Clinical trials: Intraoperative Complication
Cholecystectomy, Pain, Postoperative
Nonopioid Analgesics and Cholecystectomy
The goal of this clinical trial is to evaluate the effect of the addition of nefopam to a multimodal analgesic regimen consisting of ketoprofen and paracetamol during sevoflurane- dexmedetomidine-based anesthesia on postoperative…
- Conditions
- Cholecystectomy, Pain, Postoperative, Opioid Use
- Trial name
- NCT04622813
- Testing
- nefopam, ketoprofen, paracetamol, saline infusion, ketoprofen, paracetamol
- Where
- Lebanon
- Volunteers
- 90 people
- Sponsor
- American University of Beirut Medical Center
Stress Urinary Incontinence
Does Bladder Instillation Reduce Time to Discharge After Sling Surgery
The purpose of this randomized control trial study is to determine if intraoperative bladder instillation of fluid decreases the time to discharge after having an outpatient mid-urethral sling procedure, and to measure the cost…
- Trial name
- NCT02277288
- Testing
- Filled bladder arm
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Cedars-Sinai Medical Center
Polyuria
Polyuria Associated With Dexmedetomidine in Operating Room
Dexmedetomidine is an a2-adrenergic receptor agonist drug, widely used in intensive care for the sedation of patients on mechanical ventilation, as well as in the operating room during invasive procedures and during general…
- Trial name
- NCT06535386
- Testing
- Dexmedetomidine 0.004 MG/ML
- Volunteers
- 150 people
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
Pancreatic Neoplasms, Hypotension
Intraoperative Hypotension in Pancreatoduodenectomy: A Randomized Trial of General Versus Combined Anesthesia
This randomized clinical trial compares the hemodynamic effects of general anesthesia versus combined general anesthesia (thoracic epidural) in patients undergoing pancreatoduodenectomy.
- Conditions
- Pancreatic Neoplasms, Hypotension, Pancreatoduodenectomy
- Trial name
- NCT06953193
- Testing
- General Anesthesia, Combined General Anesthesia (Thoracic Epidural)
- Where
- Mexico
- Volunteers
- 206 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Prostate Cancer, Urinary Bladder Cancer
Lung US for PEEP Optimization in Robotic Radical Prostatectomy or Cystectomy Patients
There is an increasing trend in the use of robotic-assisted radical prostatectomy or cystectomy (RARPC). Preventing lung atelectasis without inducing overdistention of the lung is challenging.
- Conditions
- Prostate Cancer, Urinary Bladder Cancer, Surgery, Positive End Expiratory Pressure
- Trial name
- NCT06307704
- Testing
- Lung Ultrasound - guided Stepwise PEEP, Standard Ventilation Protocol
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Nazmy Edward Seif
Shoulder Arthritis, Blood Loss, Surgical
Effect of TXA on Blood Loss in Reverse Total Shoulder Arthroplasty
Tranexamic acid (TXA) is a synthetic anti-fibrinolytic agent that has been well studied and routinely used for hip and knee arthroplasty.
- Conditions
- Shoulder Arthritis, Blood Loss, Surgical, Tranexamic Acid Adverse Reaction
- Trial name
- NCT06638749
- Testing
- Tranexamic Acid, Normal Saline
- Where
- United States
- Sponsor
- University of Kansas Medical Center
Peripheral Occlusive Disease, Wound Healing
Intraoperative Application of Cold Atmospheric Plasma to Prevent Postoperative Wound Complications in the Inguinal Region of High-risk Patients With Peripheral Arterial Occlusive Disease
The goal of this clinical trial is to learn if postoperative wound complications in the inguinal region of high-risk patients with peripheral arterial occlusive disease can be prevented by the intraoperative application of cold…
- Conditions
- Peripheral Occlusive Disease, Wound Healing, Wound Healing Complication, Cold Atmospheric Plasma
- Trial name
- PICPAD (NCT07571408)
- Testing
- Cold atmospheric plasma
- Where
- Germany
- Volunteers
- 214 people
- Sponsor
- Ursula Werra
Pleural Metastases, Breast Cancer
Heated Chemotherapy for Cancers That Have Spread to the Chest Cavity
Cancers that have spread to the inner lining of the chest are classified as Stage IV and bear a poor prognosis. Surgery is rarely an option, with palliative chemotherapy and/or radiation therapy the only treatment options.
- Conditions
- Pleural Metastases, Breast Cancer, Colon Cancer, Ovarian Cancer
- Trial name
- NCT01163552
- Testing
- Surgical debulking and Intrathoracic Hyperthermic Chemotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Intraoperative Bleeding, Functional Endoscopic Sinus Surgeries
Dexmedetomidine Versus Nitroglycerin on Surgical Field Quality and Drug Cost in Functional Endoscopic Sinus Surgeries
Sinus surgery is one of the most prevalent ear, nose, and throat (ENT) surgeries, which is mainly carried out nowadays through functional endoscopic sinus surgery (FESS) and leads to significant improvement in the clinical…
- Conditions
- Intraoperative Bleeding, Functional Endoscopic Sinus Surgeries, Hypotension
- Trial name
- NCT07585201
- Testing
- controlled hypotension using dexmedetomidine, controlled hypotension hypotension using nitroglycerin
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Zagazig University
Magnesium Sulfate, Postoperative Pain
Opioid Sparing General Venous Anesthesia With Magnesium Sulfate
Magnesium sulfate has been shown to be useful in many situations in medicine, such as eclampsia prevention and treatment, pulmonary hypertension, arterial pressure, asthma, cardiac arrhythmias and pheochromocytoma.
