Clinical trials: Intractable Epilepsy, open to volunteers
Epilepsy
Assessment of MRI-guided HIFU for Patients With Drug-resistant Focal Epilepsy
The goal of this clinical trial is to assess the feasibility, safety, and tolerance of MRI-guided High-Intensity Focused Ultrasound (HIFU) for the treatment of drug-resistant focal epilepsy in adult patients with MRI-visible…
- Trial name
- EPIFUS (NCT07591350)
- Testing
- MR-guided HIFU thermoablation, EEG, MRI
- Volunteers
- 13 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Deep Brain Stimulation, Drug Resistant Epilepsy
Evaluating Modulation Effects of Temporal Interference Using SEEG
This single-center prospective study aims to investigate the electrophysiological mechanisms of temporal interference (TI) in humans by analyzing clinical, imaging, and electrophysiological data from patients aged 14-60 with…
- Trial name
- NCT06663969
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Drug Resistant Epilepsy, Brain-Computer Interfaces
StereoEEG Motor Neuronal Potentials Decoding
The goals of this study are (1) to evaluate the rate of stereoEEG brain-computer interface (BCI) classification accuracy and (2) to collect the dataset of neuronal signals recorded from stereoEEG electrodes during motor…
- Trial name
- NCT06432907
- Testing
- motor tasks
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Research Center of Neurology, Russia
Epilepsy
RESting-state Functional MRI for Prediction of Post-surgical Prognosis In Pediatric Drug-Resistant Epilepsy
Resting-state functional MRI (r-fMRI) has emerged in recent years to analyze resting networks. It allows, without active participation of the patients, to identify and analyze the different functional brain networks.
- Trial name
- RESPIRE (NCT04451278)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Focused Ultrasound, MR-guided FUS
Focused Ultrasound for Drug-resistant Epilepsy
Focused ultrasound (FUS) has been shown to differentially lesion or modulate (excite and inhibit) brain circuit and neural activity across a broad range of acoustic stimulus parameters (intensity, duty cycle, pulse repetition…
- Conditions
- Focused Ultrasound, MR-guided FUS, Drug Refractory Epilepsy, Drug Resistant Epilepsy
- Trial name
- NCT06292494
- Testing
- Exablate 4000 Transcranial MRgfUS System
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Epilepsy, Drugs Resistant Epilepsy
Clinical Utility and Safety of Human Umbilical Cord Mesenchymal Stem Cell Secretome in Drug Resistant Epilepsy Single Center, Non-randomized, Phase I Clinical Trial
The goal of this clinical trial is to learn if Human Umbilical Cord Mesenchymal Stem Cell (HUCMSC) derived secretome injection is safe and effective in patient with epilepsy. The main questions it ams to answer are: 1.
- Trial name
- NCT06638970
- Testing
- Secretome
- Where
- Indonesia
- Volunteers
- 54 people
- Sponsor
- Baermed
Tuberous Sclerosis Complex (TSC)
Treatment With Full-spectrum Cannabis Extract of Refractory Epilepsy Associated With Tuberous Sclerosis Complex (TSC)
1. To assess treatment efficacy with YCJ-01 by changes in the number of epileptic seizures in patients with refractory epilepsy secondary to Tuberous Sclerosis Complex. 2.
- Trial name
- Spectrum (NCT07403266)
- Testing
- YCJ-01 Full Spectrum cannbis Extract
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Oils4Cure
Refractory Epilepsy, Neuromodulation
Characterising the Network-Specific Effects of Piriform Cortex Stimulation Via SEEG
The prospective study aims to characterize the network-specific modulatory effects of piriform cortex stimulation in patients undergoing stereotactic EEG for drug-resistant epilepsy.
- Trial name
- NCT07305311
- Testing
- SEEG recordings and SPES
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Major Depressive Disorder, Suicide
Accelerated iTBS for Depression and Suicidality
The overall objective of this current study is to evaluate the feasibility, safety, and tolerability of "high dose" aiTBS in psychiatric inpatient and outpatients with treatment-refractory unipolar, non-psychotic major depressive…
- Trial name
- RAPID (NCT04441008)
- Testing
- Accelerated Intermittent Theta Burst (aiTBS), Electroconvulsive therapy (ECT)
- Volunteers
- 50 people
- Sponsor
- University of Iowa
Epilepsy Intractable
Neural Mechanisms of Spatial Representations Beyond the Self
Spatial navigation is a fundamental human behavior, and deficits in navigational functions are among the hallmark symptoms of severe neurological disorders such as Alzheimer's disease.
