Clinical trials: Intravenous Therapy
Pain, Sickle Cell Disease
Intranasal Fentanyl Versus Intravenous Morphine in the Treatment of Severe Painful Sickle Cell Crises in Children
Sickle cell anaemia is an inherited blood disorder which results in abnormal sickle shaped red blood cells which do not fit well through small blood vessels.
- Trial name
- NCT03682211
- Testing
- Fentanyl Citrate, Morphine sulphate
- Where
- Ireland
- Volunteers
- 31 people
- Sponsor
- University College Dublin
Community-acquired Bacterial Pneumonia
Efficacy and Safety Study of Intravenous to Oral Solithromycin (CEM-101) Compared to Intravenous to Oral Moxifloxacin in Treatment of Patients With Community-Acquired Bacterial Pneumonia
This study will evaluate the safety and efficacy of an experimental antibiotic, solithromycin, in the treatment of adult patients with community-acquired pneumonia.
- Trial name
- SOLITAIRE-IV (NCT01968733)
- Testing
- Solithromycin, Moxifloxacin
- Where
- 270 sites in United States, Argentina and 24 more
- Volunteers
- 863 people
- Sponsor
- Melinta Therapeutics, Inc.
Infective Endocarditis
Partial Oral Antimicrobials to Treat Infective Endocarditis in People Who Inject Drugs
Infective endocarditis (IE) is a serious infection associated with significant morbidity and mortality. Recent studies demonstrated an increased risk of infective endocarditis in people who inject drugs (PWIDs).
- Trial name
- NCT04544306
- Testing
- Partial oral antimicrobial therapy
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Colorectal Cancer, Ovarian Cancer
A Dose-finding Study of RO5323441 in Patients With Metastatic Treatment-Refractory Colorectal or Ovarian Cancer
This exploratory, open label study will assess the the dose-effect relationship, efficacy and safety of RO5323441 in patients with metastatic treatment-refractory colorectal or ovarian cancer.
- Trial name
- NCT01148758
- Testing
- RO5323441
- Where
- 3 sites in Belgium, Spain and 1 more
- Volunteers
- 7 people
- Sponsor
- Hoffmann-La Roche
Transplantation, Lung Rejection
Study to Evaluate the Safety and Efficacy of Intravenous Glassia® Treatment in Lung Transplantation
This study evaluates the safety and efficacy of intravenous GLASSIA® treatment in lung transplantation.
- Trial name
- NCT02614872
- Testing
- GLASSIA® and Institution standard of care (SOC)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Kamada, Ltd.
Bipolar Depression, Treatment Resistant Bipolar Depression
FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression
This is a prospective open-label observational study of patients with treatment resistant bipolar depression referred for intravenous ketamine, with an interventional component of fMRI.
- Trial name
- NCT06620042
- Testing
- Ketamine, Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Drew Cumming
Eosinophilic Esophagitis
Efficacy and Safety of QAX576 in Patients With Eosinophilic Esophagitis
This study is designed to investigate the effects of a 12 week course of intravenous QAX576 6mg/kg every 4 weeks in reducing the number of eosinophils in the esophagus of EoE patients by 75% or greater when compared with baseline.
- Trial name
- NCT01022970
- Testing
- QAX576
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- Novartis Pharmaceuticals
Neuropathic Pain
Intravenous Immunoglobulin (IVIG) for Resistant Neuropathic Pain
This project addresses a vexing problem that has alluded the best efforts of the medical/scientific community: treatment of resistant neuropathic pain.
- Trial name
- NCT00850005
- Testing
- Intravenous immunoglobulin, Normal Saline
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Calgary
Congestive Heart Failure, Angina
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Heart Disease
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord derived mesenchymal stem cells for the treatment of congestive heart failure and angina
- Trial name
- NCT05147766
- Testing
- AlloRx
- Where
- 2 sites in Antigua and Barbuda, Argentina
- Volunteers
- 3 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Anemia, Anemia, Iron Deficiency
Investigation of the Wash-out Effect of Intravenous Iron by Cell Savers (WASH-OUT)
The study is a pilot study, which involves cardiothoracic patients. Patients, who are scheduled for elective cardiosurgical procedure, will be seen in multidisciplinary anesthesia/Patient Blood Management (PBM) clinic and…
- Conditions
- Anemia, Anemia, Iron Deficiency, Iron Deficiency Anemia Treatment
- Trial name
- WASH-OUT (NCT04631679)
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- University Hospital Muenster
Cytomegalovirus Infections
Trial of Preemptive Treatment With Oral Valganciclovir Compared With Intravenous (IV) Ganciclovir for Cytomegalovirus Infection After Bone Marrow or Peripheral Blood Stem Cell Transplant
The purpose of this trial is to determine if preemptive therapy with oral valganciclovir is as effective as intravenous ganciclovir in clearing cytomegalovirus (CMV) viremia as determined by quantitative CMV polymerase chain…
- Trial name
- NCT00241345
- Testing
- Valganciclovir, Ganciclovir
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Washington University School of Medicine
Rheumatoid Arthritis
Introducing a Single IV Abatacept Treatment in RA Patients Currently Receiving Weekly SC Abatacept to Simulate a Holiday
RA (rheumatoid arthritis) patients effectively treated weekly with SC (subcutaneous) Abatacept will be switched to IV (intravenous) Abatacept and restarted with SC Abatacept four after IV application.
