Clinical trials: Intraoperative Analgesia
Colorectal Cancer
The Effect of IoC on Analgesia for Elderly Patients With Postoperative Effectiveness
The morbidity of colorectal cancer and the surgery number among elderly is growing. The investigators need to provide more advanced and specific monitoring technology for these patients.
- Trial name
- NCT02827682
- Testing
- Angel-6000D Multiparameter Anesthesia Monitor (IoC), BIS VISTA Monitor (BIS)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pain, Acute
Intrathecal Nalbuphine is a Comparable Safer Alternative to Fentanyl for Intraoperative Pain Management During Uterine Exteriorization
In case of cesarean section (CS) delivery, spinal anesthesia is the best anesthetic choice. It is simple to perform with rapid onset of anesthesia and lower incidence of failed block.
- Trial name
- NCT04689217
- Testing
- intrathecal drug injection
- Where
- Egypt
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Cairo University
Breast Cancer
Efficacy of Preoperative Pectoral Nerve Block for Intraoperative Opioid Sparing Effect and Postoperative Analgesia
The purpose of this study is to determine whether pectoral nerves blocks（PECS） would reduces the opioid consumption during the surgery and postoperative pain after breast cancer surgery.
- Trial name
- NCT03210220
- Testing
- Pecs II block
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Gachon University Gil Medical Center
Postoperative Analgesia
Continuous Epidural Fentanyl- Low Dose Bupivacaine Infusion Analgesia for Precious Single Kidney Patient.
Open surgical nephrectomy is associated with sever postoperative pain mandating alternative strong ,renal safety, minimal side effects, and minimal rescue systemic analgesics , continuous Epidural Fentanyl infusion in a dose step…
- Trial name
- NCT03606902
- Testing
- Group f : Epidural catheter insertion, Group F: Continous epidural infusion of bupivacaine plus fentanyl, Group LF :Continous epidural infusion of decreasing doses of fentanyl plus pubivacaine
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Laparoscopic Cholecystectomy, Postoperative Pain
Subcostal TAP Block and EEG Dynamics in Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy is a commonly performed minimally invasive surgical procedure. Despite its minimally invasive nature, surgical stimulation and pneumoperitoneum may cause pain-related physiological and…
- Conditions
- Laparoscopic Cholecystectomy, Postoperative Pain, Intraoperative Nociception
- Trial name
- NCT07818954
- Testing
- Remifentanil, Ultrasound-Guided Subcostal Transversus Abdominis Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Burns
Intraoperative Small-dose Esketamine Infusion for Pain Control in Burn Patients
This study aim to determine whether a small-dose esketamine infusion can be used for pain control in severe burn patients, and thereby reduce the total intra-operative opioid requirement.
- Trial name
- NCT04682782
- Testing
- Esketamine, Saline
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Obesity, Sleep Apnea
Dexmedetomidine for Postoperative Analgesia After Bariatric Surgery
The purpose of this study is to determine if Dexmedetomidine given at the end of surgery will reduce postoperative morphine consumption and improve postoperative quality of recovery as compared to morphine in patients undergoing…
- Conditions
- Obesity, Sleep Apnea, Diabetes, Hypertension
- Trial name
- NCT02213159
- Testing
- Dexmedetomidine, Morphine
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- American University of Beirut Medical Center
Intraoperative Analgesia
NOL Guided Analgesia During Elective Laparoscopic Surgery Under General Anesthesia
The aim of this study is to investigate the hypothesis that the intraoperative use of the nociception level index NOL can reduce opioid consumption in adult patients undergoing elective laparoscopic surgeries under general…
- Trial name
- NOLGADELS (NCT06104059)
- Testing
- Nociception level index (NOL™), Fentanyl
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Attikon Hospital
Laparoscopic Cholecystectomy Surgery, Perioperative Analgesia
Comparison of M-TAPA and External Oblique Intercostal Block for Intraoperative Opioid Consumption in Laparoscopic Cholecystectomy
This prospective, randomized, interventional study compares the effects of modified thoracoabdominal nerve block through perichondrial approach (M-TAPA) and external oblique intercostal plane block (EOI) on intraoperative…
- Trial name
- MTAPA-EOI (NCT07595679)
- Testing
- Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA), External Oblique Intercostal Plane Block (EOI)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara Etlik City Hospital
Acute Pain, Regional Anesthesia
Regional Analgesia in Combination With Cryoanalgesia to Prevent Acute Pain Following Nuss Procedure
Funnel chest deformation is a painful procedure, which requires high doses and long time used of opioids. It makes difficult introduction of ERAS protocol.
