Clinical trials: Intracranial Pathology
Intracranial Aneurysm, Inflammation
Unruptured Intracranial Aneurysm Aspirin Trial (UIAAT).
Does Aspirin reduce inflammation in the walls of unruptured brain aneurysms? Brain aneurysms are balloon-like outpouchings of a blood vessel resulting from a weakness in the vessel wall.
- Trial name
- UIAAT (NCT03661463)
- Testing
- Aspirin
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Chronic Subdural Hematoma
A Prospective Randomized Study Evaluating the Recurrence Rate of Chronic Subdural Hematoma After Placing a Subperiosteal Drainage Compared to a Subdural Drainage
The aim of our study is to investigate in randomized controlled fashion whether the recurrence and complication rate, after insertion of subperiosteal drainage in the treatment of chronic subdural haematoma, is higher compared to…
- Trial name
- NCT01869855
- Testing
- Subdural Drainage, Subperiosteal Drainage
- Where
- 2 sites in Switzerland
- Volunteers
- 220 people
- Sponsor
- Kantonsspital Aarau
Head Trauma, Head Injury
Delayed IntraCranial Hemorrhage in Oral AntiCoagulant Treated Patients With Mild Traumatic Brain Injury
As a low quality, weak recommendation, it is part of the Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults, that patient with a GCS of 14-15 and anticoagulation therapy and a…
- Conditions
- Head Trauma, Head Injury, Delirium, Thrombosis
- Trial name
- dICH-OAC (NCT07195760)
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Bispebjerg Hospital
Cerebrospinal Fluid Leak
Perioperative CSF Leak Management - an Opinion Study
Cerebrospinal fluid (CSF) leak is a rare condition. When it involves the ventral skull base, a surgical closure may be achieved using endoscopic skull base surgery techniques.
- Trial name
- NCT04124523
- Where
- France
- Volunteers
- 153 people
- Sponsor
- University Hospital, Montpellier
Subarachnoid Hemorrhage
Predictive Value of Mean Flow Velocity by TCD in Early Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage
Aim of this work is to evaluate the transcranial doppler in prediction of cerebral vasospasm in aneurysmal subarachnoid hemorrhage and also to evaluate their advantages over clinical scales in predicting CV.
- Trial name
- NCT04329208
- Testing
- Transcranial doppler
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University Hospital
Acute Ischemic Stroke
Permanent Intracranial Stenting for Acute Ischemic Stroke Related to a Refractory Large Vessel Occlusion
Clot extraction failure during mechanical thrombectomy is a major concern in the management of acute ischemic stroke related to large vessel occlusions.
- Trial name
- PISTAR (NCT06071091)
- Testing
- Intracranial stenting, Optimal medical care, without additional endovascular procedures
- Where
- 13 sites in France
- Volunteers
- 346 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Procedural Pain
To Explore the Optimal Dose of Dexmedetomidine for Skull Pin Fixation in Intracranial Surgery
Skull pin fixation is commonly used in intracranial surgery, which can increase the surgical field of view. Because skull pin fixation is a very irritating and painful medical treatment, it often results in tachycardia (>150-160…
- Trial name
- NCT06837818
- Testing
- Dexmedetomidine
- Volunteers
- 40 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Intracerebral Hemorrhage (ICH), Hemorrhagic Stroke, Intracerebral
Spleen Volume Change Predicts 45-Day Mortality in Neurocritical Care: A Prospective Cohort Study
This study investigates whether changes in spleen size over 72 hours can help predict the risk of death within 45 days in patients who were admitted to the emergency department with a type of bleeding in the brain called…
- Conditions
- Intracerebral Hemorrhage (ICH), Hemorrhagic Stroke, Intracerebral, Neurocritical Care, Acute Brain Injury
- Trial name
- SCOPE (NCT07132996)
- Testing
- POCUS-based Splenic Volume Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara City Hospital Bilkent
Atrial Fibrillation
Atrial Fibrillation and the Risk for Neurological Complications
B8: Atrial fibrillation and the risk of neurological complications Twenty-five thousand acute strokes are caused by atrial fibrillation every year.
- Trial name
- NCT00357227
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Chronic Subdural Hemorrhage (cSDH)
Chronic Subdural Hematoma Embolization With Detachable Coils
This is a prospective, multi-center, post market registry study designed to evaluate the safety and efficacy of treatment with Balt coils in patients with chronic subdural hematoma (cSDH).
- Trial name
- SEED (NCT07291427)
- Testing
- Balt coils: (Balt USA, LLC), MMA embolization
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Subdural Hematoma
Neuroendoscopy-assisted Drainage Versus Burr Hole Drainage for Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a frequent condition in neurosurgery, leading to fluid accumulation between the meninges, brain compression, neurological dysfunction, and potentially herniation.
- Trial name
- URANUS (NCT07144423)
- Testing
- Endoscope-assisted hematoma drainage, Burr hole hematoma drainage
- Where
- 24 sites in China
- Volunteers
- 770 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Hemorrhages
Minimal Invasive Surgical Intracerebral Hemorrhage Removal
This is a feasibility study trial to determine whether hyperacute (≤8 hour) mechanical Minimal Invasive Surgical (MIS) management is feasible and secondarily improves outcome in patients with spontaneous supratentorial…
- Trial name
- HEALME (NCT05138341)
- Testing
- Minimally invasive surgical (MIS) intracranial hemorrhage Evacuation
- Volunteers
- 16 people
- Sponsor
- The Ottawa Hospital
Ischemic Stroke
Dual Thrombolytic Therapy With Mutant Pro-urokinase and Low Dose Alteplase for Ischemic Stroke
Randomized controlled phase II trial to test the safety and preliminary efficacy of a dual thrombolytic treatment consisting of a small intravenous (IV) bolus of alteplase followed by IV infusion of mutant pro-urokinase against…
- Trial name
- DUMAS (NCT04256473)
- Testing
- mutant pro-urokinase, Alteplase
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
Subarachnoid Hemorrhage, Ruptured Intracranial Aneurysm
Safety and Efficacy Study of a Single Dose of NA-1 in Patients Undergoing Endovascular Repair of Ruptured Aneurysms
This is a randomized, double-blind, placebo-controlled, single-dose study investigating the safety and efficacy of NA-1 in patients with subarachnoid hemorrhage (SAH) undergoing endovascular repair of ruptured intracranial…
- Trial name
- ENACT-2 (NCT02056574)
- Testing
- NA-1
- Where
- 12 sites in United States, Canada
- Sponsor
- NoNO Inc.
Acute Ischemic Stroke, Intracranial Arterial Stenosis
Post-Market Active Surveillance and Health Economic Evaluation of Cerebrovascular Diagnostic and Therapeutic Devices
The research focuses on "post-market active surveillance and health economic evaluation of non-pharmacological therapies and innovative cerebrovascular diagnostic and therapeutic devices".
- Conditions
- Acute Ischemic Stroke, Intracranial Arterial Stenosis, Extracranial Arterial Stenosis, Intracranial Aneurysms
- Trial name
- NCT07828379
- Testing
- Endovascular Treatment for Acute Ischemic Stroke
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
InTracranial Haemorrhage
FAITH - Factor XA Inhibitor-Related InTracranial Haemorrhage
FAITH study is a multicentre retrospective analysis study that aims to understand the burden of ICH related to FXa inhibitors and the current treatment approaches in country/countries where specific reversal agents are not…
- Trial name
- FAITH (NCT06420011)
- Where
- 10 sites in Argentina, Brazil and 5 more
- Volunteers
- 123 people
- Sponsor
- AstraZeneca
Intracranial Pressure Increase
Posterior Fossa Intracranial Pressure (ICP) Measurement: Clinical Study
In modern medicine, doctors attempt to monitor all physiological variables to assess their evolution and to decide, based on their changes, the therapeutic attitudes to adopt.
- Trial name
- Postfossa ICP (NCT04675216)
- Testing
- Posterior fossa intracranial pressure measurement
- Where
- 2 sites in Spain
- Volunteers
- 12 people
- Sponsor
- University of Valencia
Traumatic Brain Injury, Cerebral Hemorrhage
Effect of Median Nerve Electrical Stimulation Combined With Auricular Acupuncture on Consciousness Disturbance in Patients With Craniocerebral Injury
This study aims to evaluate the effects of auricular press needle therapy, combined with conventional treatment and median nerve electrical stimulation, on promoting arousal and neurological recovery in patients with disorders of…
- Trial name
- ANECT-CCI (NCT07273864)
- Testing
- Conventional Neurosurgical and Supportive Care, Right Median Nerve Electrical Stimulation, Auricular Press-Needle Therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Li Hai
Intracranial Hypotension
The Blood Patch in the Management of Intracranial Hypotension
Intracranial hypotension results from leakage and/or hypotension of cerebrospinal fluid. It can be spontaneous or secondary to a dural puncture complicating perimedullary anesthesia or a lumbar puncture.
- Trial name
- BPIH (NCT06498804)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Stroke, Acute, Cerebrovascular Disorders
Therapy Evaluation in Patients With Minor Stroke and Large Vessel Occlusion
This multicenter registry study, which record the therapy strategy and follows up these acute ischemic stroke (AIS) patients with low NIHSS and large vessel occlusion (LVO), is intended to provide the important data for therapy…
- Conditions
- Stroke, Acute, Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases
- Trial name
- TEMPOS (NCT06633809)
- Testing
- Immediate endovascular therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sir Run Run Shaw Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.