Clinical trials: Intravenous
Acute Pain
Intranasal Sufentanil Versus Intravenous Morphine for the Management of Acute Pain
This study will be a single-center, randomized, controlled trial conducted in the Brooklyn Hospital Center's Emergency Department (ED) expected to last 2 years.
- Trial name
- NCT03224039
- Testing
- Sufentanil, Normal saline, Morphine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Brooklyn Hospital Center
Postoperative Pain, Myalgia
Effects of Preemptive Paracetamol and Ibuprofen on Headache and Myalgia in Patients After Electroconvulsive Therapy
The primary aim this prospective, randomized, double-blind, placebo-controlled clinical trial is to compare the analgesic effects of preemptive intravenous paracetamol and ibuprofen on headache and myalgia, and secondary aim is…
- Conditions
- Postoperative Pain, Myalgia, Headache
- Trial name
- ECT (NCT03783312)
- Testing
- paracetamol, ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Inonu University
Total Hip Arthroplasty
Efficacy of Intravenous Oxytocin to Speed Recovery After THA
The purpose of this study is to test whether perioperative intravenous (IV) oxytocin compared to placebo results in faster recovery in disability as measured by daily steps over 56 days after Total Hip Arthroplasty (THA).
- Trial name
- NCT07430228
- Testing
- intravenous administration of oxytocin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Arthritis, Rheumatoid
Comparative and Pragmatic Study of Golimumab Intravenous (IV) (Simponi Aria) Versus Infliximab (Remicade) in Rheumatoid Arthritis
The purpose of this study is to compare the proportion of patients with an infusion reaction in Rheumatoid arthritis (RA) patients treated with Golimumab Intravenous (IV) or Infliximab.
- Trial name
- AWARE (NCT02728934)
- Testing
- Golimumab Intravenous (IV), Infliximab, Biosimilar Infliximab
- Where
- 85 sites in United States
- Volunteers
- 1,279 people
- Sponsor
- Janssen Scientific Affairs, LLC
Diabete Mellitus, VATS
Total Intravenous and Balanced Anesthesia in Diabetic Patients Undergoing Video-Assisted Thoracoscopy
Video-assisted thoracoscopy is a minimally invasive surgical technique used to diagnose and treat problems in chest. Diabetics are more prone to infections, slower wound healing and other complications during and after surgery.
- Conditions
- Diabete Mellitus, VATS, TIVA
- Trial name
- NCT07496593
- Testing
- Propofol + fentanyl + Atracurium, Isoflurane and Atracurium
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Linezolid, Antioxidant
Efficacy of Intravenous N-Acetylcysteine in Preventing Linezolid-Induced Thrombocytopenia in Critically Ill Patients
Study the effect of acetylcysteine on decreasing the incidence of LIT in critically ill patients. Study the impact of acetylcysteine on the time to onset of LIT and the time to recovery of platelets.
- Conditions
- Linezolid, Antioxidant, Thrombocytopenia, Critical Illness
- Trial name
- NCT05944458
- Testing
- N acetyl cysteine
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Helwan University
Multiple Trauma, Critically Ill
The Clinical Role of Intravenous Glutamine in Trauma Patients Receiving Enteral Nutrition
The purpose of this trial is to investigate if pharmacologically safe dose intravenous glutamine dipeptide supplementation to multiple trauma patients receiving enteral nutrition is associated with improved clinical outcomes in…
- Trial name
- GLINT (NCT01240291)
- Testing
- Dipeptiven, normal saline
- Where
- Australia
- Volunteers
- 88 people
- Sponsor
- Royal Brisbane and Women's Hospital
Total Knee Arthroplasty
Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)
The goal of this clinical trial is to compare the efficacy of intravenous (IV) and intraosseous (IO) antibiotic administration techniques during primary total knee arthroplasty (TKA) in adults undergoing a TKA procedure at…
- Trial name
- NCT06640491
- Testing
- IO Administration of Cefazolin, IO Administration of Vancomycin, IV Administration of Cefazolin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Methodist Hospital Research Institute
Labor, Pain
Intravenous Remifentanil Patient-controlled Analgesia (PCA) and Epidural Patient Controlled Epidural Analgesia (PCEA) for Labor Analgesia
Women requesting analgesia do not always wish to receive a potent analgesic method, and may fear the risks of epidural analgesia.
- Trial name
- NCT00801047
- Testing
- Bupivacaine epidural, Remifentanil
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Multiple Myeloma
Comparison of Pharmacokinetics and Pharmacodynamics of Subcutaneous Versus Intravenous Administration of Bortezomib in Patients With Multiple Myeloma
In this open-label randomised phase I trial, bortezomib will be administrated to 2 groups of 10 patients with MM who have inclusion criteria use the extended 2nd line indication, either intravenously (group 1 = 10 patients) or…
- Trial name
- NCT00291538
- Testing
- bortezomib
- Where
- 3 sites in France
- Volunteers
- 20 people
- Sponsor
- Nantes University Hospital
Congenital Heart Disease
Remote Preconditioning and Myocardial Protection
Remote ischemic preconditioning (RIPC) of the myocardium by limb ischemia/reperfusion may mitigate cardiac damage, but its interaction with the anesthetic regimen is unknown.
