Clinical trials: Intravenous
Healthy Subjects
Phase 1, Safety and Bronchopulmonary PK Study in Healthy Volunteers
This is a Phase 1, open-label, randomized, PK and safety study in a maximum of 25 healthy subjects who have provided a bronchoalveolar lavage (BAL) sample.
- Trial name
- BAL (NCT03691584)
- Testing
- TP-6076, Bronchoalveolar lavage
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Tetraphase Pharmaceuticals, Inc
Unspecified Childhood Solid Tumor, Protocol Specific
AT9283 in Children and Adolescents With Relapsed and Refractory Solid Tumors
RATIONALE: AT9283 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I trial is studying the side effects and best dose of AT9283 in children and adolescents with…
- Trial name
- NCT00985868
- Testing
- multikinase inhibitor AT9283, enzyme-linked immunosorbent assay, immunohistochemistry staining method
- Where
- 5 sites in United Kingdom
- Volunteers
- 33 people
- Sponsor
- Cancer Research UK
β-thalassemia
A Phase 1 Study of Gene-modified Autologous Hematopoietic Stem Cell (BD211) Treating β-thalassemia Major
This study will be intented to evaluate the safety, tolerability, and engraftment efficacy after myeloablative preconditioning and transplantation of autologous CD34+ hematopoietic stem cells transduced with a lentiviral vector…
- Trial name
- NCT06465550
- Testing
- BD211
- Where
- 3 sites in China
- Volunteers
- 9 people
- Sponsor
- Shanghai BDgene Co., Ltd.
Hypertensive Urgency
Evaluation of Intravenous Cardene(Nicardipine)and Labetalol Use in the Emergency Department
The purpose of this study is to compare the safety and efficacy of Cardene I.V. to labetalol administered intravenously for the management of hypertension in the emergency department setting.
- Trial name
- CLUE (NCT00765648)
- Testing
- nicardipine intravenous, Labetalol
- Where
- 2 sites in United States
- Volunteers
- 226 people
- Sponsor
- The Cleveland Clinic
Dislodged Catheter, Catheter Related Complication
An Innovative Taping Technique for Improved Intravenous (IV) Catheter Securement
This is a prospective, single-blinded, randomized study to assess the ability of taping methods used to secure intravenous (IV) catheters to resist the IV from being pulled away from the skin.
- Trial name
- NCT05948878
- Testing
- Novel Taping Method, BCH Emergency Department Taping Method, Chevron Taping Method
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Influenza
A Study of HNC042 in Healthy Chinese Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetics
The purpose of this study is to evaluate the safety , tolerability and pharmacokinetics after multiple ascending of HNC042 given to healthy Chinese volunteers, compared to placebo.
- Trial name
- NCT04603989
- Testing
- HNC042 for Injection
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Guangzhou Henovcom Bioscience Co. Ltd.
Healthy Volunteer
A Study of TAK-951 in Healthy Adults
It is hoped that a medicine called TAK-951 will eventually be used to treat nausea and vomiting. Before then, the sponsor needs to understand how the body processes TAK-951 in healthy adults.
- Trial name
- NCT04486950
- Testing
- TAK-951
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Takeda
HIV Infections
Evaluating the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of the Monoclonal Antibody PGT121.414.LS Administered Alone and in Combination With VRC07-523LS Via Intravenous or Subcutaneous Infusions in Healthy, HIV-uninfected Adult Participants
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and antiviral activity of the monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS via intravenous or…
- Trial name
- NCT04212091
- Testing
- PGT121.414.LS, VRC07-523LS
- Where
- 5 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Intravenous Drug Usage, HIV/AIDS
Building on Needle Exchange to Optimize Prevention & Treatment
There are several biomedical interventions that can help people who inject drugs (particularly those with or at risk for HIV), but these services often do not get to the people most in need.
