Clinical trials: Intravenous Injections
Advanced Solid Tumor
RT-01 Monotherapy and in Combination With Nivolumab in Patients With Advanced Solid Tumors
This is a single-arm, open-lable study to determine the safety, tolerability and preliminary efficacy of oncolytic virus injection (RT-01) combined with or without immune checkpoint inhibitors (Nivolumab) in the treatment of…
- Trial name
- NCT05122572
- Testing
- Oncolytic Virus Injection (RT-01）
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Wuxi People's Hospital
Complicated Urinary Tract Infections(cUTI)
Evaluation of the Safety, Tolerability and Pharmacokinetics of TUL108 for Injection in Healthy Participants (SAD/ MAD)
To evaluate the safety, tolerability and pharmacokinetics of single and multiple intravenous (IV) infusion of TUL108 in healthy participants.
- Trial name
- NCT07719257
- Testing
- TUL108
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Zhuhai United Laboratories Co., Ltd.
Head and Neck Cancer
A Microdose Evaluation Study of ABY-029 in Head and Neck Oncology Surgery
The primary study objective is to determine if microdoses of ABY-029 (up to 6X) lead to detectable signals (defined as signal-to-noise ratio, SNR ≥10, with wide-field iFI) in sampled tissues with an EGFR (epidermal growth factor…
- Trial name
- NCT03282461
- Testing
- ABY-029
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Effect of Drugs, Safety Issues
A Clinical Trial to Evaluate the Safety and Tolerability of Dexlansoprazole Injection in Healthy Chinese Adults（Part 2）
This is a single center, open-label, multiple-dose phase 1 clinical trial. This study will determine the pharmacokinetics (PK), pharmacodynamics (PD), safety and side-effect profile of an investigational dexlansoprazole injection…
- Trial name
- NCT03120273
- Testing
- Dexlansoprazole Injection, Lansoprazole Injection
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Normal Healthy Volunteers
Safety and PK Trial Evaluating the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations of Minocin IV
This is a phase 1, safety and PK Open-Label trial evaluating the plasma, epithelial lining fluid, and alveolar macrophage concentrations of intravenous Minocin® (Minocycline) for injection in healthy adult subjects.
- Trial name
- NCT03291158
- Testing
- Minocycline
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company)
Rotator Cuff Tear
Postoperative Pain After Intravenous Vitamin C Injection for Arthroscopic Rotator Cuff Repair
1. Treatment of rotator cuff tear The rotator cuff tear is the most demanding part of the shoulder surgery. Rotator cuff degeneration is thought to be the largest cause of rotator cuff tear.
- Trial name
- VITCRCR (NCT02992028)
- Testing
- Intravenous Nutrition (Vitamins) injection, Intravenous Saline injection
- Where
- South Korea
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Himchan Hospital
Arthritis, Rheumatoid
Evaluating Safety of Escalating Doses of Tilmanocept by IV Injection and SPECT Imaging in Subjects With and Without RA
Prospective, open-label, multicenter, dose escalation, safety with pharmacokinetics (PK) and dosimetry study of injected Tc 99m tilmanocept in the detection of and assessment of localization to skeletal joints in subjects with…
- Trial name
- NCT02865434
- Testing
- Tc99m-tilmanocept, SPECT Imaging (60 Minutes post-injection), SPECT Imaging (180 Minutes post-injection)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Navidea Biopharmaceuticals
Post-Dural Puncture Headache
Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries
Post-dural puncture headache (PDPH) or spinal (or post-spinal) headache is one of the most common side effects of spinal anesthesia, with an incidence of 6-36%.
- Trial name
- NCT06729047
- Testing
- normal Saline, Neostigmine, Ketorolac
- Where
- Egypt
- Volunteers
- 330 people
- Sponsor
- Assiut University
Pneumonia, Pneumocystis Carinii, HIV Infections
A Study of Two Forms of Pentamidine in HIV-Infected Children Who May Have Pneumocystis Carinii Pneumonia
To evaluate the delivery of a single dose of aerosolized pentamidine to children; to evaluate the tolerance of pentamidine administration by mask; to compare intravenous pentamidine first dose pharmacokinetics (blood levels) in…
- Trial name
- NCT00000974
- Testing
- Pentamidine isethionate
- Where
- 4 sites in United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Glioblastoma
Intracranial Injection of NK-92/5.28.z Cells in Combination With Intravenous Ezabenlimab in Patients With Recurrent HER2-positive Glioblastoma
The main objective of this clinical study is to evaluate the safety and tolerability of NK-92/5.28.z and to determine the maximum tolerated dose or maximum feasible dose (MFD).