- Trial name
- A-BREAK (NCT01846975)
- Testing
- IV Abatacept
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- Rüdiger B. Müller
Ischemic Stroke
SITS (Safe Implementation of Treatments in Stroke) Open Artery by Thrombectomy in Acute Occlusive Stroke Study
Ischemic stroke, i.e. irreversible damage of a part of the patient's brain, is caused by the formation of blood clot in the major vessel which gives blood supply to a certain part of the brain.
- Trial name
- SITS Open (NCT02326428)
- Testing
- Stent retriever endovascular device for thrombectomy, Intravenous thrombolysis by alteplase (Actilyse) (optional)
- Where
- Sweden
- Volunteers
- 341 people
- Sponsor
- Karolinska Institutet
HIV, Substance Abuse, Intravenous
Contingency Management in the Delivery of HAART to Drug Users in Chennai, India
Drug use (DU) is a major risk factor for HIV infection in many regions of the world. However, as highly active antiretroviral therapy (HAART) has been rolled out in South and South East Asia, less than 2% of individuals initiated…
- Trial name
- NCT01031745
- Testing
- Contingency, Prize bowl drawings
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Johns Hopkins University
Status Epilepticus, Convulsions
Randomized Trial Comparing 3 Routes of Delivering Lorazepam to Children.
This study aims to address the hypothesis that Lorazepam (an anticonvulsant) is as effective when given via the intranasal or buccal route as the intravenous route in terminating convulsions in children.
- Trial name
- NCT00343096
- Testing
- Lorazepam
- Where
- Malawi
- Volunteers
- 800 people
- Sponsor
- Kamuzu University of Health Sciences
Acetaminophen Toxicity
Treatment of APAP Toxicity With IV and Oral NAC 2008-2011
Retrospective chart review of patients who receive N-acetylcysteine for Acetaminophen(APAP) toxicity to assess length of oral vs.
- Trial name
- NCT01465542
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Akron Children's Hospital
Bacterial Pneumonia
Comparison of Telavancin and Vancomycin for Hospital-acquired Pneumonia Due to Methicillin-resistant Staphylococcus Aureus
Study 0019 (NCT00124020) compares the safety and effectiveness of an investigational drug, telavancin, with vancomycin for the treatment of hospital-acquired pneumonia.
- Trial name
- ATTAIN2 (NCT00124020)
- Testing
- Telavancin, Vancomycin
- Where
- Israel
- Volunteers
- 771 people
- Sponsor
- Cumberland Pharmaceuticals
Junctional Epidermolysis Bullosa
Gentamicin for Junctional Epidermolysis Bullosa
Herlitz junctional epidermolysis bullosa (H-JEB), an incurable, fatal, inherited skin disease, is caused by loss-of-function mutations in the LAMA3, LAMB3 or LAMC2 genes, resulting in loss of laminin 332 and poor epidermal-dermal…
- Trial name
- NCT03526159
- Testing
- Gentamicin Sulfate
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Southern California
Acute Chest Pain
Intravenous Hydromorphone for the Treatment of Acute Pain
To observe the efficacy and safety of hydromorphone in the treatment of acute chest pain, and to explore the potential advantages of hydromorphone for analgesia in patients with acute chest pain, so as to provide more theoretical…
- Trial name
- NCT06949059
- Testing
- Hydromorphone
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Community-acquired Pneumonia (CAP), Hospital-acquired Pneumonia (HAP)
Ceftobiprole in the Treatment of Pediatric Patients With Pneumonia
This was a study of the safety and efficacy of ceftobiprole medocaril compared with intravenous (IV) standard-of-care cephalosporin treatment with or without vancomycin in pediatric patients with either hospital-acquired…
- Trial name
- NCT03439124
- Testing
- ceftobiprole medocaril, IV standard-of-care cephalosporin
- Where
- 19 sites in Bulgaria, Georgia and 2 more
- Volunteers
- 138 people
- Sponsor
- Basilea Pharmaceutica
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