- Trial name
- NCT03567174
- Testing
- Integrated care van (ICV)
- Where
- United States
- Volunteers
- 720 people
- Sponsor
- Johns Hopkins University
Non-Ischemic Congestive Heart Failure
Safety and Efficacy of Adipose Derived Stem Cells for Non-Ischemic Congestive Heart Failure
The intent of this clinical study is to answer the questions: 1. Is the proposed treatment safe 2. Is treatment effective in improving the disease pathology of patients with Heart Disease as assessed by a series of measurements…
- Trial name
- NCT01502501
- Testing
- Harvesting and Implantation of Adipose-Derived Stem Cells (ASCs)
- Where
- Mexico
- Sponsor
- Ageless Regenerative Institute
Peripheral Intravenous Catheterization
Effect of Topical Black Pepper Oil on Pain and Vein Visibility During Peripheral Intravenous Catheterization in Children
This randomized controlled trial was designed to evaluate the effects of topical black pepper (Piper nigrum L.) essential oil on vein visibility, palpability, and pain in children aged 7-12 years undergoing peripheral intravenous…
- Trial name
- NCT07909330
- Testing
- Topical Black Pepper Essential Oil Preparation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University
Blood Pressure, Dental Anxiety
Hemodynamic Changes During Implant Surgery with Intravenous Conscious Sedation
The goal of this study is to determine whether intravenous sedation would contribute to the stabilization of hemodynamics in adult patients during periodontal/implant surgery compared to receiving local anesthesia during…
- Trial name
- NCT05756439
- Testing
- Intravenous Sedatives with or Without Analgesia, No IV sedation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Covid19
Intramuscular and Intravenous VIR-7831 (Sotrovimab) for Mild/Moderate COVID-19.
The COMET-TAIL main study evaluated efficacy, safety, and tolerability of IM sotrovimab versus IV sotrovimab in high-risk patients for the treatment of mild/moderate COVID-19.
- Trial name
- NCT04913675
- Testing
- sotrovimab
- Where
- 50 sites in United States, France and 1 more
- Volunteers
- 1,065 people
- Sponsor
- Vir Biotechnology, Inc.
Intubation, Anesthesia
Comparative Efficacy of Intravenous Labetalol and Lignocaine in Mitigating Hemodynamic Responses to Laryngoscopy During Laparoscopic Cholecystectomy
Laryngoscopy and intubation during laparoscopic cholecystectomy often cause sudden increases in heart rate and blood pressure, which can be harmful in some patients.
- Conditions
- Intubation, Anesthesia, Laparoscopic Cholecystectomy, Hemodynamic Response to Laryngoscopy
- Trial name
- LAB-LIG RCT (NCT07192081)
- Testing
- Labetalol, Lignocaine
- Where
- Pakistan
- Volunteers
- 116 people
- Sponsor
- Dr. Waseem Ullah
Depression, Substance-Related Disorders
Antidepressant Medication for Reducing HIV Risk Behavior in Depressed Intravenous Drug Users
This study will evaluate the effectiveness of antidepressant medication treatment in reducing HIV risk behaviors in intravenous drug users with depression.
- Conditions
- Depression, Substance-Related Disorders, HIV Infections
- Trial name
- NCT00228007
- Testing
- Antidepressant Medication
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- Butler Hospital
Carcinoma, Pancreatic
Intra-arterial Versus Intravenous Chemotherapy for Locally Advanced Pancreatic Cancer
This study aims to explore the efficacy and safety of intra- arterial infusion of gemcitabine and oxaliplatin in locally advanced pancreatic cancer.
- Trial name
- NCT02635971
- Testing
- Transcatheter arterial infusion, Intravenous chemotherapy, Gemcitabine
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Fudan University
Postoperative Pain
Systemic Nalbuphine Versus Intravenous Regional Anesthesia
Comparison of systemic nalbuphine versus intravenous regional anesthesia in patients undergoing hand surgery.
- Trial name
- NCT03150732
- Testing
- Systemic nalbuphine, Local nalbuphine
- Where
- Egypt
- Volunteers
- 82 people
- Sponsor
- Assiut University
Anesthesia, Intravenous Fluid
Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients
In this research study we want to learn more about using non-invasive tools as a way to predict whether or not a child under general anesthesia will require and respond to fluid administration.
- Conditions
- Anesthesia, Intravenous Fluid, Blood Pressure
- Trial name
- NCT03431064
- Testing
- Lung Recruitment Maneuver, Fluid Administration
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Boston Children's Hospital
Osteoarthrosis
Effect of Methylprednisolone on Orthostatic Intolerance and Heart Rate Variability in Hip-arthroplasty Patients
The study evaluates the pathophysiological effects of a single dose Methylprednisolone administered prior to total hip-arthroplasty (THA) surgery.
- Trial name
- NCT02445898
- Testing
- Methylprednisolone, Isotonic Sodium Chloride
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Major Depressive Disorder
An Open-label, Adaptive Design, Positron Emission Tomography Study in Healthy Male Participants to Characterize Receptor Occupancy by MIJ821 in the Brain
The purpose of this study is to confirm binding of MIJ821 to the NR2B-containing NMDA receptors in the human brain and assess the PC-RO relationship over time using positron emission tomography (PET).
- Trial name
- NCT05666687
- Testing
- MIJ821
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.