Clinical trials: Intravenous
HIV Infections
Study of Itraconazole in Patients With Advanced HIV Infection
To demonstrate a dosage regimen for intravenous itraconazole that produces a plasma concentration range comparable to that obtained after currently used oral dosages of itraconazole oral solution; and to obtain preliminary safety…
- Trial name
- NCT00002370
- Testing
- Itraconazole
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Janssen, LP
Nephrectomy
Efficacy of IV Acetaminophen Versus Oral Acetaminophen
The aim of this study is to determine whether intravenous acetaminophen compared to enteric acetaminophen offers increased efficacy in patients who are scheduled for laparoscopic donor nephrectomy and for patients scheduled for…
- Trial name
- NCT03365622
- Testing
- acetaminophen
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- University of Rochester
Crohn's Disease
Safety and Treatment Outcome Study of PROCHYMAL® (Remestemcel-L) Intravenous Infusion in Subjects With Treatment-resistant Crohn's Disease
Protocol 620 provides PROCHYMAL(R) adult human mesenchymal cells to specifically chosen Crohn's disease patients at participating centers who typically have already demonstrated good response in another PROCHYMAL study, are not…
- Trial name
- NCT01510431
- Testing
- PROCHYMAL (remestemcel-L)
- Where
- 4 sites in United States
- Sponsor
- Mesoblast, Inc.
Solid Tumors
A Study of QBI-139 in Subjects With Advanced Solid Tumors
The purposes of this trial are: To evaluate the toxicity and tolerability of QBI-139 in patients with advanced refractory solid tumors.
- Trial name
- NCT00818831
- Testing
- QBI-139
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Quintessence Biosciences, Inc.
Iron Deficiency Anemia
A Single Ascending Study of IOP Injection in Patients With Iron Deficient Anemia
The purpose is to evaluate the efficacy and safety of IOP Injection (MPB-1514) for the treatment of iron-deficient anemia (IDA).
- Trial name
- NCT03485053
- Testing
- IOP Injection / MPB-1514
- Where
- 8 sites in United States
- Volunteers
- 49 people
- Sponsor
- MegaPro Biomedical Co. Ltd.
Pain, Bone Neoplasm
A Study to Assess the Efficacy of Intravenous Bondronat (Ibandronate) in Patients With Malignant and Painful Bone Disease
This 2 arm study will compare the efficacy of intravenous Bondronat with that of zoledronic acid in patients with malignant bone disease experiencing moderate to severe pain.
- Conditions
- Pain, Bone Neoplasm, Neoplasm Metastasis
- Trial name
- NCT00099203
- Testing
- ibandronate [Bondronat], zoledronic acid
- Where
- 72 sites in United States, Argentina and 16 more
- Volunteers
- 163 people
- Sponsor
- Hoffmann-La Roche
Benign Neoplasms, Vascular Malformations, Brain
Normal Saline Vrs Balanced i.v. Fluids in Neurosurgery
The purpose of this study was to investigate whether the balanced fluids therapy change plasma osmolality in neurosurgical procedures due to brain tumors, meningeomas and arterio-venous malformation.
- Trial name
- NCT03429127
- Testing
- Normal saline, Balanced fluid
- Where
- Croatia
- Volunteers
- 120 people
- Sponsor
- Clinical Hospital Centre Zagreb
Immunodeficiencies, Primary Immunodeficiencies (PID)
V-IMMUNE: A Novel Immunoglobulin Therapy for Immunodeficiency
This is a phase III, non-randomized clinical trial (VIP Study) designed to assess the safety and efficacy of V-IMMUNE®, a 5% human normal immunoglobulin preparation, in approximately 50 patients with primary immunodeficiency…
- Conditions
- Immunodeficiencies, Primary Immunodeficiencies (PID), Agammaglobulinemia
- Trial name
- VIP (NCT06954441)
- Testing
- Intravenous immunoglobulin (IVIG)
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- On Pharma Importadora, Exportadora e Distribuidora de Medicamentos LTDA.
Pain Management After Surgery
The Effect of Intraoperative Intravenous Lidocaine Infusion on Postoperative Pain and Recovery in Children (< 7 Years Old) Undergoing Thoracoscopic Surgery
This study aims to investigate the efficacy of intraoperative intravenous lidocaine infusion on postoperative pain management and recovery in pediatric patients undergoing thoracoscopic pulmonary resection.
- Trial name
- NCT06710405
- Testing
- Lidocaine (drug)
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Advanced or Recurrent Solid Tumors
Safety and Tolerability of ASA404 Administered in Combination With Docetaxel in Japanese Patients With Solid Tumors
This study will assess the tolerability of combination therapy with ASA404 and docetaxel in Japanese patients with advanced or recurrent solid tumors.
- Trial name
- NCT01285453
- Testing
- vadimezan
- Where
- 2 sites in Japan
- Volunteers
- 9 people
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis
A Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of Golimumab in Patients With Rheumatoid Arthritis (RA)
This is a Phase 1, pharmacokinetic and pharmacodynamic study of intravenous and subcutaneous administered golimumab in patients with rheumatoid arthritis.
- Trial name
- NCT01362153
- Testing
- Golimumab
- Where
- 9 sites in United States
- Volunteers
- 49 people
- Sponsor
- Centocor, Inc.
