Clinical trials: Intracranial Pathology
Myocardial Infarction, Ischemic Stroke
Understanding the Role of Autoimmune Disorders on the Initial Presentation of Cardiovascular Disease
Autoimmune diseases are diseases in which inappropriate immune responses that have the capability of harming host cells play an important role.
- Conditions
- Myocardial Infarction, Ischemic Stroke, Stroke, Subarachnoid Haemorrhage
- Trial name
- NCT02062021
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Subarachnoid Hemorrhage, Acute Kidney Injury
A Low ChloridE hyperTonic Solution for Brain Edema
This pilot study will compare the two hypertonic solutions currently used for subarachnoid hemorrhage (SAH) - related complications and to determine if the reduction of chloride load is safer, and as efficacious as the classic…
- Trial name
- ACETATE (NCT03204955)
- Testing
- Sodium chloride /sodium acetate (16.4%), Sodium chloride (23.4%), PlasmaLyte
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Emory University
Herpes Zoster, Dementia
Postherpetic Neuralgia After Herpes Zoster and Incident Dementia Risk
This retrospective observational cohort study uses de-identified electronic health record data from the TriNetX Global Collaborative Network to evaluate whether postherpetic neuralgia after herpes zoster is associated with an…
- Conditions
- Herpes Zoster, Dementia, Postherpetic Neuralgia (PHN)
- Trial name
- NCT07399288
- Testing
- Exposure: postherpetic neuralgia
- Where
- Taiwan
- Volunteers
- 73,404 people
- Sponsor
- China Medical University Hospital
Ischemic Stroke, Intracranial Hemorrhage
Registry of Acute Stroke Under New Oral Anticoagulants -Pilot (RASUNOA-Pilot)
The registry of acute stroke under new oral anticoagulants (RASUNOA) is a German multicenter, prospective, observational registry performed at about 50 study centers covering about 50.000 acute ischemic strokes and 6000 acute…
- Trial name
- RASUNOA (NCT01850797)
- Where
- Germany
- Volunteers
- 353 people
- Sponsor
- University Hospital Heidelberg
Abdominal Aortic Aneurysm, Coronary Heart Disease
Ethnicity and Onset of Cardiovascular Disease: A CALIBER Study
Specific cardiovascular diseases, such as stroke and heart attack, have been shown to vary by ethnic group. However, less is known about differences between ethnic groups and a wider range of cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease, Sudden Cardiac Death, Intracerebral Haemorrhage
- Trial name
- NCT02176174
- Volunteers
- 1,068,318 people, healthy volunteers welcome
- Sponsor
- University College, London
Intracranial Hemorrhage
Clinical Study to Evaluate the Efficacy of Febuxostat in the Treatment of Conservatively Managed Intracranial Hemorrhage Patients
To assess the effect of Febuxostat on clinical outcomes and biomarkers of oxidative stress and inflammation in patients with conservatively managed intracranial hemorrhage.
- Trial name
- NCT07701512
- Testing
- Febuxostat 40 mg, Standard medical treatment
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Tanta University
Atrial Fibrillation, Intracerebral Hemorrhage
PREvention of STroke in Intracerebral haemorrhaGE Survivors With Atrial Fibrillation
Atrial fibrillation (AF) is the most common form of irregular heart rhythm. In people with AF, blood clots often form in the heart, which can travel to the brain.
- Trial name
- PRESTIGE-AF (NCT03996772)
- Testing
- Apixaban Oral Tablet, Dabigatran, Edoxaban Tablets
- Where
- 64 sites in Austria, France and 4 more
- Volunteers
- 319 people
- Sponsor
- Imperial College London
Critically Ill Patients, Cardiac Surgery
Impact Of Antioxidant Micronutrients On Intensive Care Unit (ICU) Outcome
Critically ill patients are generally exposed to an increased oxidative stress, which is proportional to the severity of their condition.
- Conditions
- Critically Ill Patients, Cardiac Surgery, Trauma, Subarachnoid Hemorrhage
- Trial name
- Etude-AOX (NCT00515736)
- Testing
- Selenium (Se), Zinc (Zn), Vitamin C, Vitamin B1, Vitamin E
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Ischemic Stroke, Haemorrhagic Stroke
COAgulation Disorders in Ischaemic and Haemorrhagic Stroke
In this study the investigators will assess both procoagulant and anticoagulant pathways using thrombin generation and platelet function tests; as well as neuronal ischemia using cell free DNA in all patients presenting with…
- Conditions
- Ischemic Stroke, Haemorrhagic Stroke, Aneurysmal Subarachnoid Hemorrhage
- Trial name
- COADIHS (NCT05974111)
- Testing
- blood sampling
- Where
- Belgium
- Volunteers
- 379 people
- Sponsor
- Ziekenhuis Oost-Limburg
Subarachnoid Hemorrhage, Hypertension
Safety and Efficacy Study of Clevidipine to Control Hypertension in Patients Admitted With Aneurysmal Subarachnoid Hemorrhage
This study is designed to assess how rapidly and how safely Clevidipine can be used to control high Blood Pressure in patients with subarachnoid hemorrhage which is a type of brain bleed that happens because of a weak balloon…
- Trial name
- CLASH (NCT00978822)
- Testing
- Clevidipine butyrate injectable emulsion
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Henry Ford Health System
Intracerebral Hemorrhage
Simvastatin For Intracerebral Hemorrhage Study
Study Objective: To analyze if statins are effective in ameliorating perihematomal edema evolution thereby reducing mortality and improving functional outcomes following spontaneous intracerebral hemorrhage (ICH).
