- AI-Assisted CTA Interpretation, Standard CTA Interpretation
- Volunteers
- 14,400 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Cerebral Arterial Diseases, Dissecting Aneurysm of Cerebral Artery
Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRI
Intracranial artery disease has been more detected with development of HR-MR. HR-MR can depict vascular wall directly and give us more information beyond the pre-existing imaging modalities such as digital subtraction…
- Conditions
- Cerebral Arterial Diseases, Dissecting Aneurysm of Cerebral Artery, Intimal Dissection
- Trial name
- NCT02914288
- Testing
- High resolution magnetic resonance imaging for intracranial vessel walls
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Cerebral Small Vessel Diseases, CADASIL (Diagnosis)
Establishment of a CSF Bank for the Development of Biomarkers of Smooth Muscle Cell (SMC) Damage in Monogenic Cerebral Small Vessel Disease
The main objective of this research is to obtain biological markers of smooth muscle cells dysfunction or degeneration in cerebral small vessel diseases.
- Trial name
- CSF-cSVD (NCT05793424)
- Testing
- Cerebrospinal fluid (CSF) sample and additional blood samples
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intracranial Aneurysms, Seizure
Seizure Prophylaxis in Aneurysm Repair
After a thorough review of the existing literature as well as a review of our own practice, the investigators have concluded that the decision to treat patients undergoing aneurysm repair with levetiracetam has reached true…
- Trial name
- SPAR (NCT01801072)
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Michigan
Vascular Dementia
Efficacy and Safety of Butylphthalide Soft Capsule for the Treatment of Vascular Dementia
Butylphthalide soft capsule has been confirmed to have beneficial effects for patients with vascular dementia (VaD) in clinical trial of phase II study.
- Trial name
- NCT03804229
- Testing
- Butylphthalide soft capsule
- Where
- China
- Volunteers
- 707 people
- Sponsor
- Capital Medical University
Subarachnoid Hemorrhage, Intracranial Arteriovenous Malformation
NIRS Monitoring During Intracranial Interventions
Near infrared spectroscopy is a valuable tool to monitor cerebral oxygenation during intracranial interventions. However, it yields artificial results when the dye indocyanine green (ICG) is applied, which is routinely done for…
- Trial name
- NIRS_ICG (NCT03367975)
- Testing
- near infrared spectroscopy
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Hospital, Bonn
Dementia, Alzheimer Disease
Feasibility of Passive Data Collection in Dementia Subjects With Agitation
This is a multi-center, observational, feasibility study, to evaluate long term passive data collection, data quality, and user experience of HealthMode Agitation (Apps) to collect motion, location, physiological, and audio data…
- Conditions
- Dementia, Alzheimer Disease, Vascular Dementia, Frontotemporal Dementia
- Trial name
- NCT04413851
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- HealthMode Inc.
DEM, Dementia
Advanced Cognitive Stimulation Therapy (ACST)
This study is a feasibility randomised controlled trial (RCT) for an evidence-based intervention for people with moderate to severe dementia.
- Conditions
- DEM, Dementia, Dementia, Vascular, Dementia, Mixed
- Trial name
- NCT04550975
- Testing
- Advanced Cognitive Stimulation Therapy
- Volunteers
- 32 people
- Sponsor
- University College, London
Traumatic Brain Injury, Middle Cerebral Artery Stroke
Intracranial Pressure After Decompressive Craniectomy
Observational study to investigate the natural course of intracranial pressure (ICP) after decompressive craniectomy (DC) using long-term telemetric ICP monitoring.
- Conditions
- Traumatic Brain Injury, Middle Cerebral Artery Stroke, Intracranial Hemorrhages, Intracranial Hypertension
- Trial name
- NCT03364634
- Testing
- Intracranial pressure monitoring
- Volunteers
- 17 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cerebral Infarction, Atherosclerosis
Trial of Cilostazol in Symptomatic Intracranial Arterial Stenosis II
This study will recruit 480 acute stroke patients with symptomatic intracranial stenosis (M1 segment of Middle cerebral artery (MCA) or basilar artery). They will be randomly assigned into cilostazol group or clopidogrel group.
- Trial name
- TOSS-2 (NCT00130039)
- Testing
- clopidogrel, Cilostazol
- Where
- 19 sites in Hong Kong, Philippines and 2 more
- Volunteers
- 457 people
- Sponsor
- Asan Medical Center
Intracranial Aneurysms, Seizures
Seizure Prophylaxis in Aneurysm Repair
Seizures are a potential complication of surgical repair of intracranial aneurysms. In order to prevent seizures, many surgeons administer prophylactic anti-epileptic medication during the intra-operative and post-operative…
- Trial name
- NCT01974700
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Indiana University
Stent Embolisation
Efficacy and Safety of StENt-assisted Treatment for CErebral Aneurysms
Prospective registry study to evaluate safety and efficacy of stent assisted embolization of intracranial aneurysm.
- Trial name
- NCT01702584
- Testing
- stent assisted embolization
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Kobe City General Hospital
Brain Tumor, Stroke, Acute
Safety and Feasibility of the Infinity Catheter for Radial Access
The main objective of this single arm study is to evaluate the safety and feasibility of the AXS Infinity LS (Stryker, Freemont, CA, USA) and AXS Infinity LS Plus (Stryker, Freemont, CA, USA) catheters during the transradial…
- Conditions
- Brain Tumor, Stroke, Acute, Brain Aneurysm, Intracranial Arteriovenous Malformations
- Trial name
- NCT04553549
- Testing
- Transradial approach
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Rutgers, The State University of New Jersey
Atheroscleroses, Coronary, Atheroscleroses, Cerebral
Digital Secondary Prevention After Atherosclerotic Cardiovascular Disease
Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality worldwide and in Norway. Approximately 50% of the patients admitted to hospitals with an acute ASCVD event has had a previous…
- Conditions
- Atheroscleroses, Coronary, Atheroscleroses, Cerebral, Atherosclerotic Ischemic Disease
- Trial name
- NCT06738381
- Testing
- Digital intervention and motivational counselling
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Vestre Viken Hospital Trust
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