Clinical trials: Intrauterine Systems
Underweight
The Effect of Hormonal Contraceptives on Breast-milk Production and Infant Growth
The investigators propose a randomized clinical trial comparing the effect of 30 mcg ethinyl estradiol and LNG 150 combination oral contraceptive pills versus placebo, or LNG-IUS or Etonogestrel-releasing contraceptive implant…
- Trial name
- NCT01388582
- Testing
- LNG-IUS, Implanon, 30 mcg EE and 150 LNG oral contraceptive (Microvlar)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Gestational Diabetes, Diabetes
The DNA Methylation of ARHGEF11 in Macrosomia
Background Macrosomia at birth is associated with subsequent susceptibility to obesity, abnormal glucose metabolism, hypertension and dyslipidaemia.
- Conditions
- Gestational Diabetes, Diabetes, Macrosomia, Fetal
- Trial name
- NCT03165643
- Testing
- OGTT
- Volunteers
- 239 people
- Sponsor
- Peking University First Hospital
Menorrhagia
Survey on Patient Satisfaction Rate for Mirena Use in Heavy Menstrual Bleeding
The purposes of this study are: To evaluate patient satisfaction for efficacy and tolerability of heavy menstrual bleeding treatment by Mirena. To collect italian data for Mirena in clinical routine.
- Trial name
- NCT00874653
- Testing
- Levonorgestrel (Mirena, BAY86-5028)
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Bayer
Contraception
LCS12 Adolescent Study
The study will assess the safety of a sex hormone (levonorgestrel) releasing T-shaped intrauterine contraceptive system in female adolescents under 18 years of age.
- Trial name
- NCT01434160
- Testing
- Skyla (Levonorgestrel, BAY86-5028)
- Where
- 41 sites in Austria, Belgium and 6 more
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Bayer
IUD Insertion Complication, Acute Pain
LI4 Acupuncture for Analgesia in Intrauterine Device Insertion
Pain during IUD insertion is substantially psychologic in origin, responds extremely well to non-pharmacologic interventions. Considering the fact that acupuncture is a modality exerting both psychologic and physiologic effects…
- Trial name
- NCT04963582
- Testing
- Acupuncture
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Contraception, Women at Risk for Pregnancy
Evaluation of the Efficacy, Safety, and Tolerability of LevoCept
To assess the contraceptive efficacy (prevention of pregnancy) of LevoCept
- Trial name
- NCT04457076
- Testing
- LevoCept
- Where
- 27 sites in United States
- Volunteers
- 1,525 people, healthy volunteers welcome
- Sponsor
- Sebela Women's Health Inc.
Contraception
Naproxen for Pain Control With Intrauterine Device Insertion
The purpose of this study is: 1. To evaluate whether 550 mg of naproxen sodium reduces pain scores with IUD insertion on a 0-10cm visual analogue scale compared to placebo (primary outcome). 2.
- Trial name
- NCT02388191
- Testing
- Naproxen sodium
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Contraception
Levonorgestrel Contraceptive Intrauterine Systems (LCS) Pearl Index Study
This is a study on a new low dose levonorgestrel contraceptive intrauterine systems (LCS). The purpose of the study is to investigate which of the 2 administered doses is the lowest effective intrauterine dose of Levonorgestrel…
- Trial name
- NCT00528112
- Testing
- LCS12, LCS16
- Where
- 136 sites in United States, Argentina and 9 more
- Volunteers
- 2,885 people, healthy volunteers welcome
- Sponsor
- Bayer
Atypical Endometrial Hyperplasia
Megestrol Acetate Plus LNG-IUS in Young Women With Endometrial Atypical Hyperplasia
To see if megestrol acetate plus Levonorgestrel-releasing intrauterine system (LNG-IUS) will not be inferior to returning the endometrial tissue to a normal state than megestrol acetate or LNG-IUS alone in patients with…
- Trial name
- NCT03241888
- Testing
- Megestrol Acetate, Levonorgestrel-releasing Intrauterine System(LNG-IUS)
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Fudan University
Levonorgestrel Adverse Reaction, Temporomandibular Joint Disorders
Temporomandibular Disorder in Use of Levonorgestrel Intrauterine System
The goal of this clinical trial is to investigate the possible role of levonorgestrel intrauterine system use(LIU) in the pathogenesis of temporomandibular joint disorder (TMD).
- Conditions
- Levonorgestrel Adverse Reaction, Temporomandibular Joint Disorders, Temporomandibular Disorder
- Trial name
- NCT06500390
- Testing
- Examination of temporomandibular joint and masticator muscles
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University
Endometrial Polyp
The Effect of Levonorgestrel Intrauterine System in Preventing Endometrial Polyps Recurrence
The goal of this clinical trial is to determine whether the LNG-IUS is more effective to that of expectant in preventing endometrial polyp recurrence after hysteroscopic polypectomy.
