Clinical trials: Intraoperative Analgesia
Intra-operative Anesthesia and Analgesia Effects
Pediatric Ilioinguinal / Iliohyogogastric Nerve Block
Ilioinguinal / iliohyogogastric nerve blocks; It is frequently used for analgesia and anesthesia in inguinal region surgeons. However, 95% of these surgeons are under general anesthesia.
- Trial name
- NCT02990884
- Testing
- ketamine
- Volunteers
- 60 people
- Sponsor
- Erzincan University
Tonsillitis
Suprazygomatic Maxillary Nerve Block in Pediatric Tonsillectomy
Tonsillectomies are among the most common surgical procedures performed in pediatric populations, with more than 14,000 procedures performed annually in Ontario, with more than 80% being performed to treat sleep-disordered…
- Trial name
- NCT07176533
- Testing
- Suprazygomatic maxillary nerve block (SZMN) with bupivacaine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Epilepsy, Radiofrequency Ablation
Brain Regions and Functional Neuronal Network Characteristics of Dexmedetomidine Analgesia
Background: Dexmedetomidine (Dex) is a highly selective 2-adrenergic receptor agonist with significant analgesia affection. This study is planned to explore the brain regions and functional neuronal network involved in promoting…
- Conditions
- Epilepsy, Radiofrequency Ablation, Intracranial Surgery
- Trial name
- NCT05500703
- Testing
- Dexmedetomidine Injectable Solution, Sodium Chloride 0.9% Inj
- Where
- China
- Volunteers
- 28 people
- Sponsor
- China International Neuroscience Institution
Paraumbilical Hernia
Comparison of Extended Totally Extra-peritoneal Repair (ETEP) and Subcutaneous On-lay Endoscopic Approach (SCOLA) for Para-umbilical Hernia (PUH).
The goal of this clinical trial is to learn if one of two surgical techniques works better for treating paraumbilical hernias in adult men and women between 18 and 65 years old.
- Trial name
- NCT07434687
- Testing
- Extended Totally Extra Peritoneal Repair, Subcutaneous On-Lay Endoscopic Approach
- Where
- Pakistan
- Volunteers
- 86 people
- Sponsor
- King Edward Medical University
Anesthesia
Magnesium for Shivering in Epidural Lidocaine Deliveries
Magnesium has been shown to decrease the shivering experienced from neuraxial anesthesia. This study aims to investigate whether magnesium decreases the shivering experienced in parturients undergoing labor epidural anesthesia…
- Trial name
- Mag-SHIELD (NCT03439358)
- Testing
- Magnesium Sulfate, Normal Saline
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Intraoperative Neurophysiological Monitoring
Effect of Perioperative Factors on the Analgesia Nociception Index
The Analgesia Nociception Index (ANI) is a new unitless marker derived from Heart Rate Variability spectral analysis, ranging between 0 and 100 and expressing the parasympathetic tone.
- Trial name
- ANIFACT (NCT02305576)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen
Nociceptive Pain, Pain, Postoperative
Guiding Opioid Administration by Nociception Level Index (NOL) in Patients With Regional Anesthesia
General anesthesia consists of a combination of hypnotic drugs to achieve unconsciousness and opioid analgesics to ensure antinociception.
- Conditions
- Nociceptive Pain, Pain, Postoperative, Analgesia, Postoperative, Anesthesia Recovery Period
- Trial name
- NORA (NCT06905340)
- Testing
- NOL (Nociception Level Index), Control (Standard treatment)
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Analgesia, Functional Endoscopic Sinus Surgery
ANI-guided Intraoperative Analgesia in Low-pressure Anesthesia
During functional endoscopic sinus surgery(FESS), low-pressure anesthesia is often applied, aiming to decreased operative blood loss, and anesthetics, narcotics and antihypertensive agents are given to achieve desirable low blood…
- Conditions
- Analgesia, Functional Endoscopic Sinus Surgery, Heart Rate Variability, Opioid Consumption
- Trial name
- NCT04319913
- Testing
- analgesia nociception index
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Mackay Memorial Hospital
Liver Failure, Liver Transplant; Complications
Intravenous Ketamine Infusion on Postoperative Analgesia of Living Liver Donors
Because of the insufficiency of cadaveric organs and increasing need for organs, the interest in living donor liver transplantation have been greatly increased.
- Conditions
- Liver Failure, Liver Transplant; Complications, Post Operative Pain
- Trial name
- NCT05441150
- Testing
- Low dose ketamine infusion, 0.9% NaCl infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Inonu University
Age Related Cataract, Pain Management During Cataract Surgery
Iris Vascular Area Density-Based Preoperative Pain-Risk Screening and Intervention in Second-Eye Cataract Surgery
This clinical trial aims to evaluate the effectiveness of pranoprofen or prednisolone acetate eye drops for pain management in patients undergoing second-eye surgery for age-related cataracts.
- Trial name
- NCT07291089
- Testing
- Pranoprofen eye drops, Prednisolone acetate eye drops, Sodium hyaluronate eye drops
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Pain, Postoperative
Intraoperative Ketamine and Magnesium Therapy for Control of Postoperative Pain After a Liposuction and Lipoabdominoplasty
Lipoabdominoplasty and liposuction are one of the most common plastic surgeries. The management of postoperative pain is complex.
- Trial name
- KEMPLA (NCT02450214)
- Testing
- Saline, Ketamine, Ketamine + magnesium
- Where
- Chile
- Volunteers
- 63 people
- Sponsor
- University of Chile
Bariatric Surgical Pain
Intraoperative Lidocaine Infusion for Postoperative Pain Management in Obese Patients
The primary objective is to assess the feasibility and safety of administering continuous intraoperative lidocaine infusions in adult patients undergoing laparoscopic Roux en Y Gastric Bypass (RYGB).
- Trial name
- NCT01944098
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of South Florida
Macromastia (Symptomatic)
Pectoral Block in Breast Reduction for Pain Control
A reduction mammoplasty is a commonly performed procedure for patients with symptomatic macromastia. The procedure involves removing breast parenchyma for an overall reduction in breast size and to alleviate patient symptoms…
- Trial name
- NCT07527039
- Testing
- Pectoral II Nerve Block, Post Operative Pain Relievers
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Carilion Clinic
Anesthesia Recovery Period, Pain, Postoperative
Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery
The main hypothesis of this study is that preoperative administration of controlled-release (CR) oxycodone may reduce acute postoperative pain and improve time to discharge from the post-anesthesia care unit in patients…
- Trial name
- NCT00681174
- Testing
- Morphine, oxycodone, Paravertebral block
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- University of Parma
Intraoperative Monitoring
The Effect of SPI (Surgical Pleth Index) - Guided Anaesthesia on Opioid Consumption in Gastric Sleeve Surgery
This is a unicentric, prospective randomised trial that aims to evaluate the role of intra-operative monitoring of nociception through SPI (Surgical Pleth Index) in guiding analgesia and reducing opioid consumption in obese…
- Trial name
- NCT05884229
- Testing
- Intra-operative analgesia guided by SPI
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Pain, Postoperative
Cryoanalgesia Study
This study will investigate the feasibility of cryoanalgesia in patients undergoing cardiac surgery via a median sternotomy. Cryoanalgesia is a technique that uses extremely cold temperatures to temporarily ablate nerves and…
- Trial name
- NCT05859061
- Testing
- cryoICE® system (AtriCure, Inc) with CryoSphere (CryoS) probe
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Northwestern University
Anterior Cruciate Ligament (ACL) Tear, Arthroscopic Anterior Cruciate Ligament Reconstruction
Intraoperative Periarticular Injection in Arthroscopic Anterior Cruciate Ligament Reconstruction Surgery
In this prospective, assessor-blinded, single-surgeon clinical trial, the goal was to validate the efficacy of PAI in aACLR surgery with a reduced opioid dose, while achieving similar pain relief with few adverse events.
- Trial name
- PAI in ACLR (NCT06630520)
- Testing
- Periarticular injection
- Where
- Taiwan
- Volunteers
- 288 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Pain
Pupillometry - Future of Objective Pain Reaction Measurement While Unconscious
This study aims to assess the usefulness of pupillometry as a nociceptive indicator during elective orotracheal intubation in patients given intravenous lignocaine pre-intubation as compared to a placebo pre-intubation.
- Trial name
- NCT04000126
- Testing
- Pupil reflex dilation measurement (PRD), PPI (Pupillary Pain Index), lidocaine
- Where
- Poland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Warmia and Mazury
Pain, Postoperative
Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia
The purpose of this study is to determine whether, for surgery of the tibia, one dose of methadone provides better control of pain afterward as compared to morphine, which is the usual drug given to control pain after surgery.
- Trial name
- NCT01430182
- Testing
- Methadone, Morphine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
Condition: Abdominal Bone Flap Cranioplasty; Focus of Study: Perioperative Analgesia
Efficacy Of Scalp Block And Ultrasound Guided TAP Block With Clonidine As Adjuvant To Ropivacaine Versus Intravenous Fentanyl On Intraoperative Hemodynamics And Perioperative Analgesia In Abdominal Bone Flap Cranioplasties
This study assesses efficacy of scalp block and Ultrasound guided transverse abdominis plane (TAP) block with 1µg/kg clonidine as adjuvant to 0.2% ropivacaine versus intravenous fentanyl (0.1µg/kg/hr) on intraoperative…
- Trial name
- NCT03667352
- Testing
- Unilateral Scalp Block, Transversus abdominis plane block, Intravenous Fentanyl
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Dhritiman Chakrabarti