Clinical trials: Intracranial Arterial Stenosis, active
Stroke, Transient Ischemic Attack
Angiogenic Markers in Cerebrovascular Disease (ANFIS)
Intracranial atherosclerosis (ICAS) is the most common cause of stroke worldwide. It carries a worse prognosis than other stroke etiologies, with an annual rate of recurrent stroke and death of 15% despite intensive medical…
- Conditions
- Stroke, Transient Ischemic Attack, Atherosclerosis, Intracranial Arterial Stenosis
- Trial name
- ANFIS (NCT04240119)
- Testing
- According to current clinical care standards
- Volunteers
- 300 people
- Sponsor
- Cedars-Sinai Medical Center
Intracranial Atherosclerotic Disease (ICAD), Intracranial Arterial Stenosis
Photon-counting CT for Intracranial Stent Assessment
Intracranial atherosclerotic disease is an important cause of ischemic stroke, and intracranial stent implantation is increasingly used for patients with severe stenotic lesions.
- Conditions
- Intracranial Atherosclerotic Disease (ICAD), Intracranial Arterial Stenosis, Stent Restenosis, Ischemic Stroke
- Trial name
- NCT07769814
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xin Lou
Cognitive Function, Stenosis
Clinical Registration Study of Patients With Intracranial / Carotid Stenosis
Through prospective registration and follow-up, this study will collect data of patients with intracranial/carotid stenosis, including clinical information, neuropsychological scales, multimodal magnetic resonance images.
- Trial name
- NCT05322824
- Testing
- standard medical treatment, Interventional stenting
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atheroscleroses, Cerebral, Intracranial Atherosclerosis
Balloon-expandable DES for ICAS Registry Study (BDES-ICAS Registry)
To study the clinical outcomes after implantation of balloon-expandable drug-eluting stents in patients with symptomatic intracranial atherosclerotic stenosis in prevention of composite event of any stroke and death within 30…
- Conditions
- Atheroscleroses, Cerebral, Intracranial Atherosclerosis, Ischemia Stroke
- Trial name
- NCT06614972
- Testing
- Balloon-expandable drug-eluting stent
- Volunteers
- 520 people
- Sponsor
- RenJi Hospital
Intracranial Atherosclerosis
The Efficacy and Safety of Intracranial Stent (Tonbridge) in Endovascular Treatment of Symptomatic Intracranial Atherosclerotic Stenosis
The purpose of this study is to verify the efficacy and safety of the Intracranial Stent (Tonbridge) in endovascular treatment of symptomatic intracranial atherosclerotic stenosis.
- Trial name
- NCT05757505
- Testing
- Intracranial Stent (Tonbridge), Wingspan Stent System (Stryker Neurovascular)
- Where
- 13 sites in China
- Volunteers
- 200 people
- Sponsor
- Ton-Bridge Medical Tech. Co., Ltd
Ischemic Stroke, Transient Ischemic Attack
Follow-up Extension Study of Regular Physical Exercise in Patients With Symptomatic Intracranial Arterial Stenosis
This study will include the subjects with symptomatic intracranial arterial stenosis (ICAS) who have participated in and completed the 1-year follow-up of RESIST trial (NCT06615726).
- Trial name
- RESIST-FE (NCT07242768)
- Testing
- Non-Interventional Study
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- Capital Medical University
Ischemic Stroke, Transient Ischemic Attack
Regular Physical Exercise in Patients With Symptomatic Intracranial Arterial Stenosis
The objective of this study is to evaluate the effectiveness and safety of regular physical exercise in preventing ischemic stroke events in patients with symptomatic intracranial arterial stenosis.
- Trial name
- RESIST (NCT06615726)
- Testing
- Regular physical exercise, Control group
- Where
- 58 sites in China
- Volunteers
- 1,300 people
- Sponsor
- Capital Medical University
Cerebrovascular Disease, Ischemic Stroke
Florida Cerebrovascular Disease Biorepository and Genomics Center
The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by…
- Conditions
- Cerebrovascular Disease, Ischemic Stroke, Transient Ischemic Attack, Intracerebral Hemorrhage
- Trial name
- NCT05491980
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Mayo Clinic
Ischemic Stroke, Acute, TIA
Tirofiban for Patients With intraCranial Artery Stenosis and High-risk Acute Non-disabling Cerebrovascular Events(CHANCE-4）
This is a multicenter, double-blind, double-dummy, randomized clinical trial comparing the efficacy and safety of tirofiban versus placebo in preventing recurrence of stroke for patients with intracranial artery stenosis and…
- Conditions
- Ischemic Stroke, Acute, TIA, Symptomatic Intracranial Artery Stenosis
- Trial name
- NCT06319846
- Testing
- Tirofiban
- Where
- 5 sites in China
- Volunteers
- 4,674 people
- Sponsor
- Beijing Tiantan Hospital
Symptomatic Intracranial Atherosclerotic Stenosis
Drug- Eluting Stent for Symptomatic Intracranial Arterial Stenosis
This investigation is a prospective, multicenter, randomized controlled, non-inferiority clinical trial, to evaluate the safety and efficacy of the investigational device against alternative models/specifications of the control…
- Trial name
- DESIAS (NCT07197970)
- Testing
- NxiDIME™ Intracranial Drug-Eluting Stent System, NOVA DES Intracranial Drug-Eluting Stent
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Artery Disease, Symptomatic Carotid Artery Stenosis
High Coverage CARotid Stenting vs. Medical Management Alone to Prevent EmboliSm From symptomaTic Non-stenotic cARotid Disease (SyNC)
Goal is to analyse the clinical safety and efficacy of the CARESTO® heal Stent within standard clinical routine for the treatment of patients with symptomatic non-stenotic carotid disease (SyNC) and with high-risk plaque features…
- Conditions
- Carotid Artery Disease, Symptomatic Carotid Artery Stenosis, Carotid Artery Stenting, Carotid Plaque Imaging
- Trial name
- CARESTAR (NCT07166731)
- Where
- Germany
- Volunteers
- 536 people
- Sponsor
- Acandis GmbH
Intracranial Artery Stenosis
Improving Blood Lipid Management in Symptomatic Intracranial Atherosclerotic Stenosis on Clinical Outcome
sICASBLM is a prospective controlled trial, to asses the impact of improving blood lipid management on clinical outcome of moderate to severe symptomatic intracranial atherosclerotic stenosis patients (LDL-C>1.8mmol/L) without…
- Trial name
- sICASBLM (NCT05397405)
- Testing
- PCSK9 inhibitor
- Where
- 2 sites in China
- Volunteers
- 180 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
ICAS - Intracranial Atherosclerosis, Stroke Ischemic
MPR for Stroke Risk Assessment of ICAS
Intracranial atherosclerotic stenosis (ICAS) carries substantial stroke risk despite optimal medical treatment. Current risk stratification relies primarily on stenosis severity, but novel hemodynamic markers may improve…
- Conditions
- ICAS - Intracranial Atherosclerosis, Stroke Ischemic, Hemodynamic
- Trial name
- NCT07309718
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Atherosclerosis Cerebral, Carotid Plaque
RESCUE: PCSK9 Inhibitors for Carotid Vulnerable Plaque Remodeling
Carotid artery stenosis is a major cause of ischemic stroke. However, many strokes occur in patients with only mild-to-moderate stenosis.
- Conditions
- Atherosclerosis Cerebral, Carotid Plaque, Vulnerable Plaque, Carotid Stenosis
- Trial name
- RESCUE (NCT07819643)
- Testing
- Intervention 1, Intervention 3, Intervention 2
- Volunteers
- 120 people
- Sponsor
- Keqiang Zhao
Intracranial Atherosclerosis ICAS, Hemodynamic
Digital Angiography-Derived Fractional Flow Assessment for Intracranial Stenosis
The goal of this observational study is to learn whether a digital angiography derived fractional flow reserve (DPR) measurement can improve the prediction of stroke risk in adults with symptomatic intracranial atherosclerotic…
- Conditions
- Intracranial Atherosclerosis ICAS, Hemodynamic, Stroke
- Trial name
- CASSISS-DPR (NCT07309705)
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Intracranial Atherosclerosis, Cognitive Impairment
Cognitive Decline and Underlying Mechanisms in Symptomatic Intracranial Artery Stenosis Patients: A Cohort Study
The purpose of this study is to explore the mechanism of cognitive impairment in patients with symptomatic intracranial atherosclerotic stenosis (ICAS), and further plans to explore the impact of different treatment options on…
- Conditions
- Intracranial Atherosclerosis, Cognitive Impairment, Cerebrovascular Event
- Trial name
- NCT06336174
- Testing
- Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin, Endovascular therapy,Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Anhui Medical University
Intracranial Artery Stenosis
Gut Microbiota and Prognostic Outcomes in Intracranial Arterial Stenosis Patients（GROW-ICAS）
GROW-ICAS (Gut microBiota and prOgnostic Outcomes in IntraCranial Arterial Stenosis) is a prospective observational cohort study that enrolls patients with intracranial arterial stenosis to investigate the correlations between…
- Trial name
- NCT07085299
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Intracranial Atherosclerotic Disease (ICAD), Hypertriglyceridaemia
Pemafibrate for Symptomatic ICAS RCT
The goal of this clinical trial is to learn whether pemafibrate can help prevent worsening of intracranial arterial stenosis (ICAS) in patients who have symptomatic ICAS and high triglycerides (TG) levels after ischemic stroke or…
- Conditions
- Intracranial Atherosclerotic Disease (ICAD), Hypertriglyceridaemia, Stroke (CVA) or TIA
- Trial name
- PPAR-ICAS (NCT07562178)
- Testing
- Pemafibrate
- Where
- 42 sites in Japan
- Volunteers
- 270 people
- Sponsor
- Tokyo Women's Medical University
Carotid Artery Stenosis, Glioma
Detection of Microplastics and Nanoplastics in Neurosurgery Patients (DT-MiNi)
Plastic particles are a ubiquitous pollutant in the living environment and food chain, so far, plenty of studies have reported the internal exposure of microplastics and nanoplastics in human tissues and enclosed body fluids.
- Conditions
- Carotid Artery Stenosis, Glioma, Intracranial Aneurysm, Intracranial Hemorrhages
- Trial name
- DT-MiNi (NCT05968053)
- Testing
- biological samples analysis
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, TIA
Probucol for Symptomatic Intracranial and Extracranial Artery Stenosis
This study is a multicenter, double-blind, placebo-controlled, randomized clinical trial that aims to evaluate the efficacy of probucol on the reduction of the risk of recurrent stroke in patients with symptomatic intracranial or…
- Trial name
- NCT06225752
- Testing
- Probucol
- Where
- China
- Volunteers
- 5,452 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College