Clinical trials: Invasive Mechanical Ventilation
Acute Brain Injury, Brain Injuries
Comparison of Two Strategies for Endotracheal Tube Cuff Underinflation Prevention During Invasive Mechanical Ventilation
During invasive mechanical ventilation, maintaining endotracheal tube cuff pressure (Pcuff) around 25 cmH2O is recommended for sealing the upper airways.
- Trial name
- CONTIPRESS (NCT03330379)
- Testing
- Tracoe Smart CuffmanagerTM
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Haemodynamic Rebound
Hemodynamic Repercussions of Noninvasive Ventilation
The noninvasive ventilation (NIV) is a method of ventilatory support that does not require artificial airway. Its application is associated with complex hemodynamic repercussions, therefore is important to identify them for…
- Trial name
- NCT02139631
- Testing
- Noninvasive ventilation
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Hypoxemic Respiratory Failure, Hypercapnic Respiratory Failure
Evaluation of Conventional Non-invasive Mechanical Ventilation (NIV) Versus an Automatic Ventilation Mode.
To evaluate the polysomnographic performance of an automatic ventilatory mode compared with the gold standard (manual polysomnographic titration) to adjust chronic non-invasive ventilation by means of a randomized cross-over…
- Trial name
- NCT03872167
- Testing
- BIPAP, Intelligent automatic mode defined by assured volume with pressure support, BIPAP, manual tritration.
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Hospital Clinic of Barcelona
Respiratory Insufficiency
Compliance in Non Invasive Mechanical Ventilation
Database study of the adherence to treatment to non-invasive mechanical ventilation
- Trial name
- NCT05379309
- Where
- Denmark
- Volunteers
- 324 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Respiratory Disease, Artificial Respiration
Non-invasive Assessment of Inspiratory Effort and Tidal Distension During Non-invasive Ventilation (INSPIRE)
The goal of this observational study is to evaluate whether the airway occlusion pressure recorded during a sudden end-expiratory breath-hold (ΔPocc) is correlated with esophageal swing in pressure and the reliability of P0.1…
- Trial name
- INSPIRE (NCT06344234)
- Testing
- End-inspiratory Maneuvers
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Bari
Congestion, Venous
Hepatic Doppler to Assess Venous Congestion During Invasive Mechanical Ventilation (DOHECOV)
The purpose of the study is to investigate venous congestion using hepatic vein doppler for ICU patients with invasive mechanical ventilastion. The primary outcome is the systolic to diastolic hepatic vein velocity ratio S/D .
- Trial name
- DOHECOV (NCT06914336)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Chronic Obstructive Pulmonary Disease (COPD), Decompensated COPD With (Acute) Exacerbation
Breathing-swallowing Interaction in Chronic Obstructive Pulmonary Disease Patients - Impact of Non Invasive Ventilation
In the investigators' knowledge there are no data about the impact of non invasive mechanical ventilation on the breathing-swallowing interaction.
- Trial name
- NCT01518075
- Testing
- Spontaneous Breathing, Non Invasive Mechanical Ventilation
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
COPD, Mechanical Ventilation
Effect of Invasive and Non Invasive Mechanical Ventilation on Feeding Delivery in COPD Elderly Patients
COPD patients requiring ventilation may benefit from invasive or non invasive ventilation. Non invasive ventilation is often incompatible with oral or enteral feding, due to gastric dilatation and full mask therapy.
- Trial name
- NCT00417755
- Volunteers
- 40 people
- Sponsor
- Rabin Medical Center
Mechanical Ventilator Weaning, Critically Ill
Neurally Adjusted Ventilatory Assist for Weaning From Invasive Mechanical Ventilation in Critically Ill Children
The goal of this clinical trial is to compare weaning from mechanical ventilation in critically ill children. The main questions it aims to answer are: Will weaning with neurally adjusted ventilatory assist (NAVA) mode…
- Conditions
- Mechanical Ventilator Weaning, Critically Ill, Mechanical Ventilation, Neurally Adjusted Ventilatory Assist
- Trial name
- NCT06157593
- Testing
- NAVA
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Weaning From Mechanical Ventilation
Physiological Effects of Non-invasive Mechanical Ventilation Versus High-flow Nasal Cannula in Critically Ill Patients at High Risk of Extubation Failure
Weaning is one of the most complex challenges in mechanically ventilated patients. Increased work of breathing after extubation would play a central role in weaning failure.
- Trial name
- NCT05012696
- Testing
- Non-invasive ventilation (NIV), High-flow nasal cannula
- Where
- Chile
- Volunteers
- 22 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Mechanical Ventilation With Oral Intubation, Weaning Invasive Mechanical Ventilation
Endotracheal Suctionning During Positive Pressure Extubation in ICU
The aim of this clinical trial is to evaluate endotracheal suctioning during positive pressure extubation in mechanically ventilated adult patients (over 18 years old) in the intensive care unit (ICU).
- Conditions
- Mechanical Ventilation With Oral Intubation, Weaning Invasive Mechanical Ventilation, Oxygen Saturation Measurement, Rox Index
- Trial name
- INTENTION (NCT07130123)
- Testing
- Suctionning extubation, No suctionning Extubation
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University
Non-invasive Ventilation
Asynchronies in NIV With External Gas
NIV can be combined with other treatments that require to introduce gas into the circuit during the treatment. This external gas produces trigger asynchronies that worse depending on the model ventilator, trigger design and gas…
- Trial name
- NCT04884828
- Testing
- external gas during NIV
- Where
- Spain
- Volunteers
- 7 people
- Sponsor
- Corporacion Parc Tauli
Sepsis, Respiratory Failure
Inert Gas Rebreathing in Ventilated Patients
Measuring hemodynamic parameters in ventilated patients is important yet still complicated to perform. Inert gas rebreathing (IGR) showed promising results when being compared to other invasive as well as non-invasive techniques…
- Conditions
- Sepsis, Respiratory Failure, Heart Failure, Renal Failure
- Trial name
- VIGR (NCT01891253)
- Testing
- non-invasive determination of cardiac output
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsmedizin Mannheim
Deep Sedation
Clinical Performance of the Automated Closed-loop Minimum Viable Prototype
The goal of this clinical trial is to evaluate a minimum viable prototype for automated closed-loop administration of propofol in deep sedated patients under invasive mechanical ventilation in the ICU.
- Trial name
- NCT06187545
- Testing
- Minimum viable prototype, Usual care
- Where
- 3 sites in Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chile
COPD, Dyspnea
Deventilation Dyspnea in COPD Patients Using NIV
Non-invasive ventilation (NIV) has shown to be an effective therapy for patients with Chronic Obstructive Pulmonary Disease (COPD) with Chronic Hypercapnic Respiratory Failure (CHRF).
- Conditions
- COPD, Dyspnea, Mechanical Ventilation Complication
- Trial name
- NCT03503123
- Testing
- Monitoring physiology with Electrical Impedance Tomography, Electromyography and transcutaneous carbon dioxide measurements.
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Immunocompromised Patients, Acute Respiratory Failure
Initial Ventilation Strategy for Adult Immunocompromised Patients With Acute Respiratory Failure
VENIM is a multicenter, open-label, parallel-group randomized controlled trial of studying the initial ventilation strategy for adult immunocompromised patients with acute respiratory failure.
- Trial name
- NCT02983851
- Testing
- Noninvasive mechanical ventilation, Invasive mechanical ventilation
- Volunteers
- 238 people
- Sponsor
- Peking Union Medical College Hospital
Mechanical Ventilation Complication
Neural Pressure Support and Non-invasive Estimation of Transpulmonary Pressure in Spontaneous Ventilation Modes
The transition from controlled mechanical ventilation to assisted ventilation is one of the most complex and compromised phases of the ventilatory management during mechanical ventilation, affected by factors such as…
- Trial name
- EADITRAP (NCT05574829)
- Testing
- Esophageal manometry and monitoring of electrical activity of the diaphragm
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Critical Care, Weaning From Mechanical Ventilation
Lung Aeration During WEANing From Mechanical Ventilation Determined by Electrical Impedance Tomography and Lung Ultrasound
Evaluation of lung aeration during weaning from mechanical ventilation determined by electrical impedance tomography and lung ultrasound
- Conditions
- Critical Care, Weaning From Mechanical Ventilation, Electrical Impedance Tomography, End Expiratory Lung Volume
- Trial name
- IWEAN (NCT02361021)
- Testing
- - Weaning from mechanical ventilation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Mounier-Kuhn Syndrome
Airway Collapse in Patients With Mounier-Kuhn Syndrome: Titration With Positive Pressure to Reduce Collapse
Mounier-Kuhn syndrome (MKS), or congenital tracheobronchiomegaly, is an entity characterized by dilation of the trachea and bronchi, associated with respiratory infections.The main signs and symptoms are cough, bulging and…
- Trial name
- NCT03101059
- Testing
- Non invasive ventilation - Continuous Positive Airway Pressure
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo General Hospital