Clinical trials: Intraocular Pressure
Glaucoma
Evaluate the Safety and Effectiveness of iSTAR Medical's MINIject™ Implant for Lowering Intraocular Pressure (IOP) in Subjects With Primary Open-angle Glaucoma.
Evaluate the safety and effectiveness of iSTAR Medical's MINIject™ implant for lowering intraocular pressure (IOP) in subjects with primary open-angle glaucoma.
- Trial name
- STAR-V (NCT05024695)
- Testing
- MINIject™ Implant
- Where
- 37 sites in United States, Canada and 2 more
- Volunteers
- 975 people
- Sponsor
- iSTAR Medical
Glaucoma, Optic Neuropathy
Use of Bevacizumab in Trabeculectomy Surgery
When a patient with glaucoma who has a pressure that is too high and causing damage to their vision, despite receiving the maximum amount of medication that can be tolerated, the decision is made to have glaucoma surgery.
- Conditions
- Glaucoma, Optic Neuropathy, Fibrosis
- Trial name
- NCT01166594
- Testing
- Bevacizumab, Control
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- Sunnybrook Health Sciences Centre
Open Angle Glaucoma
Micropulse Laser Trabeculoplasty (MLT) Versus Selective Laser Trabeculoplasty (SLT) for Treatment of Open Angle Glaucoma
The purpose of this study is to evaluate the effectiveness of a new laser (called Micropulse Laser Trabeculoplasty or MLT) in the treatment of glaucoma compared to the conventional laser presently used which is called selective…
- Trial name
- NCT01956942
- Testing
- Micropulse Laser Trabeculoplasty, Selective Laser Trabeculoplasty
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- David Belyea
Glaucoma, Ocular Hypertension
A Study to Evaluate the Effectiveness of Cosopt® as First Line Therapy (MK-0507A-153)
Evaluate the effectiveness of dorzolamide-timolol (Cosopt®) as first line therapy in reducing intraocular pressure in patients with untreated Open angle glaucoma (OAG) or Ocular hypertension (OH).
- Trial name
- NCT00546286
- Testing
- dorzolamide hydrochloride (+) timolol maleate, Comparator: dorzolamide HCl/timolol maleate + prostaglandin
- Volunteers
- 170 people
- Sponsor
- Merck Sharp & Dohme LLC
Intraocular Pressure
Self-monitoring of the Intraocular Pressure Versus Hospital-based Diurnal Monitoring
Glaucoma remains the leading cause of irreversible blindness worldwide. Glaucoma represents a group of diseases that lead to optic nerve damage and corresponding deterioration of the visual field.
- Trial name
- NCT04485897
- Testing
- icare HOME device (Icare Oy, Vanda, Finland)
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Luzerner Kantonsspital
Glaucoma, Ocular Hypertension
AR-12286 in Combination With Latanoprost
This is a double-masked, randomized, multi-center, active-controlled, crossover comparison of the addition of AR-12286 or timolol to latanoprost in the treatment of elevated intraocular pressure (IOP).
- Trial name
- NCT01302249
- Testing
- Latanoprost 0.005%, AR-12286 Ophthalmic Solution 0.5%, Timolol maleate ophthalmic solution 0.5%
- Where
- 15 sites in United States
- Volunteers
- 66 people
- Sponsor
- Aerie Pharmaceuticals
Glaucoma, Open Angle Glaucoma
Long-term Safety and Performance of the ARGOS-SC Suprachoroidal Pressure Sensor System in Patients With Glaucoma Underwent Non-penetrating Glaucoma Surgery
The purpose of this study is to evaluate the long-term safety and performance of the ARGOS-SC system.
- Trial name
- NCT04773106
- Testing
- ARGOS-SC suprachoroidal pressure sensor
- Where
- 5 sites in Germany, Switzerland
- Volunteers
- 22 people
- Sponsor
- Implandata Ophthalmic Products GmbH
Atrial Fibrillation, Left Ventricular Failure
Non-invasive Blood Pressure and Cardiac Output Measurement by Using Applanation Tonometry
To evaluate and to validate accuracy, precision and trending ability of blood pressure and cardiac output measurement by applanation tonometry in cardiological patients having: atrial fibrillation severe impaired leftventricular…
- Conditions
- Atrial Fibrillation, Left Ventricular Failure, Left Ventricular Impaired Function, Aortic Valve Stenosis
- Trial name
- NCT02444104
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Glaucoma, Inflammatory Response
Impact Post-operative Treatment on Intraocular Pressure Post-SLT on Patients With Primary Open-angle Glaucoma
The present study's main objective is to assess if there is a significant difference between either of the treatments frequently used in post-op, namely a topic cortisone-based treatment, an non-steroidal anti-inflammatory drug…
- Trial name
- SLT (NCT01058278)
- Testing
- Selective Laser trabeculoplasty
- Where
- Canada
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Phacoemulsification
Clinical Analysis of Ocular Parameters Contributing to Intraoperative Pain During Standard Phacoemulsification
Charts of 142 patients who underwent standard phacoemulsification under topical anesthesia between March and August 2016 were reviewed.
- Trial name
- NCT03031652
- Testing
- Phacoemulsification
- Where
- South Korea
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Kyungpook National University Hospital
Cataract, Glaucoma
IOP Changes Associated With SICS and Phako
Prospective randomized trial in patients requiring cataract surgery in which IOP, angle anatomy and other demographic and clinical data are compared. Subjects randomized to both MSICS and phakoemulsification
- Trial name
- NCT02642211
- Testing
- cataract surgery
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Robin, Alan L., M.D.
Glaucoma
Subconjunctival Bevacizumab to Prevent Bleb Failure After Glaucoma Filtration Surgery
This study analyzes the safety and efficacy of off-label Subconjunctival Injection of bevacizumab (Avastin) versus 0.02% mitomycin C (MMC) for preventing bleb failure following glaucoma filtration surgery.
- Trial name
- NCT00468429
- Testing
- Subconjunctival Bevacizumab
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Grewal Eye Institute
Elevated Intraocular Pressure
A Study of AR-12286 in Patient With Elevated Intraocular Pressure (IOP)
Double-masked, randomized, multi-center, placebo-controlled parallel-comparison of AR-12286.
- Trial name
- NCT00902200
- Testing
- AR-12286, AR-12286 vehicle
- Where
- 8 sites in United States
- Volunteers
- 89 people
- Sponsor
- Aerie Pharmaceuticals
Pain, Arrythmia
Assessment of the Effect of Clonidine for Cataract Surgery
Clonidine, an agonist for alfa2 pre-synaptic, has been shown to be an effective adjuvant therapy for acute postoperative pain and has been shown an effect in sedative, intra-ocular and blood pressure and arrhythmias.The objective…
- Trial name
- NCT01677351
- Testing
- Clonidine
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Patient Cataract
Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation
we use two different technique of anaesthesia for anaesthesia of patient undergoining CPC operation (20 each) were comparable with regard to demographic data and hemodynamic variables, IOP.
- Trial name
- cyclophotocoag (NCT07445672)
- Testing
- Propofol and Fentanyl administration, Sevoflurane and fentanyl administration
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Blood Pressure
Comparison of Arterial Tonometry Sensor With Standard Oscillometric Blood Pressure Monitoring Device
The study aims at comparing the values of the blood pressure measurements obtained during 24 hours by an arterial tonometry device (BPRo) and a standard oscillometric blood pressure monitoring device (Oscar 2) under ambulatory…
- Trial name
- NCT03997461
- Testing
- BPro
- Where
- Chile
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Glaucoma, Sedation
Effect of Nitrous Oxide (N2O) on Intraocular Pressure in Healthy Volunteers
The purpose of this study is to learn if breathing nitrous oxide (also known as "laughing gas") changes the pressure in a person's eyes.
- Trial name
- NCT00967694
- Testing
- Nitrous oxide
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Blood Pressure
Body Structures Determining Differences in Forearm and Upper Arm Blood Pressures
The first purpose of this study is to see how blood pressures taken at different sites, specifically the forearm, upper arm and heart vessels, are different.
- Trial name
- NCT01087827
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Christiana Care Health Services
Glaucoma, Open-Angle
Scleral Response to Intraocular Pressure (IOP)
The study evaluated changes in the depth of the lamina cribrosa at different eye pressures.
- Trial name
- NCT03267862
- Testing
- there was no intervention
- Volunteers
- 27 people
- Sponsor
- Johns Hopkins University
Ocular Physiology, Regional Blood Flow
Effects of Vitamin C on Hyperoxia-Induced Reduction of Retinal Blood Flow
High arterial blood oxygen tension leads to vasoconstriction of retinal vessels, possibly related to an interaction between reactive oxygen species and endothelium-derived vasoactive factors.
- Trial name
- NCT00712907
- Testing
- vitamin C (Mayrhofer) 24mg/min i.v. for 64 min, 100% O2 (AGA) two times for 12 min
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna