Clinical trials: Intrauterine Adhesions
Asherman Syndrome, Intrauterine Adhesion
Evaluate Formation of IUAs After Third-generation Endometrial Ablation, With and Without Intrauterine Adhesion Barrier
Evaluate the formation of adhesions after third-generation endometrial ablation, with and without the intrauterine adhesion barrier.
- Trial name
- CLEAN (NCT05414760)
- Testing
- Womed Leaf
- Where
- 2 sites in Netherlands
- Volunteers
- 1 people
- Sponsor
- Remko P. Bosgraaf
Spontaneous Abortion, Missed Abortion
Dilation and Curettage Versus Operative Hysteroscopy for Missed Abortion
Randomizedtrial comparing success and complication rates of operative hysteroscopy versus traditional dilation and curettage (D\&C) in the management of first trimester missed abortion.
- Conditions
- Spontaneous Abortion, Missed Abortion, Intrauterine Adhesion, Retained Products of Conception
- Trial name
- NCT04705324
- Testing
- Operative Hysteroscopy, D&C, Operative Hysteroscopy - safety and feasibility
- Where
- Israel
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Database for Intrauterine Adhesion, Risk Factors for Intrauterine Adhesion
Multicentre Prospective Clinical Database for the Construction of Predictive Models on Risk of Intrauterine Adhesion
1. To establish a follow-up database for uterine adhesions and a library of biological specimens for Intrauterine Adhesion. 2. using epidemiological surveys and biological analyses to screen risk factors for the development and…
- Conditions
- Database for Intrauterine Adhesion, Risk Factors for Intrauterine Adhesion, Risk Stratification and Prognostic Assessment, Intrauterine Adhesion
- Trial name
- NCT05381376
- Testing
- Hysteroscopy, Ultrasonography
- Where
- 2 sites in China
- Volunteers
- 2,200 people
- Sponsor
- Hua Duan
Intrauterine Adhesion
Safety and Efficacy of Intrauterine Biological Barrier on Postoperative Adhesion After Hysteroscopic Adhesiolysis
To evaluate the safety and efficacy of Intrauterine Biological Barrier developed and produced by Chengdu TopRegMed Medical Technology Co., Ltd on postoperative adhesion after Hysteroscopic Adhesiolysis.
- Trial name
- NCT05475756
- Testing
- Intrauterine Biological Barrier, Intrauterine Adhesion Barrier Gel
- Where
- 6 sites in China
- Volunteers
- 264 people
- Sponsor
- Beijing Tiantan Hospital
Hysteroscopy, Intrauterine Adhesion
Early Outpatient Hysteroscopy Can Prevent Intrauterine Adhesion After Induced Abortion
Background: Intrauterine adhesions are a difficult clinical problem for reproductive infertility. The most common cause is uterine cavity surgery and post-abortion (including abortion and spontaneous abortion).
- Trial name
- NCT04166500
- Testing
- Hysteroscopy
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Intrauterine Adhesion
Assessment of Uterine Access, Uterine Patency and Intrauterine Adhesions Following Endometrial Ablation
The objective of this study is to gain information concerning the acute and longer-term morphological changes within the uterus following endometrial ablation.
- Trial name
- NCT04824430
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Rejoni Inc.
Infertility, Female, Intrauterine Adhesion
HMG Stimulation Versus HRT for Endometrial Preparation Prior to Blastocyst Transfer in Moderate to Severe IUA Patients
Evaluation of endometrial preparation using either human menopausal gonadotrophin (HMG) stimulation and hormone replacement therapy (HRT) prior to blastocyst transfer in patients with moderate to severe intrauterine adhesion…
- Trial name
- NCT03578172
- Testing
- human menopausal gonadotrophin, hormone replacement therapy
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Intrauterine Adhesion
PREvention of Intrauterine Adhesion After Hysteroscopic Surgery With Novel deGradable Film
Intrauterine adhesions (IUA) are the major long-term complication of intrauterine procedures and are associated with pelvic pain, menstrual disorders, obstetrical complication and infertility.
- Trial name
- PREG1 (NCT04381728)
- Testing
- Womed Leaf
- Where
- 6 sites in Belgium, France and 1 more
- Volunteers
- 23 people
- Sponsor
- Womed
Intrauterine Synechiae, Tissue Adhesion, Surgery-Induced
The Efficacy and Safety of Medicurtain® in Patients With Hysteroscopy (Pivotal Study)
This study was designed to assess the safety and efficacy of MEDICURTAIN, an adhesion barrier in patients who underwent hysteroscopy with uterine polyp or endometrial myoma or missed abortion (uterine lesion suspected to be…
- Trial name
- NCT04638855
- Testing
- Medicurtain®
- Where
- South Korea
- Volunteers
- 223 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Intrauterine Adhesion
Hysteroscopic "Hot Knife" and "Cold Knife" in the Treatment of the Intrauterine Adhesion
In this prospective, randomized controlled trial，the investigators wish to explore the difference of therapeutic effect and prognosis between "hot knife" and "cold knife" in the treatment of uterine adhesion under hysteroscopy.
