Clinical trials: Intracranial Neoplasms
Glioblastoma Multiforme, Anaplastic Astrocytoma
Super-Selective Intraarterial Intracranial Infusion of Avastin (Bevacizumab)
The high-grade malignant brain tumors, glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA), comprise the majority of all primary brain tumors in adults.
- Trial name
- NCT00968240
- Testing
- Super-Selective Intraarterial Intracranial Infusion of BEVACIZUMAB
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Pelvic Fracture, Prostate Cancer
A COhort Study on Factors Leading to Vulnerability in Adult Patients With Serious Medical cOnditionS: the COSMOS-I Trial
The objective of this prospective multicentre study that recruits altogether 1500 older patients from the university hospitals of Tampere, Kuopio, and Oulu is to explore the clinical significance and detection of causes of…
- Conditions
- Pelvic Fracture, Prostate Cancer, Lung Cancer, Brain Metastasis
- Trial name
- COSMOS-I (NCT07740239)
- Testing
- Test set to determine vulnerability
- Where
- Finland
- Volunteers
- 2,050 people
- Sponsor
- Tampere University Hospital
Endometrial Cancer, Abnormal Uterine Bleeding
ONSD as an ICP Marker in vNOTES and TLH
Patients undergoing conventional total laparoscopic hysterectomy (TLH) are typically placed in the Trendelenburg position with intraabdominal carbon dioxide (CO₂) insufflation.
- Conditions
- Endometrial Cancer, Abnormal Uterine Bleeding, Myoma;Uterus
- Trial name
- NCT07250178
- Testing
- vNOTES, TLH
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Intracranial Neoplasm
Fluoroethyltyrosine for the Evaluation of Intracranial Neoplasm
This is a single center study investigating the use of Fluoroethyltyrosine (FET) in the detection of brain tumors. FET accumulates in malignant cells within intracranial neoplasms and can be used to detect recurrent disease and…
- Trial name
- NCT06474533
- Testing
- Fluorethyltyrosine (18-F), Positron Emission Tomography (PET)
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- Thomas Hope
Brain Cancer Metastatic, CMV Viremia
Trial to Study Anti- HCMV Therapy in Breast Cancer Patients With Progressive Intracranial Metastases and CMV Infection
This is a phase II trial with an initial safety lead-in evaluating the efficacy, safety, neurocognitive, and quality-of-life outcomes of anti-cytomegalovirus (CMV) therapy and standard-of-care (SOC) in patients with anti-human…
- Trial name
- NCT07383649
- Testing
- Valganciclovir
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The Methodist Hospital Research Institute
Non Small Cell Lung Cancer Metastatic
A Study of Stereotactic Radiosurgery (SRS) and Standard Treatment in People With Lung Cancer That Has Spread to the Brain
The researchers are doing this study is to find out whether treating brain metastasis with SRS after 3 months of therapy with osimertinib is better than treating with osimertinib alone in people with NSCLC.
- Trial name
- NCT06741085
- Testing
- osimertinib, stereotactic radiosurgery (SRS)
- Where
- 8 sites in United States
- Volunteers
- 56 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Intracranial Glioma, Metastatic Brain Tumor
F-Tryptophan PET/CT in Human Cancers
Imaging procedures such as 1-(2-[18F]FLUOROETHYL)-L-Tryptophan PET/CT in patients with cancers may help doctors assess a patient's response to treatment and help plan the best treatment in the future.
- Conditions
- Intracranial Glioma, Metastatic Brain Tumor, Breast Cancer, Neuroendocrine Tumors
- Trial name
- NCT05556473
- Testing
- 1-(2-[18F]FLUOROETHYL)-L-Tryptophan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Intracranial Meningioma, Neurologic Deficits
Hyperbaric Oxygen Therapy Can Improve Neurological State Post Meningioma Removal Surgery
The aim of the current study is to evaluate, in a prospective cross-over, randomized study, the effect of hyperbaric oxygen therapy (HBOT) on patients with chronic neurological deficits and cognitive impairment after anterior…
- Trial name
- NCT02084927
- Testing
- HBOT
- Where
- Israel
- Volunteers
- 62 people
- Sponsor
- Assaf-Harofeh Medical Center
Glioblastoma Multiforme
Super-Selective Intraarterial Intracranial Infusion of Bevacizumab (Avastin) for Glioblastoma Multiforme
The high-grade malignant brain tumor glioblastoma multiforme (GBM) comprise the majority of all primary brain tumors in adults. This group of tumors also exhibits the most aggressive behavior, resulting in median overall survival…
- Trial name
- NCT02285959
- Testing
- Bevacizumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Global Neurosciences Institute
Brain Metastases, Adult, Non Small Cell Lung Cancer
SILibinin in NSCLC and BC Patients With Single Brain METastasis (SILMET)
This study aims to evaluate the efficacy of silibinin in preventing recurrence in the brain after complete resection of a brain metastasis (BM) from non-small-cell lung cancer (NSCLC) or breast cancer (BC).
