Clinical trials: Intrathecal Morphine
Anesthesia, Total Knee Arthroplasty
The Efficacy of Peripheral Nerve Blocks With Intrathecal Morphine in Improving Analgesia After Unilateral Total Knee Arthroplasty
The purpose of this study is to determine whether intrathecal morphine (ITM) alone or its combination with peripheral nerve blocks (PNB) provides better analgesia for patients undergoing total knee arthroplasty (TKA).
- Trial name
- NCT02135120
- Testing
- Combined spinal epidural anesthesia technique with intrathecal morphine, A combination of combined spinal-epidural (with intrathecal morphine) and femoral nerve block, A combination of combined spinal-epidural (with intrathecal morphine) and femoral nerve block as well as sciatic nerve block
- Where
- Lebanon
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Lumbar Fusion Surgery
ITM vs ITM+Clonidine for Lumbar Fusions
Dr. Parker Merrill (anesthesiologist) and Dr. Chris Neal (neurosurgeon) are working on a research study comparing two methods of pain control for patients having spinal fusion surgery.
- Trial name
- NCT07846657
- Testing
- Intrathecal Morphine + Intrathecal Clonidine, Intrathecal Morphine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- MaineHealth
Labor Pain
Labour Analgesia; Comparing a Combinations of Either Fentanyl or Bupivacaine With Intrathecal Morphine
This study is aimed at evaluating single short spinal technique as a form of labour analgesia in a setting where more expensive and labor intensive techniques are not feasible.The study will examine the safety and efficacy of two…
- Trial name
- NCT02498171
- Testing
- Intrathecal morphine with fentanyl, Intrathecal morphine with bupivacaine
- Volunteers
- 138 people
- Sponsor
- Makerere University
Pain, Postoperative
Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery
VATS/RATS is widely used for diagnosis and treatment of intrathoracic conditions. Despite many benefits, postoperative pain continues to be intense after VATS/RATS. The optimal strategy for pain management has not been defined.
- Trial name
- NCT05351229
- Testing
- Morphine Sulfate
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Northwestern University
Hip Fracture Surgeries
Dexamethasone + Intrathecal Morphine in Hip Fractures
Hip fractures (proximal femur fractures) are a global public health problem with high morbidity and mortality rates, especially in the geriatric population aged 65 years and older.
- Trial name
- NCT07037745
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Pain, Postoperative
Pain Control and Quality of Recovery After Intravenous Methadone Versus Intrathecal Morphine in Major Abdominal Surgery
Moderate to severe postoperative pain is relatively common after major abdominal surgery. It is associated with less than optimal surgical experience, poor quality of recovery, and the development of persistent postsurgical pain.
- Trial name
- NCT06387303
- Testing
- Methadone, Morphine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Morphine, Morphine Adverse Reaction
Side Effects of a Single Shot Intrathecal Morphine in Clinical Practice, a Retrospective Analysis
ITM has the potential to be a powerful tool for multimodal postoperative pain management, understanding, preventing and managing its side effects is crucial for upturn of patient safety and comfort.
- Conditions
- Morphine, Morphine Adverse Reaction, Morphine Induced Pruritis, Nausea and Vomiting, Postoperative
- Trial name
- NCT07238179
- Testing
- Intrathecal Morphine
- Where
- Belgium
- Volunteers
- 600 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Labor Pain
Quality of Labour Epidural Analgesia With Intrathecal Morphine as a Component of Combined Spinal Epidural
Neuraxial analgesia has shown to be the gold standard for effective labor pain relief, offering numerous benefits including enhanced pain control and maternal satisfaction.
- Trial name
- NCT06572241
- Testing
- Intrathecal morphine
- Where
- Canada
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Pruritus Caused by Drug
Propofol for Prophylaxis of Morphine Induced Pruritis in Caesarean Section
the goal of this randomized clinical trial is to find the optimum sub hypnotic dose of iv propofol that prevents the incidence of itching induced from intrathecal morphine used in spinal anesthesia in caesarean section operation.
- Trial name
- NCT06188546
- Testing
- Propofol
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Fractures, Bone, Nausea and Vomiting, Postoperative
Quality of Recovery After Dexamethasone, Ondansetron or Placebo Intrathecal Morphine Administration
The aim of this study is to evaluate not only the occurrence of side effects, but the quality of the recovery (QoR-40 Questionnaire) of patients submitted to spinal anesthesia with administration of low doses (0.1 mg) of…
- Conditions
- Fractures, Bone, Nausea and Vomiting, Postoperative, Pruritus, Morphine Adverse Reaction
- Trial name
- NCT03035942
- Testing
- Dexamethasone, Ondansetron, Saline
- Where
- Brazil
- Volunteers
- 135 people
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Postoperative Pain, Cesarean Delivery
Comparison of Intrathecal Bupivacaine With and Without Morphine for Post-operative Analgesia in Parturients Undergoing Elective Cesarean Section: A Randomized Controlled Trial
The goal of this clinical trial is to compare intrathecal bupivacaine with or without morphine for postoperative analgesia in patients undergoing elective cesarean section.
