Clinical trials: Intracranial Hemorrhage, Traumatic
Subdural Hematoma
Embolization of the Middle Meningeal Artery With ONYX™ Liquid Embolic System for Subacute and Chronic Subdural Hematoma
The purpose of this study is to evaluate the safety and efficacy of embolization of the middle meningeal artery (MMA) using the Onyx™ Liquid Embolic System (LES) for treatment of symptomatic subacute or chronic subdural hematoma…
- Trial name
- EMBOLISE (NCT04402632)
- Testing
- Surgical Management, Onyx™ Liquid Embolic System (LES) Embolization, Observation Only
- Where
- 49 sites in United States
- Volunteers
- 600 people
- Sponsor
- Medtronic Neurovascular Clinical Affairs
Chronic Subdural Hematoma
Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a common disease after minor head trauma, especially in elderly patients. This medical condition is characterized by blood collection in the subdural space, which can result in severe…
- Trial name
- TRACE (NCT03280212)
- Testing
- Tranexamic Acid 500 MG
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Chronic Subdural Hematoma
GET-UP Trial: Impact of an Early Out-of-bed Paradigm in Postoperative Outcomes of Chronic Subdural Hematomas
Compare rates of medical complications, recurrence and outcome in 2 randomized groups of patients with surgical chronic subdural hematomas.
- Trial name
- GET-UP (NCT03788005)
- Testing
- Early mobilization
- Where
- Portugal
- Volunteers
- 208 people
- Sponsor
- Centro Hospitalar do Porto
Chronic Subdural Hematoma
Aspirin Continuation or Discontinuation in Conservative Treatment for Chronic Subdural Hematoma
This clinical study aims to learn about the efficacy and safety of aspirin continuation or discontinuation in conservative treatment for chronic subdural hematoma.
- Trial name
- NCT07240454
- Testing
- Aspirin Continuation, Aspirin Discontinuation
- Where
- 2 sites in China
- Volunteers
- 143 people
- Sponsor
- Tao Liu
Decompressive Craniectomy, Brain Injuries
Good Prognosis Factors After Decompressive Craniectomy : a Ten-year Retrospective Study
Decompressive craniectomy is a treatment of refractory intracranial hypertension after various etiologies : malignant ischemic stroke, traumatic brain injury, intraparenchymal hemorrhage, aneurysmal subarachnoid hemorrhage…
- Conditions
- Decompressive Craniectomy, Brain Injuries, Treatment Outcome
- Trial name
- NCT04682951
- Testing
- Decompressive Craniectomy
- Where
- France
- Volunteers
- 544 people
- Sponsor
- Central Hospital, Nancy, France
Chronic Subdural Hematoma, Subdural Hematoma
Dartmouth Middle Meningeal Embolization Trial (DaMMET)
Chronic subdural hematomas (cSDH) are one form of bleeding in the head. They are one of the most common diseases encountered by neurosurgeons across the country.
- Trial name
- DAMMET (NCT04270955)
- Testing
- Embolization of the Middle Meningeal Artery, Standard of care including possible surgical evacuation of subdural hematoma
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Traumatic Brain Hemorrhage
Traumatic Acute Subdural Haematoma: Management and Outcome
Traumatic acute subdural haematomas (ASDHs) are common pathological entity in neurosurgical practice . The frequency of (ASDHs) has been proposed as approximately 10-20% of patients admitted with traumatic brain injury(TBI)…
- Trial name
- NCT03971240
- Testing
- evacuation of traumatic acute subdural hematoma
- Volunteers
- 39 people
- Sponsor
- Assiut University
Chronic Subdural Hematoma, Stroke
Comparative Study of Embolic Agents in Patients With Subdural Hemorrhage Undergoing Middle Meningeal Artery (MMA) Embolization
Single site, prospective, comparative effectiveness pilot trial comparing efficacy and safety outcomes of three embolic materials (particles, liquid embolics, and Wallaby Phenox coils) in MMA embolication for cSDH.
- Conditions
- Chronic Subdural Hematoma, Stroke, Middle Meningeal Artery Embolization
- Trial name
- NCT07757113
- Testing
- Particles (polyvinyl alcohol or similar microspheres), Liquid Embolics (Onyx, n-BCA, or equivalent), Phenox Coils (Avenir UNO Helical Coil)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sanford Health
Traumatic Subarachnoid Haemorrhage
Neurological Outcome in Patients of Traumatic Subarachnoid Haemorrhage
Traumatic brain injury is common cause of morbidity and mortality worldwide. Incidence and pattern of traumatic brain injury varies in developed and developing countries.
- Trial name
- NCT02073890
- Volunteers
- 117 people
- Sponsor
- Macmillan Research Group UK
Headache, Meningitis
Does Static Ultrasound-Preview Reduce the Incidence of Difficult Lumbar Puncture?
Does the use of ultrasound facilitate a lumbar puncture by reducing the number of difficult and traumatic lumbar punctures?
