Clinical trials: Intraoperative Pain
Pain, Acute Post-Operative, Dexmedetomidine
Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery
The aim of this study is to investigate and compare the effects of a continuous infusion of low-dose esmolol and dexmedetomidine versus placebo on intraoperative and postoperative opioid consumption and analgesic efficacy in…
- Conditions
- Pain, Acute Post-Operative, Dexmedetomidine, Analgesia, Esmolol
- Trial name
- NCT07846722
- Testing
- Esmolol hydrochloride, Dexmedetomidine, Normal (0.9%) saline
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Vasiliki Samartzi
Post-operative Pain
Comparison of Preoperative Ultrasound Guided Pectoralis Nerve Block Placement Versus Intra-operative Placement: A Prospective Randomized Trial
This study investigates the use of post-operative on-Q pain catheters for tissue expander based breast reconstruction, versus conventional ultrasound-guided blocks placed pre-operatively.
- Trial name
- NCT03201809
- Testing
- On-Q, Ultrasound guided pectoral nerve block
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Intraocular Lens Replacement
Safety and Efficacy of OMS302 in Subjects Undergoing Intraocular Lens Replacement With Phacoemulsification
The purpose of this study is to determine the safety and efficacy of OMS302 (the study drug) for maintaining intraoperative mydriasis in individuals undergoing Intraocular Lens Replacement (ILR) surgery.
- Trial name
- OMS302-ILR-003 (NCT01454063)
- Testing
- OMS302
- Where
- 16 sites in United States
- Volunteers
- 405 people
- Sponsor
- Omeros Corporation
Head and Neck Surgery, Plastic Surgery
Preoperative Maxillary Nerve Block and Remifentanil Use in Septorhinoplasty
Septorhinoplasty is generally a prolonged surgical procedure that frequently involves osteotomy, which may lead to increased intraoperative remifentanil requirements.
- Conditions
- Head and Neck Surgery, Plastic Surgery, Rhinoplasty, Pain
- Trial name
- PRISM (NCT07233538)
- Testing
- Maxillary block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara Etlik City Hospital
Postoperative Pain, Intraoperative and Postoperative Opioid Requirements
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Relationship Between Intraoperative Intravenous Acetaminophen and Postoperative Opioid Avoidance for Ambulatory Surgical Procedures
This is a research study to determine if giving acetaminophen intravenously in hte operating room will decrease the number of patients who require additional pain medicine, such as morphine, after surgery in the recovery room.
- Trial name
- Cadence (NCT01231191)
- Testing
- Intravenous acetaminophen
- Where
- United States
- Sponsor
- University of California, San Diego
Osteo Arthritis Knee
Post-op Ketamine Study
The purpose of this study is to establish the effect of sub-anesthetic dosing of ketamine with spinal anesthesia during total knee arthroplasty on post-operative pain and narcotic consumption.
- Trial name
- NCT03865550
- Testing
- Isotonic saline, Ketamine Injectable Solution
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Rothman Institute Orthopaedics
Postoperative Pain, Carpal Tunnel Release
Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries
The purpose of this study is to determine the efficacy of intra-operative administration of IV tylenol and/or IV toradol in minimizing post-operative pain for carpal tunnel patients and distal radius fracture patients.
- Conditions
- Postoperative Pain, Carpal Tunnel Release, Distal Radius Fracture
- Trial name
- NCT02313675
- Testing
- Acetaminophen, Ketorolac Tromethamine, Saline
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- John Fowler
Osteoarthritis, Total Knee Arthroplasty
Effectiveness of Intraoperative Exparel for Postoperative Pain Control in Total Knee Arthroplasty
Does the use of periarticular Exparel in total knee arthroplasty prove to more effectively manage post operative pain control than another local analgesic, Ropivacaine, when both are used as part of a multimodal pain management…
- Conditions
- Osteoarthritis, Total Knee Arthroplasty, Pain Management
- Trial name
- NCT02808728
- Testing
- Pain Cocktail with Exparel, Pain Cocktail with Ropivacaine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- DeClaire LaMacchia Orthopaedic Institute
Superior Hypogastric Plexus Block, Hysterectomy
Superior Hypogastric Plexus Blockade in Laparoscopic Hysterectomy
The primary indication for superior hypogastric plexus (SHP) block is visceral pelvic pain, most commonly from malignancy of the ovary, uterus, cervix, bladder, rectum or prostate.
- Conditions
- Superior Hypogastric Plexus Block, Hysterectomy, Minimally Invasive Surgery, Laparoscopy
- Trial name
- NCT03427840
- Testing
- Procedure/Surgery: superior hypogastric block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Derince Training and Research Hospital
Music Therapy, Anxiety
Therapy on Perioperative Anxiety and Pain in Patients
This study aims to explore the effects of preoperative education combined with intraoperative music therapy on perioperative anxiety and pain in patients undergoing elective cesarean section.