- Trial name
- NCT04936347
- Testing
- cold knife, hot knife
- Where
- China
- Volunteers
- 802 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Intrauterine Adhesion
Efficacy of Estrogen-intrauterine Stent System After Intrauterine Adhesiolysis
This is a prospective, randomized, single-blinded,multi-center trial to compare the efficacy of an Estrogen-intrauterine stent system with foley balloon combined with intrauterine cross-linked sodium hyaluronate gel in the…
- Trial name
- NCT04972032
- Testing
- Estrogen Intrauterine Stent System, Foley balloon combined with self-cross-link sodium hyaluronate gel
- Where
- China
- Volunteers
- 246 people
- Sponsor
- Limin Feng
Intrauterine Adhesion, Scar
Clinical and Basic Research on the Necessity of Scar Tissue Resection During Intrauterine Adhesions
TCRA is an important surgical method to restore normal menstrual cycle and improve the outcome of pregnancy.However, postoperative intrauterine adhesion, uterine cavity deformation and difficulty in normal intimal growth…
- Trial name
- NCT05003869
- Testing
- Scar tissue is removed
- Where
- China
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Lili Cao
Prevenetion of Intrauterine Adhesions by Hyaluronic Acid Gel
Intrauterine Hyaluronic Acid Gel for Prevention of Intrauterine Adhesions
Women undergoing operative hysteroscopy for removal of retained placenta after delivery will be randomized into two groups. 1. study group - immediately after operative hysteroscopy 5 ml hyaluronic acid gel will be injected into…
- Trial name
- NCT04975373
- Testing
- Intrauterine injection of hyaluronic acid
- Where
- Israel
- Volunteers
- 160 people
- Sponsor
- Barzilai Medical Center
Intrauterine Adhesion
Three-dimensional Ultrasound Applying in Assessment of Intrauterine Adhesions
In this prospective, multicenter, large-scale study，the investigators wish to examine the accuracy of several three-dimensional ultrasound anatomical and vascular parameters in diagnosing IUA when compared to the gold standard of…
- Trial name
- NCT04930913
- Testing
- Three-dimensional Ultrasound
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Thin Endometrium, Intrauterine Adhesion
Clinical Study of Umbilical Cord Mesenchymal Stem Cells Combined With Collagen Scaffold in the Treatment of Thin Endometrium
This is a non-blind self-control trial. We mainly compare the changes of endometrial thickness，changes in menstrual flow, and improvement in pregnancy before and after stem cell treatment in patients with thin endometrium.
- Trial name
- NCT03724617
- Testing
- umbilical cord mesenchymal stem cells combined with collagen scaffold
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Sir Run Run Shaw Hospital
Intrauterine Adhesions
Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy
Seprafilm is an FDA-approved temporary bioresorbable barrier that physically separates opposing tissue surfaces. The physical presence of the membrane separates adhesiogenic tissue while the normal tissue repair process takes…
- Trial name
- Seprafilm (NCT01632202)
- Testing
- Seprafilm, Sterile Saline Solution
- Where
- 2 sites in United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Retained Products of Conception, Intrauterine Adhesion
Hysteroscopy Assisted Suction Curettage for Early Pregnancy Loss
Retained products of conception (RPOC) and intrauterine adhesions (IUA) may occur following suction curettage for early miscarriage and cause secondary infertility, recurrent pregnancy loss and pregnancy complications.
- Trial name
- NCT04637373
- Testing
- Hysteroscopy
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Intrauterine Adhesion
Human Amniotic Epithelial Stem Cell in Treatment of Refractory Severe Intrauterine Adhesion
This project will investigate the safety and effectiveness of human amniotic epithelial stem cells for treatment of severe refractory Asherman's syndrome.
- Trial name
- NCT03381807
- Testing
- hAESCs
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intrauterine Adhesion
Autologous Platelet-Rich Plasma in the Management of Asherman Syndrome
The aim of the study is to find out the benefit of the platelet-rich plasma in preventing reformation of intrauterine adhesions after adhesiolysis in cases of Asherman syndrome
- Trial name
- NCT04308811
- Testing
- platelet rich plasma, amniotic membrane graft group, Intrauterine balloon
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Intrauterine Adhesion
Clinical Safety Study of Human Embryonic Stem Cell Derived Mesenchymal Cells in the Treatment of Moderate and Severe Intrauterine Adhesions
To observe the clinical safety of intrauterine injection of human embryonic stem cell derived mesenchymal cells in the treatment of moderate and severe intrauterine adhesion, and to preliminarily explore its clinical…
- Trial name
- NCT04232592
- Testing
- Inject a solution of stem cell preparation, Inject stem cells
- Volunteers
- 32 people
- Sponsor
- Qi Zhou