Clinical trials: Intracranial Surgery
Intracerebral Hemorrhage
TrIal of Early Minimally Invasive Catheter Evacuation With Thrombolysis in IntraCerebral Hemorrhage
TIME-ICH (TrIal of early Minimally Invasive catheter Evacuation with thrombolysis in IntraCerebral Hemorrhage) is a multicenter, randomized, adaptive clinical trial comparing best medical management to early minimally invasive…
- Trial name
- TIME-ICH (NCT07187687)
- Testing
- Early Minimally Invasive Surgery with Thrombolysis (eMIST)
- Where
- 70 sites in China
- Volunteers
- 750 people
- Sponsor
- Xuanwu Hospital, Beijing
Postoperative Cognitive Complications, Delirium
Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery
This is a prospective observational cohort study of adult patients undergoing high-risk surgery at UT Southwestern Medical Center.
- Conditions
- Postoperative Cognitive Complications, Delirium, Perioperative/Postoperative Complications, Brain Injuries
- Trial name
- NCT07577726
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Epilepsy
Hybrid Micro-macro Electrodes in Patients With Epilepsy
The aim of the MicroEPI study is to know whether it is possible to use safely a medical device (a micro-electrode) that allows recording the activity of neurons in the human brain.
- Trial name
- MicroEPI (NCT05335187)
- Testing
- micro-macro electrode implantation
- Where
- 2 sites in Switzerland
- Volunteers
- 30 people
- Sponsor
- Pierre Mégevand
Cerebral Arterial Disease, Cerebral Aneurysm
Esmolol Infusion in Patients Undergoing Craniotomy
Anesthesia techniques that minimize anesthetic requirements and their effects may be beneficial. Esmolol, a short acting hyperselective β-adrenergic blocker is effective in blunting adrenergic response to several perioperative…
- Trial name
- NCT02455440
- Testing
- Esmolol, Propofol and sevoflurane
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- George Papanicolaou Hospital
Spontaneous Intracranial Hemorrhage, Spontaneous Intraparenchymal Cerebral Hemorrhage
The Influencing Factors and Prediction Model of Poor Prognosis of Spontaneous Intraparenchymal Hemorrhage
This study was designed to explore the influencing factors of spontaneous intraparenchymal hemorrhage's prognosis and develop predictive models for poor prognosis by establishing a cohort of spontaneous intraparenchymal…
- Conditions
- Spontaneous Intracranial Hemorrhage, Spontaneous Intraparenchymal Cerebral Hemorrhage, Spontaneous Cerebellar Haemorrhage
- Trial name
- NCT03899350
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Tang-Du Hospital
Aneurysmal Subarachnoid Hemorrhage
The Optimal Dose of Mannitol for Intraoperative Brain Relaxation During the Operation of Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) tended to lead to a sudden increase in intracerebral pressure (ICP), which can cause decreased cerebral perfusion and transient global cerebral ischemia.
- Trial name
- ODAS (NCT04135456)
- Testing
- Mannitol
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Beijing Tiantan Hospital
Craniotomy Surgery
Dexmedetomidine Versus Magnesium Sulfate Infusion in Craniotomy
To compare the intraoperative effects of Dexmedetomidine and Magnesium Sulfate infusion on intracranial pressure and cerebral perfusion pressure in adult patients undergoing craniotomy
- Trial name
- NCT07199595
- Testing
- Dexamedomedine, MgSO4
- Volunteers
- 60 people
- Sponsor
- Assiut University
Intracerebral Hemorrhage
Observational Study of Safety and Outcomes After Minimally Invasive Surgery for Intracerebral Hemorrhage
This pilot study will examine the safety and the clinical outcomes after minimally invasive surgery (using a parafascicular technique guided by diffusion-tensor imaging) for intracerebral hemorrhage in patients selected according…
- Trial name
- MiSPACE (NCT01920763)
- Testing
- Clinical Measurement
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Intracranial Hemorrhages, Surgery
Evaluation of Surgery in Elderly With Traumatic Acute SubDural Hematoma
Rationale: The rapidly increasing number of elderly (≥ 65 years old) with traumatic brain injury (TBI) is accompanied by substantial medical and economic consequences.
- Trial name
- RESET-ASDH (NCT04648436)
- Testing
- Early neurosurgical hematoma evacuation, Conservative treatment (best medical management)
- Where
- Netherlands
- Volunteers
- healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Pain, Postoperative, Analgesia
Analgesia Nociception Index (ANI) in Intracranial Surgical Anesthesia
In our study, 75 patients aged 18-80 years, classified as ASA I-II risk groups, who underwent intracranial surgery performed by the Department of Neurosurgery at Trakya University Faculty of Medicine Hospital, were included.
