Clinical trials: Intracranial Pathology
Hypothermia, Aneurysmal Subarachnoid Hemorrhage
Trial of Long-term Therapeutic Hypothermia for Poor-grade Aneurysmal Subarachnoid Hemorrhage
This study is a prospective, multi-centre, randomized,controlled trial to compare the efficacy of long-term mild hypothermia with normothermic intensive management in patients with poor-grade aneurysmal subarachnoid hemorrhage.
- Trial name
- NCT03442608
- Testing
- Zoll 2000 and/or CureWrap 3500 cooling system
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Dementia, Alzheimer Disease
Serotonergic Pharmacotherapy for Agitation of Dementia
This study is a randomized, double-blind, placebo-controlled, fixed dose study currently being conducted on two geropsychiatric units at Western Psychiatric Institute and Clinic.
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular
- Trial name
- SPAD (NCT00009204)
- Testing
- Citalopram [Celexa], Perphenazine [Trilafon]
- Where
- United States
- Sponsor
- Bruce Pollock
Dementia, Alzheimer Disease
Long-term Use of Galantamine Versus Nootropics (Memory Enhancing Drugs) in Patients With Alzheimer's Dementia Under Conditions of Daily Routine
The main objective of this non-interventional study was to document the long-term application of galantamine and nootropics (memory enhancing drugs) over a period of 1 year under conditions of daily routine.
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular
- Trial name
- NCT01009476
- Testing
- Galantamine, Nootropics (ginkgo biloba, nicergoline, piracetam, or others)
- Volunteers
- 1,134 people
- Sponsor
- Janssen-Cilag G.m.b.H
Brain Injuries
The NIPA Study Naloxegol Administration to Prevent Opioids Induced Gastrointestinal Motility Disturbance in Brain Injured PAtients
Impaired gastrointestinal transit (IGT) especially constipation, is common among patients under mechanical ventilation, occurring in up to 80 % of the patients during the first week, and has been associated with worse outcome in…
- Trial name
- NIPA (NCT05008926)
- Testing
- Naloxegol
- Where
- 10 sites in France
- Volunteers
- 370 people
- Sponsor
- University Hospital, Brest
Ischemic Stroke, Hemorrhagic Stroke
A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. RhinoChill (iCOOL 1)
Mild hypothermia improves outcome in patients with global cerebral ischemia after cardiac arrest. Hypothermia seems promising also in other acute hypoxic-ischemic or in brain swelling associated cerebrovascular disease.
- Trial name
- iCOOL 1 (NCT01573117)
- Testing
- RhinoChill, Cold crystalloid infusions, 0.9%NaCl or Ringer's solution
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
Cadasil
Adrenomedullin for CADASIL
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common form of hereditary cerebral small vessel disease, with no proven disease-modifying treatments.
- Trial name
- AMCAD (NCT06072118)
- Testing
- Adrenomedullin
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- National Cerebral and Cardiovascular Center, Japan
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Epigenome-wide DNA Methylation Profiling in Aneurysmal Subarachnoid Hemorrhage and Delayed Ischemic Neurologic Deficit
The goal of this observational study is to investigate DNA methylation changes in adults with bleeding from brain aneurysm, which is called aneurysmal subarachnoid hemorrhage (aSAH), and their association with delayed ischemic…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm After Subarachnoid Hemorrhage, Intracranial Aneurysm
- Trial name
- NCT06881329
- Where
- Poland
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Cerebrovascular Stroke, Intracranial Hemorrhages
Predictive Value of Infarction Volume on Hemorrhagic Transformation in Ischemic Stroke/TIA With Non-valve Atrial Fibrillation(NVAF) Patients Using Rivaroxaban
This study was aimed at patients with newly diagnosed stroke / TIA associated with nonvalvular atrial fibrillation. We will observe the effect of early using rivaroxaban anticoagulation on hemorrhagic transformation, and explore…
- Conditions
- Cerebrovascular Stroke, Intracranial Hemorrhages, Anticoagulant, Matrix Metalloproteinases
- Trial name
- NCT03772457
- Testing
- Rivaroxaban
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Myocardial Depression, Takotsubo Syndrome
Predicting the Development of Myocardial Depression in Acute Neurological Patients
The purpose of this study is to assess the levels of serum catecholamines associated with myocardial depression (MD) in patients with acute neurological injury.
- Conditions
- Myocardial Depression, Takotsubo Syndrome, Subarachnoid Hemorrhage, Acute Ischemic Stroke
- Trial name
- NCT03801694
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Ohio State University
Cardiovascular Complications, Hemorrhagic Disorders
Comparison of Accidents and Their Circumstances With Oral Anticoagulants
Differences in efficacy and safety between new oral anticoagulants (NOAC) and vitamin K antagonist (VKA) in real practice remain uncertain.
