Clinical trials: Intracranial Atherosclerosis
Stroke, Intracranial Atherosclerosis
PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis
This will be a randomized double blind placebo-controlled pilot study using a repeated measures design in which participants with acute ischemic stroke and intracranial atherosclerotic disease are randomized to either drug or…
- Conditions
- Stroke, Intracranial Atherosclerosis, Intraplaque Hemorrhage
- Trial name
- PINNACLE (NCT03507374)
- Testing
- Alirocumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Ischemic Stroke, Acute, Intracranial Atherosclerosis
Efficacy of Butylphthalide on Symptomatic Atherosclerotic Stenosis in Middle Cerebral Artery
Ischemic stroke with high incidence, mortality, disability and recurrence rate, has become the leading threat to the health worldwide.
- Trial name
- SICAS (NCT06331494)
- Testing
- Butylphthalide
- Where
- China
- Volunteers
- 140 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Ischemic Stroke, Intracranial Atherosclerosis
Anticoagulation Using Rivaroxaban on Top of Aspirin in Intracranial Atherosclerotic Stenosis
The primary goal of the clinical trial is to test the effect of oral rivaroxaban plus aspirin in patients with recent stroke/ transient ischemic attack (TIA) caused by intracranial artery stenosis.
- Conditions
- Ischemic Stroke, Intracranial Atherosclerosis, Stenosis
- Trial name
- AA-ICAS (NCT05700266)
- Testing
- Rivaroxaban, Clopidogrel, Aspirin
- Volunteers
- 1,180 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Abdominal Aortic Aneurysm, Coronary Heart Disease NOS
Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER Study
Study of heterogeneity in associations between social deprivation and the initial presentation of 12 cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease NOS, Unheralded Corronary Death, Intracerebral Haemorrhage
- Trial name
- IP4 (NCT01937065)
- Testing
- No treatment
- Where
- United Kingdom
- Volunteers
- 1,937,360 people, healthy volunteers welcome
- Sponsor
- University College, London
Acute Ischemic Stroke, Haemorrhagic Stroke
Translational Immunodiagnostics in Stroke (TrImS)
In adult patients presenting to emergency departments within 24 hours of symptom onset with suspected acute stroke, we aim: 1. to identify early brain- and pathology-specific circulating, whole blood, plasma and serum panorOmic…
- Conditions
- Acute Ischemic Stroke, Haemorrhagic Stroke, Transient Ischemic Attacks, Cardioembolic Stroke
- Trial name
- TrImS (NCT05300997)
- Testing
- Biomarker blood draw and saliva collection
- Where
- China
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Stroke
Vascular Ultrasound Screening in Patients With Ischemic Cerebrovascular Disease: a Multi-center Registry Study
The purpose of this multicenter study is to investigate the extra-/intra-cranial atherosclerosis distribution pattern in chinese populations with transient ischemic attack and ischemic stroke and analyze the influencing factors…
- Trial name
- NCT02397655
- Where
- China
- Volunteers
- 12,012 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke AIS, Intracranial Atherosclerosis ICAS
PCSK9 Inhibitor for Intracranial Atherosclerosis Related Acute Ischemic Stroke
This study is a prospective, multicenter, double-blind, randomized, placebo-controlled clinical trial designed to evaluate whether early administration of PCSK9 inhibitors can effectively improve functional outcomes at 90 days in…
- Conditions
- Acute Ischemic Stroke AIS, Intracranial Atherosclerosis ICAS, Atherosclerotic Plaque
- Trial name
- PISTIAS-3 (NCT07466251)
- Testing
- Recaticimab plus standard therapy
- Where
- 19 sites in China
- Volunteers
- 1,212 people
- Sponsor
- Peking Union Medical College Hospital
Intracranial Atherosclerosis
Wingspan Stenting for Symptomatic Severe Stenosis of Intracranial Atherosclerosis Registry in China
This is a prospective, multi-center, non-randomized trial to study one-year outcomes of the Wingspan system for the treatment of Chinese patients with symptomatic atherosclerotic severe intracranial stenosis.
- Trial name
- WingspanSSIR (NCT00685308)
- Testing
- Stenting of atherosclerotic intracranial stenosis
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ministry of Health, China
Stroke, TIA
Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis
An observational study to determine if individuals with increased platelet FcyRIIa will have a higher risk of ischemic events.
- Conditions
- Stroke, TIA, Ischemic Stroke, Ischemic
- Trial name
- FCG (NCT05518305)
- Testing
- Medical Imaging
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Intracranial Atherosclerosis ICAS, Hemodynamic
Digital Angiography-Derived Fractional Flow Assessment for Intracranial Stenosis
The goal of this observational study is to learn whether a digital angiography derived fractional flow reserve (DPR) measurement can improve the prediction of stroke risk in adults with symptomatic intracranial atherosclerotic…
- Conditions
- Intracranial Atherosclerosis ICAS, Hemodynamic, Stroke
- Trial name
- CASSISS-DPR (NCT07309705)
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
ICAS - Intracranial Atherosclerosis
IntraCranial Angiography-derived Fraction Flow-guided Percutaneous Transluminal Angioplasty and Stenting Versus Medical Therapy (ICAS-MT)
A multicenter, open-label, blinded-endpoint, prospective, randomized controlled clinical trial with an "all comers" design.