- Trial name
- NCT05589246
- Testing
- regional analgesia with cryolesia
- Where
- 2 sites in Poland
- Volunteers
- 40 people
- Sponsor
- Pomeranian Medical University Szczecin
Quality of Life
Acupuncture and Integrative Care in Gynecological Surgery
Patients undergoing surgical procedures for gynecological cancer are frequently challenged by intense anxiety prior to surgery, reflecting the accompanying uncertainty regarding the diagnosis, treatment and prognosis of their…
- Trial name
- NCT03560388
- Testing
- Acupuncture and touch/relaxation
- Where
- Israel
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Intraoperative Pain Control
Transversus Abdominis Plane Block Versus Erector Spina Plane Block
Regional anesthesia and analgesia techniques are frequently used to provide pain control in pediatric surgical applications. The main advantages of these techniques include ease of application, good analgesic efficacy and low…
- Trial name
- NCT04095325
- Testing
- Ultrasound guided erector spinae block
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Erzincan University
Coarctation of Aorta
The Effect of Paravertebral Block With Dexamethasone on Intraoperative and Postoperative Analgesia in Children Undergoing Surgery for Coarctation of Aorta
Anesthetic management for surgery of aortic coarctation needs special care due to severe pain during lateral thoracotomy incision, the intraoperative hemodynamic instability related to skin incision at lateral thoracotomy…
- Trial name
- NCT03074773
- Testing
- Dexamethasone, ultrasound, paravertebral block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Postoperative Pain, Inguinal Hernia Unilateral
Levobupivacaine and Postoperative Pain Relief
The study analysed direct levobupivacaine instillation in surgical wound and its effectiveness in postoperative pain control. Half participants received 0,5 % levobupivacaine and the other half received 0,9% saline solution
- Trial name
- NCT04869046
- Testing
- Instillation of levobupivacaine in surgical wound
- Where
- 2 sites in Serbia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mother and Child Health Institute of Serbia Dr Vukan Cupic
Pain, Postoperative, Opioid Use
Comparison of Postoperative Nociception Between NOL-guided and Standard Intraoperative Analgesia Based on Fentanyl
Pain is defined as an unpleasant sensory and emotional conscious experience, associated with actual or potential tissue damage. Nociception is the sympathetic response to noxious stimuli during unconsciousness.
- Conditions
- Pain, Postoperative, Opioid Use, Nociceptive Pain, Postoperative Pain
- Trial name
- NOLFentanyl (NCT03858621)
- Testing
- fentanyl NOL guided
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Victor Contreras, MSN
Analgesia
Intraoperative and Postoperative Analgesia for Laparoscopic Surgery.
Main Hypothesis: laparoscopic surgery is very painful to patient during and after surgery. We would like to compare different analgesic methods.
- Trial name
- NCT00772187
- Testing
- morphine, intrathecal analgesia (morphine), general anesthesia (fentanyl)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Rambam Health Care Campus
Breast Augmentation, Pain Management in Postoperative Care
PECS I Block vs. Local Infiltration in Breast Augmentation Pain Management
This study aimed to compare the effectiveness of preoperative PECS I block and intraoperative local anesthetic infiltration in managing postoperative pain following breast augmentation surgery.
- Conditions
- Breast Augmentation, Pain Management in Postoperative Care, Pain Management After Surgery, Pain Management
- Trial name
- NCT06719726
- Testing
- PECS I Block, Local Anesthetic Infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yeditepe University Hospital
Analgesia
Analgesic Requirements for Lumbar Fixation With General Anaesthesia Versus Continuous Caudal Epidural
In this clinical study, the investigators will justify the current practice of combined continuous caudal epidural with general anaesthesia in adult patients undergoing lumbar fixation versus general anaesthesia.
- Trial name
- NCT06929611
- Testing
- Combined continous caudal epidural with general anaesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Postoperative Pain
Intraoperative Local Anaesthetic and Postoperative Pain
Background: Intraoperative wound infiltration with local anaesthetic is commonly used. Apart from the obvious immediate action it has been supported that a possible down regulation of pain receptors may lead to longer effects.
- Trial name
- Pain-1 (NCT02171299)
- Testing
- Wound infiltration with local anaesthetic, Ropivacaine
- Where
- Greece
- Volunteers
- 400 people
- Sponsor
- Hellenic Red Cross Hospital
Visceral Pain, Analgesia
Intraoperative Autonomic Blockade for Laparoscopic Cholecystectomy
This study proposes infiltrating the hepatoduodenal ligament and the serosal reflection of the gallbladder cystic plate with a combination of Bupivacaine (a long-acting local anesthetic) and Dexamethasone (a corticosteroid).
- Conditions
- Visceral Pain, Analgesia, Opioid Use, Postoperative Nausea
- Trial name
- ANB (NCT06753500)
- Testing
- Autonomic neural blockade
- Where
- 2 sites in Colombia
- Volunteers
- 60 people
- Sponsor
- Universidad Simón Bolívar