Clinical trials: Intracranial Artery Occlusion
Mild Cognitive Impairment, Alzheimer Disease
A Double-Blind, Placebo-Controlled Safety and Efficacy Study of NA-831
This study seeks to evaluate the efficacy and safety of NA-83 in subjects with mild cognitive impairment due to Alzheimer's Disease
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Alzheimer Dementia, Dementia, Vascular
- Trial name
- NCT03538522
- Testing
- N-831(Traneurocin) 10 mg QD, NA-831 (Traneurocin) 20 mg QD, NA-831 (Traneurocin) 40 mg QD
- Where
- 2 sites in New Zealand
- Volunteers
- 126 people
- Sponsor
- Biomed Industries, Inc.
Carotid Artery Disease, Symptomatic Carotid Artery Stenosis
High Coverage CARotid Stenting vs. Medical Management Alone to Prevent EmboliSm From symptomaTic Non-stenotic cARotid Disease (SyNC)
Goal is to analyse the clinical safety and efficacy of the CARESTO® heal Stent within standard clinical routine for the treatment of patients with symptomatic non-stenotic carotid disease (SyNC) and with high-risk plaque features…
- Conditions
- Carotid Artery Disease, Symptomatic Carotid Artery Stenosis, Carotid Artery Stenting, Carotid Plaque Imaging
- Trial name
- CARESTAR (NCT07166731)
- Where
- Germany
- Volunteers
- 536 people
- Sponsor
- Acandis GmbH
Ischemic Stroke, Acute, Thrombolysis
Endovascular Treatment With or Without Preceding Intravenous Tenecteplase (TNK) in Patients With Late-window acUte Ischemic Stroke Due to Middle Cerebral Artery Occlusion
The purpose of this study is to investigate the safety and efficacy of endovascular treatment with or without preceding intravenous Tenecteplase in patients with late-window (4.5-24 hours of symptom onset) acute ischemic stroke…
- Conditions
- Ischemic Stroke, Acute, Thrombolysis, Endovascular Treatment
- Trial name
- TNK-PLUS (NCT06221371)
- Testing
- Tenecteplase, direct EVT
- Where
- 21 sites in China
- Volunteers
- 391 people
- Sponsor
- Beijing Tiantan Hospital
Mild Cognitive Impairment, Alzheimer's Disease
The Swedish BioFINDER Study
The present study aims at combining biochemical methods with various types of imaging techniques to identify the pathophysiology of Alzheimer's disease (AD).
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Dementia With Lewy Bodies, Vascular Dementia
- Trial name
- NCT01208675
- Where
- 2 sites in Sweden
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Dementia, Mixed, Dementia, Vascular
Statins in Reducing Events in the Elderly Mind (STAREE-Mind) Imaging Substudy
The STAREE-Mind imaging sub-study will examine the effect of statin treatment over a 4-year period, compared with placebo, on markers of brain health.
- Conditions
- Dementia, Mixed, Dementia, Vascular, Dementia of Alzheimer Type, Cognitive Decline
- Trial name
- STAREE-Mind (NCT05586750)
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- 2 sites in Australia
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Monash University
Ischemic Stroke
Reducing Intracranial atheroSclErosis With Repatha
The purpose of this study will be to understand the underlying mechanism by which PCSK9 inhibition reduces the rate of ischemic stroke seen in the pivotal studies that led to its FDA approval for ASCVD such as ischemic stroke.
- Trial name
- RISER (NCT04573777)
- Testing
- Repatha
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, Los Angeles
Ischemic Stroke, Migraine
Sensitivity to Acute Cerebral Ischemia in Migrainers
Sensitivity to Acute Middle cerebral or intracranial Carotid artery Occlusion in MIGrainers (SMCO-MIG) is a prospective multi-center study to determine if migraine induces a faster infarct growth as assessed by initial multimodal…
- Conditions
- Ischemic Stroke, Migraine, Migraine With Aura
- Trial name
- SAMCO-MIG (NCT03301441)
- Testing
- questionnaire ef-ID Migraine
- Where
- France
- Volunteers
- 605 people
- Sponsor
- University Hospital, Montpellier
Dementia, Vascular, Alzheimer Dementia
Accurate WiFi-Based Localization of Dementia Patients For Caregiver Support:
In this Phase II SBIR project we will enhance a wireless WiFi-based insole that was designed and successfully tested during a Phase I trial with elderly persons with dementia and their caregivers, and then investigate its…
- Conditions
- Dementia, Vascular, Alzheimer Dementia, Lewy Body Dementia With Behavioral Disturbance
- Trial name
- NCT03360019
- Testing
- Activlink insole, Activlink Phone Application
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Florida
Dementia, Dementia, Vascular
Enhancing Care Coordination: Hospital to Home for Cognitively Impaired Older Adults and Their Caregivers
Aim 1. To compare across three hospital sites the effects on health and cost outcomes observed by the following three interventions, each designed to enhance adaptation and improve outcomes of hospitalized cognitively impaired…
- Conditions
- Dementia, Dementia, Vascular, Alzheimer Disease, Delirium, Dementia, Amnestic, Cognitive Disorders
- Trial name
- NCT00294307
- Testing
- Augmented Standard Care (ASC), Resource Nurse Care (RNC), Advanced Practice Nurse Care (APNC)
- Where
- 3 sites in United States
- Volunteers
- 814 people
- Sponsor
- University of Pennsylvania
Atherosclerosis, Cardiovascular Diseases
Epidemiology of Vascular Inflammation & Atherosclerosis
To investigate the relationship of vascular cell phenotypes to atherosclerosis.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Arteriosclerosis
- Trial name
- NCT00087893
- Volunteers
- 931 people
- Sponsor
- University of Vermont
Dementia, Alzheimer Disease
All About Me: An Intervention to Ease the Transition to Long Term Care
This Phase I study will involve initial development and evaluation of an innovative cross-platform software app called All About Me (AAM), which will consist of Serious Digital Health Games (SDHGs) for PWD.
