Clinical trials: Intraoperative Ventilation
Pneumocephalus
Ventilation With High Oxygen Content and Postoperative Pneumocephalus
The aim of this study is to compare the incidence and volume of postoperative pneumocephalus in patients receiving ventilation with 100% oxygen during the last stage of surgery versus a conventional 1:1 oxygen/air gas mixture.
- Trial name
- NCT02722928
- Testing
- Controlled Ventilation with 100% oxygen
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Respiratory Failure, Interstitial Lung Disease (ILD)
Routine vs On-demand ECMO for Lung Transplantation
Lung transplantation is a complex procedure performed in patients with terminal lung disease. The transplant procedure stresses the patient's heart and lungs, which are already taxed by the underlying disease process.
- Conditions
- Respiratory Failure, Interstitial Lung Disease (ILD), Pulmonary Fibrosis, COPD (Chronic Obstructive Pulmonary Disease)
- Trial name
- REVOLUTION (NCT06615492)
- Testing
- Routine ECMO, On-demand ECMO
- Where
- 4 sites in Canada
- Volunteers
- 218 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Awareness, Anesthesia, Recall Phenomenon
Awareness in Old Aged Patients During Laryngoscopy and Intubation Using Isolated Forearm Technique
Awareness during general anesthesia - that has an incidence between 0.1% and 0.9% of cases and may be more in elderly - remains a concern for anesthesiologists.
- Conditions
- Awareness, Anesthesia, Recall Phenomenon, Inhalation; Gas
- Trial name
- NCT05019560
- Testing
- Sevoflurane, TIVA
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Hernia, Ventral, Hernia Incisional
Compliance-Guided Abdominal Wall Closure Strategy in Large Ventral Hernia Repair
People undergoing repair of large ventral hernias can develop breathing problems after surgery, especially around the time when the abdominal wall is closed.
- Conditions
- Hernia, Ventral, Hernia Incisional, Postoperative Complications, Respiratory Insufficiency
- Trial name
- CLOSE-STAT (NCT07422441)
- Testing
- Compliance-Guided Abdominal Wall Closure Decision Strategy
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Swissmed Hospital
Symptomatic Irreversible Pulpitis, Postoperative Pain
Effect of Preoperative Video-Guided Breathing on Pain in Symptomatic Irreversible Pulpitis
The goal of this randomized controlled clinical trial is to evaluate whether a brief preoperative video-guided breathing exercise reduces postoperative pain in adults undergoing single-visit root canal treatment for symptomatic…
- Trial name
- NCT07859267
- Testing
- Video-Guided Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Cukurova University
Nasal Obstruction, Nasal Surgical Procedures
Antibiotic Prophylaxis in Rhinoplasty
This study compares the efficacy of a single intra-operative (intravenous) dose of "cephalexin" (first generation cephalosporin) or "clindamycin" (lincosamides), alone versus both intra-operative (intravenous) dose of…
- Trial name
- NCT04194216
- Testing
- Intra-operative single intravenous(iv) dose of "cephalexin" 2 g or "clindamycin" 900 mg., Intra-operative single dose (iv) of "cephalexin" 2 g or "clindamycin" 900 mg and postoperative oral dose of "cephalexin" 250mg (every 4 hours) or "clindamycin" 150mg(every 6 hours) for 3 days
- Where
- United States
- Volunteers
- 864 people
- Sponsor
- Stanford University
Postoperative Complications, Abdominal Surgery
Intraoperative Lung Protective Ventilation Needs Periodic Lung Recruitment Maneuvers
Postoperative Pulmonary Complications (PPC) are common. It severely affects postoperative recovery, particularly in abdominal surgery.
- Conditions
- Postoperative Complications, Abdominal Surgery, Intraoperative Mechanical Ventilation
- Trial name
- REMAIN-1 (NCT05556174)
- Testing
- periodic lung recruitment maneuvers
- Where
- China
- Volunteers
- 1,060 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Protective Lung Ventilation Using:, Low Tidal Volume (6-8 mL/kg Predicted Body Weight)
Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study)
The purpose of this study is to compare the influence of a lung protective ventilation with conventional ventilation on postoperative complications following major abdominal surgery.
- Conditions
- Protective Lung Ventilation Using:, Low Tidal Volume (6-8 mL/kg Predicted Body Weight), PEEP of 6-8 cmH2O, Intraoperative RMs
- Trial name
- NCT01282996
- Testing
- Abdominal surgery
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Clermont-Ferrand
Anesthesia, Anesthesia Complication
Sedation Complications in Urology During Spinal Anesthesia With Dexmedetomidine or Midazolam Regarding OSA Risk
Light to moderate sedation is recommended during surgery with spinal anesthesia . This study is exploring which sedation drug is better, midazolam or dexmedetomidine for transurethral resection of bladder and prostate in patients…
- Conditions
- Anesthesia, Anesthesia Complication, Osa Syndrome, Transurethral Resection of Prostate
- Trial name
- NCT04817033
- Testing
- Spinal anesthesia with intraoperative dexmedetomidine sedation, Spinal anesthesia with intraoperative midazolam sedation, Dexmedetomidine
- Where
- Croatia
- Volunteers
- 115 people
- Sponsor
- University Hospital of Split
Mechanical Power, Alveolar Recruitment Maneuvers
The Role of Periodic Alveolar Recruitment Maneuvers in Intraoperative Protective Ventilation
The goal of this clinical trial is to compare three open-lung strategies on respiratory function and lung injury in protective ventilation for laparoscopic anterior resection.
- Conditions
- Mechanical Power, Alveolar Recruitment Maneuvers, Protective Ventilation, Postoperative Pulmonary Complications
- Trial name
- REMAIN-2 (NCT05962125)
- Testing
- periodic alveolar recruitment maneuvers, positive end-expiratory pressure
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Postoperative Pulmonary Complications, Coronary Artery Bypass Graft Surgery (CABG)
Mechanical Power and Pulmonary Complications in CABG Surgery
This prospective observational study evaluates the association between intraoperative mechanical power (MP) - a composite measure of the total energy delivered to the lungs during mechanical ventilation - and postoperative…
- Conditions
- Postoperative Pulmonary Complications, Coronary Artery Bypass Graft Surgery (CABG), Prolonged Mechanical Ventilation
- Trial name
- MP-CABG (NCT07639489)
- Testing
- Intraoperative Mechanical Ventilation Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Fusun Gozen