Clinical trials: Intravenous Injections
Contrast Induced AKI
Protective Effects of Oral L-Arginine CI-AKI
This trial was performed to examine the efficacy of oral L-arginine for preventing CI-AKI in chronic kidney disease (CKD) patients.
- Trial name
- NCT02455960
- Testing
- L-arginine
- Where
- Thailand
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Phramongkutklao College of Medicine and Hospital
End Stage Renal Disease on Dialysis (Diagnosis)
Plasma Amino Acid Levels After Protein Ingestion or Amino Acid Injection During Dialysis
The aim of the study is to compare intradialytic plasma kinetics of amino acids after administration per os of Renoral or intravenous administration of amino acids in patients with end-stage renal disease treated with…
- Trial name
- NCT03807583
- Testing
- Aminoven 10%, RENORAL
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Indigo Therapeutics
Lymphoma, T-cell, Peripheral, Lymphoma, T-cell, Cutaneous
A Study of Remitoro in Participants With Recurrent or Refractory Peripheral T Cell Lymphoma and Cutaneous T Cell Lymphoma (All Case Study)
The primary purpose of the study is to investigate the incidence of adverse drug reactions (ADRs) (ADR of special interest: capillary leak syndrome, infusion reaction, rhabdomyolysis, myelosuppression, infection, hepatic…
- Trial name
- NCT05137847
- Testing
- Remitoro
- Where
- 3 sites in Japan
- Volunteers
- 118 people
- Sponsor
- Eisai Inc.
Influenza
Testing the AVI-7100 Flu Drug in Healthy Volunteers
Background: Influenza (flu) is a virus that causes people to get sick. Most of the time, the flu causes only a mild illness, but some people can become seriously ill or even die from it.
- Trial name
- NCT01747148
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anemia in Pre-Dialysis Patients
Clinical Study of R744 to Predialysis Patients
This study will assess the efficacy and safety of subcutaneous or intravenous R744 in renal anemia patients on Predialysis.
- Trial name
- NCT00433615
- Testing
- R744
- Where
- 6 sites in Japan
- Volunteers
- 124 people
- Sponsor
- Chugai Pharmaceutical
Pain
The Effect of Sucrose on Pain Relief During Venous Blood Sampling in Preterm Infants
Despite the fact that oral sucrose is the most frequently studied non-pharmacological intervention for procedural pain relief in infants, there is a paucity of data on the minimal effective dose.
- Trial name
- NCT02344368
- Testing
- 0.2 ml sucrose 25%, 0.5 ml sucrose 25%
- Where
- 2 sites in Norway, South Africa
- Volunteers
- 50 people
- Sponsor
- Norwegian University of Science and Technology
Sedation in Intensive Care
A Clinical Study Evaluating Sedation of Intravenous Administration of HSK3486 in ICU Patients Undergoing Long-Term Mechanical Ventilation
This is a multi-center, randomized, open-label, propofol-controlled exploratory clinical study. In this study, 20 ICU patients undergoing mechanical ventilation are expected to be enrolled and will be randomly assigned to the…
- Trial name
- NCT04669821
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Hemophilia A
A Safety, Tolerability, and Pharmacokinetics Study of a Single Intravenous Injection of Recombinant Coagulation Factor VIII Fc - Von Willebrand Factor - XTEN Fusion Protein (rFVIIIFc-VWF-XTEN) (BIVV001) in Previously Treated Adults With Severe Hemophilia A (EXTEN-A)
The primary purpose was to assess the safety and tolerability of a single intravenous (IV) administration of BIVV001 in adult previously treated patients (PTPs) with severe hemophilia A.
- Trial name
- NCT03205163
- Testing
- Advate (Low Dose), Advate (High Dose), BIVV001 (Low Dose)
- Where
- 10 sites in United States, Japan
- Volunteers
- 16 people
- Sponsor
- Bioverativ, a Sanofi company
Healthy
Pharmacokinetics and Pharmacodynamics Study of BCD-066 Compared to Aranesp® in Healthy Volunteers
This is a randomized double-blind crossover study of pharmacokinetics, pharmacodynamics and safety of BCD-066 (darbepoetin alfa manufactured by CJSC BIOCAD, Russia) and Aranesp® (Amgen Europe B.V., Netherlands) in healthy…
- Trial name
- NCT02506881
- Testing
- Darbepoetin alfa
- Where
- Russia
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Biocad
Pain
Decreasing Propofol Injection Pain by Pre-Treatment With Lidocaine in Pediatric Procedural Sedation
This is a double blind, randomized, controlled study. The sedationist performing the sedation procedure will inject the appropriate amount of either a 1% Lidocaine solution or a placebo before the administration of Propofol.