- Trial name
- NCT05974033
- Testing
- Stenting plus medical therapy, Medical therapy alone
- Volunteers
- 536 people
- Sponsor
- Changhai Hospital
Intracranial Atherosclerosis, Stroke
AcoArt sICAS: DCB in the Treatment of Symptomatic Intracranial Atherosclerotic Stenosis
The purpose of the RCT trial is to determine whether DCB is not inferior to stent in treating intracranial stenosis.
- Trial name
- NCT04631055
- Testing
- drug coated balloon, stent system
- Where
- 3 sites in China
- Volunteers
- 180 people
- Sponsor
- Acotec Scientific Co., Ltd
Intracranial Atherosclerosis, Acute Ischemic Stroke
Trial of PCSK9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis
This study will evaluate whether low-density lipoprotein (LDL-C) lowering with alirocumab results in greater change from baseline in intracranial atherosclerotic plaque at week 26 than control in adults with acute ischemic stroke…
- Conditions
- Intracranial Atherosclerosis, Acute Ischemic Stroke, ICAS - Intracranial Atherosclerosis
- Trial name
- TOPICAL-MRI (NCT05001984)
- Testing
- Alirocumab
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Moyamoya Syndrome, Moyamoya Disease
A Study of Cerebral Perfusion With tDCS in Chronic Hypoperfusion
This study is being done to examine whether transcranial direct current stimulation (tDCS) will increase cerebral blood flow which may provide a clinical benefit such as improving cognitive impairment.
- Conditions
- Moyamoya Syndrome, Moyamoya Disease, Atheroscleroses, Cerebral
- Trial name
- NCT06477107
- Testing
- Soterix® 4x1HD-TDCS, Soterix® 1x1 tDCS, Cognitive training program
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mayo Clinic
Intracranial Arteriosclerosis, Collateral Circulation
Study of Urinary Kallikrein to Enhance Collateral Circulation in Symptomatic Intracranial Atherosclerosis
The purpose of this study is to determine whether Urinary Kallikrein has an additional effect on enhancing collateral circulation in symptomatic intracranial atherosclerotic patients under clopidogrel and aspirin dual…
- Conditions
- Intracranial Arteriosclerosis, Collateral Circulation, Anterior Cerebral Circulation Infarction
- Trial name
- NCT04325932
- Testing
- Urinary Kallikrein
- Where
- China
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Ischemic Stroke, Atrial Fibrillation
Combination of Antiplatelet and Anticoagulation for AIS Patients Witn Concomitant NVAF and Extracranial/Intracranial Artery Stenosis
The goal of this clinical trial is to compare the safety and effectiveness of anticoagulation combined with antiplatelet therapy in acute ischemic stroke (AIS) patients with concomitant non-valvular atrial fibrillation (NVAF) and…
- Conditions
- Acute Ischemic Stroke, Atrial Fibrillation, Stenosis, Carotid, Intracranial Atherosclerosis
- Trial name
- ALLY (NCT06058130)
- Testing
- Anticoagulant Oral, Anticoagulation combined with antiplatelet therapy
- Where
- 2 sites in China
- Volunteers
- 2,171 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
ICAS - Intracranial Atherosclerosis, Cerebral Small Vessel Diseases
Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease
The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing…
- Trial name
- NCT05677607
- Testing
- Magnetic resonance imaging
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Intracranial Atherosclerosis, Stent Stenosis
Elucidate Outcomes of Elective High-grade/Total Occlusion Intracranial Arteries Using Low-profile Self-expanding Stent
Intracranial atherosclerotic disease (ICAD) is a high prevalent cause of stroke, especially in Asian population and can be categorized as either symptomatic (resulting in acute ischemic stroke) or asymptomatic.
- Conditions
- Intracranial Atherosclerosis, Stent Stenosis, Ischemic Stroke
- Trial name
- NCT05947994
- Testing
- Intracranial stenting with Credo® stent
- Where
- Vietnam
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Can Tho Stroke International Services Hospital
Acute Stroke, Ischemic Stroke
Rescue Intracranial Stenting in Acute Ischemic Stroke
In acute ischemic stroke caused by intracranial large vessel occlusion, rescue intracranial stenting has been recently a treatment option to achieve recanalization in patients with the failure of mechanical thrombectomy.
- Conditions
- Acute Stroke, Ischemic Stroke, Intracranial Atherosclerosis, Stent Stenosis
- Trial name
- RISIS (NCT04986774)
- Testing
- Rescue intracranial stenting
- Where
- Vietnam
- Volunteers
- 85 people
- Sponsor
- Can Tho Stroke International Services Hospital