- Conditions
- Brain Metastases, Adult, Non Small Cell Lung Cancer, Breast Cancer
- Trial name
- SILMET (NCT05689619)
- Testing
- Silibinin
- Where
- 6 sites in Italy
- Volunteers
- 70 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Adult Intracranial Tumor, Adult Solid Tumor
A Comparison of Remifentanil and Dexmedetomidine for Craniotomy Perioperative Hemodynamics and Postoperative Pain
This will be a randomized blinded clinical trial. Patients will be randomized to receive either a remifentanil or dexmedetomidine infusion for general anesthesia.
- Trial name
- RemivsDex (NCT01269918)
- Testing
- Remifentanil, Dexmedetomidine
- Where
- 2 sites in United States
- Volunteers
- 142 people
- Sponsor
- The Cleveland Clinic
Brain Cancer
Pilot Study of Optune (NovoTTF-100A) for Recurrent Atypical and Anaplastic Meningioma
The purpose of this study is to find out what effects, good or bad, the Optune device has on the patient and meningioma. This study is being done because currently there are no proven effective medical treatments for a…
- Trial name
- NCT01892397
- Testing
- Optune (NovoTTF-100A)
- Where
- 9 sites in United States
- Volunteers
- 6 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Dementia, Dysphagia
Family Caregiver Online Survey (Dementia and Swallowing Difficulties)
The Family Caregiver Survey is a one-time, 30-minute, online survey for people living with and caring for a family member with dementia.
- Conditions
- Dementia, Dysphagia, Dementia Alzheimers, Dementia, Vascular
- Trial name
- NCT06471660
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Intracranial Meningioma
Comparing the Radiopharmaceutical Drug, [177Lu]Lu-DOTATATE, to Standard of Care Treatment for Patients With Meningioma That Has Come Back After Prior Treatment
This is an open-label, multicenter, randomized, phase 2 clinical study to evaluate the efficacy of [177Lu]Lu-DOTATATE in patients with progressive grade 1-3 intracranial meningioma.
- Trial name
- MOMENTUM-1 (NCT06955169)
- Testing
- [177Lu]Lu-DOTATATE, Standard of Care treatments
- Where
- 17 sites in United States
- Volunteers
- 130 people
- Sponsor
- RTOG Foundation, Inc.
Intracranial Hemorrhage, Hypertensive, Craniotomy Tumor Removal Surgery
Comparison of Post-Craniotomy Blood Pressure Targets
The goal of this pragmatic clinical trial is to learn if a more intensive or more liberal blood pressure target after surgery is more effective in improving patient outcomes for adults undergoing craniotomy for removal of a brain…
- Trial name
- COMPETE (NCT07093151)
- Testing
- Target SBP <160mmHg, Target SBP <140 mmHg
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
Glioma, Glioma Intracranial
A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas
This study uses a cranial implant to deliver cortical stimulation that, when paired with physiotherapy, will remap the brain so that critical brain functions can be protected during brain tumor surgery.
- Conditions
- Glioma, Glioma Intracranial, Gliomas Benign, Brain Tumor
- Trial name
- NCT04745156
- Testing
- RNS System Implantation
- Volunteers
- 3 people
- Sponsor
- Medical College of Wisconsin
Intracranial Tumor
Observational Study of the Differences in Characteristics of the Spontaneous Electroencephalogram, Derived From the Left and Right Hemisphere in Patients With Unilateral Intracranial Tumor During Routine Anesthesia: Comparison With a Control Group Without Intracranial Pathology
Study of the influence of brain tumor on bilateral electroencephalogram (EEG) during anaesthesia.
- Trial name
- VISTA (NCT00936806)
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Cholecystitis, Ovarian Cyst
ONSD According to the Position During Laparoscopy
Increase of intracerebral pressure (ICP) during laparoscopic surgery has known to be associated with positional changes. Optic nerve sheath diameter (ONSD) has correlation with ICP and ultrasonographic measurement of optic nerve…
- Conditions
- Cholecystitis, Ovarian Cyst, Ovarian Cancer, Uterine Myoma
- Trial name
- ONSD (NCT01937104)
- Testing
- Desflurane, Remifentanil, Ultrasonographic measurement of ONSD
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Chosun University Hospital
Intracranial Germ Cell Tumor
Evaluating Structural and Functional Changes of Brain by fMRI and DTI in Patients With Intracranial Germ Cell Tumors
BOLD-fMRI and DTI scans are performed to patients with germ cell tumors in the basal ganglia before and after treatments. The changes of the MRI and muscle strength of patients during treatments are evaluated, and the association…
- Trial name
- NCT03771625
- Testing
- radiotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Neurosurgical Institute
Brain Neoplasms, Meningioma
Preoperative Embolization for Highly Vascular Brain Tumors
Highly vascular brain tumors, including meningiomas, hemangioblastomas, and certain metastases, have a rich blood supply that can lead to substantial blood loss and technical difficulties during surgical removal.
- Conditions
- Brain Neoplasms, Meningioma, Hemangioblastoma, Brain Metastases
- Trial name
- NCT07823985
- Testing
- Preoperative Endovascular Embolization
- Volunteers
- 55 people
- Sponsor
- Assiut University