Clinical trials: Intractable Pain, active
Erythromelalgia
Spinal Cord Stimulation for Refractory Pain in Erythromelalgia
Erythromelalgia is a rare disorder characterized by red, warm, and painful extremities, which is often precipitated by warm conditions. The pathophysiology is incompletely understood.
- Trial name
- NCT04039633
- Testing
- Burst Spinal Cord Stimulation
- Where
- 4 sites in Norway
- Volunteers
- 6 people
- Sponsor
- St. Olavs Hospital
Opioid-Related Disorders, Pain Management
Psilocybin in Cancer Pain Study
The overall objective of this study is to assess the feasibility, safety and preliminary efficacy of psilocybin-assisted therapy to alleviate opioid-refractory pain in patients with advanced-cancer.
- Conditions
- Opioid-Related Disorders, Pain Management, Pain Management and Care, Advanced Cancer
- Trial name
- NCT06001749
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yvan Beaussant, MD, MSci
Neuropathic Chronic Pain
Assessing the Efficacy of a High-Dose Lidocaine-Tetracaine Cream for the Treatment of Peripheral Neuropathic Pain
The goal of this clinical trial is to learn if the topical anesthetic cream works to treat neuropathic chronic pain in older adults who have not found sufficient relief undergoing other pain treatments and/or medications.
- Trial name
- NCT07396129
- Testing
- Lidocaine (23%) + Tetracaine (7%)
- Volunteers
- 30 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Celiac Plexus Block
Endoscopic Ultrasound Guided Versus Percutaneous Celiac Plexus Block in Patients With Intractable Upper Abdominal Pain
Upper abdominal pain is a common and often debilitating symptom in patients with pancreatic cancer and chronic pancreatitis, and is frequently under-treated by standard opioid therapy despite dose escalation and associated side…
- Trial name
- NCT07865286
- Testing
- Endoscopic Ultrasound-Guided Celiac Plexus Block, Percutaneous Celiac Plexus Block
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Radiation Toxicity, Chemotherapeutic Toxicity
Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2022 and 2025
The main objective of this study is to analyze the impact on the health-related quality of life of patients with refractory symptoms, who have been referred to the HUGCDN Chronic Pain Unit for adjuvant palliative treatment with…
- Conditions
- Radiation Toxicity, Chemotherapeutic Toxicity, Chemotherapy-induced Peripheral Neuropathy, Delayed Wound Healing
- Trial name
- EPOOzo (NCT05417737)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Bernardino Clavo, MD, PhD
Lower Back Pain
Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain
This clinical study is being conducted to evaluate the safety, tolerability, plasma pharmacokinetics and efficacy of an investigational drug called CNTX-3001.
- Trial name
- NCT07122453
- Testing
- CNTX-3001
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Centrexion Therapeutics
Central Post-Stroke Pain, Stroke
Accelerated Theta-Burst Stimulation for Refractory Central Post-Stroke Pain
This pilot study aims to evaluate the feasibility, safety, and preliminary efficacy of accelerated intermittent theta burst stimulation (aiTBS) as a noninvasive neuromodulation treatment for individuals with severe, refractory…
- Conditions
- Central Post-Stroke Pain, Stroke, Ischemic Stroke and Hemorrhagic Stroke
- Trial name
- NCT07909954
- Testing
- High-dose accelerated intermittent theta burst stimulation (aiTBS), Low-dose accelerated intermittent theta burst stimulation (aiTBS)
- Volunteers
- 30 people
- Sponsor
- Duke University
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis
Genicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Pilot Randomized Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment feasibility and detect any…
- Conditions
- Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
- Trial name
- SHAM-PAIN (NCT06859164)
- Testing
- Genicular Artery Embolization, Lipiodol, Simple angiogram
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Palliative Care, Refractory Pain
Single Arm, Monocentric, Pilot Feasibility Study on an Interactive Virtual Reality Program in 20 Complex In-clinic Palliative Care Patients
Palliative care patients frequently face a "symptom cluster" of pain (up to 96%), fatigue (up to 90%), and anxiety (up to 79%), which severely degrades their quality of life in their final months.The study is built on the concept…
- Conditions
- Palliative Care, Refractory Pain, Anxiety, Depression Disorders
- Trial name
- ZENCTUARY_VR+ (NCT07545928)
- Testing
- ZenctuaryVR+ Interactive Virtual Reality
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Neuropathic Pain, Chronic Pain
Insula Neuromodulation for Chronic Neuropathic Pain
This study will comprehensively investigate the insula as a brain target for neuromodulation to treat chronic neuropathic pain.
- Trial name
- NCT05404581
- Testing
- neuromodulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Coccyx Disorder
Analgesic Efficacy of Capsaicin 8% Patch (QUTENZA®) in Coccygodygnia
A retrospective study over a period of 6 years to explore analgesic efficacy of 8% Capsaicin patch (QUTENZA®) in coccygodynic patients, as well as neuropathic predictive factors of therapeutic response.
- Trial name
- CAPSACOXp (NCT05983263)
- Testing
- Capsaicin
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Nantes University Hospital
Trigeminal Neuralgia
MR Guided Focused Ultrasound (FUS) for the Treatment of Trigeminal Neuralgia
The purpose of this study is to assess the safety and effectiveness of MRI-guided focused ultrasound (MRgFUS) for treating Trigeminal Neuralgia.
- Trial name
- NCT04579692
- Testing
- ExAblate Transcranial treatment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Recurrent Low Back Pain, Degenerative Disc Disease (DDD)
Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive
This will be a multicenter, prospective, double blind, randomized phase 2/3 trial comparing culture-expanded allogeneic adult BM-MSCs with sham-treated controls.
- Trial name
- RESPINE (NCT03737461)
- Testing
- Allogenic BM-MSCs Injection
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 113 people
- Sponsor
- University Hospital, Montpellier
Refractory Angina, Microvascular Angina
Coronary Sinus Reducer Implantation in Patients With Ischaemia and Non-obstructed Coronary Arteries and Coronary Microvascular Dysfunction.
To demonstrate the feasibility and efficacy of the CS Reducer for the treatment of patients with ischaemia and non-obstructed coronary arteries (INOCA) and coronary microvascular dysfunction (CMD) and through a nested mechanistic…
- Conditions
- Refractory Angina, Microvascular Angina, Microvascular Coronary Artery Disease, Coronary Disease
- Trial name
- REMEDY-PILOT (NCT05492110)
- Testing
- Coronary sinus reducer, Invasive coronary physiology
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Imperial College London
Refractory Angina, Chronic Myocardial Ischemia
CardiAMP Cell Therapy Chronic Myocardial Ischemia Trial
Prospective, multi-center, 2:1 randomized (Treatment : Sham Control), sham-controlled, double-blinded trial to compare treatment using the CardiAMP cell therapy system to sham treatment Treatment Group: Subjects treated with aBMC…
- Trial name
- CardiAMP-CMI (NCT03455725)
- Testing
- CardiAMP Cell Therapy System
- Where
- 2 sites in United States
- Volunteers
- 343 people
- Sponsor
- BioCardia, Inc.
Refractory Pain
OP2C : Prialt® Observatory in Clinical Practice
Ziconotide is a strong analgesic marketed since 2005 in Europe and reserved for the intrathecal route. Its efficacy has been proven in particular by 3 randomized clinical studies.
- Trial name
- OP2C (NCT04321408)
- Testing
- Ziconotide Injection
- Where
- 17 sites in France, Germany and 1 more
- Volunteers
- 300 people
- Sponsor
- Institut Cancerologie de l'Ouest
Pain, Intractable
A Study of the Safety and Tolerability of GA in the Treatment of Patients With Refractory Neuropathic Pain
Previous studies have shown that the anterior cingulate cortex is involved in the regulation of pain and its associated negative emotions, that pyramidal neurons are highly excitable in chronic neuropathic pain conditions, and…
- Trial name
- NCT06596681
- Testing
- GA+clozapine
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Pain
Observational Study of Ketamine Infusions for the Treatment of Chronic Pain
This observational study will collect prospectively specified data on patient characteristics and clinically relevant outcomes in patients who receive a ketamine infusion at Stanford Pain Management Center for the treatment of…
- Trial name
- NCT05477004
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Theresa Lii
Refractory Migraine, Headache
Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment
The goal of this clinical trial is to test whether injecting lidocaine into two blood vessels of the brain can help treat chronic headaches (migraines)
- Trial name
- LIGHT 2 (NCT07361549)
- Testing
- Lidocaine (drug), Saline
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Daniel A Tonetti, MD
Chronic Pain, Intractable Pain
Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control
Study to evaluate the effectiveness of time variant pulse (TVP)-SCS in patients with chronic pain using commercially approved Boston Scientific SCS Systems per local Instructions for use (IFU).
- Conditions
- Chronic Pain, Intractable Pain, Low Back Pain, Chronic Low-back Pain
- Trial name
- MOSAIC (NCT07190807)
- Testing
- Boston Scientific WaveWriter Alpha™ SCS Systems
- Where
- 7 sites in United States
- Volunteers
- 70 people
- Sponsor
- Boston Scientific Corporation