Clinical trials: Intraoperative
Colorectal Cancer, Metastatic Colon Cancer
SGM-101 in Colorectal Lung Metastases
Near-infrared fluorescence-guided oncologic surgery (FGOS) with the use of a tumor specific tracer (SGM-101) developed by Surgimab can provide valuable intra-operative information about tumor location and extensiveness.
- Trial name
- SGM-CLM (NCT04737213)
- Testing
- SGM-101
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- Leiden University Medical Center
Blood Loss, Surgical, Blood Transfusion
Bleeding in Knee Arthroplasty After Preconditioning With Sevoflurane
Knee arthroplasty is performed with restriction of blood flow by use of the pressure tourniquet. Ischemia of skeletal musculature is accompanied by the formation of reactive oxygen species and release of vasoactive factors.
- Trial name
- NCT03379103
- Testing
- Sevoflurane, Propofol
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Cerebrovascular Disorders, Intracranial Neoplasms
Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions
This study focuses on implementing Yellow 560 for the direct intraoperative visualization of Fluorescein Sodium stained intracranial lesions to facilitate extend of surgery, develop better treatment protocols, and improve the…
- Trial name
- Fluoescein (NCT02478346)
- Testing
- Fluorescein Sodium
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- AdventHealth
Emergence Delirium
Effect of Music on Emergence Delirium
The researchers are conducting a research study to see whether listening to music during an operation will have a positive effect on the way that children wake up from surgery/anaesthetic.
- Trial name
- NCT02999542
- Testing
- Music, No music
- Volunteers
- 40 people
- Sponsor
- University of Pretoria
Refractory Localization-related Epilepsy
A New Method for Delineation of Epileptic Brian Tissue During Epilepsy Surgery (The HFO Study)
Epilepsy occurs in 0.5-0.7% of the population, of which 25% are children. 30% Of patients with focal epilepsy do not respond well to medication and half of them are eligible for epilepsy surgery.
- Trial name
- NCT02207673
- Testing
- Tailoring of the resection based on biomarker in aEcoG during epilepsy surgery
- Where
- 2 sites in Netherlands
- Volunteers
- 78 people
- Sponsor
- UMC Utrecht
Sarcoma Metastatic
Pilot Study of TumorGlow for Intraoperative Molecular Imaging of Sarcoma Metastases to the Lungs in Pediatric Patients
Subjects will undergo infusion of 5 mg/kg indocyanine green, ICG ("TumorGlow") intravenously up to 5-days prior to surgery. Then, during the surgical procedure the next day, the subjects will undergo standard-of-care surgery.
- Trial name
- TumorGlow (NCT07658768)
- Testing
- ICG INFUSION 5MG/KG
- Volunteers
- 20 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Postoperative Pulmonary Complications, Coronary Artery Bypass Graft Surgery (CABG)
Mechanical Power and Pulmonary Complications in CABG Surgery
This prospective observational study evaluates the association between intraoperative mechanical power (MP) - a composite measure of the total energy delivered to the lungs during mechanical ventilation - and postoperative…
- Conditions
- Postoperative Pulmonary Complications, Coronary Artery Bypass Graft Surgery (CABG), Prolonged Mechanical Ventilation
- Trial name
- MP-CABG (NCT07639489)
- Testing
- Intraoperative Mechanical Ventilation Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Fusun Gozen
Intraoperative Neurophysiological Monitoring, Spine Surgery
Ciprofol and Remimazolam for Intraoperative Neurophysiological Monitoring During Spine Surgery
Intraoperative neurophysiological monitoring, including motor evoked potentials and somatosensory evoked potentials, is commonly used during spine surgery to help detect impending neurological injury.
- Conditions
- Intraoperative Neurophysiological Monitoring, Spine Surgery, Anesthesia
- Trial name
- CIRIONM (NCT07718152)
- Testing
- Ciprofol, Remimazolam
- Volunteers
- 60 people
- Sponsor
- Affiliated 2 Hospital of Nantong University
Hypotension, Brain Injuries
Correlation Between Circulating Biomarkers of Organs Damage and Intraoperative Hypotension Management
Intraoperative hypotension (defined as mean arterial pressure below 65 mmHg) is associated with increased organs dysfunction and mortality.
- Conditions
- Hypotension, Brain Injuries, Renal Failure, Endothelial Dysfunction
- Trial name
- NCT03527758
- Testing
- Flo TracIQ with HPI software
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Catania
Thyroid Surgery
Neuromuscular Block Monitoring During Monitored Thyroidectomy
Titration of neuromuscular block (NMB) plays a key role in intraoperative recurrent laryngeal nerve monitoring during thyroid surgery.
- Trial name
- NCT04982185
- Where
- Taiwan
- Volunteers
- 116 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Surgical Blood Loss, Surgery
Modeling of the Hemoglobin Drop in the Uncomplicated Postoperative Course
transfusion-related decisions in the perioperative setting are often complex due to acute variations in the hemoglobin levels, which typically experience a progressive decrease within days.
- Conditions
- Surgical Blood Loss, Surgery, Perioperative/Postoperative Complications
- Trial name
- NCT03740438
- Testing
- Hemoglobin concentration
- Where
- Spain
- Volunteers
- 154 people
- Sponsor
- Hospital Clinic of Barcelona
Bleeding Active
Effectiveness and Safety of CELSTAT for Hemostasis in Intraoperative Tissue Bleeding
The study is to evaluate the effectiveness and safety of CELSTAT vs active control.
- Trial name
- CELSTAT (NCT02640235)
- Testing
- CELSTAT, Surgicel Original
- Where
- 25 sites in United States, Czechia and 2 more
- Volunteers
- 260 people
- Sponsor
- Baxter Healthcare Corporation
Acute Post Operative Pain, Motor Activity
Compartive Study Between Caudal and Perianal Block During Anal Sphincter Sparing Procedures Under General Anesthesia
Anal fistula is an abnormal tract communicating an external opening in the perianal skin with an internal opening in the anal canal. Anal fistula is treated by fistulotomy .
- Trial name
- NCT05557734
- Testing
- caudal block, perianal block
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Cairo University
Coronary Artery Disease
Phitys I™ Percutaneous Left Ventricular Assist System Study
The primary purpose of this clinical trial is to evaluate the safety and efficacy of the percutaneous left ventricular assist system versus intra-aortic balloon pump (IABP) for Circulatory Support during High-risk PCI.
- Trial name
- NCT06357026
- Testing
- Percutaneous Ventricular Assist System（Phigine Medical）, intra-aortic balloon pump (IABP)
- Where
- 8 sites in China
- Volunteers
- 344 people
- Sponsor
- Shanghai NewMed Medical Co., Ltd.
Pain, Anesthesia
NoL and BIS Monitoring on Patients Recovery and Safety After Surgery
So far, only vital signs (mostly, blood pressure and heart rate) helped the anesthesiologist to administer hypnotic agents or analgesics.
- Trial name
- CINAAMON (NCT03410485)
- Testing
- BIS index/NoL index, Variation of baseline mean arterial pressure
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Ventricular Fibrillation, Ventricular Tachycardia
Further Acute Research of a Subcutaneous Implantable Defibrillator (S-ICD) System
The purpose is to further evaluate the operation, safety, and feasibility of a subcutaneous implantable defibrillator (S-ICD) system in patients who require an implantable cardioverter defibrillator (ICD)for treating ventricular…
- Trial name
- NCT00399217
- Testing
- Subcutaneous Implantable Defibrillator (S-ICD) system, ICD
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- Boston Scientific Corporation
Lung Cancer
Application of SERS Technology Based Intraoperative Navigation System in Lung Cancer
This study aims to explore the application of Surface-enhanced Raman Scatting (SERS) technology in lung cancer surgery and clarify its mechanism through multi-omics mass spectrometry platform, and then further prove the clinical…
- Trial name
- NCT05881057
- Volunteers
- 200 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Pediatrics
Effect of Intraoperative Remifentanil Infusion Rate on Postoperative Tolerance and Analgesic Consumption in Pediatric Laparoscopic Ureteroneocystostomy
Effect of intraoperative remifentanil infusion rate on postoperative tolerance and analgesic consumption in pediatric laparoscopic ureteroneocystostomy.
- Trial name
- NCT01147757
- Testing
- remifentanil
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Intraoperative Ventilation
A Comparison of Different Ventilation Strategies in Children Using the Proseal™ Laryngeal Mask Airway
The purpose of this research study is to compare difference between breathing by oneself or with the partial help from an anesthesia machine in children under general anesthesia.
- Trial name
- NCT00966433
- Testing
- Spontaneous ventilation, Pressure support Ventilation, Pressure control ventilation
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Wake Forest University Health Sciences
Patients With ASA Status I-III Scheduled for Surgery
Intraoperative Air-Test
Although imaging techniques are the reference standard to diagnose alveolar collapse, in the postoperative period and using the peripheral hemoglobin oxygen saturation (SpO2), a non-invasive simple and accurate test (Air-Test)…
- Trial name
- NCT03469648
- Testing
- Air-Test
- Where
- 2 sites in Spain
- Volunteers
- 180 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia