Clinical trials: Investigation Time
Cytomegalovirus Infections, Cytomegalovirus Disease
Letermovir Prophylaxis Duration Guided by CMV-Specific T-cell Monitoring After Allo-HSCT.
The purpose of this study is to evaluate the efficacy and safety of a personalized strategy for discontinuing Letermovir (a drug used to prevent Cytomegalovirus [CMV] infection) based on the recovery of the patient's own immune…
- Conditions
- Cytomegalovirus Infections, Cytomegalovirus Disease, Hematopoietic Stem Cell Transplantation, Graft vs Host Disease
- Trial name
- NCT07569653
- Testing
- CMV-Specific T-cell Guided Letermovir Discontinuation, Standard Letermovir Prophylaxis
- Where
- 12 sites in China
- Volunteers
- 120 people
- Sponsor
- WeiShi
Parkinson's Disease
A Study of Istradefylline (KW-6002) in Treating Patients With Parkinson's Disease on Levodopa
To establish the efficacy of 10, 20 and 40 mg/d dose of istradefylline for reducing the percentage of OFF time in patients with advanced Parkinson's disease (PD) treated with levodopa.
- Trial name
- NCT00199420
- Testing
- Istradefylline (KW-6002)
- Where
- 2 sites in United States
- Volunteers
- 580 people
- Sponsor
- Kyowa Kirin, Inc.
Heart Failure
Assessment of Cardiac Resynchronization Therapy in Patients With Wide QRS and Non-specific Intraventricular Conduction Delay: a Randomized Trial
The aim of the NICD-CRT study is to assess whether CRT may be clinically beneficial in HF patients with NICD and reduced ejection fraction on 12-month HF status.
- Trial name
- NICD-CRT (NCT02454439)
- Testing
- CRT implantation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand
Mental Health in Expectant First-time Fathers
An Intervention Study to Evaluate a Website Tailored to New Dads to Promote Mental Health
The purpose of this study is to develop and pilot test HealthyDads.ca, a website for expectant first-time fathers who have known risk factors for depression.
- Trial name
- NCT02503670
- Testing
- Psychoeducational modules to prevent/reduce depression, Control Group
- Where
- 3 sites in Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- McGill University
Typhoid Fever
Safety and Immunogenicity of a Novel Conjugate Vaccine Against Salmonella Typhi and Salmonella Paratyphi A in Healthy Adults
A bivalent Typhoid and Paratyphoid A conjugate investigational vaccine aimed to prevent both typhoid and paratyphoid enteric fever in infants and older age groups has been developed by GlaxoSmithKline (GSK).
- Trial name
- NCT05613205
- Testing
- TYP04A Low Dose without Alum investigational vaccine, TYP04B Full Dose without Alum investigational vaccine, TYP03A Low Dose with Alum investigational vaccine
- Where
- Belgium
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Intubation, Expected Duration of Ventilation > 48h
Evaluation of a Closed Suction System to Remove Secretions From the Endotracheal Tube
Cleaning the endotracheal tube with a specifically designed device results in lower amount of secretions at extubation, assessed by micro CT scan
- Trial name
- NCT01912105
- Testing
- Airway medix closed suction system, standard closed suctioning systems
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Accelerometry
A Smartphone Application to Evaluate Energy Expenditure and Duration of Activities in Free-living Conditions (eMouve2)
The aim of this study was to validate functions for estimating energy expenditure in free-living conditions. This method was based on accelerometry data acquired from a smartphone worn in a trouser pocket.
- Trial name
- NCT01995162
- Testing
- Energy expenditure estimation
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Gastroparesis
A Study to Evaluate Safety, Side Effects, Muscle Activity and Speed of Gastric Emptying of GSK962040
Motilin is a peptide whose action is controlled by motilin receptors located in the gut. Action of Motilin at motilin receptors increases the gastric emptying rate (rate of emptying of food and fluid from the stomach).
- Trial name
- NCT00562848
- Testing
- GSK962040
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Anterior Shoulder Dislocation, Shoulder Dislocation Closed Traumatic
Shoulder Dislocation: Assessment of Lesions, Trajectories and Outcomes (SALTO)
The goal of this prospective observational cohort study is to provide epidemiological and prognostic data from a defined urban population and to improve understanding of risk factors and long-term outcomes following first-time…
- Conditions
- Anterior Shoulder Dislocation, Shoulder Dislocation Closed Traumatic, First Time Shoulder Dislocation, Shoulder Instability
- Trial name
- SALTO (NCT07486440)
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Oslo University Hospital
Hepatic Encephalopathy, Acute on Chronic Liver Failure (ACLF)
A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic Encephalopathy
A Phase 2, Randomized, Controlled, Open-Label, Adaptive Dose Design, Proof-of-Concept Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Two Different Dwell Times of VS-01 on Top of Standard of Care versus Standard…
- Conditions
- Hepatic Encephalopathy, Acute on Chronic Liver Failure (ACLF), Decompensated Cirrhosis
- Trial name
- NCT06987968
- Testing
- VS-01 on top of SOC (Active Treatment Group), SOC
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 3 people
- Sponsor
- Genfit
Sleep
Cannabis Association With Sleep Study
The purpose of this study is to learn more about cannabis use, sleep, and stress, and whether there is any relationship between the three.