- Conditions
- Music Therapy, Anxiety, Health Education
- Trial name
- NCT06970431
- Testing
- eoperative Education + Intraoperative Music Therapy Arm, Preoperative Education Alone Arm
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Postoperative Pain
Intraoperative Opioids and Postoperative Recovery After Hepatobiliary or Foregut Surgery
The primary aim of this randomized, double-blind study is to examine the effect of a single intraoperative dose of methadone on analgesic requirements during the first three days after hepatobiliary or foregut surgery.
- Trial name
- NCT01546948
- Testing
- Methadone, Hydromorphone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Endeavor Health
Spinal Anesthesia
Hyperbaric Prilocaine 2% vs Hyperbaric Bupivacaine 0.5% in Caesarean Section
Comparison between effects of hyperbaric bupivacaine 0.5% vs Hyperbaric prilocaine 2% in spinal anesthesia of women undergoing elective caesarean section such as onset time of sensory and motor block, duration of sensory and…
- Trial name
- NCT06680167
- Testing
- Spinal anesthesia (heavy bupivacaine 0.5%), spinal anesthesia (hyperbaric Prilocaine 2%)
- Where
- Egypt
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Sohag University
Pain Postoperative, Intraoperative Hemorrhage
Efficacy of Peritonsillar Dexmedetomidine Infiltration for Postadenotonsillectomy Pain
The purpose of the present study is the clinical assessment of the efficacy of preincisional peritonsillar infiltration of dexmedetomidine on postoperative pain relief in children undergoing adenotonsillectomy.
- Trial name
- NCT02013570
- Testing
- Dexmedetomidine
- Volunteers
- 71 people
- Sponsor
- TC Erciyes University
Burns
Intraoperative Small-dose Esketamine Infusion for Pain Control in Burn Patients
This study aim to determine whether a small-dose esketamine infusion can be used for pain control in severe burn patients, and thereby reduce the total intra-operative opioid requirement.
- Trial name
- NCT04682782
- Testing
- Esketamine, Saline
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Thoracic Anesthesia, Geriatric Anesthesia
The Effect of Single Lung Ventilation Duration and Intraoperative Brain Oxygenation on Cognitive Function and Postoperative Pain in Geriatric Patients
One lung ventilation (OLV) is commonly used in thoracic surgery. Although the lack of ventilation of the lung in the surgical area (independent lung) during OLV redirects pulmonary blood flow to the dependent lung, shunt…
- Conditions
- Thoracic Anesthesia, Geriatric Anesthesia, One Lung Ventillation (OLV), POCD - Postoperative Cognitive Dysfunction
- Trial name
- NCT07339124
- Testing
- Cognitive Remediation, Pain Medicine
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Intraoperative Hypertension, Pain Threshold
Post SARS-Cov-2 Disease Anesthesia Events
Estimating and recording the rate of occurrence of pulmonary and cardiovascular complications during the perioperative period in patients with past covid infection
- Conditions
- Intraoperative Hypertension, Pain Threshold, Postoperative Pain, Postoperative Hypoxemia
- Trial name
- NCT05252234
- Testing
- Observation of hemodynamic status and post operative pain
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University
Pain
Assess Intraoperative Pain for Restorative Treatment of Maxillary 1st Permanent Molars Using Artinibsa Versus Artpharma in Children During Infiltration Technique
The aim of this study is to assess Intraoperative pain for restorative treatment of Maxillary First Permanent Molars using Artinibsa Versus Artpharma in children during infiltration technique.
- Trial name
- NCT04303234
- Testing
- Artinibsa, Artpharma
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Nociceptive Pain, Pain, Postoperative
Guiding Opioid Administration in Patients With Regional Anesthesia
General anesthesia is a combination of hypnotic drugs to achieve unconsciousness and opioid analgesics to ensure antinociception.
- Conditions
- Nociceptive Pain, Pain, Postoperative, Analgesia, Anesthesia Recovery Period
- Trial name
- GORA (NCT06040307)
- Testing
- SPI (Surgical Pleth Index)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Anesthesia, Pain
Surgical Pleth Index (SPI) Versus Standard Clinical Approach Analgesia
The study is aimed at confronting a surgical pleth index based protocol for intraoperative analgesia in a desflurane based general anesthesia for thyroidectomy, versus a standard clinical approach.
- Conditions
- Anesthesia, Pain, Surgery
- Trial name
- SPIDER (NCT03218306)
- Testing
- Surgical Pleth Index, Clinical guidance
- Where
- Italy
- Volunteers
- 198 people
- Sponsor
- University of Cagliari