Clinical trials: Intracranial Pathology
Aneurysmal Subarachnoid Hemorrhage
Cilostazol and Nimodipine Combined Therapy After Aneurysmal Subarachnoid Hemorrhage (aSAH)
The investigators seek to demonstrate that the combined use of cilostazol and nimodipine will significantly decrease the rate of delayed cerebral infarction and cerebral vasospasm after cerebrovascular intervention when compared…
- Trial name
- NCT04148105
- Testing
- Cilostazol 100 MG
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Henry Ford Health System
Idiopathic Intracranial Hypertension
Idiopathic Intracranial Hypertension Treatment Trial
Idiopathic intracranial hypertension (IIH), also called pseudotumor cerebri, is a disorder of elevated intracranial pressure of unknown cause [Corbett, et al., 1982; Wall, et al., 1991].
- Trial name
- IIHTT (NCT01003639)
- Testing
- Acetazolamide, Formal weight loss counselling program
- Where
- 41 sites in United States, Canada
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Intracerebral Hemorrhage, CAA - Cerebral Amyloid Angiopathy
MRI-markers to Monitor Small Vessel Disease Dynamics in the Prognosis of Small Vessel Disease-associated, Cerebrovascular Events
This is a nested cohort study in the PRO-SVD cohort. Small vessel disease is a chronic disease and is thought to progress over time.
- Conditions
- Intracerebral Hemorrhage, CAA - Cerebral Amyloid Angiopathy, Cerebral Small Vessel Diseases
- Trial name
- MRI-PRO-SVD (NCT05773235)
- Testing
- Combined 3- and 7 Tesla-MRI
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Subarachnoid Hemorrhage, Aneurysmal
Shuxuening Injection for the Prevention of CVS in Patients With aSAH(SXN-CVS)
Aneurysmal subarachnoid hemorrhage (SAH) is a frequent worldwide cause for stroke with a mortality of around 30%. Worldwide, almost 500 000 patients have aneurysmal SAH annually.An incidence of 2-16 cases of spontaneous SAH per…
- Trial name
- SXN-CVS (NCT06138353)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xiaolin Chen, MD
Infant, Newborn, Infant, Small for Gestational Age
Vitamin E for Extremely Preterm Infants
The purpose of this pilot trial is to test the safety and efficacy of administering one dose of vitamin E, via a tube into the stomach, to extremely preterm infants (less than 27 weeks gestation and less than 1000 grams birth…
- Conditions
- Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Infant, Premature
- Trial name
- NCT01193270
- Testing
- Vitamin E
- Where
- 16 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Subarachnoid Hemorrhage, Aneurysmal
Angiotensin Metabolite Profile After Subarachnoid Hemorrhage
The outcome of subarchnoid hemorrhage depends on the severity of the bleeding and the development of secondary neurologic deficits caused by cerebral vasospasm.
- Trial name
- NCT05222542
- Testing
- Sampling of plasma and cerebrospinal fluid at specified time points
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Dr. Roman Ullrich
Chronic Subdural Hematoma
GET-UP Trial: Impact of an Early Out-of-bed Paradigm in Postoperative Outcomes of Chronic Subdural Hematomas
Compare rates of medical complications, recurrence and outcome in 2 randomized groups of patients with surgical chronic subdural hematomas.
- Trial name
- GET-UP (NCT03788005)
- Testing
- Early mobilization
- Where
- Portugal
- Volunteers
- 208 people
- Sponsor
- Centro Hospitalar do Porto
Subarachnoid Hemorrhage
French Validation of the SAHOT Outcome Scale After Subarachnoid Haemorrhage
Survivors of subarachnoid haemorrhage (SAH) frequently experience cognitive, psychological, physical and social sequelae, but no French-language instrument covers all these dimensions.
- Trial name
- SAHOT-FR (NCT07894666)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Intraventricular Hemorrhage, Cerebral Hemorrhage
Early Lumbar Drainage for Intraventricular Hemorrhage
This is a multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) trial in Chinese patients with intraventricular hemorrhage (IVH), comparing early lumbar drainage added to standard care with standard care…
- Trial name
- LD-IVH (NCT07625449)
- Testing
- Control treatment plus lumbar drainage, Control treatment schedule
- Where
- 31 sites in China
- Volunteers
- 392 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Stroke
ACT-GLOBAL Adaptive Platform Trial for Stroke
Stroke is causing 6.6 million deaths and is a major cause of disability worldwide in 2019. There remains an urgent need for interventions that improve outcomes which can be implemented with wide applicability for stroke.
