Clinical trials: Intravenous
Knee Arthroscopy
Intra-articular Versus Intravenous Dexmedetomidine in Arthroscopic Knee Surgeries Under Local Anesthesia
The present study will be carried to evaluate the efficacy of intra-articular 0.5 bupivacaine with intra-articular or intravenous alpha-2agonist; Dexmedetomidine; for intraoperative anesthesia and postoperative analgesia after…
- Trial name
- NCT02730845
- Testing
- Intra-articular dexmedetomidine, Intravenous dexmedetomidine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Healthy Volunteers, Bacterial Infections
Safety, Tolerability, Pharmacokinetics of Intravenous RPX7009 in Healthy Adult Subjects
RPX7009 (beta-lactamase inhibitor) is being studies in combination with a carbapenem biapenem to treat bacterial infections, including those due to multi-drug resistant bacteria.
- Trial name
- NCT01751269
- Testing
- RPX7009
- Where
- Australia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company)
Scleroderma
A Study to Evaluate Safety and Tolerability of Multiple Doses of MEDI-546 in Adult Subjects With Scleroderma
To evaluate the safety and tolerability of a multiple-dosed drug (MEDI-546) in adults with scleroderma.
- Trial name
- MEDI-546 (NCT00930683)
- Testing
- MEDI-546
- Where
- 11 sites in United States
- Volunteers
- 34 people
- Sponsor
- MedImmune LLC
Acute Myocardial Infarction
Metoprolol in Acute Myocardial Infarction. A PK/PD Study
The objective of the study was to compare treatment with two different oral formulations of metoprolol, metoprolol immediate release (IR) and metoprolol extended release (CR/XL) in patients with acute myocardial infarction…
- Trial name
- NCT01523054
- Testing
- Metoprolol- Toprol XL, Metoprolol- Lopressor
- Volunteers
- 27 people
- Sponsor
- AstraZeneca
Anemia, Iron-Deficiency, Colorectal Cancer
Efficacy of Preoperative Intravenous Iron in Anaemic Colorectal Cancer Surgical Patients
Iron deficiency anaemia is a common condition among colorectal surgical patient. Untreated anaemia would lead to increase in blood transfusion, surgical complications and mortality.
- Trial name
- NCT03565354
- Testing
- iron isomaltoside(Monofer®)
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Peripheral Intravenous Phlebitis, Injection Site Pain
Ice Application for Oxacillin-Related Phlebitis and Pain
This randomized controlled trial evaluated whether ice application could reduce pain and peripheral intravenous phlebitis associated with oxacillin administration.
- Conditions
- Peripheral Intravenous Phlebitis, Injection Site Pain, Pain
- Trial name
- NCT07820956
- Testing
- Ice Application, Room-Temperature Water-Bag Application
- Where
- Taiwan
- Volunteers
- 86 people
- Sponsor
- Central Taiwan University of Science and Technology
Solid Tumors
A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)
This study is open to adults with different types of advanced cancer. People can take part if previous treatment was not successful, or no treatment exists.
- Trial name
- NCT05471856
- Testing
- BI 1703880, Ezabenlimab
- Where
- 21 sites in United States, Japan and 4 more
- Volunteers
- 66 people
- Sponsor
- Boehringer Ingelheim
Postoperative Nausea and Vomiting
Comparison Between Intravenous Ondanosteron and Metclopromide Versus Ondanesteron and Dexamethasone Effects on the Prevention of Postoperative Nausea and Vomiting in Cesarean Section
The goal of this clinical trial is to prevent intraoperative nausea and vomiting (IONV) and postoperative nausea and vomiting (PONV) through comparing the efficacy of combination ondanosteron plus metclopromide versus…
- Trial name
- NCT06810531
- Testing
- Ondanesterone plus dexamethasone combination, ondanesterone plus metoclopramide combination
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Aiman Al-Touny
Healthy
Study Evaluating the Safety and Tolerability of a New Intravenous Formulation of MOA-728 in Healthy Subjects
The primary objective is to determine the safety and tolerability of the new IV formulation versus the current formulation of MOA-728 focusing on the theoretical potential for infusion-related and formulation-related…
- Trial name
- NCT00464802
- Testing
- MOA-728
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Colorectal (Colon or Rectal) Cancer, Inflammation
Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery
Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta).
- Trial name
- NCT06272461
- Testing
- Lidocaine IV, Ketamine Injectable Solution
- Where
- Tunisia
- Volunteers
- 50 people
- Sponsor
- University Tunis El Manar
Postoperative Pain
Study to Investigate TIVA With Propofol on Postoperative Pain and Side Effects
Propofol is a commonly used anaesthetic with rapid recovery and less side effects and total intravenous anaesthesia (TIVA) with propofol is a common technique now.
