Clinical trials: Intravenous
Not Applicable as This is a Mass Balance/Pharmacokinetic Study Performed in Healthy Subjects
Elacytarabine Mass Balance Study in Healthy Volunteers
This study is performed to measure the quantity of i.v. applied elacytarabine that leave the body, by which route and how fast.
- Trial name
- NCT01783964
- Testing
- [14C]-Elacytarabine
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Clavis Pharma
Anemia
A Study of Intravenous Mircera (C.E.R.A or Methoxy Polyethylene Glycol-epoetin Beta) for the Maintenance Treatment of Hemodialysis Participants With Chronic Renal Anemia
This 2 arm study will compare the efficacy and safety of monthly administration of intravenous (IV) Mircera versus epoetin alfa for the maintenance of hemoglobin levels in hemodialysis patients with chronic renal anemia.
- Trial name
- NCT00605293
- Testing
- methoxy polyethylene glycol-epoetin beta, Epoetin alfa
- Where
- 19 sites in Spain
- Volunteers
- 101 people
- Sponsor
- Hoffmann-La Roche
Hepatitis B, Chronic
A Multicenter Study to Determine the Depth and Duration of Hepatitis B Surface Antigen (HBsAg) Reduction After Single or Multiple Doses of ARC-520, in Combination With Entecavir in Patients With Chronic Hepatitis B Virus (HBV) Infection
The purpose of this study is to determine whether ARC-520 in combination with entecavir is effective in the treatment of patients with chronic HBV Infection.
- Trial name
- NCT02065336
- Testing
- ARC-520, entecavir, chlorpheniramine
- Where
- 2 sites in Hong Kong
- Volunteers
- 58 people
- Sponsor
- Arrowhead Pharmaceuticals
Healthy Volunteers
Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ASP5354 in Healthy Adult Japanese Male Participants
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of single intravenous doses of ASP5354 in healthy, adult Japanese male participants.
- Trial name
- NCT04878471
- Testing
- Pudexacianinium chloride
- Where
- Japan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Coronavirus Disease 2019 (COVID-19)
Pharmacokinetics, Safety, and Tolerability of CSL760, an Intravenous Anti-SARS-CoV-2 Hyperimmune Globulin, in Healthy Adult Subjects
CSL760 is a human hyperimmune product of the purified gamma immunoglobulin (IgG) fraction of human plasma containing polyvalent neutralizing antibodies to SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2).
- Trial name
- NCT04638634
- Testing
- CSL760
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- CSL Behring
Asthma
Efficacy and Safety Study of GSK679586 in Patients With Severe Asthma
Treatment, Randomised, Double Blind, Parallel Assignment, Safety/efficacy Study
- Trial name
- NCT00843193
- Testing
- INTRAVENOUS GSK679586, FLUTICASONE PROPIONATE
- Where
- 35 sites in United States, France and 6 more
- Volunteers
- 198 people
- Sponsor
- GlaxoSmithKline
Diffuse Large B-cell Lymphoma
SAR3419 as Single Agent in Relapsed-Refractory Diffuse Large B-Cell Lymphoma (DLBCL) Patients
Primary Objective: Participants achieving an Objective Response Rate Secondary Objective: Progression Free Survival Overall Survival Response Duration Safety
- Trial name
- STARLYTE (NCT01472887)
- Testing
- SAR3419
- Where
- 28 sites in United States, Belgium and 7 more
- Volunteers
- 61 people
- Sponsor
- Sanofi
Melanoma
A Study of Tasisulam-sodium Versus Paclitaxel as Treatment for Metastatic Melanoma
The primary purpose of this study was to see how tasisulam-sodium affected metastatic melanoma when compared against paclitaxel as measured by overall survival.
- Trial name
- SUMMIT-1 (NCT01006252)
- Testing
- Tasisulam-sodium, Paclitaxel
- Where
- 122 sites in United States, Australia and 16 more
- Volunteers
- 336 people
- Sponsor
- Eli Lilly and Company
Cytomegalovirus Retinitis, HIV Infections
A Multicenter Study of Oral Versus Intravenous Hydration in AIDS Patients With CMV Retinitis Treated With Foscavir (Foscarnet Sodium)
To assess the relative efficacy of oral versus intravenous hydration during foscarnet sodium (Foscavir) induction therapy, as determined by changes in creatinine clearance.
- Trial name
- NCT00002125
- Testing
- Foscarnet sodium
- Where
- 11 sites in United States
- Volunteers
- 112 people
- Sponsor
- Astra USA
Acute Myelogenous Leukemia
Dose Escalation, Safety and Pharmacokinetic Study of SAR103168 in Patients Refractory/ Relapsed Acute Leukemias or High-risk Myelodysplastic Syndromes
Primary objectives: To determine the maximum tolerated dose (MTD) of SAR103168 and to characterize the dose limiting toxicities (DLTs) in the proposed dose regimen To evaluate the pharmacokinetic (PK) profile of SAR103168…
- Trial name
- NCT00981240
- Testing
- SAR103168
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Sanofi
Solid Tumor, Adult
A Study of ATTR-01 in Participants With Select Epithelial Solid Tumours
ATTR-01 is the experimental drug being studied in the ATTEST clinical trial. The drug is made from a common cold virus that has been changed to only infect and multiply in cancer cells.
- Trial name
- ATTEST (NCT06977737)
- Testing
- ATTR-01
- Where
- 8 sites in Spain, United Kingdom
- Volunteers
- 72 people
- Sponsor
- Accession Therapeutics Limited
Infections
Study of the Safety, Tolerability, and PK of SZEY-2108 Administered Intravenously to HVs in SAD and MAD Cohorts
This phase 1 study was designed to evaluate the safety and tolerability of SZEY-2108 in single and multiple intravenous infusions, the pharmacokinetic profile of SZEY-2108 after single and multiple intravenous infusions, and the…
- Trial name
- NCT06055777
- Testing
- SZEY-2108 for injetion
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Suzhou Erye Pharmaceutical Co., Ltd.
Glioma
A Safety Study of RTA 744 in Patients With Recurrent High-Grade Gliomas
This study assesses the tolerability, safety, efficacy and pharmacokinetics of RTA 744 in recurrent high-grade gliomas.
- Trial name
- NCT00526812
- Testing
- RTA 744, RTA 744 injection
- Where
- 4 sites in United States
- Volunteers
- 54 people
- Sponsor
- Biogen
Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders
Safety, Tolerability and Abuse Liability Study of Intravenous NRP104 in Adults With Stimulant Abuse Histories
This research is being done to evaluate if NRP 104 is a safe drug. The other purpose is to learn if NRP104, when injected into a vein, produces a high and any other effects like amphetamine and other stimulant drugs that are…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00247572
- Testing
- NRP104
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- New River Pharmaceuticals
Neoplasms
Phase I Dose Escalation Study of BAY94-9343 Given by Intravenous Infusion Every 3 Weeks in Japanese Subjects With Advanced Malignancies
The primary objectives of the Phase I study 15404 are to evaluate the safety, tolerability and pharmacokinetics of BAY94-9343 given once every 3 weeks in Japanese subjects with advanced, refractory solid tumors.
- Trial name
- NCT02485119
- Testing
- BAY94-9343
- Where
- 2 sites in Japan
- Volunteers
- 12 people
- Sponsor
- Bayer
Enteral Feeding Intolerance (EFI)
Efficacy, Safety, and Pharmacokinetics (PK) Study of Ulimorelin in Patients With Enteral Feeding Intolerance (EFI): The PROMOTE Trial
The purpose of this study is to evaluate the effect Ulimorelin in patients with enteral feeding intolerance.
- Trial name
- PROMOTE (NCT02784392)
- Testing
- Ulimorelin, Metoclopramide
- Where
- 5 sites in United States, Netherlands and 1 more
- Volunteers
- 120 people
- Sponsor
- Lyric Pharmaceuticals
Healthy Volunteer
A Single-Ascending-Dose Study of RO5469754 in Healthy Volunteers
This randomized, observer-blinded, placebo-controlled study will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of RO5469754 in healthy volunteers.
- Trial name
- NCT01620931
- Testing
- RO5469754
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Hemophilia A
A Study of BAX 888 in Male Adults With Severe Hemophilia A
The main aim of this study is to check if there are side effects from BAX 888 and to determine the dose of BAX 888 for treating severe hemophilia A in male adults.
- Trial name
- NCT03370172
- Testing
- BAX 888
- Where
- 26 sites in United States, Austria and 4 more
- Volunteers
- 4 people
- Sponsor
- Baxalta now part of Shire
Multiple Myeloma
Phase I Dose Escalation of i.v. BI 836909 Monotherapy in Last Line Multiple Myeloma Patients
The primary objective of this trial is to determine the maximum tolerated dose (MTD) of BI 836909 administered by continuous i.v. infusion in patients with relapsed and/or refractory multiple myeloma.
- Trial name
- NCT02514239
- Testing
- BI 836909
- Where
- 5 sites in France, Germany
- Volunteers
- 43 people
- Sponsor
- Boehringer Ingelheim
Advanced Cancer
Study of XIAP Antisense for Advanced Cancers
This study is designed to find the maximum tolerated dose, safety and toxicity profile, and to identify any dose limiting toxicities of AEG35156 administered in 2-hour infusions to patients with advanced cancers.
- Trial name
- NCT00385775
- Testing
- AEG35156
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Aegera Therapeutics
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