- Trial name
- NCT02512783
- Testing
- Lidocaine, Normal Saline, Propofol
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Pneumonia, Pneumocystis Carinii, HIV Infections
A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral / Oral Trimethoprim - Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia in AIDS
This is a randomized double-blinded controlled study comparing aerosolized pentamidine with trimethoprim plus sulfamethoxazole (TMP / PurposeX).
- Trial name
- NCT00002056
- Testing
- Pentamidine isethionate
- Where
- United States
- Sponsor
- LyphoMed
Pulmonary Arterial Hypertension
A Study to Investigate Safe and Tolerable Dose of GMA301 Injection in Healthy Volunteers
This study is a single-centre, randomized, double-blind, placebo-controlled, dose escalation study to assess the safety, tolerability and PK of GMA301 Injection in healthy subjects.
- Trial name
- NCT04505137
- Testing
- GMA301 Injection
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gmax Biopharm Australia Pty Ltd.
Healthy
Multiple-Dose, Dose-Escalation Safety, Pharmacodynamics, and Pharmacokinetics Study of Imprime PGG™ Injection
The study is a Phase Ib, randomized, double-blind, placebo-controlled, multiple-dose (7 day), dose-escalation study assessing the safety, pharmacodynamics, and pharmacokinetics of intravenous Imprime PGG™ Injection in healthy…
- Trial name
- NCT00542464
- Testing
- Imprime PGG TM for Injection
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- HiberCell, Inc.
Advanced Nasopharyngeal Carcinoma
A Clinical Study to Evaluate the Safety and Tolerability of JS001sc in Advanced Nasopharyngeal Carcinoma
The purpose of this phase I clinical study was to evaluate the safety and tolerability of JS001sc monotherapy and combination with gemcitabine and cisplatin (GP) in patients with Advanced nasopharyngeal carcinoma.
- Trial name
- NCT05751486
- Testing
- Toripalimab injection(subcutaneous)/JS001sc, Toripalimab /JS001
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Epilepsy, Status Epilepticus
Lacosamide Intravenous Injection for Emergency Termination of Status Epilepticus
Status epilepticus (SE) is an acute and critical form of neurological and systemic diseases involving multiple clinical disciplines, with an annual incidence of (20-73) per 100,000 people and a clinical case fatality rate of 20%.
- Trial name
- NCT06966830
- Testing
- Lacosamide (LCM)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Depression, Substance-Related Disorders
Antidepressant Medication for Reducing HIV Risk Behavior in Depressed Intravenous Drug Users
This study will evaluate the effectiveness of antidepressant medication treatment in reducing HIV risk behaviors in intravenous drug users with depression.
- Conditions
- Depression, Substance-Related Disorders, HIV Infections
- Trial name
- NCT00228007
- Testing
- Antidepressant Medication
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- Butler Hospital
Cancer
The Pharmacokinetics and Safety Characteristics of Docetaxel in Patients With Cancer
The purpose of this study is to compare the pharmacokinetic and safety characteristics of European Taxotere® and American Taxotere® with Hospira Docetaxel injection in patients with cancer.
- Trial name
- NCT01268163
- Testing
- European Taxotere®, American Taxotere®, Hospira Docetaxel Injection
- Where
- 4 sites in Russia, United Kingdom
- Volunteers
- 32 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Pain on IV Injection of Propofol.
Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection
The main objective is to evaluate if combining placing the Synera patch and using Propofol /Lidocaine mixture will further decrease the pain associated with the IV injection of Propofol.
- Trial name
- NCT02240628
- Testing
- Lidocaine/tetracaine transdermal patch, Saline, Lidocaine
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Dilated Cardiomyopathy
Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy
The purpose of this study is to determine the safety and clinical effectiveness of umbilical cord mesenchymal cells transplanted by intravenous infusion in patients with heart failure.
- Trial name
- RIMECARD (NCT01739777)
- Testing
- ucMSC, Controls
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad de los Andes, Chile
Pompe Disease (Late-onset)
Evaluation of the Safety and Efficacy of Late-onset Pompe Disease Gene Therapy Drug
This study is being conducted to evaluate the safety and effectiveness of GC301 adeno-associated virus vector expressing codon-optimized human acid alpha-glucosidase (GAA) as potential gene therapy for Pompe disease.
- Trial name
- NCT06391736
- Testing
- GC301
- Where
- China
- Volunteers
- 33 people
- Sponsor
- GeneCradle Inc