Clinical trials: Intravenous Therapy
Influenza
Safety and Dose Study of Peramivir for Influenza Treatment
This study will evaluate the safety and tolerability of peramivir, a new drug to treat influenza. The study will administer gradually increasing doses of the drug in successive small groups of subjects to determine the optimal…
- Trial name
- NCT00297050
- Testing
- Peramivir
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hemorrhagic Fever
Treatment of Hemorrhagic Fever With Ribavirin
Multisite protocol to provide IV Ribavirin treatment to patients with probable or suspected case of Hemorrhagic Fever with Renal Syndrome (HFRS)
- Trial name
- NCT04283513
- Testing
- Virazole
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Graves' Disease, Graves Ophthalmopathy
Coagulation After Intravenous Methylprednisolone Administration
The alterations of coagulation and fibrinolysis parameters have been described in patients with endogenous Cushing's syndrome (CS) and those treated with glucocorticosteroids (GCs).
- Conditions
- Graves' Disease, Graves Ophthalmopathy, Blood Coagulation, Venous Thromboembolism
- Trial name
- NCT03535090
- Testing
- Methylprednisolone
- Volunteers
- 26 people
- Sponsor
- Piotr Miskiewicz
HER2+ Breast Cancer
Pyrotinib Combined With Trastuzumab Subcutaneously Compared Intravenous Administration in the Treatment of HER2-positive Early Breast Cancer
This study evaluated the clinical benefits of intravenous administration of pyrotinib combined with trastuzumab subcutaneous preparation by comparing the efficacy and quality of life of intravenous administration in the treatment…
- Trial name
- NCT06537674
- Testing
- Trastuzumab intravenous drip/Trastuzumab Subcutaneous Injection
- Volunteers
- 100 people
- Sponsor
- Jiangsu Famous Medical Technology Co., Ltd.
Crohn's Disease
A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease
The main aim of this study is to learn whether vedolizumab and upadacitinib given together (also called dual targeted therapy or DTT) reduces bowel inflammation and ulcers in the bowel compared to vedolizumab only (also called…
- Trial name
- VICTRIVA (NCT06227910)
- Testing
- Vedolizumab, Upadacitinib
- Where
- 138 sites in United States, Austria and 24 more
- Volunteers
- 396 people
- Sponsor
- Takeda
Cytomegalovirus Infections, Cytomegalovirus Retinitis
Open Label Ganciclovir Therapy for Sight- or Life-Threatening Cytomegalovirus Disease in the Immunocompromised Patient
To make intravenous (IV) ganciclovir available to immunocompromised patients with life-threatening or sight-threatening Cytomegalovirus (CMV) infection, where the symptoms of the disease are too severe to allow admission to a…
- Conditions
- Cytomegalovirus Infections, Cytomegalovirus Retinitis, HIV Infections
- Trial name
- NCT00002025
- Testing
- Ganciclovir
- Where
- United States
- Sponsor
- Hoffmann-La Roche
Ischemic Stroke
Extending the Time for Thrombolysis in Emergency Neurological Deficits - Intra-Arterial
Patients presenting to the emergency department with acute ischaemic stroke, who are eligible for standard intravenous tPA therapy within 4.5 hours of stroke onset will be assessed for "dual target" major vessel occlusion and…
- Trial name
- EXTEND-IA (NCT01492725)
- Testing
- Intra-arterial Clot Retrieval with Solitaire device, intravenous tissue plasminogen activator (tPA)
- Where
- 9 sites in Australia, New Zealand
- Volunteers
- 70 people
- Sponsor
- Neuroscience Trials Australia
Postoperative Pain
Assessing the Efficacy of Intravenous Acetaminophen Versus the Oral Formulation for Perioperative Pain Treatment
To compare oral (PO) to intravenous (IV) acetaminophen with postoperative pain scores, and consumptions of opiates, among orthopedic surgery patients undergoing total knee replacement with spinal anesthesia.
- Trial name
- NCT02216682
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Massachusetts General Hospital
Hypertension, Pulmonary, Cardiac Failure
Treatment of Pulmonary Hypertension in High-risk Cardiac Surgery Patients Using Inhalational and Intravenous Agents
The aim of this study is to examine and compare the effect of Levosimendan and Milrinone administered intravenously and via inhalation respectively in cardiac surgery patients with pulmonary hypertension and right ventricular…
- Conditions
- Hypertension, Pulmonary, Cardiac Failure, Pulmonary Vascular Resistance Abnormality
- Trial name
- levos-milr (NCT04718350)
- Testing
- levosimendan at a dose of 6 mcg/kg, milrinone at a dose of 50 mcg/kg
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Aretaieion University Hospital
Intracerebral Hemorrhage
Safety of NXY-059 for the Treatment of Patients Who Have Suffered From a Stroke
This study will determine if NXY-059 is safe in patients with an acute stroke caused by bleeding in the central nervous system. The primary objective was to assess the safety and tolerability of NXY-059 compared to placebo.