- Conditions
- Cardiovascular Complications, Hemorrhagic Disorders, Embolism and Thrombosis
- Trial name
- CACAO (NCT02376777)
- Testing
- Follow up
- Where
- 33 sites in France
- Volunteers
- 4,162 people
- Sponsor
- CNGE IRMG Association
Aneurysmal Subarachnoid Hemorrhage
The Optimal Dose of Mannitol for Intraoperative Brain Relaxation During the Operation of Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) tended to lead to a sudden increase in intracerebral pressure (ICP), which can cause decreased cerebral perfusion and transient global cerebral ischemia.
- Trial name
- ODAS (NCT04135456)
- Testing
- Mannitol
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Beijing Tiantan Hospital
Acute Coronary Syndrome, Venous Thrombosis
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)
This prospective cohort study will provide information about: Characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed standard of care for the first…
- Conditions
- Acute Coronary Syndrome, Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation
- Trial name
- NCT02468102
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Standard of care drugs
- Where
- Sweden
- Volunteers
- 99,999 people
- Sponsor
- Bayer
Intracranial Hemorrhages, Acute Ischemic Stroke
AI Assisted Reader Evaluation in Acute Computed Tomography (CT) Head Interpretation
This study has been added as a sub study to the Simulation Training for Emergency Department Imaging 2 study (ClinicalTrials.gov ID NCT05427838).
- Conditions
- Intracranial Hemorrhages, Acute Ischemic Stroke, Hydrocephalus, Cerebral Infarction
- Trial name
- AI-REACT (NCT06018545)
- Testing
- Ground truthing, Reading
- Where
- 4 sites in United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Severe Brain Injury
Study of PbiO2 Variation by Body Temperature and Capnia in Severe Head Trauma Patients Treated With Targeted Temperature Control
Serious head trauma is a common and pathology and responsible of high morbidity and mortality. The major challenge, from the very first hours, is to limit cerebral ischemia by controlling secondary brain injury factors.
- Trial name
- TODAY (NCT04109430)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Brest
Brain Death
Organ Donation and Hydrocortisone Treatment
Brain death patients who are selected for organ donation very often suffer from haemodynamic instability. To treat this, high amounts of vasoactive drugs(norepinephrine) may be needed to raise blood pressure.
- Trial name
- HYDRO (NCT00675272)
- Testing
- hydrocortisone, sodium chloride
- Where
- 2 sites in Finland
- Volunteers
- 38 people
- Sponsor
- Kuopio University Hospital
Basal Ganglia Hemorrhage
A Trial for Minimally Invasive Neurosurgery With AI-assisted Robotic Guidance for Moderate Basal Ganglia Hemorrhage (RAINBOW-MBH)
A nationwide, prospective, multicenter randomized controlled clinical trial to evaluate the therapeutic effects of the fiber tract-based artificial intelligence (AI) Robot Guiding System on the perioperative and long-term…
- Trial name
- RAINBOW-MBH (NCT06465719)
- Testing
- Minimally invasive basal ganglion hematoma evacuation with Tract-based AI Robot Guiding System, Patients will be managed with guideline-based medications
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Acute Traumatic Brain Injury
Clinimetric Application of FOUR Scale as in Treatment and Rehabilitation of Patients With Acute Cerebral Injury
The aim of this study is to increase the effectiveness of clinical monitoring of patients with acute cerebral insufficiency by improving the discriminative ability of the FOUR scale.
- Conditions
- Stroke, Acute Traumatic Brain Injury, Subarachnoid Hemorrhage
- Trial name
- FOURACI (NCT06043167)
- Testing
- The predictive value russian rendition the FOUR score.
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Surgut Clinical Trauma Hospital
Subarachnoid Hemorrhage, Intracranial Arteriovenous Malformation
NIRS Monitoring During Intracranial Interventions
Near infrared spectroscopy is a valuable tool to monitor cerebral oxygenation during intracranial interventions. However, it yields artificial results when the dye indocyanine green (ICG) is applied, which is routinely done for…
- Trial name
- NIRS_ICG (NCT03367975)
- Testing
- near infrared spectroscopy
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Hospital, Bonn
Headaches Associated With Subarachnoid Hemorrhage (SAH)
IA Lidocaine and Methylprednisolone for Headache Associated With Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a type of bleeding around the brain that can cause sudden and severe headaches. These headaches can be debilitating and persist for weeks, significantly impacting a patient's comfort and recovery.
- Trial name
- LIMSAH (NCT07054801)
- Testing
- Lidocaine hydrochloride, Methylprednisolone sodium succinate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Daniel Raper, MBBS
High Altitude Headache
Intracranial Pressure in Experimental Models of Headache
The purpose of this study is to determine whether increased pressure in the head is elevated in people who suffer from High Altitude Headache.
- Trial name
- NCT01288781
- Testing
- Acetazolamide, Lactose monohydrate
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Bangor University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.