Clinical trials: Intrauterine Adhesion
Myoma
Intrauterine Adhesion Rate After Hysteroscopic Myomectomy and Application of HYALOBARRIER Gel
The purpose of this study is to evaluate the intrauterine adhesion rate after the application of HYALOBARRIER Gel at the end of hysteroscopic myomectomy. Secondary endpoints were tolerance and side effect and subsequent fertility.
- Trial name
- HYGEM (NCT01412489)
- Testing
- HYALOBARRIER Gel
- Where
- France
- Volunteers
- 189 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thin Endometrium, Intrauterine Adhesion
Clinical Study of Umbilical Cord Mesenchymal Stem Cells Combined With Collagen Scaffold in the Treatment of Thin Endometrium
This is a non-blind self-control trial. We mainly compare the changes of endometrial thickness，changes in menstrual flow, and improvement in pregnancy before and after stem cell treatment in patients with thin endometrium.
- Trial name
- NCT03724617
- Testing
- umbilical cord mesenchymal stem cells combined with collagen scaffold
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Sir Run Run Shaw Hospital
Intrauterine Adhesion
Autologous Platelet-Rich Plasma in the Management of Asherman Syndrome
The aim of the study is to find out the benefit of the platelet-rich plasma in preventing reformation of intrauterine adhesions after adhesiolysis in cases of Asherman syndrome
- Trial name
- NCT04308811
- Testing
- platelet rich plasma, amniotic membrane graft group, Intrauterine balloon
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Intrauterine Polyp, Intrauterine Synechiae
Study on the Effective Dose and Safety of Esketamine in Hysteroscopic Surgery Under Monitored Anesthesia Care
Cervical dilation-induced somatic responses remain a critical challenge in ambulatory hysteroscopic surgery. Esketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, exhibits unique analgesic and sedative properties that…
- Trial name
- NCT07034963
- Testing
- Determine the ED50 and ED95 of esketamine, Intravenous the dose of esketamine ED95, Intravenous remifentanil 1μg∙kg-1
- Where
- China
- Volunteers
- 95 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Uterine Septum
Intrauterine Balloon and Postoperative Estrogen Therapy in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis
Patients who want to go TCRS will randomly divided 3 groups. In Group 1(100 patients), women received postoperative estrogen therapy.
- Trial name
- NCT02617108
- Testing
- Foley balloon
- Volunteers
- 310 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Pregnancy Complications
Study on the Effect of Combined Estrogen and Progestogen Therapy on Endometrial Repair After Induced Abortion
Induced abortion is a common method to terminate pregnancy, but during the operation, it is necessary to dilate the cervix and aspirate the uterine cavity.
- Trial name
- NCT06546397
- Testing
- 17β-estradiol/dydrogesterone tablets
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Asherman Syndrome
Pre-Surgical Grading System of Asherman Syndrome
Utilising a novel pre-surgical grading system to class cases of asherman syndrome into 3 groups based on expected difficulty of surgery and potential prognostic outcomes.
- Trial name
- NCT05901948
- Testing
- Classification
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Ebtesama Hospital
Intrauterine Adhesion
Comparing the Efficacy of Two Methods for the Therapy of Uterine Adhesion
Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility.
- Trial name
- NCT03329898
- Testing
- dried biological amnion graft, disposable balloon uterine stent, estradiol valerate tablets
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Moderate-Severe Intrauterine Adhesions
A Study of GD007 (Human iPSC-Exosome Liquid Dressing) for Safety and Dose-Finding in Moderate-Severe Intrauterine Adhesions
Intrauterine adhesions (IUA) remain highly prevalent in China, with incidence rates steadily increasing due to the rising number of intrauterine procedures.
- Trial name
- GD007 (NCT07101484)
- Testing
- GD007 Low-dose drug group, GD007 Mid-dose drug group, GD007 High-dose drug group
- Where
- China
- Volunteers
- 29 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pregnancy Complicated With Intrauterine Adhesion
Comparison of Operative Hysteroscopy and Vacuum Aspiration for Terminating First-trimester Pregnancy With Intrauterine Adhesions
In cases of early pregnancy complicated with intrauterine adhesions (IUAs), termination of pregnancy is prone to incomplete abortion with retained gestational products, failed abortion or uterine perforation due to altered…
- Trial name
- NCT07883057
- Testing
- Vacuum Aspiration Group, Hysteroscopy adhesiolysis combined with vacuum aspiration
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Abnormal Uterine Bleeding, Postmenopausal Bleeding
Use of Nitrous Oxide During Office Hysteroscopy
The goal of this clinical trial is to assess the use of inhaled nitrous oxide during office hysteroscopy. The main questions it aims to answer are: Does it reduce pain during the procedure? Does it increase the success rate? Does…
- Conditions
- Abnormal Uterine Bleeding, Postmenopausal Bleeding, Endometrial Polyps, Retained Products of Conception
- Trial name
- NCT07074795
- Testing
- Inhalation of Nitrous Oxide (N₂O) during Office Operative Hysteroscopy, inhalation of ambient air during office hysteroscopy
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Maaynei Hayesha Medical Center
Intrauterine Adhesion
Efficacy and Safety of Crosslinked Hyaluronan Gel for Preventing Intrauterine Adhesion
Intrauterine adhesion (IUA) is the adhesion of intrauterine tissues due to the exposure of myometrial tissues caused by the endometrial basal injury.
- Trial name
- NCT02220621
- Testing
- Crosslinked hyaluronic acid gel, Foleys balloon catheter
- Where
- 3 sites in China
- Volunteers
- 120 people
- Sponsor
- Xiaozheng Shu
Pelvic Floor Muscle Electrophysiologic Therapy, Fast-Track Surgery
Effect of Pelvic Floor Muscle Electrophysiologic Therapy on Enhanced Recovery After Gynecologic Surgery
This study is to evaluate the effect of pelvic floor muscle electrophysiologic therapy on enhanced recovery after gynecologic surgery,to solve muscle soreness and retention of urine after laparoscopy, and endometrial repair after…
- Trial name
- NCT03524807
- Testing
- Electrophysiologic therapy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Infertility, Abnormal Uterine Bleeding (AUB)
Evaluation of the Uterine Cavity After Operative Hysteroscopy
This study will focus on evaluation of the uterine cavity after operative hysteroscopy using three dimensional transvaginal ultrasonography and office hysteroscopy to detect and residual or recurrent abnormalities or intrauterine…
- Conditions
- Infertility, Abnormal Uterine Bleeding (AUB), Intrauterine Adhesion, Submucous Leiomyoma of Uterus
- Trial name
- NCT06924437
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Asherman Syndrome, Endometrial Polyp
Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery
The study purpose is to examine the influence of INTERCOAT in prevention of intra-uterine adhesions formation after any hysteroscopic surgery.
- Conditions
- Asherman Syndrome, Endometrial Polyp, Uterine Myoma
- Trial name
- NCT01637974
- Testing
- INTERCOAT administration
- Where
- Israel
- Volunteers
- 130 people
- Sponsor
- Carmel Medical Center
Myoma;Uterus, Adhesion; Uterus, Internal
Incidence of Intrauterine Adhesions After Myomectomy With Intrauterine Anti-Adhesion Gel
This prospective randomized study aims to evaluate whether the application of an intrauterine anti-adhesion gel reduces the incidence of intrauterine adhesions (IUAs) following robotic-assisted laparoscopic myomectomy.
- Trial name
- NCT07280286
- Testing
- Women will receive the application of an anti-adhesion gel at the end of the myomectomy procedure
- Volunteers
- 62 people
- Sponsor
- Federico II University