- Conditions
- Magnesium Sulfate, Postoperative Pain, Opioid Use
- Trial name
- NCT04005599
- Testing
- Remifentanil group, Magnesium sulfate group
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Blood Loss, Surgical
Tranexamic Acid for Total Knee Arthroscopy
The purpose of this investigation is to determine the most effective regimen of administration of tranexamic acid to improve clinical outcome among patients undergoing total knee arthroplasty.
- Trial name
- NCT04443920
- Testing
- Tranexamic acid (TXA)
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- The Miriam Hospital
Uterine Cervical Dysplasia
LLETZ Under Direct Colposcopic Vision
To assess the benefits of large Loop excision of the transformation Zone (LLETZ) under direct colposcopic Vision.
- Trial name
- NCT02910388
- Testing
- LLETZ with colposcopy, LLETZ without colposcopy
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
Blood Loss, Surgical
Retransfusion or Not of Cardiotomy Blood
This randomised controlled trial has a non-inferiority design. The aim is to test if the blood loss (volume in mL and hemoglobin) is effected by heart and lung cardiotomy retransfusion, or not? Forty CABG (Coronary Artery By pass…
- Trial name
- NCT04574128
- Testing
- No retransfusion of cardiotomy blood
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Örebro University, Sweden
Intraoperative Complications, Surgery--Complications
Intra-Operative Complication Assessment and Reporting With Universal Standards: Survey
Perioperative complications, especially intraoperative adverse events (iAEs), carry significant potential for long-term sequelae in a patient's postoperative course.
- Conditions
- Intraoperative Complications, Surgery--Complications, Surgery, Surgical Procedure, Unspecified
- Trial name
- ICARUS-S (NCT04994392)
- Where
- United States
- Volunteers
- 4,821 people
- Sponsor
- University of Southern California
Bladder Cancer, Urinary Diversion
Effects of Noradrenaline Administration Combined With Restrictive Intraoperative Fluid Substitution on Perioperative Outcome in Patients Undergoing Radical Cystectomy
Perioperative fluid management in abdominal surgery is a subject of controversy and current standard fluid therapy is not evidence based. Compensating decreasing blood pressure by volume substitution is common praxis.
- Trial name
- NCT01276665
- Testing
- restrictive intraoperative fluid substitution, assessment of the pelvic venous pressure
- Where
- Switzerland
- Volunteers
- 190 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pelvic Fracture, Transfusion Reaction
Blood Transfusion Among Patients With Pelvic Fracture in China
According to the patient's blood management concept, this study intends to collect basic information, surgical data, blood transfusion related data and patient prognosis data of patients with pelvic fractures, and to construct a…
- Conditions
- Pelvic Fracture, Transfusion Reaction, Blood Transfusion Complication
- Trial name
- PBM (NCT03855644)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Surgical Blood Loss, Hemorrhage
The Cryopreserved vs. Liquid Platelets Trial
This trial is a phase III multicentre blinded randomised controlled clinical non-inferiority trial of cryopreserved platelets vs. conventional liquid-stored platelets for the management of surgical bleeding.
- Trial name
- CLIP II (NCT03991481)
- Testing
- Cryopreserved platelets, Liquid-stored platelets
- Where
- 6 sites in Australia
- Volunteers
- 388 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Atrial Fibrillation Rapid, Postoperative Complications
Preoperative Carbohydrate Load and Intraoperative w3-PUFA in CAGB Surgery
Omega-3 polyunsaturated fatty acids (w-3-PUFA) may have a potential role in enhance the postoperative balance of host immunity and reduce the incidence of postoperative atrial fibrillation (POAF).
- Trial name
- NCT03017001
- Testing
- CHO (carbohydrate), intravenous w-3 PUFA, CHO (carbohydrate) plus intravenous w3-PUFA
- Volunteers
- 60 people
- Sponsor
- Federal University of Mato Grosso
Blood Loss, Surgical
Pre-surgical Evaluation for the Quantra System in Adult Patients Undergoing Cardiac Surgery
This study will evaluate the performance of the Quantra System comprised of the Quantra Hemostasis Analyzer with the QPlus Cartridge in patients taking anitplatelet medication that are scheduled to undergo cardiac surgery.
- Trial name
- NCT03931031
- Testing
- Quantra System
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- HemoSonics LLC
Hypotension, Postoperative Complications
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Major adverse cardiovascular events (MACE) are a leading cause of serious complications and death following major noncardiac surgery.
- Conditions
- Hypotension, Postoperative Complications, Acute Coronary Syndrome, Heart Failure
- Trial name
- BBB (NCT02533128)
- Testing
- Liberal blood pressure management, Tight blood pressure management
- Where
- Switzerland
- Volunteers
- 458 people
- Sponsor
- Miodrag Filipovic, Prof. Dr. med.