- Conditions
- Postoperative Pain, Cesarean Delivery, Analgesia, Obstetrical
- Trial name
- NCT07094802
- Testing
- Intrathecal morphine with bupivacaine, Hyperbaric Bupivicaine
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Acute Pain Following Decompressive Lumbar Spinal Surgery
The Use of Intrathecal Morphine in the Management of Acute Pain Following Decompressive Lumbar Spinal Surgery
The primary aim of this study is to assess the impact of intrathecal morphine on post-operative pain following instrumented fusion for degenerative lumbar spine disease.
- Trial name
- ITMP (NCT01053039)
- Testing
- Intrathecal Morphine, Intrathecal Saline
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of Calgary
Post-operative Pain
Intrathecal Morphine vs. Intrathecal Morphine and Regional Anesthesia After Cesarean Section.
The objective of the study is to optimize post-operative analgesia and improve patient satisfaction while reducing total opioid consumption after cesarean section
- Trial name
- NCT06114121
- Testing
- erector spinae plane block (ESP), Duramorph, Ropivacaine
- Sponsor
- University of Miami
Postoperative Pain
Ultrasound Guided ESP Block Versus Intrathecal Morphine for Postoperative Analgesia in Major HPB Surgery.
To compare the efficacy of USG-guided bilateral Erector spinae plane block (ESPB) with intrathecal morphine (ITM) for postoperative analgesia after major hepatopancreaticobiliary surgery (HPB)
- Trial name
- NCT04635644
- Testing
- Erector Spinae Plane Block, Intrathecal morphine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Postoperative Nausea and Vomiting, Postoperative Pain
Spinal Morphine and Atropine Added to General Anaesthesia for Nausea and Pain After Abdominal Laparoscopy
Laparoscopic abdominal surgery carries one of the highest risks of postoperative nausea and vomiting (PONV), and postoperative opioids given for pain are themselves emetogenic.
- Conditions
- Postoperative Nausea and Vomiting, Postoperative Pain, Anesthesia, Anesthesia Spinal
- Trial name
- NCT07851870
- Testing
- Intrathecal bupivacaine, morphine and atropine, General anaesthesia, Multimodal analgesia and antiemetic prophylaxis
- Where
- Indonesia
- Volunteers
- 63 people
- Sponsor
- Universitas Indonesia
Postoperative Analgesia
Quadratus Lumborum in Cesarean Section Trial
Postoperative pain of a caesarean section may be of high intensity, especially in the first 48 hours after the procedure, which affects the mother / newborn relationship, in addition to having the potential to progress to chronic…
- Trial name
- QUALICS (NCT03673280)
- Testing
- Quadratus Lumborum Block
- Where
- Brazil
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Cesarean Section Complications
Comparison of the Erector Spinae Plane Block Versus Intrathecal Morphine on Post-Cesarean Delivery Analgesia
This study is a Randomized Control Trial comparing the Erector Spinae Plane Block with intrathecal morphine for post cesarean delivery analgesia.
- Trial name
- ESPCS (NCT04256642)
- Testing
- Erector Spinae Plane Block, Intrathecal morphine
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pain, Postoperative
Intrathecal Morphine and Local Infiltration Analgesia in Total Knee Arthroplasty
Double-blinded randomized control study investigating intrathecal morphine as an additive to spinal anesthesia in patients undergoing elective total knee arthroplasty.
- Trial name
- NCT03434951
- Testing
- Bupivacaine Hydrochloride, Spinal, Morphine hydrochloride, Spinal
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- South Carelia Central Hospital
Postoperative Pain
Intrathecal Morphine for Thoracoscopic Surgery
Thoracic surgery is one of the surgeries where postoperative pain is intense. In this study, the investigators aimed to compare the efficacy of two different intrathecal morphine doses administered for postoperative analgesia…
- Trial name
- NCT05588336
- Testing
- Morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Postoperative Nausea
Intrathecal Atropine to Prevent Postoperative Nausea and Vomiting
optimal postoperative pain control with intrathecal morphine, with proper prevention of postoperative nausea and vomiting. Dexamethasone, and or atropine could offer some protection against nausea and vomiting.
- Trial name
- NCT03387956
- Testing
- Intrathecal atropine, dexamethasone
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University