Lock Solution, Catheter Related Blood Stream Infections
Randomized, Multicenter, Double-blind, Vancomycin-controlled Study to Evaluate the Efficacy of Ethanol Lock Solution for the Curative Treatment of Implantable Venous Access Port Infection Due to Coagulase-negative Staphylococci
Implantable venous access port infections are mainly due to coagulase negative staphylococci and may be managed by antibiotic lock therapy with retention of the port. Most of the time a vancomycin lock is used.
- Conditions
- Lock Solution, Catheter Related Blood Stream Infections, Central Venous Catheter Infection, Intravenous Drug Delivery Systems
- Trial name
- Etha-LOCK (NCT02411331)
- Testing
- Ethanol 40% + Enoxaparine 400UI/ml, Vancomycine 5 mg/ml + Héparine 2500UI/ml
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Clermont-Ferrand
Anesthetics, Recovery
Remimazolam Improves the Safety in Elderly Patients Undergoing Gastrointestinal Endoscopy
Gastroenteroscopy diagnosis and treatment drugs need to meet the needs of quick onset, quick recovery and less anesthesia complications. Remimazolam is an anesthetic sedative independently developed by China.
- Conditions
- Anesthetics, Recovery, Drug Effect, Safety
- Trial name
- NCT05406102
- Testing
- Remimazolam, Propofol group
- Where
- 9 sites in China
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Staphylococcal Infection, Streptococcal Infection
Effectiveness of Intravenous Immunoglobulins (IVIG) in Toxic Shock Syndromes in Children
IGHN2 is an international, multicenter, double blind, randomized controlled trial aimed at assessing the efficacy on organ dysfunctions of Intravenous Immunoglobulins (IVIG) treatment in the acute phase of streptococcal or…
- Trial name
- IGHN2 (NCT02899702)
- Testing
- PRIVIGEN (CSL Behring), Albumin
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Chronic Inflammatory Diseases, Type 2 Diabetes Mellitus
NOX-E36 First-in-Human (FIH) Study
This is the first time NOX-E36 will be administered to man. The principal aim of this study is to obtain safety and tolerability data when NOX-E36 is administered by single intravenous (IV) and subcutaneous (SC) doses to healthy…
- Conditions
- Chronic Inflammatory Diseases, Type 2 Diabetes Mellitus, Systemic Lupus Erythematosus
- Trial name
- NCT00976729
- Testing
- NOX-E36
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- TME Pharma AG
Patients Undergoing Spine Surgery
Comparison of Postoperative QoR-15 Scores Between Propofol and Remimazolam
Remimazolam is a ultra-short-acting benzodiazepine, and unlike conventional benzodiazepine drugs, it is rapidly metabolized in plasma and not accumulates in the body for long periods of infusion or even with high dose…
- Trial name
- NCT04994704
- Testing
- Propfol group, Remimazolam group
- Where
- South Korea
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Healthy
A Study to Test How Well Multiple Doses of BI 765423 Are Tolerated by Healthy Men
The main objectives of this trial are to investigate safety, tolerability and pharmacokinetics of BI 765423 in healthy male subjects.
- Trial name
- NCT06232252
- Testing
- BI 765423
- Where
- Belgium
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Diseases
Effect of Magnesium Sulphate Infusion on Lung Mechanics and Oxygenation in COPD Patients Undergoing Total Laryngeal
Chronic Obstructive Pulmonary Disease [COPD] is a major cause of chronic morbidity and mortality worldwide. COPD is characterized by persistent progressive airflow limitation that adversely affects the ventilation/perfusion (V/Q)…
- Trial name
- COPD (NCT03461328)
- Testing
- Magnesium Sulphate
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
NSCLC, NSCLC (Advanced Non-small Cell Lung Cancer)
A Study of [225Ac]Ac-AKY-2519 in Patients With B7-H3 Expressing Solid Tumors
This is a Phase 1b, 2-part, multi-center, open-label study to evaluate the safety, tolerability, dosimetry, and pharmacokinetics (PK) of [64Cu]Cu-AKY-2519 and/or [225Ac]Ac-AKY-2519, as well as the preliminary anti-tumor activity…
- Conditions
- NSCLC, NSCLC (Advanced Non-small Cell Lung Cancer), ES-SCLC, Small Cell Lung Cancer Extensive Stage
- Trial name
- BActinium-2 (NCT07887971)
- Testing
- [225Ac]Ac-AKY-2519 (therapeutic), [64Cu]Cu-AKY-2519 (imaging)
- Where
- 2 sites in United States
- Volunteers
- 152 people
- Sponsor
- Aktis Oncology, Inc.
Melanoma
A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma
The purpose of this study is to demonstrate that the study drug exposure level of the nivolumab + relatlimab FDC subcutaneous (SC) formulation is not worse than nivolumab + relatlimab FDC intravenous (IV) administration in…
- Trial name
- RELATIVITY-127 (NCT05625399)
- Testing
- Nivolumab + Relatlimab, rHuPH20
- Where
- 149 sites in United States, Australia and 17 more
- Volunteers
- 579 people
- Sponsor
- Bristol-Myers Squibb
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