Clinical trials: Investigation Time
Medication Adherence, Antibiotic Resistance, Microbial
7-VINCut Antibiotic Stewardship Intervention to Decrease Duration of Antibiotic Treatment and Carbapenem Use in Surgery
Antimicrobial resistance (AMR) is one of the top ten public health threats facing humanity. The misuse and overuse of antibiotics has been identified as a major factor in the development of drug-resistant pathogens, and 30% of…
- Conditions
- Medication Adherence, Antibiotic Resistance, Microbial, Medication Errors and Other Product Use Errors and Issues
- Trial name
- 7_VINCUT (NCT05813821)
- Testing
- Antimicrobial stewardship in surgery
- Where
- Spain
- Volunteers
- 32,499 people
- Sponsor
- Hospital de Granollers
Normal Pregnancy
Determination of Reference Values for Diluted Russell's Viper Venom Time (dRVVT) Specific to Pregnant Women (GRAPL)
Pregnancy is associated with significant changes in several aspects of haemostasis, especially an imbalance between procoagulant and anticoagulant factors.
- Trial name
- GRAPL (NCT06133621)
- Testing
- dosage dRVVT
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Cocaine-Related Disorders
Evaluation of N-Acetylcysteine Efficacy to Reduce the Craving and to Prolong Abstinence Time of Coca Paste
Introduction: The Cocaine Base Paste (or Coca Paste or CBP), a highly toxic and addictive smokable drug (a by-product of the cocaine extraction chain), has become in the last years a real social scourge for Chile.
- Trial name
- NAC-PBC (NCT03556371)
- Testing
- N-Acetylcysteine
- Where
- 5 sites in Chile
- Volunteers
- 140 people
- Sponsor
- University of Concepcion, Chile
Occlusal Caries
Evaluation of Clinical Performance of 3D Printed Polyether Ether Ketone (PEEK) Inlays
In patients using Inlay restorations will the use of 3D printed PEEK material and technique have superior clinical performance to milled PEEK one or to milled composite resin inlays, evaluation of restorations will be done at…
- Trial name
- NCT04532671
- Testing
- Poly ether ether ketone (PEEK), CADCAM Poly ether ether ketone (PEEK), indirect resin composite
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Drunk Driving, Alcohol Drinking
Design and Evaluation of an In-Vehicle Real-Time Drunk Driving Detection System
To analyze driving behavior of individuals under the influence of alcohol while driving in a real car. Based on the in-vehicle variables, the investigators aim at establishing algorithms capable of discriminating sober and drunk…
- Conditions
- Drunk Driving, Alcohol Drinking, Impaired Driving
- Trial name
- DRIVE (NCT05796609)
- Testing
- Driving under the influence of alcohol
- Where
- Switzerland
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Bern
Neutropenia, Breast Cancer
Open-Label, Phase 1 Study to Evaluate Duration of Severe Neutropenia After Same-Day Dosing of Eflapegrastim in Patients With Breast-Cancer
The purpose of this study is to compare the effect of Eflapegrastim on duration of neutropenia in patients with early-stage breast cancer when administered at varying intervals following Docetaxel and Cyclophosphamide…
- Trial name
- NCT04187898
- Testing
- Eflapegrastim, Docetaxel, Cyclophosphamide
- Where
- 8 sites in United States
- Volunteers
- 59 people
- Sponsor
- Spectrum Pharmaceuticals, Inc
Hepatitis B, Hepatitis A
Long Term Follow-up Study at Years 2, 3, 4 and 5 Where 2 Dosing Schedules of the Combined Hepatitis A and B Vaccine Were Compared
To evaluate the persistence of anti-hepatitis A virus (HAV) and anti-hepatitis B surface antigen (HBs) antibodies up to 2, 3, 4 and 5 years after administration of the first dose of the study vaccine.
- Trial name
- NCT00197184
- Testing
- Twinrix™ Adult, Twinrix™ Junior
- Where
- 7 sites in Australia, Belgium and 1 more
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acute Compartment Syndrome
Real-time Soft Tissue Assessment Using a Technologically Advanced pH Monitoring System
Acute Compartment Syndrome (ACS) can occur when there is a gradual reduction in the blood supply to injured limbs, most commonly after fractures or crush injuries.
- Trial name
- SoftpH (NCT04725604)
- Testing
- pH probe
- Where
- 7 sites in United Kingdom
- Volunteers
- 150 people
- Sponsor
- University of Aberdeen
Arterial Occlusion, Angina Pectoris
Comparing TR Band to Statseal in Conjunction With TR Band
The primary objectives of this study are to evaluate the performance of StatSeal Advanced used in conjunction with the TR Band (SSA) as compared to the TR Band without SSA (TRB) relative to: the incidence of peri-procedural…
- Conditions
- Arterial Occlusion, Angina Pectoris, Cardiovascular Diseases, Atherosclerosis
- Trial name
- NCT03028025
- Testing
- StatSeal, TR Band
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- VA Long Beach Healthcare System
Spinal Cord Injuries, Neurogenic Bladder
Detrusor Activity Recovery in Acute Traumatic Spinal Cord Injuries
Determining the most appropriate time to evaluate detrusor activity in urodynamic studies for both traumatic and non-traumatic spinal cord injuries
- Conditions
- Spinal Cord Injuries, Neurogenic Bladder, Spinal Shock
- Trial name
- NCT05207826
- Testing
- Cystometrogram
- Sponsor
- Pusan National University Yangsan Hospital
Athlete Assessment, Archery
Validity and Test-Retest Reliability of Reactive Neurocognitive Upper Extremity Tests in Archers
In archery, the evaluation of reaction time and neurocognitive functions plays a critical role in the management of upper extremity (UE) injuries and return-to-play (RTP) processes.