- Trial name
- CaSS (NCT06982950)
- Testing
- Manipulation of Sleep Duration
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Colic, Infantile, Crying Time in Colicky Infants
The Effect of Colic Massage and Kangaroo Care on Babies and Their Mothers
Background: Infantile colic is a condition characterized by inconsolable crying in infants under three months of age. Purpose: The aim of this study is to determine the effects of colic massage and kangaroo care on infantile…
- Conditions
- Colic, Infantile, Crying Time in Colicky Infants, Postpartum Depression, Postpartum Anxiety
- Trial name
- randomized (NCT06727760)
- Testing
- massage, kangroo care
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Gulsah Sunay Ertem
Foot and Ankle Procedures
Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery
The purpose of this research study to evaluate the effects of dexamethasone as an addition to peripheral nerve block (Put the nerve to sleep with Bupivacaine a numbing medication) on length of pain relief (analgesia)…
- Trial name
- NCT01975285
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Polyp, Colorectal
Colorectal Polyp Clinical Decision Support Device Study
The study objective is to establish the efficacy of the colorectal polyp Clinical Decision Support Device (CDSD) in clinical use.
- Conditions
- Polyp, Colorectal, Colonoscopy
- Trial name
- CDSD (NCT04437615)
- Testing
- Colonoscopy, Clinical Decision Support Device
- Where
- United States
- Volunteers
- 2,379 people
- Sponsor
- Olympus Corporation of the Americas
Breast Cancer, Cancer of the Breast
Real-time Intraoperative Breast Cancer Visualization for Margin Assessment
The investigators' preclinical data have demonstrated the feasibility of fluorescence-guided tumor resection by Cancer Vision Goggles (CVG) with LS301 in animal models.
- Trial name
- NCT02807597
- Testing
- LS301, Cancer Vision Goggles and standard fluorescence imaging systems, Surgery
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Samuel Achilefu
Hypertension
A Study to Identify an Optimal Dose of QCZ484 in Mild to Moderate Hypertensive Patients
The purpose of this study is to evaluate the efficacy, safety and tolerability of QCZ484 or placebo, given subcutaneously, every 6 months, at different dose levels in patients with mild to moderate hypertension
- Trial name
- NCT06857955
- Testing
- Saline, QCZ484
- Where
- 72 sites in United States, Japan and 1 more
- Volunteers
- 396 people
- Sponsor
- Novartis Pharmaceuticals
Short Bowel Syndrome, Parenteral Nutrition Associated Liver Disease
Study of NST-6179 in Healthy Subjects
A double-blind, randomized, placebo controlled, single and multiple oral dose study to assess safety and tolerability of single and multiple doses of NST-6179 in healthy male and female subjects.
- Trial name
- NCT05181085
- Testing
- NST 6179
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- NorthSea Therapeutics B.V.
Mixed Dentition Using Sequential Dental Aligners
This Study Will Examine Shortened Treatment Wear Time for Patients With Mixed Dentition Using AirFlex Aligner, Sequential Dental Aligners.
This study will examine shortened treatment wear time for patients with mixed dentition using sequential dental aligners. Using the existing AirFlex aligner design that patients with permanent dentition use, it may be possible to…
- Trial name
- NCT07220317
- Testing
- Sequential Aligners
- Volunteers
- 45 people
- Sponsor
- OrthoFX
Parkinson Disease
A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations
This is a Phase 2 study in people with Parkinson's disease who experience motor fluctuations while taking levodopa. The study will evaluate how effective two different doses of the study drug AP-472 are when added to levodopa…
- Trial name
- NCT07432958
- Testing
- AP-472
- Where
- 30 sites in United States
- Volunteers
- 150 people
- Sponsor
- Appello Pharmaceuticals, Inc.
Cerebral Palsy
WittyChildren - Advanced Technology for Response Time Evaluation in Children Affected by Developmental Disorders
The WittyChildren project aims to evaluate the response to visual stimuli in terms of reaction times and movement execution using advanced instruments.
- Trial name
- NCT07240740
- Testing
- The WittySEM system, in addition to simultaneously allowing the evaluation of the movement associated with the execution of the task, also provides for an active and "play-like" involvement of the sub
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Eugenio Medea
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