- Conditions
- Headache, Meningitis, Subarachnoid Hemorrhage
- Trial name
- NCT00317382
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Chronic SDH and the Efficacy of Embolization
Endovascular Embolization for Chronic Subdural Hematomas Following Surgical Evacuation
This study is designed to evaluate the effectiveness of endovascular embolization of middle meningeal artery following evacuation of subdural hematomas (SDHs) to assess rate of recurrence.
- Trial name
- endovascular (NCT04272996)
- Testing
- Craniotomy only, Craniotomy + Endovascular embolization of the middle meningeal vessels
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Augusta University
Hematoma, Subdural, Chronic
Irrigation of Chronic Subdural Hematomas - is More Better?
There are numerous reported ways to treat chronic subdural hematomas (CSDH) and practice is still differing considerably between departments.
- Trial name
- NCT01930617
- Testing
- Burr hole surgery with various drainage techniques
- Where
- 3 sites in Norway, Sweden
- Volunteers
- 1,258 people
- Sponsor
- St. Olavs Hospital
Intracerebral Hemorrhage
Optimization of the Management of Non-Traumatic Intracerebral Hemorrhage (OPT-ICH)
Intracerebral non-traumatic intraparenchymal hemorrhages (ICH) account for 15 to 20% of strokes. One third of the patients dies within the month following ICH, and survivors often experience residual disability with a high risk…
- Trial name
- OPT-ICH (NCT06802588)
- Where
- 3 sites in France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Tours
Aspirin Treatment, Traumatic Intracranial Bleed
Platelet Administration To Patients With Traumatic Brain Injury Who Were Treated With Aspirin
Traumatic brain injury (TBI) is a devastating disease with high morbidity and mortality. Although not fully proved, it is commonly accepted that the morbidity and mortality and proportional to the extent of intracranial bleeds…
- Conditions
- Aspirin Treatment, Traumatic Intracranial Bleed, Hemorrhage Growth, Neurological Outcome
- Trial name
- NCT01135862
- Testing
- platelets
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Mild Head Injury, Anticoagulant
Medico-economic Interest of the Protein S100b in Mild Head Trauma Under Anti-thrombotics
Head trauma is a common injury in emergency department. Investigation to search for complication is guided by the clinical examination and the case history, such as taking anti-thrombotics.
- Conditions
- Mild Head Injury, Anticoagulant, Antiplatelet
- Trial name
- ISTCAT (NCT04305821)
- Testing
- Dosage of S100β protein
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Rennes University Hospital
Seizures, Subdural Hematoma
Diagnostic Subdural EEG-electrode And Subdural hEmatoma (DISEASE)
Epileptic seizures are one of the frequent complications in patients with traumatic brain injury; the incidence lies approximately at 20%.
- Trial name
- NCT04211233
- Testing
- invasive subdural grid electrode, Control arm
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University Clinic Frankfurt
Aneurysm, Ruptured, Aneurysmal Subarachnoid Hemorrhage
Brain Imaging After Non-traumatic Intracranial Hemorrhage (SAVEBRAINPWI)
The study is an observational prospective evaluation of an approved and unchanged clinical management, evaluating different diagnosis methods to assess brain perfusion in patients with an aneurysmal or AVM-related intracranial…
- Conditions
- Aneurysm, Ruptured, Aneurysmal Subarachnoid Hemorrhage, Arteriovenous Malformations, Intracranial Aneurysm
- Trial name
- SAVEBRAINPWI (NCT05276934)
- Testing
- Brain computed tomography
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Erasme University Hospital
Chronic Subdural Hematoma
Middle Meningeal Artery (MMA) Embolization Compared to Traditional Surgical Strategies to Treat Chronic Subdural Hematomas (cSDH)
Chronic Subdural Hematoma (cSDH) is a common hematologic problem particularly in older patients. The purpose of this study is to evaluate the safety and efficacy of middle meningeal artery (MMA) embolization compared to…
- Trial name
- NCT04095819
- Testing
- Middle Meningeal Artery procedure, Traditional Surgery
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Atlantic Health System
Chronic Subdural Hematoma
The Clinical Study of Atorvastatin and Dexamethasone on Treatment for Chronic Subdural Hematoma in the Patients With Coagulation Disorders
To evaluate Efficacy and Safety of oral Atorvastatin and Dexamethasone on conservative treatment for Chronic Subdural Hematoma (CSDH) patients with Coagulation Disorders
- Trial name
- NCT02192320
- Testing
- Atorvastatin, Atorvastatin and Dexamethasone
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Oriental Neurosurgery Evidence-Based-Study Team
Traumatic Brain Injury, Intracranial Hemorrhages
Improving Diagnosis and Prediction of Outcome in Patients With Severe Disorders of Consciousness
Patients with acute severe brain injury are usually admitted to the Intensive Care Unit. A substantial proportion of these patients will have disorders of consciousness (DOC) after interruption of sedation.
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Subarachnoid Hemorrhage, Meningitis
- Trial name
- IMPROVE-DOC (NCT06283901)
- Where
- 5 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)