- Trial name
- NCT06620939
- Testing
- Levonorgestrel Intrauterine System (LNG-IUS)
- Volunteers
- 558 people
- Sponsor
- Zhang Jian
Endometrial Cancer
Treatment With Medroxyprogesterone Acetate Plus LNG-IUS in Young Women With Early Stage Endometrial Cancer
A prospective multicenter trial has been started in Korea to investigate the treatment efficacy of Levonorgestrel-releasing intrauterine system (LNG-IUS) plus Medroxyprogesterone Acetate(MPA) in Young Women with Early Stage…
- Trial name
- NCT01594879
- Testing
- MIrena(LNG-IUS), oral MPA
- Where
- South Korea
- Volunteers
- 39 people
- Sponsor
- Korean Gynecologic Oncology Group
Menorrhagia
Study of a Levonorgestrel 52 mg Intrauterine System for the Treatment of Heavy Menstrual Bleeding
To assess the efficacy of a levonorgestrel 52 mg intrauterine system as a treatment for heavy menstrual bleeding.
- Trial name
- NCT03642210
- Testing
- Levonorgestrel 52 mg intrauterine system
- Where
- 29 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Medicines360
Contraception
European Active Surveillance Study of LCS12
This study is designed to investigate whether LCS12 is associated with an increased risk of unintended pregnancy compared to Mirena and to copper IUDs. The objective is to assess among new users the risks of certain events (e.g.
- Trial name
- EURAS_LCS12 (NCT02146950)
- Where
- Germany
- Volunteers
- 97,265 people, healthy volunteers welcome
- Sponsor
- Center for Epidemiology and Health Research, Germany
Gestational Diabetes, Glucose Intolerance
Postpartum Glucose Tolerance With Levonorgesterel IUD Use in Women With Recent Gestational Diabetes
The study is being done in order to gain information on the most suitable types of birth control in women who recently had gestational diabetes, or diabetes diagnosed during pregnancy.
- Conditions
- Gestational Diabetes, Glucose Intolerance, Type 2 Diabetes, Intrauterine Contraception
- Trial name
- NCT01022645
- Testing
- Mirena (Levonorgestrel IUD), Paragard (Copper IUD ) or Tubal Ligation
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Northwestern University
Contraception
Levonorgestrel-Intrauterine System (LNG-IUS) Insertion in the Postpartum Period
The investigators study is a prospective randomized trial of women undergoing the levonorgestrel intrauterine system (LNG-IUS: Mirena©, Bayer) at three separate time periods: immediate post placental (IPP) defined as insertion…
- Trial name
- NCT01088178
- Testing
- Levonorgestrel Intrauterine System (LNG-IUS: Mirena, Bayer)
- Where
- United States
- Sponsor
- United States Naval Medical Center, Portsmouth
Obesity, Overweight
Mazdutide Plus LNG-IUS for Fertility-Sparing Treatment of AEH or Early Endometrial Cancer
This is a prospective, multicenter, randomized, double-blind, placebo-controlled, parallel-group clinical trial designed to evaluate the efficacy and safety of mazdutide combined with a levonorgestrel-releasing intrauterine…
- Conditions
- Obesity, Overweight, Atypical Endometrial Hyperplasia, Endometrial Carcinoma Stage I
- Trial name
- MELIA (NCT07781150)
- Testing
- Mazdutide(Dual GLP-1R/GCGR Agonist), Levonorgestrel-releasing intrauterine system
- Where
- 6 sites in China
- Volunteers
- 128 people
- Sponsor
- Tongji Hospital
Infertility, Polycystic Ovarian Syndrome
Ovarian Stimulation and Intrauterine Insemination in Women With Polycystic Ovarian Syndrome
The study null hypothethesis is: intrauterine insemination (IUI) does not improve pregnancy rates in women with polycystic ovary syndrome.
- Conditions
- Infertility, Polycystic Ovarian Syndrome, Intrauterine Insemination
- Trial name
- OSIPS (NCT01675843)
- Testing
- Intrauterine insemination (IUI)
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Mansoura University
Chronic Hepatitis B, Gestation
Efficacy and Safety Study of Telbivudine to Prevent Perinatal Transmission
The purpose of this study is to evaluate the efficacy and safety of Telbivudine in pregnancy for the prevention of HBV perinatal transmission in highly viraemic mothers.
- Trial name
- NCT00939068
- Testing
- Telbivudine, engineered HB vaccine
- Volunteers
- 180 people
- Sponsor
- Southeast University, China
Pelvic Floor Muscle Electrophysiologic Therapy, Fast-Track Surgery
Effect of Pelvic Floor Muscle Electrophysiologic Therapy on Enhanced Recovery After Gynecologic Surgery
This study is to evaluate the effect of pelvic floor muscle electrophysiologic therapy on enhanced recovery after gynecologic surgery,to solve muscle soreness and retention of urine after laparoscopy, and endometrial repair after…
- Trial name
- NCT03524807
- Testing
- Electrophysiologic therapy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University