Clinical trials: Intravenous
Critical Illness, Delirium
Maximizing trEatment of Neurological Dysfunction Using INtravenous Guanfacine Study
This proof-of-concept study examines whether the acute brain dysfunction that occurs in critically ill patients is improved by administration of intravenous guanfacine.
- Conditions
- Critical Illness, Delirium, Cognitive Impairment
- Trial name
- MENDING (NCT04742673)
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Vanderbilt University Medical Center
Stroke
Evaluating Neuroprotection in Aneurysm Coiling Therapy
This is a randomized, double-blind, placebo-controlled, single-dose, design investigating the safety, tolerability and efficacy of NA-1, a peptide designed to reduce ischemic brain damage.
- Trial name
- ENACT (NCT00728182)
- Testing
- NA-1
- Where
- 14 sites in United States, Canada
- Volunteers
- 185 people
- Sponsor
- NoNO Inc.
Hemorrhagic Shock
Resuscitative Endocrinology: Single-dose Clinical Uses for Estrogen-Traumatic Hemorrhagic Shock (RESCUE - Shock)
Based on encouraging results from animal studies, the investigators hypothesize that early administration of IV Premarin® in patients with hemorrhagic shock will safely reduce secondary injury, and improve survival.
- Trial name
- RESCUE-Shock (NCT00973102)
- Testing
- Premarin IV
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Diastolic Dysfunction
A Trial of Intravenous Calcium and Myocardial Diastolic Dysfunction During Separation From Cardiopulmonary Bypass
Successful heart surgery requires the resumption of a strong beating heart prior to separation from the heart and lung machine. There are different ways to do this.
- Trial name
- NCT00955266
- Testing
- Calcium Chloride
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Brigham and Women's Hospital
Anemia
Safety and Tolerability of a Single Dose of FCM vs. Standard of Care in Treating Iron Deficiency Anemia
The objective of this study is to evaluate the safety of FCM in patients with anemia who are not dialysis dependent
- Trial name
- NCT00704353
- Testing
- Ferric Carboxymaltose, Standard Medical Care (SMC)
- Where
- United States
- Volunteers
- 735 people
- Sponsor
- American Regent, Inc.
Vascular Access Complications
Comparison of AccuCath IV Catheter and Conventional IV Catheter in Interventional Radiology
The study will test a hypothesis that the AccuCath™ System will have a higher rate of successful first attempt peripheral IV placement and higher clinician and patient satisfaction compared to Conventional IV Catheters.
- Trial name
- NCT01940354
- Testing
- AccuCath IV Catheter System, Conventional IV Catheter System
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- C. R. Bard
Heart Failure
Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart Failure
Broad Objectives: To determine the comparative efficacy of commonly employed strategies to overcome loop diuretic resistance when added to concomitant loop diuretics in hospitalized decompensated heart failure patients with…
- Trial name
- NCT02606253
- Testing
- tolvaptan, Chlorothiazide, Metolazone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University
Adolescent Suicide, Adolescent Depression
Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous Ketamine
The purpose of this study is to determine if intravenous ketamine reduces suicidal thinking compared to an active placebo (midazolam) in adolescents who have treatment resistant depression and a recent history of a suicide event…
- Trial name
- NCT04613453
- Testing
- Ketamine Infusion, Midazolam Infusion
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Yale University
Induction of Labor in Multiparous Women
A Study Comparing Vaginal Misoprostol and Intravenous Oxytocin for Induction of Labor
This study will compare the effectiveness of vaginal misoprostol (Cytotec) and intravenous oxytocin (Pitocin) in multiparous women who present at term for labor induction.
- Trial name
- NCT01634854
- Testing
- Vaginal Misoprostol, Intravenous Oxytocin
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Bacterial Infections
A Study To Assess The Effect Of Linezolid On QTc Interval
The FDA has asked Pfizer to assess the risk of linezolid on QT interval (obtained from ECG readings) which could predispose patients to ventricular arrhythmias. This study is conducted to satisfy this requirement.
- Trial name
- NCT00795145
- Testing
- Linezolid 900 mg, Linezolid 1200 mg, Linezolid 600 mg
- Where
- Singapore
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Pfizer
Moderate Asthma
A Study to Assess Pharmacokinetics, Safety and Tolerability of Multiple Doses of CAT-354 in Subjects With Moderate Asthma
The study includes participants with moderate asthma who were randomly assigned to receive the study medication (CAT-354) or placebo.
- Trial name
- NCT00974675
- Testing
- CAT-354 1mg/kg, CAT-354 5 mg/kg, CAT-354 10mg/kg
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- MedImmune LLC
COVID-19
Study of Intravenous Ampion in Adult COVID-19 Patients Requiring Supplemental Oxygen
This is a Phase 2 randomized study to evaluate the safety and efficacy of IV Ampion in improving the clinical course and outcomes of adult COVID-19 patients requiring supplemental oxygen.
- Trial name
- NCT04839965
- Testing
- Ampion, Saline
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Pulmonary Hypertension
Safety of SonoVue on Pulmonary Hemodynamics
This is an intra-subject crossover comparative safety study to evaluate the effect of intravenous (IV) bolus injection of SonoVue on pulmonary hemodynamics.
- Trial name
- NCT01306292
- Testing
- SonoVue
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Bracco Diagnostics, Inc
Healthy
Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes
This study involves 60 healthy volunteers aged between 18 and 50 recruited from the general community. It involves doing a set of simple memory tests while inside a fMRI machine.
- Trial name
- Amygdala (NCT00504894)
- Testing
- Propofol, Thiopental
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Heart Failure, Cardiac Failure
A Study of Continuous Infusions of HNO (Nitroxyl) Donor in Patients With Heart Failure and Impaired Systolic Function
The purpose of this study is to evaluate the effects of BMS-986231 on systolic and diastolic parameters in patients with heart failure and low ejection fraction.
- Conditions
- Heart Failure, Cardiac Failure, Reduced Ventricular Ejection Fraction
- Trial name
- NCT03357731
- Testing
- HNO Donor, Nitroglycerin (NTG)
- Where
- 18 sites in United States, Japan and 2 more
- Volunteers
- 49 people
- Sponsor
- Bristol-Myers Squibb
Pain
Surgical Surveillance Trial to Evaluate a Shortened Infusion Time of Intravenous Ibuprofen
The primary objective of this study is to determine the safety of a single dose of intravenous ibuprofen administered over 5-10 minutes for the preemptive treatment of postoperative pain.
- Trial name
- NCT01334957
- Testing
- Intravenous ibuprofen
- Where
- 22 sites in United States
- Volunteers
- 300 people
- Sponsor
- Cumberland Pharmaceuticals
Hepatitis C, Cirrhosis
Intravenous Interferon During Liver Transplant
The main goal of this study is to prevent liver allograft infection with Hepatitis C virus in hepatitis C positive patients undergoing liver transplantation.
- Trial name
- NCT01192698
- Testing
- IV interferon
- Volunteers
- 15 people
- Sponsor
- Wake Forest University Health Sciences
Adenotonsillitis, Tonsillitis
Analgesic Effect of IV Acetaminophen in Tonsillectomies
Acetaminophen (paracetamol) is a first-line antipyretic and analgesic for mild and moderate pain for pediatric patients. Its common use (particularly in oral form) is underscored by its wide therapeutic window, safety profile…
- Trial name
- NCT01691690
- Testing
- Acetaminophen (paracetamol), Normal Saline Flush, Midazolam
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Nationwide Children's Hospital
Unspecified Adult Solid Tumor, Protocol Specific, Vascular Access Device Complications
Study Comparing Two Types of Ports in Patients With Cancer Receiving Intravenous Chemotherapy
RATIONALE: Giving chemotherapy drugs through an implanted port reduces the need for multiple needle sticks. It is not yet known whether one type of port is more effective than another in reducing infections and other side effects…
- Trial name
- NCT00607880
- Testing
- vascular access device placement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Renal Insufficiency
Pharmacokinetic Study of Aztreonam-Avibactam in Severe Renal Impairment
This Phase 1 study is being conducted to evaluate the effect of severe renal impairment on the PK, safety and tolerability of Aztreonam-Avibactam.
- Trial name
- NCT04486625
- Testing
- Aztreonam-Avibactam
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Pfizer
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