- Trial name
- NCT00718328
- Testing
- Simvastatin 80 mg
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Chronic Subdural Hematoma
Aspirin Continuation or Discontinuation in Conservative Treatment for Chronic Subdural Hematoma
This clinical study aims to learn about the efficacy and safety of aspirin continuation or discontinuation in conservative treatment for chronic subdural hematoma.
- Trial name
- NCT07240454
- Testing
- Aspirin Continuation, Aspirin Discontinuation
- Where
- 2 sites in China
- Volunteers
- 143 people
- Sponsor
- Tao Liu
Subarachnoid Hemorrhage, Traumatic Brain Injury
Intensive Insulin Therapy for Strict Glycemic Control in Neurosurgical Patients: Safety and Efficacy
Strict glycemic control improves mortality and morbidity of patients admitted to the postoperative intensive care unit (ICU). The investigators would like to know if this therapy could improve the long term neurologic and…
- Conditions
- Subarachnoid Hemorrhage, Traumatic Brain Injury, Intracranial Hemorrhage
- Trial name
- NCT00505505
- Testing
- Insulin (Actrapid)
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- University of Roma La Sapienza
Chronic Intracranial Subdural Hematoma
Interest of Oral Corticosteroids in the Treatment of Chronic Subdural Hematomas
The chronic subdural hematoma is a common disease in the population over 60 years. For example, in patients over 70 years, it occurs every year 7 new cases per 100,000 people.
- Trial name
- hemacort (NCT01380028)
- Testing
- oral corticosteroids
- Where
- France
- Volunteers
- 162 people
- Sponsor
- University Hospital, Montpellier
Collateral Circulation, Large-artery Occlusion
Study of Collateral Circulation in Patients With Symptomatic Intracranial Anterior Circulation Occlusion
Intracranial artery stenosis is the leading cause of stroke onset or recurrence in Asian. Multiple studies have shown that anterior circulation is most common in intracranial artery stenosis, especially the middle cerebral artery…
- Conditions
- Collateral Circulation, Large-artery Occlusion, Cerebral Infarction
- Trial name
- NCT04091412
- Testing
- Butylphthalide Soft Capsules
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Hebei Medical University
Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus
Quality of Life in Elderly After Aneurysmal Subarachnoid Hemorrhage (SAH)
In all the Western populations, the annual incidence of subarachnoid hemorrhage (SAH) increase with age. In patients older than 70 years, the occurrence of SAH exposes them to high risk of morbidity and a poor quality of life.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus, Cerebral Vasospasm
- Trial name
- FASHE (NCT00692744)
- Where
- 2 sites in France
- Volunteers
- 353 people
- Sponsor
- University Hospital, Rouen
Subarachnoid Hemorrhage, Aneurysmal
Predicting 28-Day Mortality in Subarachnoid Hemorrhage
The investigators investigated the predictive ability of clinical and radiological scores, including the Glasgow coma scale (GCS), Hunt-Hess, World Federation of Neurological Surgeons (WFNS), and modified Fisher scales, as well…
- Trial name
- SAHstdy (NCT06563219)
- Testing
- Glasgow coma scale, Hunt-Hess scale, World Federation of Neurological Surgeons (WFNS) scale
- Where
- Turkey (Türkiye)
- Volunteers
- 451 people
- Sponsor
- Haseki Training and Research Hospital
Chronic Subdural Hematoma, Surgical Procedures, Operative
A National Study Examining the Most Effective Drainage Method After Burr Hole Evacuation of Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a common disease. The main treatment is neurosurgical evacuation and subsequent hematoma drainage.
- Conditions
- Chronic Subdural Hematoma, Surgical Procedures, Operative, Recurrence, Mortality
- Trial name
- SUPERDURA (NCT06621407)
- Testing
- 24 hours active subperiostal drainage, 24 hours passive subdural drainage
- Where
- 4 sites in Denmark
- Volunteers
- 354 people
- Sponsor
- Aalborg University Hospital
Cadasil, Angiopathy; Cerebral
Development of New Biomarkers With Magnetic Resonance Imaging for Longitudinal Studies in CADASIL Angiopathy
CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is an cerebral microangiopathy secondary to mutations in the NOTCH3 gene located on chromosome 19.
- Trial name
- BIOMRI_CADA (NCT04036084)
- Testing
- Cerebral Magnetic resonance imaging (MRI)
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intracranial Bleed, Falls
Falls Validation Study
Each year, one in three adults over the age of 65 has a fall. These falls lead to half a million Canadian emergency department patient visits annually and falls in older adults account for more than 3% of all emergency department…
- Trial name
- NCT07536906
- Testing
- Clinical Decision Rule
- Where
- 7 sites in United States, Canada
- Volunteers
- 4,000 people
- Sponsor
- Dr. Kerstin de Wit
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