Clinical trials: Intracranial Surgery
Subarachnoid Aneurysm Hemorrhage, Microsurgery
Structural and Clinical Predictors of Cognitive Impairment After Surgical Treatment for Ruptured Cerebral Aneurysms
This study investigates the clinical and structural predictors of long-term cognitive impairment in patients who underwent microsurgical clipping for aneurysmal subarachnoid hemorrhage.
- Conditions
- Subarachnoid Aneurysm Hemorrhage, Microsurgery, Cognitive Impairment
- Trial name
- SCOPE-aSAH (NCT07723131)
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- University of Campinas, Brazil
Middle Cerebral Artery Aneurysm
Middle Cerebral Artery Aneurysm Trial
Intracranial aneurysms located on the middle cerebral artery (MCA) are considered by many surgeons to represent a distinct subgroup of aneurysms for which clipping may still be the best management option.
- Trial name
- MCAAT (NCT05161377)
- Testing
- Surgical management, Endovascular management
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- University of Alberta
Craniotomy Surgery
Dexmedetomidine Versus Magnesium Sulfate Infusion in Craniotomy
To compare the intraoperative effects of Dexmedetomidine and Magnesium Sulfate infusion on intracranial pressure and cerebral perfusion pressure in adult patients undergoing craniotomy
- Trial name
- NCT07199595
- Testing
- Dexamedomedine, MgSO4
- Volunteers
- 60 people
- Sponsor
- Assiut University
Brain Tumor, Post-Op Complication
Postoperative Risk Prediction Score After Elective Intracranial Neurosurgery Operation
The aim of our study is to prevent unnecessary intensive care unit hospitalizations by developing a scoring system to detect low-risk patients after elective intracranial neurosurgery operation.
- Conditions
- Brain Tumor, Post-Op Complication, Anesthesia
- Trial name
- NCT04585633
- Testing
- Quality of Recovery-15, Glasgow Result Scale, Risk Factors
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Trakya University
Moyamoya Disease, Magnetic Resonance Imaging
Predicative Value of Multimodal MRI in Moyamoya Disease
Moyamoya disease (MMD) is a nonatherosclerotic cerebrovascular abnormality, characterized by a progressive stenosis or occlusion of the intracranial internal carotid arteries (ICAs) and their proximal branches, with subsequent…
- Trial name
- NCT03785171
- Testing
- surgical revascularization
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Intracerebral Hemorrhage, Cerebral Hemorrhage
ENRICH: Early MiNimally-invasive Removal of IntraCerebral Hemorrhage (ICH)
This is a multicenter, randomized, adaptive clinical trial comparing standard medical management to early (<24 hours) surgical hematoma evacuation using minimally invasive parafascicular surgery (MIPS) in the treatment of acute…
- Conditions
- Intracerebral Hemorrhage, Cerebral Hemorrhage, Intracerebral Haemorrhage
- Trial name
- ENRICH (NCT02880878)
- Testing
- Early Surgical Hematoma Evacuation
- Where
- 36 sites in United States
- Volunteers
- 300 people
- Sponsor
- Nico Corporation
Stroke
Can Acupuncture Benefit Surgical Patients With Haemorrhagic Stroke?
The purpose is to establish whether acupuncture in addition to conventional rehabilitation programme can improve the functional outcome and quality of life of surgical patients with haemorrhagic stroke, as compared to…
- Trial name
- NCT01037894
- Testing
- Acupuncture, Conventional rehabilitation
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Chinese University of Hong Kong
Intracranial Aneurysm, Surgical Clip
Rapid Ventricular Pacing in Surgical Treatment of Intracranial Aneurysms
Treatment of complex unruptured intracranial aneurysms (UIA) remains challenging to date. Therefore, advanced techniques are required to achieve an optimal result in treating these patients safely.
- Trial name
- NCT02766972
- Testing
- Rapid Ventricular Pacing
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Clinic Frankfurt
Aneurysmal Subarachnoid Hemorrhage
The Optimal Dose of Mannitol for Intraoperative Brain Relaxation During the Operation of Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) tended to lead to a sudden increase in intracerebral pressure (ICP), which can cause decreased cerebral perfusion and transient global cerebral ischemia.
- Trial name
- ODAS (NCT04135456)
- Testing
- Mannitol
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Beijing Tiantan Hospital
Brain Ischemia
The Neuroprotection of Sevoflurane Preconditioning on Intracranial Aneurysm Surgery
The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery.
- Trial name
- NCT01204268
- Testing
- Sev-I group, Sevo continuous inhalation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xijing Hospital
Chronic Subdural Hematoma
Efficacy of Atorvastatin in Chronic Subdural Haematoma
This prospective, double-blind, randomized, placebo-controlled study aims to evaluate the efficacy and safety of atorvastatin in patients with chronic subdural haematoma.
