Clinical trials: Intraoperative Analgesia
Anesthesia and Analgesia, Laparoscopic Surgical Procedure
Record and Analyze the Data of Patient Undergoing Anesthesia for Laparoscopic Cholecystectomy From Patient Monitoring Instruments
To record the digital data from monitoring instruments (standard patient monitor) containing cardiovascular system information, and from depth-of-anesthesia monitoring modules (Bispectral index, Entropy module, Surgical…
- Conditions
- Anesthesia and Analgesia, Laparoscopic Surgical Procedure, Monitoring, Physiologic, Hemodynamic Monitoring
- Trial name
- NCT03691103
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Median Sternotomy, Pain Management
Effect of Parasternal Plane Block on Intraoperative Nociception
Effective pain control during pediatric cardiac surgery remains a major clinical challenge, particularly in procedures involving median sternotomy, which is associated with intense nociceptive stimulation.
- Trial name
- NCT07354750
- Testing
- Parasternal Plane Block, Group without peripheral nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Pain Management, Recto Intercostal Nerve Block
Recto-intercostal Fascial Plane Block in Cholecystectomy
This study aims to evaluate whether an ultrasound-guided recto-intercostal fascial plane block performed before surgical incision in patients undergoing laparoscopic cholecystectomy reduces intraoperative opioid and volatile…
- Trial name
- NCT07502833
- Testing
- Procedure: Recto-intercostal fascial plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ankara Etlik City Hospital
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University
Laminectomy
Esmolol Infusion During Laminectomy: Effect on Quality of Recovery
The purpose of this study is to evaluate the effects of esmolol, a drug which is commonly administered during surgery to help control blood pressure and heart rate, on postoperative pain levels and requirements for pain…
- Trial name
- NCT01179113
- Testing
- Esmolol, Saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Cedars-Sinai Medical Center
Chronic Post-thoracotomy Pain, Acute Post-thoracotomy Pain
Intraoperative Cryoanalgesia for Extended Pain Management Following Thoracotomy
The ICE Study study will compare standard therapy (thoracic epidural) versus a novel approach (Cryoanalgesia combined with thoracic epidural) in subjects undergoing unilateral thoracotomy.
- Conditions
- Chronic Post-thoracotomy Pain, Acute Post-thoracotomy Pain, Post-thoracotomy Pain Syndrome
- Trial name
- ICE (NCT03538340)
- Testing
- Thoracic Epidural, Intercostal Cryoanalgesia
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- University of Maryland, Baltimore
Pain, Postoperative, Nociceptive Pain
The Prediction for Postoperative Pain
If the individual patient's pain is assessed and the amount of analgesic needed after surgery is predicted, appropriate injection of pain control and excessive injection of narcotic analgesic can be prevented.
- Conditions
- Pain, Postoperative, Nociceptive Pain, Analgesia, Patient-Controlled, Analgesics
- Trial name
- NCT03585088
- Testing
- surgical pleth index
- Where
- South Korea
- Volunteers
- 53 people
- Sponsor
- Samsung Medical Center
Anesthesia
Impact of NOL Intraoperative Guided Fentanyl Analgesia vs SCC for Elective Major Abdominal Surgery
Recently, a newly developed index, the Nociceptive Level (NOL) index, was validated and showed superiority over heart rate and blood pressure for recognition and grading of intense and mild nociceptive stimuli during surgery…
- Trial name
- NCT03970291
- Testing
- PMD-200
- Where
- Israel
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Medasense Biometrics Ltd
ERAS, Colorectal Surgery
Epidural Analgesia and Intraoperative Fluid Management in Colorectal Surgery
The Enhanced Recovery After Surgery (ERAS) protocols have demonstrated their efficacy in expediting recovery and minimizing postoperative complications, especially in patients undergoing abdominal surgery.
- Conditions
- ERAS, Colorectal Surgery, Goal-directed Fluid Therapy, Conventional Fluid Therapy
- Trial name
- NCT06810648
- Testing
- GDFT, GDFT/ED, CFT
- Where
- 2 sites in Greece
- Volunteers
- 121 people
- Sponsor
- University of Ioannina
Bariatric Surgery Candidate
Intraoperative Methadone for Postoperative Pain Control
To compare patient pain perception and satisfaction as well as opioid-related side effects during inpatient and outpatient care when undergoing bariatric enhanced recovery after surgery protocols with and without methadone.
- Trial name
- NCT05845359
- Testing
- Methadone
- Sponsor
- Montefiore Medical Center
Analgesia
Nociception Level During Opioid-sparing Anaesthesia Versus Conventional Opioid-based Anaesthesia
The aim of this double blind, randomised controlled non-inferiority trial is to compare the antinociceptive efficiency of an opioid-sparing and a conventional opioid-based anaesthesia protocol with the help of the CEcertificated…
- Trial name
- NOL_Basel (NCT05485480)
- Testing
- conventional opioid-based group, opioid-sparing group
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University Hospital, Basel, Switzerland
Anesthesia, General, Gynecologic Surgical Procedures
DSA vs. BIS for Anesthesia and Analgesia Management
The purpose of this study is to compare two different methods of monitoring brain activity (anesthesia depth) during gynecological surgeries.
- Conditions
- Anesthesia, General, Gynecologic Surgical Procedures, Intraoperative Monitoring, Anesthesia Depth Monitoring
- Trial name
- DSA-PRECISION (NCT07502261)
- Testing
- Density Spectral Array (DSA) Monitoring, Bispectral Index (BIS) Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Colorectal Cancer
Xenon Combined With Intraoperative Thoracic Epidural Analgesia
This is a monocentric study in 2 steps: A safety part to assess the feasibility of using Xenon in association with a thoracic epidural analgesia (TEA) with a sequential recruitment of 3, 6 or 9 patients according to predefined…
- Trial name
- NCT01696630
- Testing
- Xenon, Desflurane
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Centre Leon Berard
Pain
Evaluation of NoL Index and ANI After Nociceptive Stimulation at Different Infusion Rates of Remifentanil Infusion
Contrary to "immobility" and, to a lesser extent, to the "hypnosis/unconsciousness" component of general anaesthesia, the monitoring of "analgesia" remains largely elusive, evaluated mainly through poorly sensitive and…
- Trial name
- NCT02602379
- Testing
- Tetanic stimulation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Pain, Postoperative
Intraoperative Methadone Administration for Improved Pain Control in Spinal Fusion Patients
Methadone has several advantages over standard narcotic medications, especially when considering use after a typically painful surgery such as lumbar fusion.
- Trial name
- MAPS (NCT02989597)
- Testing
- Methadone Hydrochloride, Standard pain regimen, Spinal Fusion Surgery
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Lung Cancer
Regional Anesthesia and Lung Cancer Recurrence
Test the effect of combined regiona/general anesthesia on lung cancer recurrence compared to general anesthesia alone.
- Trial name
- NCT01179308
- Testing
- General-epidural anesthesia, Balanced general anesthesia and postoperative opioids
- Where
- 2 sites in United States, China
- Volunteers
- 67 people
- Sponsor
- The Cleveland Clinic
Anesthesia, Pain
Surgical Pleth Index (SPI) Versus Standard Clinical Approach Analgesia
The study is aimed at confronting a surgical pleth index based protocol for intraoperative analgesia in a desflurane based general anesthesia for thyroidectomy, versus a standard clinical approach.
- Conditions
- Anesthesia, Pain, Surgery
- Trial name
- SPIDER (NCT03218306)
- Testing
- Surgical Pleth Index, Clinical guidance
- Where
- Italy
- Volunteers
- 198 people
- Sponsor
- University of Cagliari
Pain
ADVANCE: Assessment for Defining Variability in Anesthesia Through Novel Clinical EEG
The present study is designed to compare prospectively whether sBIS, sEMG, or CVI variability (brain monitoring) can be used to predict unwanted intraoperative responses (high blood pressure, fast heart rate, tearing, etc.) to…
- Trial name
- CVI (NCT00689130)
- Where
- 4 sites in United States, Spain
- Volunteers
- 120 people
- Sponsor
- Medtronic - MITG
Analgesia, Obstetrical, Coagulation Defect; Postpartum
IV Ketorolac on Platelet Function Post-Cesarean Delivery
Cesarean delivery has become the most common surgical procedure in the US. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to improve the quality of post-cesarean analgesia and markedly reduce opioid consumption.
- Conditions
- Analgesia, Obstetrical, Coagulation Defect; Postpartum, Nonsteroidals (NSAIDs)Toxicity, Postpartum Hemorrhage
- Trial name
- KetoPltAgg (NCT03805607)
- Testing
- Ketorolac Tromethamine 30 MG/ML
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Abdominal Aorta Aneurysm, Abdominal Aorta Atheroma
Impact of Intra- and Postoperative Continuous Infusion of Lidocaine on Analgesia in Vascular Anaesthesia
The aim of the study is to test the effectiveness and safety of the use of lidocaine infusion in multimodal analgesic management.
- Conditions
- Abdominal Aorta Aneurysm, Abdominal Aorta Atheroma, Surgery, Pain, Postoperative
- Trial name
- NCT04691726
- Testing
- lidocaine 10mg/ml, Metamizole, Morphine
- Where
- Poland
- Volunteers
- 87 people
- Sponsor
- Łukasz Krzych