- Trial name
- CAR2BRAIN (NCT03383978)
- Testing
- NK-92/5.28.z, Ezabenlimab
- Where
- 5 sites in Germany
- Volunteers
- 42 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Acute Venous and Arterial Thrombotic and Thromboembolic Events, Healthy Volunteers
A Study to Learn About How Safe BAY3018250 is and What Happens to it in Healthy Japanese Men and Adult Participants Aged 18 to 55 Years
Researchers are looking for a better way to treat people who have acute venous and arterial thrombotic and thromboembolic events. These are severe medical problems due to blood clots forming in and blocking blood vessels.
- Trial name
- NCT06562985
- Testing
- BAY3018250 Dose 1, BAY3018250 Dose 2 infusion, BAY3018250 Dose 2 injection
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Bayer
Bacterial Infection
: Bacterial Infections in Injecting Drug Users
Bacterial infections in people who inject psychoactive substances
- Trial name
- NCT04550767
- Where
- France
- Volunteers
- 117 people
- Sponsor
- University Hospital, Montpellier
COVID-19 Infection
A Study on the Effects in Healthy People of a New Drug Called PDI204 for Treating COVID-19
The goal of this clinical trial is to learn if a new drug called PDI204, developed for treating or preventing COVID-19, is safe and well-tolerated in healthy volunteers. This is a first-in-human study.
- Trial name
- PHONIC (NCT06965751)
- Testing
- PDI204, 0.9 % saline
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Fever
Safety, Efficacy, and Pharmacokinetic Study of Intravenous Ibuprofen in Pediatric Patients
The primary objective of the study is to determine the superiority of a single dose of intravenous ibuprofen compared to acetaminophen for the treatment of fever during the first two hours of treatment.
- Trial name
- NCT01002573
- Testing
- ibuprofen, acetaminophen
- Where
- 17 sites in United States
- Volunteers
- 118 people
- Sponsor
- Cumberland Pharmaceuticals
Pain
Pain Ease Spray in Reducing Needle Pain Associated With Intravenous Insertion in Children
The purpose of this study is to investigate the use of a new vapocoolant spray, Pain Ease, to reduce intravenous (IV) insertion pain in school-aged children receiving treatment in the Emergency Department.
- Trial name
- NCT00130650
- Testing
- Pain Ease
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Children's Hospital of Eastern Ontario
Solid Tumors
A Study of QBI-139 in Subjects With Advanced Solid Tumors
The purposes of this trial are: To evaluate the toxicity and tolerability of QBI-139 in patients with advanced refractory solid tumors.
- Trial name
- NCT00818831
- Testing
- QBI-139
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Quintessence Biosciences, Inc.
Chronic Fatigue
High-dose Ascorbic Acid Intravenous Injection Decreases Mitochondrial DNA Damage in Chronic Fatigue Patients: Randomized-controlled Study
Reactive Oxygen Species (ROS) can cause oxidative damage, resulting in oxidation of lipids, proteins and DNA. In fatigue patients, there are some evidences of oxidative damage to DNA.
- Trial name
- NCT01926132
- Testing
- ascorbic acid 10g/20ml, Normal Saline 150ml
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Osteoporosis in Post-menopausal Women, Osteoporosis
Intravenous Infusion of Human Mesenchymal Stem Cells (HMM910 ) in Postmenopausal Women With Osteoporosis at High Risk of Fracture
The primary objective of this study is to evaluate the safety and tolerability of human umbilical cord-derived mesenchymal stem cells for injection (HMM910 ) in postmenopausal women with osteoporosis who are at high risk of…
- Trial name
- NCT06949137
- Testing
- Human Umbilical Cord-derived Mesenchymal stem cell
- Where
- China
- Volunteers
- 9 people
- Sponsor
- HELP Therapeutics Co., Ltd.
Severe Hemophilia A
Study of Recombinant Factor VIII Fc Fusion Protein (rFVIIIFc) in Subjects With Severe Hemophilia A
The study is to investigate the safety, tolerability, and pharmacokinetics (the determination of the concentration of the administered drug in blood over time) of recombinant Factor VIII Fc fusion protein (rFVIIIFc) in…
- Trial name
- NCT01027377
- Testing
- rFVIIIFc
- Where
- 7 sites in United States, Hong Kong and 1 more
- Volunteers
- 16 people
- Sponsor
- Bioverativ Therapeutics Inc.
Liver Neoplasms, Liver Cirrhosis
Chemotherapy or Not, Following Complete Treatment of Hepatic Cancer in Cirrhotic Patients
Besides liver transplantation, the curative treatment of primary hepatic cancer with cirrhosis remains the surgical resection. Radiofrequency or cryotherapy currently allow local ablation of small cancer, with very good results.
- Conditions
- Liver Neoplasms, Liver Cirrhosis, Carcinoma, Hepatocellular, Recurrence
- Trial name
- GEMOXIAL (NCT00470340)
- Testing
- Oxaliplatin, gemcitabine, cisplatin, lipiodol
- Where
- France
- Volunteers
- 263 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris