Clinical trials: Intracranial Large Vessel Occlusion
Stroke
Minor Stroke Therapy Evaluation
Stroke represents the fourth leading cause of death in industrialized nations, after heart disease, cancer, and chronic lower respiratory disease.
- Trial name
- MOSTE (NCT03796468)
- Testing
- Best Medical Therapy, Mechanical Thrombectomy
- Where
- France
- Volunteers
- 824 people
- Sponsor
- University Hospital, Montpellier
Stroke, Stroke, Acute Ischemic
IntraCranial Atherosclerosis Related Large-vessel Occlusion Treated With Urgent Stenting (ICARUS)
The goal of this international, multi-center, randomized clinical trial is to compare two treatment options, early intracranial stenting and continued stent-retriever or aspiration based endovascular treatment, for stroke…
- Conditions
- Stroke, Stroke, Acute Ischemic, Intracranial Atherosclerosis
- Trial name
- NCT06472336
- Testing
- Intracranial stenting, Continuation of conventional endovascular therapy (EVT)
- Where
- Switzerland
- Volunteers
- 498 people
- Sponsor
- University Hospital, Basel, Switzerland
Malignant Media Infarction, Stroke
Optic Nerve Sonography to Monitor Intracranial Pressure After Ischemic sTrokE - The ONSITE Study
The goal of the ONSITE study is to investigate whether an increase Optic nerve sheath diameter (ONSD) may help to predict intracranial hypertension (IH) after stroke.
- Conditions
- Malignant Media Infarction, Stroke, Intracranial Hypertension
- Trial name
- ONSITE (NCT06939114)
- Where
- Switzerland
- Volunteers
- 107 people
- Sponsor
- University of Zurich
Acute Ischemic Stroke
Imaging Guided Patient Selection for Interventional Revascularization Therapy
The primary objective of this clinical evaluation is to determine the safety and effectiveness of the Penumbra System in a stroke cohort who presents within 8 hours from symptom and with a known core infarct volume at admission.
- Trial name
- START (NCT00963989)
- Testing
- Penumbra System
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Penumbra Inc.
Brain Stroke, Stenting Treatment
Emergent Large Vessel Occlusion Endovascular Rescue Therapy With Underlying Intracranial Stenosis
The study objective is to establish the safety and efficacy of endovascular adjunct stenting for patients undergoing mechanical thrombectomy (MT) that are found to have residual stenosis (70-99%) following attempted clot…
- Conditions
- Brain Stroke, Stenting Treatment, Acute Ischemic Stroke
- Trial name
- EVEREST (NCT07356284)
- Testing
- Mechanical Thrombectomy plus adjunct stenting, Mechanical Thrombectomy
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- ProMedica Health System
Acute Ichemic Stroke, Anterior Cerebral Artery Stroke
Safety and Efficacy of Baricitinib After Endovascular Treatment in Acute Anterior Circulation Large Vessel Occlusion: A Multicenter, Randomized Controlled Clinical Trial
The primary purpose of this study is to evaluate the efficacy and safety of Baricitinib combined with endovascular therapy in patients with acute anterior circulation large vessel occlusion, to address futile recanalization with…
- Conditions
- Acute Ichemic Stroke, Anterior Cerebral Artery Stroke, Baricitinib
- Trial name
- NCT07449910
- Testing
- 2mg Baricitinib, 4mg Baricitinib, Guideline-based therapy
- Where
- China
- Volunteers
- 750 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Intracranial Atherosclerotic Stenosis-Related Large Vessel Occlusion, Acute Ischemic Stroke
Efficacy and Safety of Bailout Intracranial Angioplasty or Stenting After Thrombectomy for Acute Intracranial Atherosclerotic Large Vessel Occlusion (ANGEL-REBOOT 2)
A multicenter, randomized, open-label, blinded-endpoint trial with a concurrent prospective observational cohort to compare bailout intracranial angioplasty or stenting versus standard therapy on functional outcome, stroke…
- Conditions
- Intracranial Atherosclerotic Stenosis-Related Large Vessel Occlusion, Acute Ischemic Stroke, Bailout Angioplasty or Stenting
- Trial name
- NCT07618052
- Testing
- Bailout Intracranial Angioplasty or Stenting, Standard Thrombectomy
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Feng Gao
Acute Ischemic Stroke
Intravenous Tirofiban After Bridging Therapy for Acute Stroke With Atherosclerotic Large Artery Occlusion
The investigators propose to assess the efficacy and safety of intravenous tirofiban after bridging therapy (endovascular therapy [EVT] following intravenous Tenecteplase) for acute ischemic stroke due to intracranial…
- Trial name
- RESCUE-AS (NCT07335107)
- Testing
- Intravenous Tirofiban, Standard Medical Therapy
- Where
- China
- Volunteers
- 564 people
- Sponsor
- Beijing Tiantan Hospital