- Trial name
- NCT06352632
- Testing
- Standard-dose intravenous tenecteplase, Low-dose intravenous tenecteplase, No intravenous tenecteplase
- Where
- 2 sites in Australia, Canada
- Volunteers
- 20,000 people
- Sponsor
- The George Institute
Headache, Aneurysm
Headache After Coil Embolization for Unruptured Intracranial Aneurysms
Perform a prospective cohort study to compare the incidence and severity of headache between non-stent assisted coiling and stent assisted coiling of unruptured intracranial aneurysms.
- Conditions
- Headache, Aneurysm, Endovascular Procedures
- Trial name
- NCT03359252
- Testing
- non-stent assisted coiling, stent assisted coiling
- Where
- South Korea
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Subarachnoid Hemorrhage, Aneurysm
Dexmedetomidine and Subarachnoid Haemorrhage
The purpose of this study is to investigate how dexmedetomidine affects static and dynamic autoregulation, intracranial pressure (ICP) and cerebral oxygenation in aneurysmal subarachnoid haemorrhage (SAH) patients.
- Trial name
- NCT01664520
- Testing
- Dexmedetomidine infusion
- Where
- Finland
- Volunteers
- 10 people
- Sponsor
- Turku University Hospital
Procedural Pain
To Explore the Optimal Dose of Alfentanil for Skull Pin Fixation in Intracranial Surgery
Forty patients were enrolled, and all patients used total intravenous anesthesia (alfentanil-propofol based TIVA) as anesthesia induction and maintenance.
- Trial name
- NCT06563297
- Testing
- Alfentanil
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Aneurysm, Intracranial Aneurysm
Appraising the Embolization of Aneurysms Using Balt Optima™ Coil System (APPLY Study)
In recent years, many developments have been made to the tools and techniques used to treat IAs via endovascular intervention. Specifically, to the detachable coils themselves.
- Conditions
- Aneurysm, Intracranial Aneurysm, Ruptured Aneurysm, Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- APPLY (NCT04499508)
- Testing
- Optima Coil System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vascular Neurology of Southern California Inc.
Perinatal Death, Respiratory Distress Syndrome, Newborn
Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities
Hyperoxygenation for resuscitation of abnormal fetal heart rate tracings has been routine obstetric practice. However, there have not been any studies to support this practice.
- Conditions
- Perinatal Death, Respiratory Distress Syndrome, Newborn, Hypoxic-Ischemic Encephalopathy, Neonatal Seizure
- Trial name
- NCT03996317
- Testing
- Room air
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Alzheimer Disease (AD), Mild Cognitive Impairment (MCI)
China HEalthy Aging and Dementia Study (HEAD)
The China HEalthy Aging and Dementia (HEAD) study is a large-scale, community-based, multi-center prospective cohort study covering eastern, northern, southern, and central-western regions of China.
- Conditions
- Alzheimer Disease (AD), Mild Cognitive Impairment (MCI), Dementia, Vascular Dementia (VaD)
- Trial name
- NCT07912710
- Where
- 30 sites in China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Subarachnoid Hemorrhage, Spontaneous
Multicenter Registry of Patients With Subarachnoid Hemorrhage
The purpose of this registry is to collect detailed information on the characteristics, treatment, and outcomes of patients with a subarachnoid hemorrhage.
- Trial name
- MEASURE (NCT07482124)
- Testing
- None, observational study
- Where
- 9 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
CADASIL
Generation of a Cellular Model of CADASIL From Skin Fibroblasts
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leucoencephalopathy (CADASIL) is an archetypal small vessel disease of the brain caused by dominant mutations in the NOTCH3 receptor.
- Trial name
- NCT02032225
- Testing
- Skin biopsy
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Intracerebral Haemorrhage
Surgical Trial in Lobar Intracerebral Haemorrhage
To establish whether a policy of earlier surgical evacuation of the haematoma in selected patients with spontaneous lobar ICH will improve outcome compared to a policy of initial conservative treatment.
- Trial name
- NCT01320423
- Testing
- Surgical Trial
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- Taipei Medical University WanFang Hospital
Communicating Hydrocephalus, Cerebral Intraventricular Hemorrhage
The Safety and Efficacy of Rapamycin on Communicating Hydrocephalus Secondary to Intraventricular Hemorrhage
This prospective, multicenter, open-label clinical trial is designed to evaluate the safety and efficacy of rapamycin in the treatment of communicating hydrocephalus secondary to intraventricular hemorrhage.
- Conditions
- Communicating Hydrocephalus, Cerebral Intraventricular Hemorrhage, Secondary Normal Pressure Hydrocephalus, Post Hemorrhagic Hydrocephalus
- Trial name
- Saturn (NCT06563817)
- Testing
- Rapamycin
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Beijing Tiantan Hospital
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