Clinical trials: Intracranial Hypertension
End- Stage Renal Disease Patients
The Hemodynamic Effects During Sustained Low-efficiency Dialysis Versus Continuous Veno-venous Hemofiltration for Patients With Intracranial Hypertension in a Cross Over Study
Hemodynamic instability occurs frequently during dialysis treatment and still remains as significant cause of patient mobility and mortality.
- Trial name
- NSARF (NCT01781585)
- Testing
- hemodialysis
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Intracranial Pressure Increase, Mechanical Ventilation Complication
Lung Recruitment and PEEP Effects on Intracranial Pressure in Cranial Surgery
High positive end-expiratory pressure (PEEP) levels required to achieve clinical benefits may increase ICP and reduce cerebral perfusion pressure (CPP) in patients at risk of intracranial hypertension.
- Trial name
- NCT06771232
- Testing
- Subdural pressure measurement
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- University of Chile
Intracranial Pressure Increase
Effect of Acetazolamide on Optic Nerve Sheath Diameter in Laparoscopic Donor Nephrectomies
The purpose of the trial is to study the effect of acetazolamide administered via Ryle's tube on optic nerve sheath diameter in laparoscopic live donor nephrectomy patients.
- Trial name
- NCT03005665
- Testing
- Acetazolamide, Normal Saline
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Posterior Reversible Encephalopathy Syndrome
Posterior Reversible Encephalopathy Syndrome in the Critically Ill Patients
Posterior Reversible Encephalopathy Syndrome prospective (PRES) registry. Data collection using a standardized form : demographic data and data related to the PRES, including circumstances of onset, dates and times of onset and…
- Trial name
- NCT03470467
- Testing
- No intervention
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ictal Group
Idiopathic Intracranial Hypertension
MR Lymphatic Imaging in Idiopathic Intracranial Hypertention
In the brain and its borders, blood vessels coexist with lymphatic vessels exclusively in the dura mater, the outermost layer of meninges.
- Trial name
- LYMPHIMAGIIH (NCT05762367)
- Testing
- 3T MRI with Gadobutrol injection
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Intracranial Pressure Increase, Postoperative Cognitive Dysfunction
The Effect of Optic Nerve Diameter on Postoperative Cognitive Function in Laparoscopic Hysterectomy
Prospective study, 40 patients ASA 2-3, 30-75 years old who were planned for laparoscopic hysterectomy operation will be included.One day before the operation and postoperative 1.3.7.
- Trial name
- NCT05286697
- Testing
- measuring optic nerve diameter
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Intracranial Hypertension
Clinical Value of Noninvasive Intracranial Pressure Measurement
The aim of the study is to evaluate accuracy and precision of non-invasive intracranial pressure measurement device (Vittamed 205) for selected patients compared with cerebrospinal fluid pressure measured during lumbar puncture
- Trial name
- Braincare (NCT02130219)
- Testing
- Non-invasive intracranial pressure measurement, Brain MRI/CT, Lumbar puncture and cerebrospinal fluid pressure measurement
- Where
- Lithuania
- Volunteers
- 45 people
- Sponsor
- Lithuanian University of Health Sciences
Traumatic Brain Injury
Measurement of Optic Nerve Sheath in Traumatic Raised Intracranial Pressure
Trauma patients are at risk for serious head trauma. The consequences of serious head trauma are often life altering. Currently, the only method available to rapidly assess the severity of head injury and need for neurosurgical…
- Trial name
- MOONSTRIP (NCT00783809)
- Where
- Canada
- Volunteers
- 560 people
- Sponsor
- McMaster University
Severe Brain Injury
Study of PbiO2 Variation by Body Temperature and Capnia in Severe Head Trauma Patients Treated With Targeted Temperature Control
Serious head trauma is a common and pathology and responsible of high morbidity and mortality. The major challenge, from the very first hours, is to limit cerebral ischemia by controlling secondary brain injury factors.
- Trial name
- TODAY (NCT04109430)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Brest
Idiopathic Intracranial Hypertension (IIH)
Intracranial Venous Stenting Evaluation in Patients With Idiopathic Intracranial Hypertension in the Early Phase
This study is aimed at patients suffering from recently discovered intracranial hypertension, caracterized by visual loss, chronic headache and/or tinnitus.
- Trial name
- DIVE IIN EARLY (NCT06919744)
- Testing
- Best medical care, Intervention (stenting)
- Where
- 3 sites in France
- Volunteers
- 114 people
- Sponsor
- University Hospital, Montpellier
Idiopathic Intracranial Hypertension
Ocular Perfusion in Patients With Idiopathic Intracranial Hypertension
The proposed study aims to evaluate optic nerve head blood flow and microcirculation in patients with idiopathic intracranial hypertension.