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular, Dementia, Mixed
- Trial name
- AAM (NCT05516134)
- Testing
- SAFE at Home
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Hopeful Aging
Alzheimer Disease, Mild Cognitive Impairment
Novel Diagnostic and Disease Stage Biomarkers in AD
This study will investigate the efficacy of novel biomarkers, namely blood-based biomarkers, pupillometry and actigraphy to track and predict progression of Alzheimer's disease (AD).
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Neuro-Degenerative Diseases, Vascular Dementia
- Trial name
- TRACK-AD (NCT05175664)
- Testing
- Long-term study, Short-term study, Cross-sectional study
- Where
- Denmark
- Volunteers
- 350 people
- Sponsor
- Danish Dementia Research Centre
Moyamoya Disease
Cardiac Index-Guided Intraoperative Hemodynamic Management in Pediatric Moyamoya Surgery
This prospective randomized controlled trial evaluates whether individualized cardiac index-guided intraoperative hemodynamic management reduces postoperative transient ischemic episodes in pediatric patients undergoing…
- Trial name
- NCT07304947
- Testing
- Cardiac Index-Guided Hemodynamic Management, Blood Pressure-Guided Standard Hemodynamic Management
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Dementia, Alzheimer Disease
A Study of the Effectiveness and Safety of Risperidone in the Treatment of Behavioral Disturbances in Patients With Dementia
The purpose of the study is to compare the safety and efficacy of risperidone (an antipsychotic medication) to that of placebo in the treatment of behavioral disturbances associated with dementia.
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular
- Trial name
- NCT00249145
- Testing
- risperidone
- Volunteers
- 349 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Atherosclerosis, Cardiovascular Diseases
Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC
To evaluate common genetic variations, that in combination with exposure to tobacco smoke, may modify the risk of atherosclerosis.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00064545
- Volunteers
- 1,500 people
- Sponsor
- University of North Carolina, Chapel Hill
Mild Cognitive Disorder, Alzheimer Disease
Digital Dementia Registry Bavaria (digiDEM Bayern): a Multicentre, Prospective, Longitudinal Register Study Including People With Mild Cognitive Impairment and Dementia as Well as Their Family Caregivers
Around 57 million people worldwide live with dementia, with approximately 10 million new cases diagnosed each year. By the end of 2023, around 1.8 million people were living with dementia in Germany, the majority of whom were…
- Conditions
- Mild Cognitive Disorder, Alzheimer Disease, Vascular Dementia, Dementia in Other Diseases Classified Elsewhere
- Trial name
- digiDEM Bayern (NCT07721701)
- Where
- 12 sites in Germany
- Volunteers
- 5,000 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Vascular Dementia
Prospekta in the Treatment of Cognitive, Behavioral and Psychiatric Disorders in Patients With Vascular Dementia.
Study purpose: evaluate clinical efficacy ands afety of Prospekta in the treatment of cognitive, behavioral and psychiatric disorders in patients with vascular dementia.
- Trial name
- NCT04552041
- Testing
- Prospekta
- Where
- 33 sites in Russia
- Volunteers
- 406 people
- Sponsor
- Materia Medica Holding
Hyperperfusion Syndrome, Moyamoya Disease
Sevoflurane and Hyperperfusion Syndrome
The aim of the present study is to evaluate the effect of sevoflurane postconditioning on the incidence of postoperative hyperperfusion syndrome following revascularization surgery in moyamoya patients.
- Trial name
- NCT02510586
- Testing
- Sevoflurane
- Volunteers
- 152 people
- Sponsor
- Seoul National University Hospital
Stroke, Ischemic, Stroke Hemorrhagic
Prediction Model for Chronic Intracranial Arterial Occlusion With Radiomic Features
Chronic intracranial arterial occlusion is associated with a "bidirectional stroke risk," with a significantly increased risk of both ischemic stroke and cerebral hemorrhage.
- Trial name
- NCT06066593
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Hospital
Occlusion and Stenosis of Unspecified Cerebral Artery
Prevention for the Restenosis of Intracranial Artery Stent Implantation Treated With Herbal Medicine C117
Prevention for the Restenosis of Intracranial artery Stent Implantation Treated with herbal medicine C117--PRISIT Trial
- Trial name
- PRISIT (NCT03008798)
- Testing
- Herbal Medicine C-117
- Volunteers
- 180 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine