Clinical trials: Intracranial Pathology
Chronic Subdural Hematoma
The Efficacy of the Longeviti ClearFit Implant in Craniectomies for Post-Operative Monitoring in Chronic Subdural Hematomas
Chronic subdural hematomas are frequent neurosurgical issues that are most often treated with burr hole craniectomies to drain the subdural fluid.
- Trial name
- NCT06127615
- Testing
- ClearFit
- Sponsor
- University of Kansas Medical Center
Acute Ischemic Stroke, Haemorrhagic Stroke
Translational Immunodiagnostics in Stroke (TrImS)
In adult patients presenting to emergency departments within 24 hours of symptom onset with suspected acute stroke, we aim: 1. to identify early brain- and pathology-specific circulating, whole blood, plasma and serum panorOmic…
- Conditions
- Acute Ischemic Stroke, Haemorrhagic Stroke, Transient Ischemic Attacks, Cardioembolic Stroke
- Trial name
- TrImS (NCT05300997)
- Testing
- Biomarker blood draw and saliva collection
- Where
- China
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Central Nervous System Diseases
Dexmedetomidine for Prevention of Postoperative Delirium After Intracranial Operation for Brain Tumor
Postoperative delirium is common after major surgery, and is associated with adverse outcomes. Systematic reviews and meta-analyses of randomized controlled trials have shown that perioperative administration of dexmedetomidine…
- Trial name
- DEPOD (NCT04399343)
- Testing
- Dexmedetomidine, Normal saline
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Capital Medical University
Intracerebral Hemorrhage, Hemorrhagic Stroke, Intracerebral
Safety and Feasibility of Using Cerebrolysin in the Treatment of Primary Intracerebral Hemorrhage - a Prospective Randomized Open Blinded End-point Trial
This study is designed to determine the safety and feasibility of using Cerebrolysin in treating primary intracerebral hemorrhage (ICH).
- Conditions
- Intracerebral Hemorrhage, Hemorrhagic Stroke, Intracerebral, Hemorrhagic Stroke, Stroke
- Trial name
- CLINCH (NCT06899464)
- Testing
- 14-day Cerebrolysin treatment, Standard of Care (SOC)
- Volunteers
- 30 people
- Sponsor
- Cardinal Stefan Wyszynski University
Stroke, Transient Ischemic Attack
Efficacy and Safety of Stent Implantation in Symptomatic Extra- and Intracranial Artery Stenosis
The purpose of this study is to evaluate the efficacy and safety of stent implantation in patients with symptomatic extra- and intracranial artery stenosis and to determine its role in secondary prevention of ischemic stroke.
- Conditions
- Stroke, Transient Ischemic Attack, Atherosclerosis, Stenosis
- Trial name
- ESSCAS (NCT00691314)
- Testing
- Stent implantation (Wingspan, Coroflex, and TiTAN2), Standard medical treatment
- Where
- 10 sites in China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Infant, Newborn, Infant, Low Birth Weight
Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage
This large randomized trial tested whether phenobarbital given to a pregnant woman about to deliver a premature infant would prevent brain injuries in their newborns.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Phenobarbital (NCT00009620)
- Testing
- Phenobarbital, Saline
- Where
- 11 sites in United States
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Lactate, Brain Tumor
Evaluation of Lactate in Patients Undergoing Glial and Non Glial Mass Surgery With Craniotomy
The aim of this study is to determine the effects of the level of metabolites used in routine on mortality and morbidity in patients who will undergo intracranial surgery with craniotomy.
- Conditions
- Lactate, Brain Tumor, Post-Op Complication
- Trial name
- NCT04584827
- Testing
- lactate level, Glasgow Outcome Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Trakya University
Traumatic Brain Injury, Ischemic Stroke
Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor
The goals of the project are to evaluate a noninvasive monitor of brain metabolism and blood flow in critically ill humans. If validated, such a reliable noninvasive brain blood flow and metabolism monitor, by allowing…
- Conditions
- Traumatic Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- NNOM (NCT02983786)
- Testing
- Indocyanine Green
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Pennsylvania
CVA (Cerebrovascular Accident), Cerebral Hemorrhage
Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage
The purpose of the study is to determine whether lowering high blood pressure levels after the start of a stroke caused by bleeding in the brain (intracerebral haemorrhage) will reduce the chances of a person dying or surviving…
- Conditions
- CVA (Cerebrovascular Accident), Cerebral Hemorrhage, Intracranial Hemorrhages
- Trial name
- NCT00226096
- Testing
- Labetalol Hydrochloride, Metoprolol tartrate, Hydralazine Hydrochloride
- Where
- 20 sites in Australia, China and 1 more
- Volunteers
- 404 people
- Sponsor
- The George Institute
Cerebral Hemorrhage
Restart Anticoagulation in Patients With Spontaneous Intracerebral Hemorrhage and Mechanical Heart Valves
The investigators retrospectively reviewed the electronic medical records of the patients with spontaneous cerebral hemorrhage and mechanical valves from 2015 to 2020 in the second affiliated hospital of Zhejiang university…
- Trial name
- NCT04450446
- Testing
- Low molecular weight heparin
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intracerebral Hemorrhage
Retrospective Study of Intracerebral Hemorrhage Patients in Hospital Parc Taulí
This is a retrospective observational study to investigate the clinical, analytical and neuroimaging data generated during routine clinical management of intracerebral hemorrhage.
- Trial name
- NCT04877405
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 137 people
- Sponsor
- Universitat Autonoma de Barcelona
Intracranial Hemorrhages
Decompressive Craniectomy Combined With Hematoma Removal to Treat ICH
Decompressive craniectomy has been reported for the treatment of patients with intracerebral hemorrhage. But no prospective randomised controlled trials have yet been undertaken to confirm its effect.The purpose of the study is…
- Trial name
- CARICH (NCT02135783)
- Testing
- Decompressive Craniectomy, non-Decompressive Craniectomy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Southwest Hospital, China
Stroke (CVA) or Transient Ischemic Attack, Cerebral Hemorrhage
COAST Study - Cholesterol Optimization After Stroke
This study (acronym COAST Trial) is a multicenter observational registry aiming to document: patients' adherence and persistence to lipid-lowering therapy prescribed for secondary prevention; the proportion of patients achieving…
- Trial name
- COAST (NCT07256171)
- Testing
- low-fat diet, supplements, statins, ezetimibe, bempedoic acid, PCSK9 inhibitors, fibrates, or other lipid-lowering agents
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Subarachnoid Hemorrhage, Cerebral Vasospasm
Sildenafil for DCI
Each year, approximately 30,000 people in the United States suffer an intra-cranial hemorrhage due to aneurysmal rupture. Of those surviving the initial event, up to 40% will go on to have further neurological injury secondary to…
- Trial name
- NCT03028298
- Testing
- Low dose sildenafil citrate, High dose sildenafil citrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Mississippi Medical Center
Anesthesia Awareness
Glasgow Coma Scales and General Anesthesia
The study evaluates the general anesthesia management with BIS monitorization in terms of hemodynamic stability, drug concentrations and drug consumption in patients who underwent surgery due to intracranial pathology and who…
- Trial name
- NCT03521414
- Testing
- Bispectral index (BIS) monitoring, Sevoflurane
- Volunteers
- 45 people
- Sponsor
- Trakya University
Brain-injury, Stroke
Mechanical Ventilation in Brain-injured Patients
Protective ventilation (association of a tidal volume < 8 ml/kg with a positive end expiratory pressure) is poorly used in severe brain-injured patients.
- Conditions
- Brain-injury, Stroke, Subarachnoid Haemorrhage, Traumatic Brain Injury
- Trial name
- BI-VILI (NCT01885507)
- Testing
- Pass recommendations on ventilation factors and extubation
- Where
- 22 sites in France
- Volunteers
- 560 people
- Sponsor
- Nantes University Hospital
Intra Cerebral Hemorrhage, Stroke
Ultra-Early, Minimally inVAsive intraCerebral Haemorrhage evacUATion Versus Standard trEatment
A randomized controlled trial of ultra-early, minimally invasive, hematoma evacuation versus standard care within 8 hours of intracerebral hemorrhage.
- Trial name
- EVACUATE (NCT04434807)
- Testing
- Minimally invasive hematoma evacuation
- Where
- 13 sites in Australia
- Volunteers
- 240 people
- Sponsor
- University of Melbourne
Stroke, Acute Ischemic, Intracerebral Hemorrhage
The Stroke Aetiology and VascuLar Disease in Stroke and TIA Study - A Clinical Study Analysing the Effects on Cardiovascular Health and Disease With an Extended Investigation Into Conditions Causative of Stroke and Concomitant Cardiovascular Disease in Patients Admitted for Acute Stroke or TIA
Annually, about 4000 Swedes suffer a recurrent stroke, and for many, their lives change dramatically. To prevent recurring strokes, knowledge about the individual's risk of recurrence is needed to tailor an effective preventive…
- Conditions
- Stroke, Acute Ischemic, Intracerebral Hemorrhage, TIA, Hypertension
- Trial name
- SALSA (NCT07491744)
- Testing
- Extended assessment
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Stockholm
Myocardial Injury, Lung Injury
Neurogenic Myocardial and Lung Injury in SAH Patients
Up to this day, little is known whether the extent of brain damage in patients with SAH correlates with the degree neurogenic myocardial injury and neurogenic lung injury.
- Conditions
- Myocardial Injury, Lung Injury, Subarachnoid Hemorrhage
- Trial name
- NCT05408988
- Testing
- hs-TnT (high-sensitive cardiac troponin T) plasma concentration, CK-MB (creatine kinase myocardial band) plasma concentration, CPK (creatine phosphokinase) plasma concentration
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Silesia
Traumatic Brain Injury, Subarachnoid Hemorrhage
Cerebral Perfusion Pressure (CPP) Management Information Feedback and Nursing
The aim of the initial proposal was to evaluate, in the context of optimal medical management, the impact of a bedside system of cerebral perfusion pressure (CPP) information feedback on nursing moment-to-moment management of…
- Trial name
- NCT00194441
- Testing
- Bedside display of cerebral perfusion pressure information
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- University of Washington
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