- Trial name
- NCT06545981
- Testing
- Lumbar puncture and administration of medication
- Where
- Austria
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Head Injury
Effect of Intrathoracic Pressure Regulation on Traumatic Brain Injury
The purpose of this study is to demonstrate proof of clinical concept that application of the Intrathoracic Pressure Regulator (ITPR) will result in an increase in Cerebral Perfusion Pressure (CPP) and a decrease in Intracranial…
- Trial name
- NCT01824589
- Testing
- -7 cm H2O ITPR, -12cm H2O ITPR
- Volunteers
- 1 people
- Sponsor
- Advanced Circulatory Systems
Hypertension
The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients
Patients with acute brain injury are at risk for complications such as increased pressure in the brain (intracranial pressure (ICP)), decreased blood flow, bleeding, and brain swelling (cerebral edema).
- Trial name
- NCT01526876
- Testing
- clevidipine butyrate
- Sponsor
- Columbia University
Acute Liver Failure, Hepatic Encephalopathy
The Effect of Prometheus (R) Liver Support Dialysis on Cerebral Metabolism in Acute Liver Failure
The main objective of this study is to investigate the effect of Prometheus liver support dialysis on intracranial pressure, cerebral metabolism and circulation in patients with acute liver failure.
- Conditions
- Acute Liver Failure, Hepatic Encephalopathy, Intracranial Hypertension
- Trial name
- NCT00655304
- Testing
- Prometheus (R) liver support dialysis, CVVHDF (Continuously Veno-Venous Hemodiafiltration)
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Liver Failure
Role of Hypertonic Saline Versus Mannitol in the Management of Raised Intracranial Pressure in Patients With ALF
Patients with ALF (Acute liver Failure) would undergo a detailed clinical evaluation. Information would be collected regarding the onset and duration of symptoms, etiology, and severity of disease, other baseline clinical…
- Trial name
- NCT02460510
- Testing
- Mannitol, 3% hypertonic saline
- Where
- India
- Volunteers
- 52 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Idiopathic Intracranial Hypertension
Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension.
Assessing the safety and effectiveness of a 11-βhydroxysteroid dehydrogenase type 1 inhibitor (AZD4017), in a placebo controlled trial, in acute idiopathic intracranial hypertension (IIH) IIH is a condition of young, overweight…
- Trial name
- IIH:DT (NCT02017444)
- Testing
- AZD4017
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- University of Birmingham
Liver Transplantation
Incidence of Intracranial Hypertension During Liver Transplantation Estimated by Non-invasive Ultrasound Methods.
Acute or chronic liver failure (fulminant hepatitis or advanced cirrhosis) disrupts brain physiology. Beyond classical hepatic encephalopathy, intracranial hypertension may occur.During liver transplantation (LT) surgery, many…
- Trial name
- TOH-HTIC (NCT02695823)
- Testing
- Ultrasound
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Hospices Civils de Lyon
Benign Intracranial Hypertension
Diagnostic and Prognostic Biomarkers of Idiopathic Intracranial Hypertension
Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, primarily affecting overweight females of childbearing age.
- Trial name
- NCT04032379
- Testing
- Standard treatment
- Where
- 2 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Danish Headache Center
Optic Nerve Sheath Diameter Measurement, Intracranial Pressure Increase
Assessment of Optic Sheat Diameter (ONSD) and Eyeball Transverse Diameter (ETD) Ratio Measurement From Ocular Ultrasound
The aim of this study is to evaluate the effects of different carbon dioxide gas insufflation pressures on the ultrasound-guided optic nerve sheath diameter in patients undergoing laparoscopic cholecystectomy and to determine the…
- Conditions
- Optic Nerve Sheath Diameter Measurement, Intracranial Pressure Increase, Laparoscopic Cholecystectomy Surgery
- Trial name
- ONSD ETD (NCT07784361)
- Testing
- Low Pressure Group, High Pressure Group
- Volunteers
- 68 people
- Sponsor
- Gaziantep City Hospital
Intracranial Hypertension
Assessment of Venous Drainage in Idiopathic Intracranial Hypertension
Intracranial hypertension (IIH) is a disorder producing a syndrome of increased intracranial pressure secondary to a compressive intracranial lesion or said to be idiopathic.
- Trial name
- HYPERPIC (NCT04115553)
- Testing
- MRI examination, ECG
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens