Clinical trials: Intravenous Therapy
Kidney Neoplasms
EPO906 Therapy in Patients With Advanced Kidney Cancer
This study will examine whether the investigational drug EPO906, given by intravenous infusion (IV directly into the vein), is effective in shrinking tumors and preventing the growth of cells that cause kidney cancer.
- Trial name
- NCT00035243
- Testing
- epothilone b
- Where
- 8 sites in United States, France
- Volunteers
- 53 people
- Sponsor
- Novartis Pharmaceuticals
Cytomegalovirus Retinitis, HIV Infections
Suppression of Cytomegalovirus Retinitis Utilizing High Dose Intravenous Acyclovir and Oral Zidovudine in Patients With AIDS
To study the use of acyclovir (ACV) and zidovudine (AZT) in the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS who would otherwise be treated with ganciclovir (DHPG) alone.
- Trial name
- NCT00000693
- Testing
- Zidovudine, Acyclovir
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Metastatic Colorectal Cancer
Intravenous Ferric Carboxymaltose vs. Oral Iron Substitution in Patients With Metastatic Colorectal Cancer (CRC) and Iron Deficiency Anemia: a Randomized Multicenter Treatment Optimization Study.
Iron deficiency has a high prevalence in colorectal cancer patients ranging at ca. 60%. About 70% of these patients suffer from iron deficiency anemia (IDA) which adds both physical and cognitive impediments to an already…
- Trial name
- NCT02469480
- Testing
- FerInject, Ferro sanol
- Where
- 18 sites in Germany
- Volunteers
- 64 people
- Sponsor
- Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Social Determinants of Health (SDOH)
Effects of Social Determinants of Health on IV Iron Treatments
This study investigates how social determinants of health (SDOH) like income, employment, transportation, food, and housing affect patients' ability to receive IV iron treatments.
- Trial name
- SDOH IV (NCT06591182)
- Testing
- Survey using a questionnaire.
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- BayCare Health System
Alcohol Withdrawal, Alcohol Abstinence
Intravenous Acetate as an Adjunctive Treatment for Alcohol Withdrawal in Hospitalized Patients
Alcohol withdrawal syndrome is a highly morbid condition affecting a substantial percentage of patients hospitalized who have alcohol use disorders, estimated at 5-6% of all hospitalized patients.
- Conditions
- Alcohol Withdrawal, Alcohol Abstinence, Alcohol Use Disorder
- Trial name
- NCT07810946
- Testing
- Sodium Acetate
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Colorado, Denver
Benign Neoplasms, Vascular Malformations, Brain
Normal Saline Vrs Balanced i.v. Fluids in Neurosurgery
The purpose of this study was to investigate whether the balanced fluids therapy change plasma osmolality in neurosurgical procedures due to brain tumors, meningeomas and arterio-venous malformation.
- Trial name
- NCT03429127
- Testing
- Normal saline, Balanced fluid
- Where
- Croatia
- Volunteers
- 120 people
- Sponsor
- Clinical Hospital Centre Zagreb
Renal Colic
Treatment of Renal Colic in the Emergency Departement (ED).
to evaluate the analgesic effect of a standard dose of intravenous magnesium added to intramuscular diclofenac compared to intravenous lidocaine combined to intramuscular diclofenac or intramuscular diclofenac alone in patients…
- Trial name
- NCT03199924
- Testing
- Diclofenac, Magnesium Sulfate, Lidocaine
- Where
- Tunisia
- Volunteers
- 600 people
- Sponsor
- University of Monastir
Sickle Cell Disease, Vaso-occlusive Crisis
Steroid Treatment for Sickle Cell Pain Crisis
The painful episode is the most common problem experienced by children with sickle cell disease. Although various treatments are available during painful episodes, the medication most commonly given for pain is a pain medication…
- Trial name
- NCT00263562
- Testing
- Steroid arm
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Baylor College of Medicine
Dry Eye
IVIG-eye Drops Treatment for Dry Eye Disease
The main objective of this study is to establish whether patients with Dry Eye Disease are able to safely tolerate receiving Intravenous Immunoglobulin (IVIG) eye drops two times a day for eight weeks (primary 'safety and…
- Trial name
- NCT03992482
- Testing
- Intravenous Immune Globulin (IVIG)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Sandeep Jain, MD
Duchenne Muscular Dystrophy
A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)
This is a multicenter, open-label, non-randomized study to investigate the safety, tolerability, and efficacy of a single intravenous (IV) infusion of SGT-003 in participants with Duchenne muscular dystrophy.
- Trial name
- NCT06138639
- Testing
- SGT-003
- Where
- 15 sites in United States, Canada and 2 more
- Volunteers
- 60 people
- Sponsor
- Solid Biosciences Inc.
Postoperative Pain, Inflammation
Steroids in Total Knee Arthroplasty
The purpose of this study is to evaluate if the use of two small doses of intravenous (IV) steroids around the time of knee replacement surgery decrease a patient's pain or use of pain medication.
- Conditions
- Postoperative Pain, Inflammation, Osteoarthritis
- Trial name
- NCT02219581
- Testing
- Dexamethasone 10 mg, Dexamethasone 20 mg, Standard multimodal pain management regimen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Thomas L Bradbury
COVID-19
A Safety and Efficacy Study of Human Monoclonal Antibodies, BRII-196 and BRII-198 for the Treatment of Patients With COVID-19
This study is to evaluate the safety, efficacy and pharmacokinetics profile of human monoclonal antibodies, BRII-196 and BRII-198 compared with placebo in patients with COVID-19.
- Trial name
- NCT04770467
- Testing
- BRII-196 and BRII-198
- Where
- China
- Sponsor
- Brii Biosciences, Inc.
Post-Poliomyélitis Syndrom
Treatment of Post-poliomyelitis Syndrome by Intravenous Immunoglobulin
Our study evaluates the efficacy of IGIV treatment in PPS on clinical (walking and pain) and isokinetic (muscle strength) criteria, on patients with PS at Montpellier's Hospital
- Trial name
- PPS and IGIV (NCT04004390)
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Montpellier
Sydenham Chorea, Post Streptococcal Movement Disorder
Intravenous Immunoglobulins as Effective Treatment in Sydenham's Chorea
Children are at risk of developing an involuntary movement disorder after streptococcal throat infections. Not all children are affected and the severity is individually variable.
- Trial name
- NCT00615797
- Testing
- Intravenous immunoglobulin, standard interventions penicillin VK and haloperidol
- Where
- South Africa
- Volunteers
- 20 people
- Sponsor
- University of Cape Town
Acute Ischaemic Stroke
Efficacy and Security of an Endovascular Treatment as First Choice Procedure Compared With a Standard Intravenous Thrombolytic Therapy Treatment for Patients With Acute Ischemic Stroke Within 4.5 Hours After Onset
This study will compare two ways of treatment for acute ischemic stroke: an endovascular treatment (EVT), defined as intraarterial thrombolysis and/or mechanical thrombectomy as a first choice treatment versus intravenous…
- Trial name
- FUN-TPA (NCT02164357)
- Testing
- EVT (endovascular treatment ), IVT (intravenous thrombolytic therapy)
- Where
- 5 sites in Spain
- Volunteers
- 124 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Liver Transplantation, Blood Loss
Treatment of Anemia With Intravenous Iron in Patients Listed for Orthotopic Liver Transplantation
The aim of this study is to investigate whether therapy with intravenous iron carboxymaltose in patients with iron deficiency anemia (IDA) listed for orthotopic liver transplantation (OLT) increases hemoglobin concentrations and…
- Trial name
- TRAILER (NCT04475887)
- Testing
- Iron Carboxymaltose
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Colorectal Cancer, Peritoneal Metastases
Dual Administration Of Intraperitoneal And Intravenous TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy For Colorectal Cancer-Related Peritoneal Carcinomatosis: A Phase 1/2 Trial ("Chip-CRC Trial")
To find the highest dose of NK cells that can be given by vein and intraperitoneally (given directly into the abdominal cavity) in combination with cetuximab to patients with colorectal cancer that has spread to the peritoneum.
- Conditions
- Colorectal Cancer, Peritoneal Metastases, Carcinomatosis
- Trial name
- NCT07411599
- Testing
- Cyclophosphamide, Fludarabine, Cetuximab
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- M.D. Anderson Cancer Center
Pneumonia, Pneumocystis Carinii, HIV Infections
A Study of Trimetrexate in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Not Previously Treated for PCP
To evaluate the safety and effectiveness of trimetrexate (TMTX) given at increasing doses along with the leucovorin calcium (LCV) for treating Pneumocystis carinii pneumonia (PCP) in AIDS patients TMTX is an experimental new drug…
- Trial name
- NCT00000998
- Testing
- Trimetrexate glucuronate, Leucovorin calcium
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lupus
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for Lupus
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of Lupus
- Trial name
- NCT05018858
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 15 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Iron-Deficiency Anemia
Ferric Carboxymaltose in Subjects With Functional Iron Deficiency Undergoing Chemotherapy
Anaemia and functional iron deficiency are common conditions in patients with lymphoid malignancies, conditions which reduce significantly the quality of life and increase morbidity and mortality.
- Trial name
- FID-CHEMO (NCT01101399)
- Testing
- Ferric carboxymaltose
- Where
- 2 sites in Germany, Sweden
- Volunteers
- 19 people
- Sponsor
- Vifor Pharma
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