- Trial name
- REACH (NCT03956368)
- Testing
- Atorvastatin 20mg
- Where
- 7 sites in Hong Kong
- Volunteers
- 690 people
- Sponsor
- Chinese University of Hong Kong
Intracranial Hypertension
Augmented Reality-Assisted Neurosurgical Drain Placement
The goal of this clinical trial is to learn if high-accuracy augmented reality (AR) guidance for external ventricular drain (EVD) placement using a standalone head-worn navigation system can improve current shortcomings of…
- Trial name
- ARANED (NCT06571539)
- Testing
- AR-assisted EVD placement, Freehand EVD placement
- Where
- Belgium
- Volunteers
- 11 people
- Sponsor
- Universitair Ziekenhuis Brussel
Chronic Cerebral Ischemia, Moyamoya Disease
Application of Extended Reality (XR)-Assisted Computed Tomography (CT)-Guided Localization in Extracranial-intracranial (EC-IC) Bypass Surgery
This study will evaluate the application of a metaverse-based surgical simulation platform in extracranial-intracranial (EC-IC) bypass surgery.
- Conditions
- Chronic Cerebral Ischemia, Moyamoya Disease, Bypass Surgery, Augmented Reality
- Trial name
- NCT07711457
- Testing
- NTU OpVerse surgical simulation platform
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Intracranial Pressure Increase
Change of Optic Nerve Sheath Diameter After Deflation of Pneumatic Tourniquet
The purpose of this study is to evaluate the change of the optic nerve sheath diameter after deflation of pneumatic tourniquet.
- Trial name
- NCT03782077
- Testing
- Deflation of pneumatic tourniquet
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Stroke Hemorrhagic
Rapid Evacuation and Access of Cerebral Hemorrhage Trial
The main purpose of this study is to compare patients with a deep bleed in the brain undergoing surgery to patients receiving routine medical care.
- Trial name
- REACH (NCT06870812)
- Testing
- Surgical management, Medical Management
- Where
- 24 sites in United States
- Volunteers
- 600 people
- Sponsor
- Emory University
Intracranial Aneurysm
Supraphysiologic Insulin to Improve Outcomes After Surgical Treatment of Unruptured Cerebral Aneurysms
We hypothesize that in patients undergoing surgical treatment of unruptured intracranial aneurysms, the increase in blood sugar as a result of surgical stress is detrimental to outcome, as measured by blood levels of proteins…
- Trial name
- NCT00615381
- Testing
- Insulin
- Where
- United States
- Sponsor
- Northwestern University
Atrial Fibrillation, Cerebral Embolism
Left Atrial Appendage Closure During Open Heart Surgery
Because atrial fibrillation occurs frequently in heart surgery patients, our overall hypothesis is that systematic closing the left atrial appendage during surgery will reduce cerebral embolism coming from the thrombus formation…
- Conditions
- Atrial Fibrillation, Cerebral Embolism, Stroke
- Trial name
- LAACS (NCT02378116)
- Testing
- Surgical closure of the left atrial appendage
- Where
- Denmark
- Volunteers
- 205 people
- Sponsor
- Frederiksberg University Hospital
Ventilation, Bariatric Surgery
Effects of Different Anesthesia Machine Modalities on Bariatric Surgery Patients: a Prospective Randomized Controlled Study
The goal of this clinical trial is to explore the clinical significance and value of the PRVC ventilation mode in Bariatric Surgery Patients.
- Conditions
- Ventilation, Bariatric Surgery, Intracranial Pressure, Carbon Dioxide
- Trial name
- NCT06547411
- Testing
- PC Ventilation mode, VC Ventilation mode, PRVC Ventilation mode
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Yu-Long Jia
Traumatic Brain Injuries, Intracranial Hypertension
Effectiveness of Surgical Procedures for Acute Cranial Expansion in Traumatic Brain Injury
Traumatic brain injury (TBI) patients often exhibit an increase in their intracranial volume due to blood collection or brain tissue edema.
- Trial name
- E-SPACE-TBI (NCT06776614)
- Testing
- Decompressive Craniectomy, Expansion Craniotomy
- Volunteers
- 292 people
- Sponsor
- Meditech Foundation
Epilepsy
Hybrid Micro-macro Electrodes in Patients With Epilepsy
The aim of the MicroEPI study is to know whether it is possible to use safely a medical device (a micro-electrode) that allows recording the activity of neurons in the human brain.
- Trial name
- MicroEPI (NCT05335187)
- Testing
- micro-macro electrode implantation
- Where
- 2 sites in Switzerland
- Volunteers
- 30 people
- Sponsor
- Pierre Mégevand