- Trial name
- NCT03058354
- Testing
- Propofol, general anaesthesia
- Where
- Hong Kong
- Sponsor
- The University of Hong Kong
Healthy Male Participants
A Safety and Pharmacokinetic Study of AG-881 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C] AG-881 and Concomitant Intravenous Microdose of [13C315N3] AG-881
The purpose of this Phase I, open-label study is to evaluate the absorption, distribution, metabolism, excretion, absolute bioavailability, and to characterize the metabolites of AG-881 in healthy male participants following…
- Trial name
- NCT03960502
- Testing
- AG-881, [13C315N3]AG-881
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Agios Pharmaceuticals, Inc.
Metastatic Endometrial Carcinoma, Recurrent Endometrial Adenocarcinoma
VSV-hIFNbeta-NIS With or Without Ruxolitinib Phosphate in Treating Stage IV or Recurrent Endometrial Cancer
This phase I trial studies the side effects and best dose of vesicular stomatitis virus-human interferon beta-sodium iodide symporter (VSV-hIFNbeta-NIS) with or without ruxolitinib phosphate in treating patients with stage IV…
- Conditions
- Metastatic Endometrial Carcinoma, Recurrent Endometrial Adenocarcinoma, Recurrent Endometrial Carcinoma, Recurrent Endometrial Clear Cell Adenocarcinoma
- Trial name
- NCT03120624
- Testing
- Biopsy, Computed Tomography, Fluorine F 18 Tetrafluoroborate
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Mayo Clinic
Heart Failure
Efficacy and Safety of Treatment With Simdax® Versus Dobutrex® in Decompensated Heart Failure Patients.
The purpose of this study is to compare the effects of levosimendan with dobutamine on heart function in patients suffering of severe chronic heart failure.
- Trial name
- NCT00219388
- Testing
- Levosimendan
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Orion Corporation, Orion Pharma
Procedural Anxiety, Fear
Effects of Virtual Reality, Cold-Vibration Due To Intravenous Catheterization on Pain, Fear and Anxiety on Children
This is a randomized controlled trial. The aim of the study is to the effects of Virtual Reality and Local Cold-Vibration applications in reducing anxiety, fear and pain due to intravenous catheterization (PIC) in children aged…
- Conditions
- Procedural Anxiety, Fear, Procedural Pain, Child, Only
- Trial name
- NCT05435105
- Testing
- Virtual reality, Local cold-vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Myelodysplastic Syndromes
A Phase II Study of Intravenous Azacitidine Alone in Patients With Myelodysplastic Syndromes
The primary endpoint of this study is to estimate morphologic complete remission rate. Estimation of response rate is also a secondary objection.
- Trial name
- NCT00384956
- Testing
- Azacitidine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Graves Ophthalmopathy
A Safety and Tolerability Study of Otelixizumab in Thyroid Eye Disease
The purpose of this study is to investigate the safety and tolerability of otelixizumab in patients with Graves' ophthalmopathy (thyroid eye disease).
- Trial name
- NCT01114503
- Testing
- Otelixizumab - low dose, Otelixizumab - medium low dose, Otelixizumab - medium high dose
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- GlaxoSmithKline
Atrial Fibrillation
Effects of Intravenous K201 on the Restoration of Sinus Rhythm in Subjects With Symptomatic Atrial Fibrillation
The purpose of this study is to evaluate the effects of a single intravenous infusion of K201 compared to placebo in a dose escalating manner on conversion to sinus rhythm, reduction of subject's symptom score, and safety.
- Trial name
- TUNDRA-AF (NCT01259622)
- Testing
- saline, K201
- Where
- 17 sites in Denmark, Israel
- Volunteers
- 80 people
- Sponsor
- Sequel Pharmaceuticals, Inc
Obesity, Morbid
The Effect of Timing of Intravenous Paracetamol Administration on Post-surgical Pain
This study is designed as a population-based prospective randomized cohort study. A prospective cohort of patients admitted to laparoscopic sleeve gastrectomy due to morbid obesity
- Trial name
- NCT03221998
- Testing
- IV paracetamol, IV saline (NaCl 0.9 %)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Anesthesia
Effects of Systemic or Adjunct Tramadol Addition to Lidocaine Used for IVRA in Patients Undergoing Hand Surgery
Intravenous regional anesthesia (IVRA) is used in outpatient hand surgery as an easily applicable and cost-effective technique with clinical advantages.
- Trial name
- NCT02658721
- Testing
- Lidocaine, lidocaine+adjunct tramadol, lidocaine+systemic tramadol
- Volunteers
- 60 people
- Sponsor
- Bagcilar Training and Research Hospital
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