- Trial name
- NCT05406349
- Testing
- Self-navigation task, Observation task
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston University Charles River Campus
Drug Resistant Epilepsy
PRediction of Vagal Nerve Stimulation EfficaCy In Drug-reSistant Epilepsy
Vagal nerve stimulation (VNS) can be indicated in patients with drug-resistant epilepsy who are not eligible for resective epilepsy surgery with responders rates about 50% (≥50% seizure reduction).
- Trial name
- PRECISE (NCT04935567)
- Testing
- Statistical model for the prediction of VNS efficacy
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Masaryk University
Epilepsy, Hypothalamus
Study of the Link Between Structural Alterations in the Hypothalamus and Cardiac Dysautonomia in Drug-resistant Epilepsy
Patients with drug-resistant epilepsy may have cardiac dysautonomia, with reduced heart rate variability and increased sympathetic tone.
- Conditions
- Epilepsy, Hypothalamus, Seizures- Cardiac Dysautonomia, SUDEP
- Trial name
- HYPOLEPSIE (NCT07888543)
- Testing
- MRI scan, electrocardiogram
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Drug Resistant Epilepsy, Epilepsy
A Pilot Study to Evaluate the Efficacy and Safety of NaviFUS™ System Neuromodulating Treatment for Patients With Drug Resistant Epilepsy
This will be a prospective, pilot, open-label, two-arm, parallel-group, randomized study to evaluate the efficacy and safety of low-intensity focused ultrasound (LIFU) neuromodulation using NaviFUS System in patients with…
- Conditions
- Drug Resistant Epilepsy, Epilepsy, Epilepsy, Temporal Lobe, Seizures, Focal
- Trial name
- NCT06492720
- Testing
- Focused ultrasound (FUS) treatment
- Where
- Taiwan
- Volunteers
- 16 people
- Sponsor
- NaviFUS Corporation
Idiopathic Generalized Epilepsy
High-Intensity Focused Ultrasonic Ablation of the Centromedian Thalamic Nucleus for Treatment of Medically Refractory Generalized Epilepsy in Patients Ages 18 Years to 89 Years
The purpose of this study is to find out if magnetic resonance (MRI)-guided high-intensity focused ultrasound (HIFU) is safe and effective for treating medically refractory generalized epilepsy.
- Trial name
- HIFU for MRGE (NCT07803692)
- Testing
- Intervention 1, Intervention 2
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Drug Resistant Epilepsy
Functional Study of Inhibitory Neurotransmission in the Human Epileptic Brain.
Epilepsy is a neurological condition that afflicts 1% of the world population. 30% of patients become drug-resistant to classic antiepileptic treatment and only a small percentage, 5%, can undergo a neurosurgical resection of…
- Trial name
- NCT05459090
- Testing
- ex-vivo study
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Neuromed IRCCS
Intractable Epilepsy
Network Effects of Therapeutic Deep Brain Stimulation
The purpose of this study is to map the acute, short-term cortical evoked responses to thalamic electrical stimulation in persons with intractable epilepsy
- Trial name
- NCT05600738
- Testing
- RNS/DBS activation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The University of Texas Health Science Center, Houston
Epilepsy (Treatment Refractory)
CEST-based Biomarkers to Delineate the Epileptogenic Zone
Epilepsy is a common neurological disorder with an incidence of 1%. Although many anti-seizure medications are available, about 30% of patients are resistant to drug treatments.
- Trial name
- CEST-BEST (NCT07316972)
- Testing
- CEST sequence on a 7-Tesla MRI
- Volunteers
- 20 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Focal Epilepsy, Temporal Lobe Epilepsy
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
- Conditions
- Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders
- Trial name
- NCT07580183
- Testing
- Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I)
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Drug-resistant Focal Epilepsies in Pediatric Population
Genetic and Electrophysiologic Study in Focal Drug-resistant Epilepsies
Brain somatic mutations are increasingly recognized as a major cause of focal epilepsies. These include mTOR pathway mutations underlying cortical malformations such as focal cortical dysplasia and hemimegalencephaly, and SLC35A2…
- Trial name
- GENEPHY (NCT02890641)
- Testing
- Sampling of blood, frozen resected tissues, and cerebrospinal fluid (CSF)
- Where
- France
- Volunteers
- 450 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Epilepsy, Epilepsy, Temporal Lobe
Surgery as a Treatment for Medically Intractable Epilepsy
Background: Drug resistant epilepsy is the term used to describe epilepsy that cannot be controlled by medication. Many people whose seizures do not respond to medication will respond to surgical treatment, relieving seizures…
- Conditions
- Epilepsy, Epilepsy, Temporal Lobe, Partial Epilepsy
- Trial name
- NCT01273129
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)