- Conditions
- Athlete Assessment, Archery, Neurocognitive Functional Performance Tests
- Trial name
- NCT07103824
- Testing
- Upper Extremity Neurocognitive Tests
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Mantle Cell Lymphoma
Efficacy and Safety of Obinutuzumab Preemptive Treatment at the Time of the Molecular Relapse
The objective of the study is the evaluation of efficacy and safety of obinutuzumab preemptive treatment at the time of the molecular relapse after first line immunochemotherapy with autologous stem cell transplantation in mantle…
- Trial name
- OPERA-PLRG10 (NCT03229382)
- Testing
- Obinutuzumab
- Where
- Poland
- Volunteers
- 1 people
- Sponsor
- Polish Lymphoma Research Group
Chronic Pain
Elosan Efficacy Study (EES)
The "Elosan Cabin" is a closed, electrically insulated, biocompatible cabin for the short-term application of electrostatic high voltage in patients with chronic pain, especially those with rheumatic diseases.
- Trial name
- NCT03823729
- Testing
- Elosan Cabin
- Where
- 3 sites in Switzerland
- Volunteers
- 39 people
- Sponsor
- Elosan AG
Intubation; Difficult or Failed, Sore-throat
Intubation with Different Angled Intubation Tubes Using C-macr D Blade Videolaringoscope;
In this study we compared post-operative sore throat, ease and time of intubation, hoarseness, subglottic damage and hemodynamic changes to orotracheal intubation using three different intubation stylets with C-MAC R…
- Conditions
- Intubation; Difficult or Failed, Sore-throat, Hoarseness
- Trial name
- NCT06011967
- Testing
- Intubation using C-MAC D blade videolariyngoscope
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Gallbladder; Functional Disturbance
The Optimal Measurement Time for the New Gallbladder Function Assessment Method
This is a multicenter, prospective, randomized, double-blind, crossover study involving healthy individuals, aiming to evaluate the stability of oral protein bars + olive oil as a new method for determining gallbladder…
- Trial name
- NCT07321431
- Testing
- oral administration of 2 fried eggs, oral protein bars + 50ml olive oil
- Where
- 5 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Clinical Study to Evaluate the Impact of the Accu-Chek SmartGuide CGM Solution on the Mean Change in Time in Range Compared With Self-Monitoring of Blood Glucose in Participants With Type 1 and Type 2 Diabetes Mellitus
This is an open label, two-arm, randomized multi-center clinical device study in adult subjects with Type 1 diabetes (T1D) or insulin-dependent Type 2 diabetes (T2D) on a multiple daily injection (MDI) regime.
- Trial name
- NCT06704672
- Testing
- Accu-Chek SmartGuide CGM Solution, Accu-Chek SmartGuide Sensor and Blinded Apps, SMBG Device
- Where
- 20 sites in Poland, Turkey (Türkiye)
- Volunteers
- 270 people
- Sponsor
- Hoffmann-La Roche
Diabetes Mellitus
Closed-loop Insulin Delivery in the General Ward
The study assesses the efficacy and safety of closed-loop glucose control in patients with insulin-treated type 2 diabetes. Phase 1 The study objective is to compare conventional insulin therapy with closed-loop glucose control…
- Trial name
- ANGIE02 (NCT01774565)
- Testing
- Fully Automated Closed-Loop Insulin Delivery, Conventional insulin therapy
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 43 people
- Sponsor
- University of Cambridge
Hematologic Diseases, Anaemia, Sickle Cell
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Oral GSK4172239D Compared With Placebo in Sickle Cell Disease Participants Aged 18 to 50 Years
This will be a first time in human (FTIH) study in sickle cell diseases (SCD) participants. The FTIH study is planned to evaluate the safety, tolerability, and pharmacokinetics of GSK4172239D.
- Trial name
- NCT05660265
- Testing
- GSK4172239D
- Where
- 6 sites in United States
- Volunteers
- 11 people
- Sponsor
- GlaxoSmithKline
Low Back Pain, Osteoarthritis
Long-term Open-Label Safety Study to Evaluate EN3409
The purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of EN3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended…
- Conditions
- Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01755546
- Testing
- EN3409
- Where
- 57 sites in United States
- Volunteers
- 304 people
- Sponsor
- BioDelivery Sciences International
Pulmonary Tuberculosis
Evaluation of 8 Weeks of Treatment With the Combination of Moxifloxacin, PA-824 and Pyrazinamide in Patients With Drug Sensitive and Multi Drug-Resistant Pulmonary Tuberculosis (TB) (NC-002)
The purpose of this study is to assess the mycobactericidal activity of the moxifloxacin plus PA-824 plus pyrazinamide regimen after 8 weeks of treatment.
- Trial name
- NCT01498419
- Testing
- Moxifloxacin (M), Pretomid (Pa), Pyrazinamide (Z)
- Where
- 8 sites in South Africa, Tanzania
- Volunteers
- 207 people
- Sponsor
- Global Alliance for TB Drug Development
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