- Conditions
- Pain, Postoperative, Analgesia, Supratentorial Brain Tumor, Infratentorial Neoplasms
- Trial name
- ANI (NCT06752824)
- Testing
- ANALGESIA NOCICEPTION INDEX MONITORING
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Trakya University
Epilepsy, Healthy Volunteers
Simultaneous MEG or fMRI And INtracranial EEG
The SEMAINE project will investigate intracranial EEG (icEEG) simultaneously recorded with either fMRI or MEG to 1) improve identification of the epileptogenic zone in patients suffering from drug-resistant partial epilepsy, and…
- Trial name
- SEMAINE (NCT02342938)
- Testing
- MEG or fMRI And INtracranial EEG, fMRI
- Where
- France
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Cerebrospinal Fluid Leak
Perioperative CSF Leak Management - an Opinion Study
Cerebrospinal fluid (CSF) leak is a rare condition. When it involves the ventral skull base, a surgical closure may be achieved using endoscopic skull base surgery techniques.
- Trial name
- NCT04124523
- Where
- France
- Volunteers
- 153 people
- Sponsor
- University Hospital, Montpellier
Chronic Subdural Hematoma
Efficacy of Atorvastatin in Chronic Subdural Haematoma
This prospective, double-blind, randomized, placebo-controlled study aims to evaluate the efficacy and safety of atorvastatin in patients with chronic subdural haematoma.
- Trial name
- REACH (NCT03956368)
- Testing
- Atorvastatin 20mg
- Where
- 7 sites in Hong Kong
- Volunteers
- 690 people
- Sponsor
- Chinese University of Hong Kong
Intracerebral Hemorrhage
Efficacy and Safety of Factor VIIa on Rebleeding After Surgery for Spontaneous Intracerebral Hemorrhage (ICH)
Although the role of surgical treatment is still controversial, surgical evacuation of intracerebral hematoma is a frequent practice. Rebleeding is a frequent complication in patients submitted to hematoma evacuation.
- Trial name
- PRE-SICH (NCT00128050)
- Testing
- rFactor VIIa (Eptacog alfa, NovoNordisk), rFVIIa, Sodiun chloride 0.9%
- Where
- 3 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Middle Cerebral Artery Aneurysm
Middle Cerebral Artery Aneurysm Trial
Intracranial aneurysms located on the middle cerebral artery (MCA) are considered by many surgeons to represent a distinct subgroup of aneurysms for which clipping may still be the best management option.
- Trial name
- MCAAT (NCT05161377)
- Testing
- Surgical management, Endovascular management
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- University of Alberta
Atrial Fibrillation, Cerebral Embolism
Left Atrial Appendage Closure During Open Heart Surgery
Because atrial fibrillation occurs frequently in heart surgery patients, our overall hypothesis is that systematic closing the left atrial appendage during surgery will reduce cerebral embolism coming from the thrombus formation…
- Conditions
- Atrial Fibrillation, Cerebral Embolism, Stroke
- Trial name
- LAACS (NCT02378116)
- Testing
- Surgical closure of the left atrial appendage
- Where
- Denmark
- Volunteers
- 205 people
- Sponsor
- Frederiksberg University Hospital
Basal Ganglionic Hemorrhage
Prognostic Factors for Surgical Management of Large Hypertensive Basal Ganglionic Haemorrhage
The aim of this study is to present current and comprehensive recommendations for surgical treatment of this hematoma and to determine the factors that may improve the survival rate
- Trial name
- NCT06309940
- Testing
- Prognostic factors of surgical evacuation of basal ganglionic haemorrhage
- Volunteers
- 25 people
- Sponsor
- Assiut University
Glioma, Glioma Intracranial
A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas
This study uses a cranial implant to deliver cortical stimulation that, when paired with physiotherapy, will remap the brain so that critical brain functions can be protected during brain tumor surgery.
- Conditions
- Glioma, Glioma Intracranial, Gliomas Benign, Brain Tumor
- Trial name
- NCT04745156
- Testing
- RNS System Implantation
- Volunteers
- 3 people
- Sponsor
- Medical College of Wisconsin
Intracerebral Hemorrhage
Minimally Invasive Surgery and rtPA for Intracerebral Hemorrhage Evacuation
The purpose of this trial is to determine the safety of using a combination of minimally invasive surgery and clot lysis with rt-PA to remove intracerebral hemorrhage (ICH).
- Trial name
- MISTIE (NCT00224770)
- Testing
- MIS+Cathflo Activase (drug), Intraoperative stereotactic CT-Guided Endoscopic Surgery
- Where
- 29 sites in United States, Canada and 2 more
- Volunteers
- 141 people
- Sponsor
- Daniel Hanley
Intracerebral Hemorrhage (ICH)
Early Minimally Invasive Image Guided Endoscopic Evacuation of Intracerebral Haemorrhage
The aim of this pilot study is to provide an assessment of safety and feasibility of early minimally invasive image guided endoscopic hematoma evacuation (within 24 hours of symptom onset) in patients suffering from intracerebral…
- Trial name
- NCT04805177
- Testing
- hematoma evacuation
- Where
- 2 sites in Switzerland
- Volunteers
- 11 people
- Sponsor
- University Hospital, Basel, Switzerland