- Trial name
- NCT02877238
- Testing
- Sevoflurane plus remote ischemic preconditioning, Total intravenous anesthesia plus remote ischemic preconditioning
- Where
- Egypt
- Volunteers
- 91 people
- Sponsor
- Assiut University
Giant Cell Arteritis
A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Tocilizumab (TCZ) Administered to Participants With Giant Cell Arteritis (GCA).
This study will evaluate the pharmacokinetics, pharmacodynamics, and safety of two dose levels of tocilizumab (TCZ) administered by intravenous (IV) infusion every 4 weeks (Q4W) to participants with giant cell arteritis (GCA).
- Trial name
- NCT03923738
- Testing
- Tocilizumab
- Where
- 2 sites in Switzerland
- Volunteers
- 24 people
- Sponsor
- Hoffmann-La Roche
Colonoscopy
Assessment of Ventilation Using Respiratory Volume Monitor Compared to Capnography During Intravenous Sedation
A. Determine if Respiratory Volume Monitor (RVM) can be used during procedural sedation to adequately monitor patient's respiratory status as compared to capnograph Aims B.
- Trial name
- NCT02860143
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Brigham and Women's Hospital
Spinal Cord Neoplasms, Spinal Neoplasms
Remimazolam vs Propofol for Motor and Somatosensory Evoked Potentials in Spinal Tumor Surgery
Intraoperative neurophysiological monitoring (IONM) using motor evoked potentials (MEP) and somatosensory evoked potentials (SEP) is routinely applied during spinal tumor resection to detect impending neurological injury.
- Trial name
- NCT07901504
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Healthy
Study to Assess the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of AZD3043
This is a Phase I, single centre, open label study to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of intravenous AZD3043 after single ascending doses in healthy male volunteers.
- Trial name
- NCT00918515
- Testing
- AZD3043
- Where
- Sweden
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Myelodysplastic Syndromes
Phase II Cont. IV of ON 01910.Na in MDS w/ Trisomy 8/Intermed-1, 2/High Risk
This study is under Molecular and Cellular Characterization of Myelodysplastic Syndromes (MDS) (eProtocol 15369). The purpose of this proposed study is to analyze existing samples taken from participants participating in a…
- Trial name
- NCT00987584
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Peter L Greenberg
Carcinoma, Squamous Cell of the Head and Neck
Phase 2 Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin in Patients With Head and Neck Carcinoma
The purpose of this Phase 2 study is to investigate whether intravenous administration of REOLYSIN® therapeutic reovirus in combination with Paclitaxel and Carboplatin is effective and safe in the treatment of squamous cell…
- Trial name
- NCT00753038
- Testing
- REOLYSIN®, Carboplatin, Paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Oncolytics Biotech
Critical Illness
Effect of Combined IV Bolus Amino Acid Supplementation and Mobilisation on Skeletal Muscle During the First 10 Days in the ICU: A RCT
A single-centre, two-arm, parallel randomised controlled trial (RCT) to compare the combined effect of early intravenous bolus amino acid supplementation and mobilisation versus standard of care on changes in muscle mass over the…
- Trial name
- ProMob-ICU (NCT04099108)
- Testing
- Combined cycle ergometry and bolus amino acid supplementation
- Where
- South Africa
- Volunteers
- 50 people
- Sponsor
- University of Stellenbosch
Postoperative Nausea and Vomiting (PONV), Subarachnoid Block
Comparison of Haloperidol and Ondansetron in Reducing Postoperative Nausea and Vomiting in RA-SAB Patients
This study aims to evaluate and compare the effectiveness of intravenous haloperidol and ondansetron in preventing postoperative nausea and vomiting (PONV) in patients undergoing surgery with subarachnoid block (spinal…
- Conditions
- Postoperative Nausea and Vomiting (PONV), Subarachnoid Block, Spinal Anesthesia
- Trial name
- HALO-PONV (NCT07087925)
- Testing
- Haloperidol, Ondansetron 4mg
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Rully Riyandika
Healthy Volunteers
SAD and MAD Study With IV and SC Doses of ARGX-117
This is a phase 1, first-in-human, double-blinded, randomized, placebo-controlled, escalating single and multiple dose levels trial to evaluate the safety, pharmacokinetics, pharmacodynamics, and immunogenicity of ARGX-117…
- Trial name
- ARGX-117 (NCT04532125)
- Testing
- ARGX-117, ARGX-117 + rHuPH20, ARGX-117 PH20 SC
- Where
- Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- argenx
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