- Trial name
- NCT00075959
- Testing
- NXY-059
- Where
- 64 sites in United States
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Colorectal Cancer
Radiation Therapy and Either Capecitabine or Fluorouracil With or Without Oxaliplatin Before Surgery in Treating Patients With Resectable Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine, fluorouracil, and oxaliplatin work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00058474
- Testing
- capecitabine, fluorouracil, oxaliplatin
- Volunteers
- 1,608 people
- Sponsor
- NSABP Foundation Inc
Fibromyalgia
ESKETamine for FIBromyalgia Treatment
Fibromyalgia is a cause of chronic pain, classified by the Internal Classification of Diseases (ICD) as a primary chronic pain with specific diagnostic criteria established by the American College of Rheumatology (ACR).
- Trial name
- ESKEFIB (NCT04436250)
- Testing
- Active comparator, S-Ketamine Low dose, S-Ketamine High dose
- Where
- Belgium
- Volunteers
- 23 people
- Sponsor
- Grand Hôpital de Charleroi
Hemodialysis Complication, Anemia
Intravenous Versus Oral Iron Therapy in Hemodialysis Patients
This study is aim to compare the efficacy of intravenous versus oral iron therapy regarding the hemoglobin levels, iron status and erythropoietin dosage in maintenance hemodialysis patients
- Conditions
- Hemodialysis Complication, Anemia, Iron Deficiency Anemia
- Trial name
- IVO-IRON (NCT04464850)
- Testing
- Intravenous iron, Oral iron
- Where
- Thailand
- Volunteers
- 124 people
- Sponsor
- Chiang Mai University
Carcinoma, Non-Small-Cell Lung
Xentuzumab (BI 836845) Plus Afatinib in Patients With Epidermal Growth Factor Receptor (EGFR) Mutant Non-small Cell Lung Cancer (NSCLC)
Part A: To determine the maximum tolerated dose (MTD) and/or recommended phase II dose (RP2D) of Xentuzumab (BI 836845) in combination with afatinib in patients with non-small cell lung cancer with progression following prior…
- Trial name
- NCT02191891
- Testing
- Xentuzumab, Afatinib
- Where
- 10 sites in Japan, Singapore and 2 more
- Volunteers
- 32 people
- Sponsor
- Boehringer Ingelheim
Colorectal Cancer
TACE With Irinotecan Drug-eluting Beads and Intravenous (IV) Cetuximab in Refractory Colorectal Cancer
The primary objective of this study is to evaluate the efficacy of Irinotecan Beads in combination with intravenous cetuximab versus intravenous irinotecan in combination with intravenous cetuximab in the treatment of patients…
- Trial name
- DEBIRITUX (NCT01060423)
- Testing
- Cetuximab, Irinotecan, Irinotecan eluting BEADS
- Where
- 13 sites in Germany
- Volunteers
- 8 people
- Sponsor
- Hans-Joachim Schmoll, MD
Cytomegalovirus Retinitis, HIV Infections
Valganciclovir in Patients With CMV Retinitis and AIDS Who Cannot Take Drugs by Injection
The purpose of this study is to make valganciclovir available, before it is approved for marketing, to HIV-infected patients who have cytomegalovirus (CMV) retinitis (eye infection) and cannot take drugs by injection.
- Trial name
- NCT00017784
- Testing
- Valganciclovir
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 500 people
- Sponsor
- Hoffmann-La Roche
Hepatitis c
Pegylated Interferon Plus Ribavirin in the Treatment of Active and Past Intravenous Drug Users Infected With Hepatitis C
Hepatitis C infects as many as 300,000 Canadians. Up to 25% of those infected will develop cirrhosis and be at risk for liver failure and liver cancer.
- Trial name
- NCT00203606
- Testing
- pegylated interferon alfa-2a ( Roche) and ribavirin
- Where
- 2 sites in Canada
- Volunteers
- 66 people
- Sponsor
- University of Calgary
Tremor
Intravenous Dexmedetomidine for Treatment of Shivering During Cesarean Section Under Neuraxial Anesthesia
The purpose of this study is to determine whether dexmedotomidine is effective in the treatment of shivering associated with neuraxial anesthesia during cesarean delivery.
- Trial name
- NCT02384343
- Testing
- Dexmedetomidine, Normal saline
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- St. Justine's Hospital
Diabetes Mellitus
Comparison of Fasting Blood Glucose Measurements From Fingertip and Intravenous on Patient Satisfaction in Patients With Diabetes Mellitus
The study was designed as a randomized controlled experimental study in order to compare the fasting blood glucose values measured by puncturing the fingertips and using the intravenous route of patients diagnosed with diabetes…
- Trial name
- NCT05976191
- Testing
- Patients whose blood glucose is measured intravenously and from the fingertip
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Liver Abscess
Empirical Intravenous Beta-Lactam Plus Metronidazole Vs Oral Cefixime Plus Metronidazole for the Treatment of Liver Abscess
Liver abscess (LA) is potentially life threatening medical emergency requiring prompt medical intervention. The backbone of therapy is prompt empirical antimicrobial with or without percutaneous drainage/ aspiration of the…
- Trial name
- NCT06847126
- Testing
- Intravenous beta-lactam antimicrobial for 2 weeks Plus Intravenous Metronidazole (750 mg q 8 hourly) for 2 weeks, Tablet Cefixime (200 mg q 12 hourly) for 2 weeks Plus Tablet Metronidazole (800 mg q 8 hourly) for 2 weeks, Standard medical care
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
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